You have accessJournal of UrologyAdrenal1 Apr 2018MP03-13 DELAYED RECOVERY OF KIDNEY FUNCTION IN PATIENTS WITH OBESITY AFTER LAPAROSCOPIC SURGERY FOR CUSHING′S SYNDROME Kazuyuki Numakura, Taketoshi Nara, Sohei Kanda, Hiroshi Tsuruta, Mitsuru Saito, Shintaro Narita, Takamitsu Inoue, Shigeru Satoh, and Tomonori Habuchi Kazuyuki NumakuraKazuyuki Numakura More articles by this author , Taketoshi NaraTaketoshi Nara More articles by this author , Sohei KandaSohei Kanda More articles by this author , Hiroshi TsurutaHiroshi Tsuruta More articles by this author , Mitsuru SaitoMitsuru Saito More articles by this author , Shintaro NaritaShintaro Narita More articles by this author , Takamitsu InoueTakamitsu Inoue More articles by this author , Shigeru SatohShigeru Satoh More articles by this author , and Tomonori HabuchiTomonori Habuchi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.3056AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Glucocorticoid (GC) is known to be involved in the deterioration of renal function by directly affecting glomeruli and renal tubules and indirectly affecting cardiovascular function. Independent GC secretion is the main characteristic of Cushing′s syndrome (CS) and subclinical Cushing′s syndrome (SCS). We assessed kidney function and the predictive factors for improved renal function in patients with CS after laparoscopic adrenalectomy. METHODS In Akita University from September 1997 to July 2017, we performed 175 laparoscopic adrenalectomies for adrenal tumor. Of those, 30 cases were included in this study; patients were diagnosed with SCS and CS based on preoperative endocrinological evaluations and followed for at least one year after surgery. Patients with severe renal dysfunction before surgery were excluded. The mean age of the 30 patients was 57.5 years (range, 33-79 years; males, 4; females, 26), and the right and left sides were affected in 9 and 21 patients, respectively. RESULTS Of the 30 patients, 18 were diagnosed with CS and 12 with SCS. Supplemental steroid treatment was required in all cases after surgery. In 16 patients, metabolic disorders improved. Estimated glomerular filtration rate (eGFR) at one year after surgery was significantly improved (78.4 [64.8-95.8] mL/min vs 84.1 [66.8-104.0] mL/min, p=0.012). To compare between patients with recovered kidney function by more than 5% and those with less than 5%. On univariate analysis, patients with left adrenal mass, increased BMI, and preoperative unsuppressed ACTH were associated with decreased recovery of kidney function. No meaningful associations were observed for metabolic disorders, clinical symptoms of CS, and gross proteinuria. On multivariate analysis, patients with increased BMI (≥24 kg/m2) decreased recovery rate of kidney function one year after surgery (odds ratio 12.98, 95% CI 1.17-142.86, p = 0.037). CONCLUSIONS Kidney function improved in patients with CS and SCS after surgery. Patients with increased BMI might experience a delay in recovery of kidney function. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e27 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Kazuyuki Numakura More articles by this author Taketoshi Nara More articles by this author Sohei Kanda More articles by this author Hiroshi Tsuruta More articles by this author Mitsuru Saito More articles by this author Shintaro Narita More articles by this author Takamitsu Inoue More articles by this author Shigeru Satoh More articles by this author Tomonori Habuchi More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...