Subcutaneous Angiolymphoid Hyperplasia Research Articles

Morbus Kimura mit minimal-proliferierender Glomerulonephritis

A 45-year-old Turk had a year ago noticed a submandibular and a retroauricular node-like swelling, about 2 cm in diameter each, firm and freely mobile. During the preceding two months he had polydipsia and polyuria. Recently he developed a nephrotic syndrome with lower-leg oedema and proteinuria (14 g albumin in 24-hour urine). The concentrations of IgE (250 IE/ml) and IgA (745 mg/dl) were raised, and there was eosinophilia of 14%. Renal needle biopsy revealed glomerulonephritis with minimal proliferation. Excision of part of the nodular tumour revealed histologically the typical signs of Kimura's disease (eosinophilic follicular lymphadenitis of the skin; subcutaneous angiolymphoid hyperplasia with eosinophilia). During treatment with prednisolone, 20 mg daily by mouth, the clinical and biochemical findings regressed within two weeks. But eight weeks later, after dose reduction to 10 mg daily, the nephrotic syndrome recurred so that the dosage had to be increased again to 20 mg prednisolone daily. On this treatment the patient has now been symptom-free for six months. This case demonstrates the unusual association of Kimura's disease with minimally proliferative glomerulonephritis.

Angiolymphoid hyperplasia with eosinophilia: A case report

A case of angiolymphoid hyperplasia with eosinophilia of the hand is described. This tumor has also been described as subcutaneous angiolymphoid hyperplasia with eosinophilia and as an atypical pyogenic granuloma. It usually occurs in the head or neck. This highly recurrent tumor has not been previously described in the hand. It was completely excised and had not recurred 4 years after surgery.

A propos d’un cas de pseudo-granulome pyogénique de l’oreille

The authors have recently come across a female patient with pseudo-pyogenic granuloma and have taken this opportunity to recall the clinical and histological features of this disease which was described in 1969 by Wilson Jones and Bleehein. In this connection, they have studied the relationship of this disease with similar entities, i.e. subcutaneous angiolymphoid hyperplasia with eosinophilia (described by Wells and Whinster in 1969) on the one hand and kimura's disease (described by Kimura in 1948) on the other hand. Whereas subcutaneous angiolymphoid hyperplasia with eosinophilia seems to be an evolutive form developing from pseudopyogenic granuloma, Kimura's disease differs from it clinically and histologically and is considered as a borderline form.

Subcutaneous Angiolymphoid Hyperplasia of the Inguinal Region and Anteromedial Side of the Proximal Thigh: A case report

Subcutaneous Angiolymphoid Hyperplasia of the Inguinal Region and Anteromedial Side of the Proximal Thigh: A case report

Juvenile temporal arteritis. Biopsy study of four cases

Two young adults (aged 21 and 22 years) and two children (aged 7 and 8 years) complained of an unsightly, soft, painless unilateral nodule in the temporal region, ranging from 0.5 to 1.5 cm in diameter, clinically diagnosed as lipoma, sebaceous cyst, or dermoid cyst. In each instance, the patient had no evidence of systemic disease or history of trauma, and the nodule was excised for cosmetic reasons. Histologic examination of the lesions showed non-giant-cell granulomatous inflammation of the temporal arteries with intimal proliferation and microaneurysmal disruption of the media. Whether the lesions represent a juvenile form of temporal arteritis, an unusual form of localized polyarteritis nodosa, or Kimura disease (subcutaneous angiolymphoid hyperplasia with eosinophilia) remains conjectural.

Dermal angiolymphoid hyperplasia with eosinophilia versus pseudopyogenic granuloma.

SUMMARY.– A case of multiple nodules of the left ear clinically misdiagnosed as granuloma faciale was found to show the histological features characteristic of subcutaneous angiolymphoid hyperplasia with eosinophilia as described by Wells and Whimster (1969). It is suggested that subcutaneous angiolymphoid hyperplasia with eosinophilia and pseudopyogenic granuloma, as described by Wilson Jones and Bleehen (1969), could represent the same disease process taking place at different tissue levels.

Inflammatory angiomatous nodules with abnormal blood vessels occurring about the ears and scalp (pseudo or atypical pyogenic granuloma).

SUMMARY.— Persistent angiomatous nodules and plaques about the ears and scalp with distinctive histological features are described. Of the 12 women and 2 men affected, 9 showed involvement of the external auditory meatus, the pinna or the retroauricular fold. Three patients presented with lesions in the occipital region and solitary nodules affecting the nasolabial fold and forehead occurred in 2 patients. Eight patients had multiple lesions with bleeding and pruritus as the main symptoms. Several recurred after removal. The characteristic histological features were the presence of abnormal hypertrophied capillaries with greatly swollen endothelial cells and an associated lympho-histiocytic and eosinophil infiltrate. The abnormal endothelial cells showed absent or greatly diminished alkaline phosphatase activity, but enhanced reactions were obtained to certain hydrolytic and oxidative enzymes as compared to normal capillary endothelium. Pseudopyogenic granuloma appears to be an entirely benign reactive condition. Its relationship to ordinary pyogenic granuloma and to subcutaneous angiolymphoid hyperplasia with eosinophilia is discussed.

Subcutaneous angiolymphoid hyperplasia with eosinophilia.

SUMMARY.— Persistent subcutaneous nodules on the head and neck with distinctive histological features of angiolymphoid hyperplasia with eosinophilia are reported in nine patients. They were all young adults and had one or more lesions ranging from 1 to 10 cm. in diameter. Apart from blood eosinophilia, there were no systemic manifestations. While some lesions persisted for several years, the condition appears to be benign. The nodules lie mainly in the sub-cutis but sometimes extend into the overlying dermis and deeply into muscle or fascia. They are composed of unencapsulated masses of angiolymphoid hyperplasia with the following components: 1. Exuberant proliferation of capillary vessels, often with imperfectly canalized masses of endothelium. 2. Massive infiltration with eosinophils and an excess of mast cells. 3. Reticulin formation but little collagenous fibrosis. 4. Lymphoreticular hyperplasia, increasing with the duration of the lesion and leading to lymphoid follicle formation in lesions of one year or more duration. The clinical and histological features suggest enough common ground for regarding subcutaneous angiolymphoid hyperplasia with eosinophilia as a distinct pathological entity. Its relation to Kimura's disease as described in Japan is discussed.