Styrene Sulfonic Acid Research Articles

A PEDOT: PSS/GO fiber microelectrode fabricated by microfluidic spinning for dopamine detection in human serum and PC12 cells.

Rapid and accurate in situ determinationof dopamine is of great significance in the study of neurological diseases. In this work, poly (3,4-ethylenedioxythiophene): poly (styrenesulfonic acid) (PEDOT: PSS)/graphene oxide (GO) fibers were fabricated by an effective method based on microfluidic wet spinning technology. The composite microfibers with stratified and dense arrangement were continuously prepared by injecting PEDOT: PSS and GO dispersion solutions into a microfluidic chip. PEDOT: PSS/GO fiber microelectrodes with high electrochemical activity and enhanced electrochemical oxidation activity of dopamine were constructed by controlling the structure composition of the microfibers with varying flow rate. The fabricated fiber microelectrode had a low detection limit (4.56 nM) and wide detection range (0.01-8.0 µM) for dopamine detection with excellent stability, repeatability, and reproducibility. In addition, the PEDOT: PSS/GO fiber microelectrode prepared was successfully used for the detection of dopamine in human serum and PC12 cells. The strategy for the fabrication of multi-component fiber microelectrodes isa new and effective approach for monitoring the intercellular neurotransmitter dopamine and has highpotential as an implantable neural microelectrode.

Flexible electrochemical sensor based on a ZnO-doped SnO2 heterojunction for simultaneous electrochemical determination of p-aminophenol and acetaminophen

In this work, a novel flexible electrochemical sensor was successfully developed for the simultaneous determination of p-aminophenol and acetaminophen. The sensor is composed of a methanesulfonic acid-treated poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonic acid) film on a poly(ethylene terephthalate) substrate, which has been modified using a zinc oxide-doped tin oxide heterojunction applied through drop-coating (C-ZnO/SnO2-PEDOT/PET). The oxygen vacancies resulting from zinc oxide-doped tin oxide heterojunctions within highly conductive metal oxide nanomaterials enhance mass transfer and synergize seamlessly with methanesulfonic acid-treated electrically conductive dielectric PEDOT/PET films, leading to a substantial improvement in electrochemical activity. Under the optimal conditions, a wider linear range and lower detection limits were shown for p-aminophenol (2–511 μM, LOD=0.437 μM) and acetaminophen (2–591 μM, LOD=0.562 μM). In addition, the sensors demonstrated high accuracy in detecting p-aminophenol and acetaminophen in real samples, with recoveries of 99.36 %-99.60 % and 97.56 %-99.80 %, respectively. Furthermore, the flexible sensors maintained a superior electrochemical response when detecting p-aminophenol and acetaminophen at different bending angles, with relative standard deviations of 0.62 % and 1.68 %, respectively. These findings suggest potential applications for the development of wearable sensors in the future.

Self-powered PEDOT: PSS/CSWCNT/Mxenes thermoelectric films and wearable electronics devices

In this work, Ti3C2–Cl is introduced into poly(3,4-ethylenedioxythiophene): poly(4-styrenesulfonic acid) / single-walled carbon nanotubes (PEDOT: PSS/SWCNT, noted as PPSC) films to prepare ternary thermoelectric films of PEDOT: PSS/SWCNT/Ti3C2–Cl (PPSCT). The microscopic morphology, structures, and thermoelectric properties of PPSC and PPSCT films show that the introduction of Ti3C2–Cl results in a tendency of decreasing electrical as well as thermal conductivity, and the Seebeck coefficient is increased. When the content of Ti3C2–Cl reaches 8 wt%, the conductivity, Seebeck coefficient, and thermal conductivity of the PPSCT films reach the optimum values of 1683 S/cm, 21.69 μV/K, and 14.97 W/mK, respectively, and the power factor (PF) and thermoelectric figure of merit (ZT) are 79.23 μW/mK2 and 1.58 × 10–3. The UPS and Hall effect results reveal that the improvement of the Seebeck effect of PPSCT mainly results from the ternary interfacial energy barrier as well as the change of carrier concentration. In addition, the wearable electronics devices demonstrate an output voltage of 4.5 mV and an output power of 54.36 nW under a 50 K temperature difference. The device displays a good monitoring sensitivity by reaching an output voltage of 0.6 mV at a 7 K temperature difference between the skin and the environment.

Enhanced Silicon Anodes with Robust SEI Formation Enabled by Functional Conductive Binder

AbstractThe application of silicon (Si) anode is limited by the drastic volume change of silicon in the lithiation/delithiation process, the repeated formation of the solid electrolyte interface (SEI), and the low intrinsic conductivity. In this work, a small amount of poly (3,4‐ethylenedioxythiophene):poly (styrene sulfonic acid) (PEDOT:PSS) (PP), citric acid (CA), isopropyl alcohol (IPA), and silicon nanoparticles (SiNPs) are mixed and vacuum treated at a specific temperature to obtain silicon‐based anode electrode composite Si@PP@CA. The interphase forms a robust elastic network with hydrogen and chemical bonds, which have good mechanical properties and self‐repairing characteristics. The modified PEDOT:PSS as the conductive medium significantly improves the charge transfer rate. Moreover, the rapid formation of SEI by CA on the surface of SiNPs enhances the structural stability of the material. The electrochemical results show that the capacity of Si@PP@CA composite electrode canretain more than 2200 mAh g−1 after 200 cycles at 0.2 A g−1. It still shows a high capacity retention of 89% even at the current density of 1.0 A g−1 after 2000 cycles. More importantly, such excellent performance can be obtained using an electrode with an active material content of up to 90 wt%, which is essential for practical applications.

κ‐Carrageenan/poly(sodium styrenesulfonate‐co‐acrylic acid) macroporous anionic monoliths: Dye adsorption and oil–water separation properties

Abstractκ‐Carrageenan (κC) is a widely used food hydrogel, but its use as an environmental adsorption separation material still needs to be further developed. Herein, a novel macroporous anionic monolith was synthesized by the oil‐in‐water high internal phase emulsion template method. The monolith was obtained by the continuous phase polymerization of sodium styrenesulfonate (NaSS) and acrylic acid (AA), in which κC was introduced to form a semi‐interpenetrating network structure to improve its overall performance. The results showed that the mechanical strength of the monolith increased with κC content. Because of the use of two strong hydrophilic monomers, NaSS and AA, the porous monolith proved to be superoleophobic underwater. In addition, the porous materials had a strong cationic dye adsorption capacity (2455 mg/g for malachite green, 1180 mg/g for methylene blue) and a fast removal rate, good reusability, and oil–water separation. This work highlights their potential application value in the purification of complex water environments.

Enhancing thermoelectric performance of single-walled carbon nanotube films by poly(styrene sulfonate acid) dispersing and sequential base treatment

Despite single-walled carbon nanotubes (SWCNTs) have attracted great interest for thermoelectric (TE) conversion, the strong van der Waals forces between SWCNTs cause them to aggregate into bundles with poor dispersibility, which dramatically deteriorates the charge carrier transport, and thereby induces low electrical conductivity and TE power factor. Herein, we report a facile and efficient approach to enhance TE performance of SWCNTs via the addition of poly(styrene sulfonic acid) (PSSH) and sequential base treatment. PSSH is served as a dispersant and dopant to improve the dispersibility of SWCNTs and facilitate charge carrier conduction, contributing to high electrical conductivity of 3749 ± 122 S cm−1 and power factor of 117.7 ± 3.4 μW m−1 K−2 for 20 wt% PSSH/SWCNT composite film. Further base treatment induces partial removal of insulative PSSH and de-doping effect of SWCNTs, which decreases the barriers between adjacent nanotubes junctions and modulates charge carrier transport to synergistically optimize the electrical conductivity and Seebeck coefficient. With fine-tuning base treatment temperature, the PSSH/SWCNT composite film reaches highest power factor of 160.6 ± 7.9 μW m−1 K−2, higher than pristine SWCNTs of 70.2 ± 4.4 μW m−1 K−2. This work demonstrates the feasibility of this approach to boost the TE properties of SWCNTs, exhibiting potential application for high performance renewable energy harvesting.

Adsorption of Cu (II) ions from aquatic environment using pre-irradiated Ethylene Tetrafluoroethylene Film

Although copper (Cu) is a very beneficial metal, having too much of it in the body can cause lung issues, severe anemia, nausea, and vomiting. In order to extract Cu (II) ions from aqueous solution, an adsorbent was constructed in this study employing pre-irradiation grafted Ethylene tetrafluoroethylene (ETFE) film. The grafting method was used to binary monomers of sodium styrene sulfonate (SSS) and acrylic acid (AA), where NaCl served as an additive. The grafted polymer was also subjected to studies of tensile strength, water uptake, surface area extension, Scanning Electron Microscopy (SEM), and Fourier Transform Infrared spectroscopy (FTIR). The adsorption of Cu (II) was investigated with respect to pH, starting metal ion concentrations, contact time, monomer concentrations, and temperature. With 50 kGy of radiation dose, 4% NaCl, and 30% of monomer solution (SSS:AA = 1:2) in water generated the highest graft yield of 470%. The maximum adsorption capacity (412 mg g−1) was discovered with an initial concentration of 2500 mg L−1, a pH of 4.86, and a contact time of 24 h at room temperature (25 ℃). A monolayer adsorption was recommended by the good linking between experimental data and the Langmuir Isotherm Model. The kinetic adsorption data closely fitted with the pseudo-second-order reaction. Due to its increased adsorption capacity and reusability, the synthesized new grafted polymer can be considered an efficient adsorbent for Cu (II) removal from wastewater.

Preparation of flower-like molecularly imprinted polymers based on metal coordination for selective extraction of hemoglobin

In this study, we present a facile strategy to prepare flower-like molecularly imprinted polymer (CuS/MIPs) for highly specific separation of hemoglobin (Hb) under neutral conditions. Cu2+ were first grafted on the surface of polydopamine-modified flower-like hollow CuS. Then, template proteins were immobilized on the Cu2+-modified CuS through coordination interaction. Subsequently, an imprinted layer was formed using acrylamide (AM) and 4-styrene sulfonic acid sodium salt (SSS) as functional monomers. After the template removal process, the cavities that can specific bind Hb were obtained. The effects of metal ions, functional monomers, pH on the adsorption capacity of the CuS/MIPs were investigated. Benefiting from the combination of multiple binding and imprinting effects, the CuS/MIPs not only exhibited large adsorption capacity (182.74 mg/g) and fast adsorption kinetics (60 min) toward template protein, but also showed satisfactory reusability and selectivity. Meanwhile, the CuS/MIPs could selectively capture Hb from bovine serum sample, demonstrating that the CuS/MIPs will be an auspicious candidate for protein separation.

Selective ion migration in a polyelectrolyte driving a high-performance flexible moisture-electric generator.

We propose a novel moisture-electric generator that utilizes the unique properties of a blended poly(4-styrene sulfonic acid) and poly(vinyl alcohol) with phytic acid by screen printing and scrape coating, achieving an impressive open-circuit voltage of 0.88 V from ambient humidity. This innovative design significantly enhances ion transport, moisture adsorption, and flexibility, making a marked improvement in converting environmental humidity to electrical energy.

Effect of substrate morphology on characteristics of layer-by-layer self-assembly nanofiltration membrane for micropollutants removal

Layer-by-layer (LBL) hollow fiber nanofiltration (NF) membranes have emerged as a promising technology for the removal of micropollutants (MPs). Previous research has been largely focused on polyelectrolyte pairs and coating parameters. This paper studied the substrate morphology, a critical factor often being overlooked. Poly (allylamine hydrochloride) /poly (styrene sulfonic acid) sodium salt (PAH/PSS) coating was utilized to evaluate the impact of the substrate morphology. Two polyethersulfone substrates were selected: Substrate 1# with dense skins at both lumen/shell and Substrate 2# with skin at the lumen and an open shell surface. All LBL NF membranes showed molecular weight cut-off ranging from 180 to 223 Da and MgCl2 rejection around 94 %. For LBL membrane 1#, with coatings on both shell/lumen sides, the outer coating was defective due to scratches. For LBL membrane 2# with a coating at the lumen, significant PAH overcompensation was observed, because of the open inner and outer surfaces comparing to LBL membrane 1#. Higher rejection to positively charged MPs was resulted from Donnan effect, outperforming steric exclusion. The backwash stability of both membranes was excellent and independent of the substrate structure. This work provides a basis for substrate selection for fabricating LBL NF membranes.

Ultra-stretchable, sensitive and breathable electronic skin based on TPU electrospinning fibrous membrane with microcrack structure for human motion monitoring and self-powered application

With the rapid development of wearable electronic, electronic skin with excellent performance for human motion detection have been widely investigated recently. In this work, a multifunctional electronic skin with three-dimensional conductive network skeleton was prepared based on synergistic conductive filler (carboxylated multi-walled carbon nanotubes (C-MWCNT) and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonic acid) (PEDOT:PSS)) decorated breathable thermoplastic polyurethane (TPU) electrospinning fibrous membrane. Then, microcrack structure was constructed via pre-stretching and the strain sensitivity of the resultant C-MWCNT/PEDOT:PSS/TPU (CPT) conductive fibrous membrane could be effectively adjusted by changing the microcrack density. Due to the three-dimensional conductive network skeleton, microcrack structure and the bridging effect of C-MWCNT between the adjacent crack fragments, ethylene glycol treated CPT (mass ratio of C-MWCNT and PEDOT:PSS is 9/1) (e-CPT9/1) strain sensor exhibited high sensitivity (6008.3), wide response range (680 %), fast response/recovery time (200 ms/200 ms), low detection limit (0.5 %), excellent durability and repeatability (6000 cycles). The excellent strain sensing performances enables it to accurately monitor motion activities and physiological signals, and can also be used as a smart sensing glove to identify different letters gesture and numeric gestures. Furthermore, owing to the photothermal conversion ability and thermoelectric effect of C-MWCNT and PEDOT:PSS, the obtained e-CPT9/1 device also displayed efficient “light-thermal-electric” conversion ability and showed the great potential as self-powered strain sensor.

Pervaporation separation of azeotrope water–isopropanol mixtures through poly(vinyl alcohol)-based membranes incorporated with modified CNTs

ABSTRACT Although carbon nanotubes possess unique characteristics to be used for separation purposes, one of the most challenging problems affecting the preparation of carbon nanotubes-incorporated-mixed matrix membranes has been ascribed to Van der Waals interactions among carbon nanotubes walls, which hinder the pristine nanotubes’ ability to make good interfacial interactions within the polymer matrix. To overcome this challenge, herein, poly (styrene sulfonic acid)-grafted- multi-walled carbon nanotubes were prepared via in-situ radical polymerisation and then incorporated into poly (vinyl alcohol), resulting in enhanced pervaporation performance of poly (vinyl alcohol) membranes. The observed results indicated that poly (styrene sulfonic acid)-modified carbon nanotubes could effectively vanquish the Van der Waals forces between nanotube walls. In general, our experiments revealed that the attachment of a bulky polymer containing hydrophilic sulfonic groups could improve the pervaporation performance of a poly (vinyl alcohol) membrane.

Asymmetrical Schottky Junction Built by Metal/Conducting Polymer Targeting Efficient Flexible Direct Current Tribovoltaic Generator

Direct current (DC) from mechanical energy built on the tribovoltaic effect is promising for the development of self‐powered flexible electronics. A semiconductor triboelectric generator is one of the optimized solutions for DC output. However, it remains underutilized because of its low output power and insufficient insight into the fundamental principles of charge generation and transport at dynamic interfaces. Herein, a flexible fabric‐based DC generator that relies on a metal–semiconducting polymer interface constructed by an asymmetric Schottky junction between a poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonic acid) (PEDOT:PSS)‐coated fabric and an aluminum (Al) foil is reported. The dependence of the electrical output performance of the device on the doping carrier concentration using different types of PEDOT:PSS to modulate the Schottky barrier height, validating both the work function and conductivity of the triboelectric material, which plays a fundamental role in DC generation, is explored. A large work function difference is required to create a high built‐in electric field for efficient separation of electron–hole pairs. Decent conductivity also fulfills an integral role in the innate carrier‐transport capability. Accordingly, an open‐circuit voltage (Voc) of 800 mV, a short‐circuit current (Isc) of 80 μA, and a power density of 6.7 mW cm−2 are yielded simultaneously.

Textile Actuators Comprising Reduced Graphene Oxide as the Current Collector

AbstractElectronic textiles (E‐textiles) are made using various materials including carbon nanotubes, graphene, and graphene oxide. Among the materials here, e‐textiles are fabricated with reduced graphene oxide (rGO) coating on commercial textiles. rGO‐based yarns are prepared for e‐textiles by a simple dip coating method with subsequent non‐toxic reduction. To enhance the conductivity, the rGO yarns are coated with poly(3,4‐ethylene dioxythiophene): poly(styrenesulfonic acid) (PEDOT) followed by electrochemical polymerization of polypyrrole (PPy) as the electromechanically active layer, resulting in textile actuators. The rGO‐based yarn actuators are characterized in terms of both isotonic displacement and isometric developed forces, as well as electron microscopy and resistance measurements. Furthermore, it is demonstrated that both viscose rotor spun (VR) and viscose multifilament (VM) yarns can be used for yarn actuators. The resulting VM‐based yarn actuators exhibit high strain (0.58%) in NaDBS electrolytes. These conducting yarns can also be integrated into textiles and fabrics of various forms to create smart e‐textiles and wearable devices.

Facile, low-cost and scalable preparation of V2O5/PEDOT:PSS inks for solution-processed multicolor electrochromic films

Poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonic acid) (PEDOT:PSS) is extensively used as a commercial ink for electrochromic coatings. However, PEDOT:PSS film has the defect of a single color change, which limits the wide range of applications. The development of hybrid electrochromic inks containing PEDOT:PSS has attracted considerable attention attributed to their high electrical conductivity, large optical modulation, excellent cycling stability and multicolor variation. In this work, the color range of electrochromic PEDOT:PSS ink was adjusted by a simple and low-cost solution blending process method. The solution-processable multicolor vanadium pentoxide (V2O5) nanoribbons synthesized by a facile solution treatment process were used as additives to enlarge the color range of PEDOT:PSS ink. The electrochromic performance of V2O5-PEDOT:PSS hybrid films with V2O5 nanoribbon inclusions ranging from 0 wt% to 100 wt% was systematically studied. Our results demonstrate that the V2O5/PEDOT:PSS hybrid film can combine the color range of mixing inorganic and organic electrochromic materials. The spray-coated hybrid film with 40 % V2O5 nanoribbon (40VPE) shows a reversible multicolor change ranging from navy blue, yellow-green, orange, grey to blue. Moreover, the 40VPE hybrid film also exhibits high optical contrast (50.2 % at 660 nm), rapid response speed (2.7/3.8 s) and excellent cycling stability (sustaining 97 % of initial contrast after 100 cycles). The solution-processable and large-scale V2O5-PEDOT:PSS hybrid inks exhibit promising applications in multicolor electrochromic devices.

Research progress on the modification of organic highly conductive polymer PEDOT: PSS

PEDOT: PSS (poly(3,4-ethylenedioxythiophene): poly(4-styrenesulfonic acid)) is a high-profile organic conductive polymer, which is widely used because of its excellent conductivity and stability. The application of PEDOT: PSS is of great significance in the fields of energy, electronics, medical treatment and the environment. It offers an efficient, transparent, flexible, and environmentally friendly material option that drives various innovations and advancements. However, the traditional PEDOT: PSS can no longer meet the high requirements of today's electronic devices. Therefore, changing the conductivity, ductility and other properties of PEDOT: PSS through various physical and chemical methods has become an important topic. This paper reviews the progress of effectively improving the conductivity of PEDOT: PSS by reviewing PSS doping optimization, solvent doping modification (inorganic acid, organic reagent), and nanomaterial modification (CNTs, Graphene), so as to provide researchers with directions. Overall, PEDOT: PSS, as a material with excellent performance and wide application potential, has broad prospects for its application. With the continuous demand for flexible electronics, renewable energy, smart optoelectronic devices and biomedical applications, PEDOT: PSS will play an important role in these fields and promote the further development and innovation of related technologies.

The Effect of Organic Acid Dopants on the Specific Capacitance of Electrodeposited Polypyrrole-Carbon Nanotube/Polyimide Composite Electrodes

Energy storage materials are constantly being improved and developed to cope with the ever-increasing demand of the electronic devices industry. Various synthetic approaches have been used to manufacture electrode materials. This paper is focused on the use of intrinsically conductive polymers such as polypyrrole (PPy) in the development of single-walled carbon nanotube-polyimide, SWCNT-PI, supercapacitor electrode materials. The polypyrrole used in the study is doped with different organic acid dopants of various sizes, including styrene sulfonic acid, SSA, toluene sulfonic acid, TSA, dodecylbenzene sulfonic acid, DBSA, naphthalene disulfonic acid, NDSA, and naphthalene trisulfonic acid, NTSA. The number of sulfonic acid functional group per dopant molecule varied from one to three, while the number of benzene rings in the aromatic unit varied from one to two. It is believed that, as the sulfonic acid to the dopant molecule ratio changes, the morphology and electrochemical properties of the doped PPy-coated electrode material will change accordingly. The change in the morphology of the doped PPy, due to the respective dopant, is correlated with the change in the electrochemical properties of the modified composite electrode. The naphthalene trisulfonic acid (NTSA) dopant was found to produce the highest specific capacitance of about 119 F/g at 5 mV/s. Furthermore, the NTSA-doped PPy electrode system showed the highest porosity and highest tan delta damping peak height for the a-transition. The styrene sulfonic acid-doped PPy/SWCNT-PI electrode material showed an impressive storage modulus of more than 2 GPa, but lower porosity. Styrene polymerization is believed to have occurred. The results obtained indicate that the porosity and electrochemical properties of the electrode materials are correlated.

PH-responsive LBL coated silica nanocarriers for controlled release of chlorhexidine

As resistant microbial strains continue to appear, antibiotic-based therapies become less effective. Hence, development of non-antibiotic antimicrobial delivery systems, such as those containing chlorhexidine, is urgently needed for the prevention and treatment of infections. For many biological applications as well as for efficient therapy, controlling the release kinetics of these antimicrobials is crucial. In this study, chlorhexidine was loaded into silica nanoparticles via layer-by-layer (LbL) coating technique. Different polyelectrolytes including polyacrylic acid (PAA), poly(diallyldimethylammonium) chloride (PDDA), poly(allylamine hydrochloride) (PAH) and poly(4-styrenesulfonic acid) (PSS) were utilized in LbL coatings. Three types of coatings were studied: (1) PSS and PDDA (2) PAA and PAH (3) PSS and PAH. Zeta potential, transmission electron microscope, and a thermogravimetric analysis were used to characterize the nanoparticles. Acetate buffer pH 5 and PBS pH 7.4 were used as release media to assess the chlorhexidine release from nanoparticles. The chlorhexidine LbL-coated nanoparticles were effective in extending the duration of the medication release to 40 days. Chlorhexidine release was affected by pH of the release media and type of LbL coating, with a greater release at pH 5. PAA and PAH LbL coating had the highest amount of chlorhexidine release. This work illustrates that the LbL coating is an efficient technique for controlling the release of chlorhexidine from silica nanocarriers, with PAA and PAH coat being most effective among other polyelectrolytes tested. Different release profiles can be adapted for a variety of biomedical uses such as orthopedic or dental applications.

Study of the doping of PEDOT:PSS films and the reversibility in organic electrochemical transistors

In this work, the effect in the performance of organic electrochemical transistors (OECTs) due to the doping with a secondary dopant solvent of poly(3,4ethylenedioxythiophene): poly (styrene sulfonic acid) (PEDOT:PSS) films) has been studied. We found an improvement in the performance of the OECTs related to the increase of conductivity of the PEDOT:PSS film due to the doping with ethylene glycol (EG). We found that PEDOT:PSS films doped with EG showed higher conductivity due to the improvement of conducting paths between the PEDOT+ chains, which causes a higher transconductance and response of the OECTs. However, a higher concentration of EG is detrimental to the OECT performance due to the removal of PSS- chains caused by the EG secondary doping, which was corroborated by X-ray diffraction.We propose that the good reversibility between low-resistance state (ON) to high-resistance state (OFF), is caused by the injection/removal of cations in the polymeric film to maintain the electroneutrality. We found applying more negative gate voltage pulses in the transfer characteristics of the OECTs is necessary to reach the complete oxidation of the PEDOT:PSS film, as lower negative voltages only partially dedope the film.

Iontophoretically controlled insulin delivery via water-soluble conductive polymer PANI:PSS and thermoplastic polyurethane matrix.

Transdermal insulin delivery is an alternative route to deliver insulin through the body skin with the challenges to overcome the low drug skin permeability and high molecular weight. Polyaniline doped with poly(4-styrenesulfonic acid) (PANI:PSS), a conductive polymer with the high electrical conductivity, was synthesized and utilized as a drug carrier to improve the drug delivery capability from a porous thermoplastic polyurethane (TPU) matrix. The insulin was electrostatically attached to PANI:PSS based on the ion exchange between insulin and PSS. For the in vitro drug release of insulin loaded PANI:PSS relative to the pristine insulin alone, the amount of insulin released was improved to 84.70% with the time to equilibrium of 2h under the electrical field of 6V. For the ex vivo release-skin permeation, the amount insulin released and permeated became lower at 57.02% with time to equilibrium of 2h, due to the pig skin acting as a barrier for insulin permeation. The modified insulin transdermal delivery, with PANI:PSS as the drug carrier and drug enhancer relative to without, is shown here to influence the insulin release rate, amount, and duration, suitable to treat diabetes patients.