The geodynamic setting of Late Triassic magmatic activity along the Longmu Co–Shuanghu suture zone (LSSZ) in central Qiangtang, Tibet is a matter of debate. This paper presents zircon LA–ICP–MS U–Pb ages, zircon Hf isotopic compositions, and whole-rock geochemical data for the Sangehu (SGH) granitic intrusion in central Qiangtang, and addresses the petrogenesis of Late Triassic magmatism, and the history of collision between the northern and southern Qiangtang terranes. The SGH pluton consists mainly of biotite adamellite with mafic microgranular enclaves (MMEs), and small amounts of K-feldspar granite. The biotite adamellite, MMEs, and K-feldspar granite give ages of 207.8±3.0Ma, 212.4±31Ma, and 211.6±3.8Ma, respectively. The MMEs show magmatic textures and acicular apatite, and are coeval with the host biotite adamellite, suggesting they were produced by magma mixing. All samples from the SGH pluton show high Sr and low Y contents, and positive Eu anomalies, similar to adakitic rocks. The high K2O contents and low Mg#, Cr, and Ni contents, and enriched Hf isotopic characteristics of the zircons indicate that these magmas were derived from the partial melting of thickened crust. However, the whole-rock geochemical data and zircon Hf isotopic compositions also reveal heterogeneity at the source. The combined magmatic and metamorphic records suggest that Triassic magmatic activity in central Qiangtang was closely related to the collision of the northern and southern Qiangtang terranes. The large-scale Late Triassic (225–200Ma) magmatic event in central Qiangtang may have resulted from the breakoff of the Longmu Co–Shuanghu Tethys Ocean lithospheric slab in the early Late Triassic (236–230Ma). The Late Triassic magmatic rocks, including adakitic rocks, are coeval with retrograde high-pressure (HP) to ultrahigh-pressure (UHP) metamorphic rocks in central Qiangtang, and show characteristics of syn-exhumation magmatism. The early adakitic rocks (>220Ma) were generated by melting of the edge of the slab, which was heated by upwelling asthenospheric mantle after subduction slab breakoff, and the late adakitic rocks (<220Ma) were generated by partial melting of the thickened crust.