The transition to turbulence in conduits is among the longest-standing problems in fluid mechanics. Challenges in producing or saving energy hinge on understanding promotion or suppression of turbulence. While a global picture based on an intrinsically 3-D subcritical mechanism is emerging for 3-D turbulence, subcritical turbulence is yet to even be observed when flows approach two dimensions, e.g. under intense rotation or magnetic fields. Here, stability analysis and direct numerical simulations demonstrate a subcritical quasi-two-dimensional (quasi-2-D) transition from laminar flow to turbulence, via a radically different 2-D mechanism to the 3-D case, driven by nonlinear Tollmien–Schlichting waves. This alternative scenario calls for a new line of thought on the transition to turbulence and should inspire new strategies to control transition in rotating devices and nuclear fusion reactor blankets.