The progressive strengthening of the continental lithosphere triggered a secular transition in tectonic style during Neoarchean times, allowing the progressive establishment of Plate Tectonics on our planet. Structural investigations in Neoarchean cratons offer therefore a critical tool to constrain how such transition took place. The highly-mineralized Yilgarn Craton of Western Australia exposes one of the largest and best preserved portions of Archean continental crust worldwide. The Yilgarn crust was intensely deformed during the c. 2730–2650 Ma Neoarchean Yilgarn Orogeny, which was accompanied by widespread granitic magmatism, and was mostly unaffected by post-Archean pervasive tectonic events, representing therefore an ideal area for the study of Neoarchean tectono-magmatic events. Here, I combine new structural data with a re-examination of the recent regional structural literature, to offer an updated view of the structural evolution of the Murchison Domain, one of the best-exposed and mineralized portions of the Yilgarn Craton. The result is a new fourfold scheme for the structural evolution of the domain, supported by a detailed and structurally-controlled geochronological dataset. The preserved tectono-magmatic evolution of the domain started with a pre-orogenic period of dominant polydiapirism, during times of prevailing tectonic quiescence. This was followed by a sequence of orogenic deformation events that produced north-striking large-scale shear zones, along which syntectonic plutons, up to 100 km in size, were emplaced during three major tectonic pulses characterized by bulk east–west shortening, between 2730 and 2660 Ma. The deformation events identified here at the scale of the Murchison Domain are likely the local expression of Yilgarn-wide tectono-magmatic events, highlighting the importance of syntectonic granitic magmatism in shaping Neoarchean orogens.