Objective: We aimed to compare amyloid burden between patients with amnestic MCI (aMCI) and subcortical vascular MCI(svMCI). Background Most studies on mild cognitive impairment (MCI) have been focused on aMCI which is the preclinical stage of Alzheimer9s disease (AD). In contrast, only a few studies have involved patients in the preclinical stages of subcortical vascular dementia(svMCI). A recent study using Pittsburg compound-B (PiB) PET suggested that over 30% of patients who had been clinically diagnosed with SVaD showed significant amyloid deposits. However, to our knowledge, there has been no study investigating amyloid burden in patients with svMCI. We aimed to compare amyloid burden between patients with aMCI and svMCI, and to evaluate the effects of amyloid burden on cognition in patients with svMCI. Design/Methods: Participants consisted of 45 aMCI and 67 svMCI patients. All aMCI patients met Petersen9s criteria and all svMCI patients met Petersen9s criteria with some modifications that were previously described. Patients with svMCI had extensive white matter hyperintensities (WMH). All the patients underwent 3.0T MRI, 11C-Pittsburgh compound B (PiB) PET and detailed neuropsychological testing. Results: Twenty eight (62.2%) of the 45 patients with aMCI were positive PiB (PiB(+)), while twenty two (32.8%) of the 67 patients with svMCI were PiB(+). The mean uptake ratio of PiB was higher in aMCI (1.868 ± 0.512) than svMCI (1.504±0.402) (p Conclusions: Our findings suggested that patients with svMCI showed lower amyloid burdens than aMCI. We also found that amyloid burden affected memory dysfunction in patients with svMCI. Disclosure: Dr. Lee has nothing to disclose. Dr. Seo has nothing to disclose. Dr. Na has nothing to disclose.