Subject Index Research Articles

Index of Subjects

Index of Subjects

Subject Index to Volume 48

Subject Index to Volume 48

Dominant Characteristics of Subject Categories in a Multiple-Category Hierarchical Scheme: A Case Study of Scopus

The Scopus journal classification method, known as All Science Journal Classification (ASJC), follows a hierarchical organization of subject categories: minor, major, and supergroups. At the minor level, journals are assigned to one or more subject categories. We refer to this classification scheme as a multiple-category hierarchical scheme. The objective of this study is to investigate the dominant characteristics of subject categories within the Scopus database and quantify their dominance using various subject indices. To conduct the study, we formulated a set of subject category indices, including the Number of Journals (J), Total Instances of Subject Categories (SC), Number of Unique Subject Categories (USC), and Dominance Index (DOMI). The results showed that high DOMI values in subject categories indicate specialization and limited associations with other fields. There were minimal correlations between DOMI and other subject category indices like J, SC, and USC, demonstrating their uniqueness and independence. The study also revealed that subject categories within the Health Sciences exhibited higher DOMI values and greater specialization compared to those in the Physical Sciences, indicating a pronounced dominance in Health Sciences minor categories. Finally, minor subject categories exhibited more variation in subject category indices compared to their upper-level subject categories, highlighting the intricate variations within the hierarchical system of the Scopus classification. These findings have implications for researchers, emphasizing the need to consider a subject category’s dominance and associations when selecting journals for their research.

Comparative Evaluation of Lipid Accumulation Product, and Triglyceride-Glucose Indices in Apparently Healthy Subjects in Predicting Cardiovascular Risks in Port-Harcourt

Lipid accumulation product is a novel biomarker of central lipid accumulation related to the risk of diabetes and cardiovascular diseases. In certain metabolic diseases, insulin resistance is often present which could be attributed to an abnormality in the insulin-specific receptors in various tissues, obesity, or visceral adiposity. This study aimed at determining the triglyceride–glucose index and lipid accumulation product index of apparently healthy individuals in Port Harcourt. A total of 150 healthy individuals were assessed for anthropometric and biochemical measurement, lipid accumulation production (LAP), and triglyceride --glucose index TyG. Comparison of mean values of biophysical variables body mass index (BMI), lipid accumulation product indices, cardiovascular, triglyceride–glucose index, insulin, C-peptide, glycated haemoglobin (HbAIC), Fasting blood sugar (FBS), and Body Mass Index (BMI) of male and female subjects were measured using standard procedures. A detailed comparison of mean values of biophysical variables of male and female subjects shows that the mean age for the male subjects (41.55±6.99 years) was significantly higher (p=0.0159) when compared to the mean age for female subjects (39.04±5.6 years. There was no significant difference in the mean weight, height, BMI, waist circumference, SBP, DBP, T. Chol, triglyceride, HDL, LDL, C-peptide level, HbAIc, FBS level, T. CHOL/HDL ratio, T. CHOL/LDL ratio, and TyG index between the male and female subjects. However, there was a significantly higher level of insulin for male than female subjects and higher LAP for female than male subjects. Also, there was a higher HOMA-R for male subjects than female subjects. Additionally, there was a positive correlation between BMI and the following; mean age, systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), and insulin levels. The Receiver's Operating Characteristics (ROC) curve for the LAP test had a high AUC value of 0.9970. Similarly, the ROC curve analysis of the TyG test had a high AUC of 0.8344. However, these findings emphasize the LAP test has a stronger discriminatory ability than TyG. Healthy individuals may have the cardiovascular risk of being evaluated by LAP, which is very cost-effective.

Automating subject indexing at ZBW

Subject indexing, i.e., the enrichment of metadata records for textual resources with descriptors from a controlled vocabulary, is one of the core activities of libraries. Due to the proliferation of digital documents, it is no longer possible to annotate every single document intellectually, which is why we need to explore the potentials of automation on every level. At ZBW the efforts to partially or completely automate the subject indexing process started as early as 2000 with experiments involving external partners and commercial software. The conclusion of that first exploratory period was that commercial, supposedly shelf-ready solutions would not suffice to cover the requirements of the library. In 2014 the decision was made to start doing the necessary applied research in-house which was successfully implemented by establishing a PhD position. However, the prototypical machine learning solutions that they developed over the following years were yet to be integrated into productive operations at the library. Therefore in 2020 an additional position for a software engineer was established and a pilot phase was initiated (planned to last until 2024) with the goal to complete the transfer of our solutions into practice by building a suitable software architecture that allows for real-time subject indexing with our trained models and the integration thereof into the other metadata workflows at ZBW. In this paper we address the question of how to transfer results from applied research into a productive service, and we report on the milestones we have reached so far and on those that are yet to be reached on an operational level. We also discuss the challenges we were facing on a strategic level, the measures and resources (computing power, software, personnel) that were needed in order to be able to affect the transfer, and those that will be necessary in order to subsequently ensure the continued availability of the architecture and to enable a continuous development during running operations. We conclude that there are still no shelf-ready open source systems for the automation of subject indexing – existing software has to be adapted and maintained continuously which requires various forms of expertise. However, the task of automation is here to stay, and librarians are witnessing the dawn of a new era where subject indexing is done at least in part by machines, and the respective roles of machines and human experts may shift even further and more rapidly in a not-so-distant future. We argue that in general, the format of “project” and the mindset that goes with it may not suffice to secure the commitment that an institution and its decision-makers and the library community as a whole will have to bring to the table in order to face the monumental task of the digital transformation and automation in the long run. We also highlight the importance of all parties – applied researchers, software engineers, stakeholders – staying involved and continuously communicating requirements and issues back and forth in order to successfully create and establish a productive service that is suitable and equipped for operation.

Subject and Author Index.

Subject and Author Index.

Subject and Drug Indexes to Adverse Drug Reaction Bulletin: Nos 338–343 February 2023 – December 2023

Subject and Drug Indexes to Adverse Drug Reaction Bulletin: Nos 338–343 February 2023 – December 2023

SUBJECT INDEX

SUBJECT INDEX

Prevention of limb function deterioration in patients with cerebral infarction by clinical nursing pathway management

Objective: To analyze the application effect of clinical nursing pathway in patients with cerebral infarction (CI) and its influence on the deterioration of limb function, so as to find effective prevention methods. Methods: A total of 80 patients with CI admitted to our hospital from November 2020 to May 2022 were included in the study. The subjects were divided into two groups based on different nursing interventions, with one group receiving clinical nursing pathway intervention, referred to as the nursing group (n = 40), and the other group receiving standard nursing care, referred to as the routine group (n = 40). The limb function, neurological function, mobility and quality of life before and after intervention were analyzed, and the incidence of safety endpoints after 3 months of follow-up was observed. Results: The results showed that before the intervention, there were no significant differences in each function and index of the study subjects (p>0.05). After the intervention, the limb function, neurological function, mobility and quality of life of the two groups were higher than those before the intervention, and the degree of improvement was higher in the nursing group (p<0.05). At the same time, the adverse events in the nursing group were significantly less than those in the conventional group (p<0.05). Conclusion: It is suggested that clinical nursing management pathway can significantly reduce the deterioration of limb function of patients with CI, improve their mobility and quality of life, which is worthy of clinical promotion.

Author Index and Subject Index

Author Index and Subject Index

Peripapillary Vascular Density in Childhood Glaucoma: A Pilot Comparative Study with Age and Sex Matched Healthy Subjects.

The aim of this study concerns the evaluation of peripapillary vessel indices in childhood glaucoma (CG) and healthy subjects. In this prospective, unicenter, observational cross-sectional study, patients with CG and age and sex-matched healthy subjects were included. We compared retinal nerve fiber layer (RNFL) measurements in optical coherence tomography (OCT), peripapillary vessel density (PVD), and the flux index (FI) of the superficial vascular plexus from OCT angiography (OCT-A) between CG patients and control groups. We included 39 patients (68 eyes) with CG and 50 (95 eyes) healthy subjects. The peripapillary RNFL thickness, vessel density, and flux index were significantly lower in the CG group than in the control group. The mean PVD of CG patients was 0.52 ± 0.043%, compared with 0.55 ± 0.014%, p < 0.0001 in healthy subjects. The mean FI was 0.32 ± 0.054 versus 0.37 ± 0.028, p < 0.0001, in CG patients and healthy subjects, respectively. PVD and FI in the superior, inferior, and temporal sectors were significantly lower in CG. The peripapillary RNFL thickness showed a higher area under the ROC curve (AUROC) for discriminating healthy and CG eyes and was significantly different than the PVD (0.797, 95%CI 0.726-0.869; p < 0.0001 vs. 0.664, 95%CI 0.574-0.752; p 0.00037), p 0.012. PVD and FI show lower values in CG and correlate with RNFL thickness measurement but have lower diagnostic ability than RNFL thickness measurement. Our results reveal possible differences in the pathogenesis of microvascular compromise in childhood glaucoma patients.

Subject Index to Volume 36

Subject Index to Volume 36

Association between triglyceride glucose-body mass index and heart failure in subjects with diabetes mellitus or prediabetes mellitus: a cross-sectional study.

The triglyceride glucose-body mass index (TyG-BMI) is a surrogate indicator of insulin resistance. However, the association of TyG-BMI with heart failure (HF) in individuals with diabetes mellitus or prediabetes mellitus is unknown. This study included 7,472 participants aged 20-80 years old with prediabetes or diabetes from the National Health and Nutrition Examination Survey (2007-2018). The TyG-BMI was calculated as Ln [triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2] × BMI, and individuals were categorized into tertiles based on TyG-BMI levels. The relationship of TyG-BMI with HF was analyzed using multiple logistic regression models. Subgroup analyses were stratified by gender, age, hypertension, and diabetes mellitus status. This cross-sectional study had 7,472 participants (weighted n = 111,808,357), including 329 HF participants. Participants with a high TyG-BMI were prone to HF. The highest tertile group with a fully adjusted model was more likely to have HF compared to the lowest tertile group (odds ratio [OR], 2.645; 95% CI, 1.529-4.576). Restricted cubic spline analysis showed a significant dose-response relationship between TyG-BMI and HF (P < 0.001). In subgroup analyses, similar results were seen in terms of age (≥50 years old), gender, hypertension, and diabetes mellitus status. A high TyG-BMI is significantly associated with HF risk in participants with diabetes mellitus or prediabetes mellitus.

The Effects of Bovine Colostrum on the Stress-Hyperglycemia Ratio and the Triglyceride-Glucose Index in Exercise-Trained Healthy Subjects: A Double-Blind, Placebo-Controlled Clinical Study

Bovine colostrum (BC) is a natural substance that has been shown of benefits for exercising, and reducing the blood glucose levels in type 2 diabetes. Stress hyperglycemia is a brief rise in blood glucose levels caused by physiological stress. This placebo-controlled clinical study aimed to investigate the effects of BC on stress hyperglycemia and the triglyceride-glucose index in healthy subjects who trained in resistance exercise. This research was carried out at Al-Kut University College from April 30th to November 30th, 2022. Fifty healthy young men were randomly assigned: Group I (n = 24) received a placebo, whereas Group II (n = 26) received a 500mg single oral dosage of BC nutraceutical pill. During the treatment period, both groups of volunteers engaged in resistance exercise training. Body mass index (BMI), waist circumference (WC), stress glucose ratio (SGR), triglyceride-glucose index (TyGI), and rate pressure product (as a hemodynamic response) were all measured at the start and end of the eight-week study.‎ Stress blood glucose levels were considerably higher in Group II following resistance training (89.0±6.5 vs 102.1±11.5mg/dL, p&lt;0.001), whereas stress HbA1c% did not alter (4.70±0.25 vs 4.66±0.29, p=0.608). Bovine colostrum significantly increases the SGR from 1.01±0.03 to 1.18±0.13, p&lt;0.001. The TyGI at the stress glucose level was increased by 2.7%. We conclude that bovine colostrum significantly elevates the stress hyperglycemic ratio without inducing significant changes in the TyGI following exercise. This impact is accompanied by a stabilizing hemodynamic response.&#x0D; &#x0D;

An Effective and Universal Long-Read Sequencing-Based Approach for SMN1 2 + 0 Carrier Screening through Family Trio Analysis

Abstract Background Population-wide carrier screening for spinal muscular atrophy (SMA) is recommended by professional organizations to facilitate informed reproductive options. However, genetic screening for SMN1 2 + 0 carriers, accounting for 3%–8% of all SMA carriers, has been challenging due to the large gene size and long distance between the 2 SMN genes. Methods Here we repurposed a previously developed long-read sequencing-based approach, termed comprehensive analysis of SMA (CASMA), to identify SMN1 2 + 0 carriers through haplotype analysis in family trios (CASMA-trio). Bioinformatics pipelines were developed for accurate haplotype analysis and SMN1 2 + 0 deduction. Seventy-nine subjects from 24 families composed of, at the minimum, 3 were enrolled, and CASMA-trio was employed to determine whether an index subject with 2 SMN1 copies was a 2 + 0 carrier in these families. For the proof-of-principle, SMN2 2 + 0 was also analyzed. Results Among the 16 subjects with 2 SMN1 copies, CASMA-trio identified 5 subjects from 4 families as SMN1 2 + 0 carriers, which was consistent with pedigree analysis involving an affected proband. CASMA-trio also identified SMN2 2 + 0 in six out of 43 subjects with 2 SMN2 copies. Additionally, CASMA-trio successfully determined the distribution pattern of SMN1 and SMN2 genes on 2 alleles in all 79 subjects. Conclusions CASMA-trio represents an effective and universal approach for SMN1 2 + 0 carriers screening, as it does not reply on the presence of an affected proband, certain single-nucleotide polymorphisms, ethnicity-specific haplotypes, or complicated single-nucleotide polymorphism analysis across 3 generations. Incorporating CASMA-trio into existing SMA carrier screening programs will greatly reduce residual risk ratio.

Author and Subject Index.

Author and Subject Index.

88 Considering Lateralization and Localization of Neurosurgical Intervention for Predicting Treatment Response to Computerized Cognitive Remediation (CCR) Targeting Attention and Working Memory: A Case Series

Objective:Lateralization and localization of neuropathology helps determine the extent to which eloquent cortex and diseased brain tissue share loci, important information for neurosurgical decision-making, and predicting neurocognitive outcomes. Emerging data suggest that lateralization and localization can inform specific neurorehabilitation approaches following acquired brain injury (ABI). In recent years, computerized cognitive remediation (CCR) of attention and working memory (WM) has been included among treatment guidelines to enhance cognition in post-acute recovery following ABI. Although CCR has shown promise for improving attention and executive functioning in ABI, it is unknown how treatment response may be predicted by locus of ABI. Even less is known about the effects of CCR following neurosurgery. The current study explores neurosurgical lateralization and localization as potential variables for predicting treatment response to CCR.Participants and Methods:Adult patients with a variety of neurological diagnoses (N = 17; ∼47% women) completed a full course of Cogmed Working Memory Training (CWMT) s/p neurosurgical intervention. All participants engaged in 30 sessions of CWMT over eight weeks, as well as neuropsychological (NP) assessment at pre-training baseline, immediate post-training, and at 3-month follow-up. Objective and subjective indices of attention, working memory, executive functioning, and emotional well-being were evaluated at three time-points. Neurosurgical loci included left-hemisphere frontal, temporal, and temporoparietal lobes, as well as right-hemisphere frontal, frontotemporal, and temporal lobes.Results:NP data were reviewed and yielded a clinical impression of cognitive and affective functioning for a cohort of patients with heterogeneous diagnoses (e.g., brain tumor, epilepsy, NPH). Preliminary NP findings suggested that treatment response to CCR for WM was consistent with extant literature on brain-behavior relationships according to lateralization and localization of neurosurgical intervention.Conclusions:Neurosurgical patients experience neurocognitive and affective dysfunction that may respond well to cognitive rehabilitation (CR) that includes CCR. Additionally, it is possible that lateralization and localization of surgical intervention may contribute to individual differences in treatment response. Further neurorehabilitation research is warranted to identify patients most likely to benefit from CCR and better tailor CR modalities to optimize recovery s/p neurological surgery.

Investigation of performance and energy cost of automobile air-conditioner using alternative refrigerants based on thermal comfort using various cooling seats

During hot summer days, the rapid rise in temperature inside a vehicle and the direct transmission of radiant energy cause significant discomfort to drivers, and the driving distance of an electric vehicle is greatly reduced due to the operation of the air-conditioner. Therefore, it is essential to provide a thermally comfortable environment to the driver and reduce the energy consumption of air-conditioners in the EV. This study investigated the thermal comfort of the driver according to the use of a basic seat (BSS), ventilation seat (VLS), and cold-water seat (CWS) in the car cabin under summer condition. Also, based on thermal comfort, the system performance and energy cost of an automobile air-conditioner using various alternative refrigerants were analyzed and compared. As a result, when the CWS was used, the stress index of subjects was the lowest in the PPG, and the relative β/α of the subjects decreased in the EEG. In addition, the results of the subjective questionnaires and bio-signal measurement showed the most thermally comfortable when using the CWS. The COPs of the air-conditioner using R134a, R1234yf, R1234ze(E), and R152a increased by 19.3 %, 18.9 %, 19.0 %, and 19.3 %, respectively, and annual energy consumption of the air-conditioner decreased. In addition, in the five European countries, the annual electric charging costs and annual eq-CO2 emissions for using the CWS showed the most significant reduction in Germany. Therefore, it was confirmed that using CWS can provide a thermally comfortable environment for drivers inside the vehicle during summer and effectively reduce power consumption used for air conditioning in EVs.

Prediction and Validation of Metabolic Dysfunction-Associated Fatty Liver Disease Using Insulin Resistance-Related Indices in the Japanese Population.

Background: Recently, metabolic dysfunction-associated fatty liver disease (MAFLD), which is based on evidence of hepatic steatosis and any of the following three conditions: overweight/obesity, presence of type 2 diabetes mellitus, or evidence of metabolic dysregulation, has been proposed. It is uncertain how indices that predict insulin resistance (IR) are associated with MAFLD. Methods: Among subjects who had undergone health examinations at our hospital, 1,257 (787 men and 474 women) who underwent fatty liver evaluation, were included in this cross-sectional study. The discriminatory ability of each index for MAFLD was tested using a receiver operating characteristic curve analysis. The associations between the homeostasis model assessment-IR (HOMA-IR), triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, triglyceride-glucose (TyG) index, and MAFLD were investigated using multiple logistic regression analysis. Results: The mean age and body mass index of MAFLD subjects were 58.1 years and 26.0 kg/m2 in men and 63.0 years and 26.1 kg/m2 in women, respectively. The cutoff values of HOMA-IR, TG/HDL-C ratio, and TyG index in men and women were 1.40 (area under the curve [AUC]: 0.81) and 1.90 (AUC: 0.88); 1.56 (AUC: 0.75) and 1.06 (AUC: 0.78); and 8.62 (AUC: 0.75) and 8.45 (AUC: 0.80), respectively. All indices were significantly higher in both men and women with MAFLD. In the multivariate models, the odds of MAFLD were higher among both men and women in the highest tertile than those in the lowest tertile. When subjects were divided by sex, presence of MAFLD, and alanine aminotransferase (ALT) values, all indices were significantly higher in both men and women with high ALT levels who were diagnosed with MAFLD. Conclusion: IR strongly correlated with MAFLD, particularly in subjects with high ALT levels.

A new technique for uterine-preserving pelvic organ prolapse surgery: Laparoscopic rectus abdominis hysteropexy for uterine prolapse by comparing with traditional techniques.

Contemporary understanding of the dynamic anatomy of pelvic floor support has led us to new conservative surgery for uterine prolapse (UP). In this study, we comprehensively evaluate the safety and feasibility of a new technique for uterine-preserving pelvic organ prolapse surgery: laparoscopic rectus abdominis hysteropexy for uterine prolapse (LRAHUP). A retrospective study was conducted between 2006 and 2016. Sixty-five women diagnosed with advanced prolapsed uterus were eligible and grouped into traditional vaginal surgery (TVS, n = 30) group and new laparoscopic surgery (NLS, n = 35) group. Evaluated items of 65 cases included surgery-related parameters and postoperative outcomes. Surgical safety evaluating indicators, including operation time, blood loss, postoperative hospitalized day, and operation complications, also showed great significant difference between two groups (P < 0.05). The subjective index of post-operative Pelvic Floor Distress Inventory-short form 20 scores and some objective anatomic outcomes all showed great difference between pre- and post-operation (P < 0.05). Although the TVL showed no difference between pre- and post-operation in the same group, the TVL displayed a remarkable elongation. And a remarkable tendency was a higher cumulative recurrence ratio in the TVS group and a shorter follow-up period in the NLS group. LRAHUP may be a good procedure to manage women with advanced prolapsed uterus.