Marine seismic reflection profiles across the Early Proterozoic Makkovikian ‐ Ketilidian Orogen in the Labrador Sea region suggest that it is a doubly vergent, asymmetric orogenic belt, comparable in width to younger collisional orogens. A southeast dipping reflector package is correlated with on‐land shear zones that mark the southeastern limit of exposed reworked Archean crust and is also associated with a cryptic isotopic boundary in granites, which documents a transition from “ancient” to “juvenile” basement. This boundary is interpreted as a suture, along which juvenile Proterozoic crust has been juxtaposed over (thrust over ?) the Archean craton. A major synorogenic to postorogenic plutonic terrane to the southeast has a poorly reflective upper crust but shows strong subhorizontal reflectivity in the lower crust and Moho regions. The southeastern part of the profile correlates with metasedimentary terranes of the Ketilidian Belt in Greenland and contains low‐angle, northwest dipping, reflector packages suggestive of large‐scale crustal imbrication by thrusting. At least two broad zones of reflectivity at mantle depths (up to 16 s) are also recognized. One dips northwest below the Archean craton, but the most widespread mantle reflectivity is southeast dipping in opposition to the dominant fabric in the overlying crust. These contrasting crustal and subcrustal reflectivity patterns define a geometric “focus” beneath the orogenic belt and may provide information about subduction polarity during its development. The doubly vergent reflectivity pattern resembles images from possibly correlative Precambrian orogenic belts such as the Penokean and Svecofennian and also younger “small collisional orogens” such as the Appalachian and Pyrenean belts. It also broadly resembles some results of geodynamic crustal deformation models based on detachment and underthrusting of mantle lithosphere following collision and the squeezing of “weak” zones between rigid bounding blocks. A speculative multistage model for the belt incorporates initial northward subduction beneath the craton, shifting to later southward subduction, followed by oblique accretion of a composite arc terrane and juvenile (?) continental block. The accreted, hotter, juvenile, Proterozoic crust behaved differently than the stable, cool, Archean crust and experienced subhorizontal shearing in lower crustal and Moho regions, associated with southeast directed imbrication of the middle and upper crust by thrusting. However, the present reflectivity pattern of the orogen may also include elements related to post collisional extensional collapse.