People exposed to high concentration levels of radon face an increased risk of developing lung cancer. The risk is directly proportional to the length and level of radon exposure. Because of health reasons, it is safer to build new houses with radon mitigation systems installed in slab-on-grade houses. However, the interrelationships between parameters and factors governing radon entry and control are highly complex. A study performed by the University of Florida has examined the effectiveness of different radon entry control approaches. The analysis was based on 47 houses from three research projects conducted by the University of Florida (14 houses), Florida Solar Energy Center (13 houses), and GEOMET Technologies (20 houses). The evaluation of the performance and effectiveness of improved floor slabs, space conditioning, and ventilating systems were analyzed. Statistical analyses of the interrelationship between various parameters were also performed. Study findings such as the important factors in reducing radon entry and the effectiveness of passive construction approach and active subslab depressurization systems are presented in this paper.