Resonance Studies Research Articles

Study of Resonance between Bogie Hunting and Carbody Mode via Field Measurements and Dynamic Simulation.

By addressing the phenomenon of carbody abnormal vibrations in the field, the acceleration of the carbody and bogie was measured using accelerometers, and the diamond mode of the carbody was identified. The equivalent conicity of the wheelset and the acceleration at the frame end indicated that the shaking of the carbody was caused by bogie hunting. In the SIMPACK simulation, the acceleration frequency and amplitude at the frame end and midsection of the side beam were calculated. The lateral deformation amplitude of the side beam in the finite element model was extracted, and a modal shape function for the diamond-shaped mode was established. By utilizing the modal vibration equation, the modal generalized forces of the carbody were computed, revealing that, during carbody shaking, the yaw damper force contributed significantly among the forces of the secondary suspension, with the phase difference between the front and rear bogies approaching 180°. This insight offers a novel perspective for subsequent active control strategies. Subsequently, these modal generalized forces were applied as external excitation to a coupled vibration model encompassing both the carbody and transformer. Aiming to reduce the acceleration amplitude at the side beam, the transformer was treated as a dynamic vibration absorber, allowing for the optimization of its lateral suspension parameters. As a result, the lateral and vertical acceleration amplitudes at the side beam were concurrently reduced, with the maximum decrease reaching 58.5%, significantly enhancing the ride comfort.

Study of Resonances in Exotic Drip-Line Nuclei by the Use of Super-Symmetric Quantum Mechanics

Study of Resonances in Exotic Drip-Line Nuclei by the Use of Super-Symmetric Quantum Mechanics

Early assessment of circulating exosomal lncRNA-GC1 for monitoring neoadjuvant chemotherapy response in gastric cancer.

The timing of surgery for patients with gastric cancer (GC) who undergo neoadjuvant chemotherapy (neoCT) was mainly guided by serial radiologic imaging. However, an earlier assessment was indispensable to avoid delayed treatment for nonresponders and excessive toxicity for responders. Our previous study has identified circulating extracellular vesicles-derived lncRNA-GC1 as a biomarker for early detection and monitoring progression of GC. However, the potential role of neoCT remains poorly understood. In this explorative biomarker analysis, we conducted a multi-cohort study to examine longitudinal levels of circulating extracellular vesicles-derived lncRNA-GC1 in 798 patients enrolled in the RESONANCE study (NCT01583361). Both circulating extracellular vesicles-derived lncRNA-GC1 and traditional gastrointestinal biomarkers were assessed at defined time nodes. Computed tomography (CT) scans were performed before treatment and 8-10 weeks and assessed based on the RECIST criteria. Circulating extracellular vesicles-derived lncRNA-GC1 could be detected in 96.3% of patients at baseline, and significant reductions were observed before cycle 2 (P<0.0001). Levels of circulating extracellular vesicles-derived lncRNA-GC1 showed a stronger correlation with tumor burden and exhibited earlier dynamic changes than the traditional gastrointestinal biomarkers during the first cycle of neoCT. Strong agreement was observed between circulating extracellular vesicles-derived lncRNA-GC1 response (reduction >50%) and radiographic response (Cohen's κ, 0.704). Importantly, circulating extracellular vesicles-derived lncRNA-GC1 maintained predictive value in two external cohorts. Patients with circulating extracellular vesicles-derived lncRNA-GC1 response showed superior disease-free survival [hazard ratio (HR), 0.6238; 95% CI, 0.4095-0.9501; P=0.0118] and overall survival (HR, 0.6131; 95% CI, 0.4016-0.9358; P=0.0090). Circulating extracellular vesicles-derived lncRNA-GC1 is an early marker of neoCT efficacy and predicts superior survival in GC patients treated with neoCT.

The Elements of Cultural Power: Novelty, Emotion, Status, and Cultural Capital

Why do certain ideas catch on? What makes some ideas more powerful than others? Using a novel dataset that traces Chinese netizens’ discussion of U.S. politics on an online forum, this study examines key predictors of cultural power—novelty, emotion, status, and linguistic features—using an innovative diachronic word-embedding method. The study finds a curvilinear relationship between novelty and resonance, as well as a positive relationship between status and cultural power. Contrary to theoretical expectations, moderate emotions, whether positive or negative, are found to be more effective in evoking resonance than more intense emotions, possibly due to the mediating effect of the forum’s “group style.” Thus, it appears that although extreme sentiments toward the United States may exist, they are not likely to be resonant, at least among more educated Chinese netizens. The study also finds significant effects of linguistic features, such as lexical diversity and the use of English in Chinese discussions. This suggests a Bourdieusian “cultural capital signaling and selection” path to cultural power, which has not been considered in most studies of resonance.

Kinetic mass shifts of ρ(770) and K⁎(892) in Au+Au reactions at Ebeam = 1.23 A GeV

We explore the properties of the last generation of ρ(770) and K⁎(892) resonances created in Au+Au reactions at Elab=1.23AGeV via the reconstruction in the hadronic channel using the UrQMD model. Such resonance studies allow to obtain detailed information on the emission source in such reactions in a complementary way to di-lepton or HBT studies. We observe a freeze-out hierarchy and predict mass shifts for the ρ(770) resonance (Δmρ≈−330 MeV) and the K⁎(892) resonance (ΔmK⁎≈−30 MeV). These mass shifts are related to the regeneration cycles of each resonance species and are of purely kinetic origin. Experimentally our predictions can be tested using the GSI-HADES experiment or the lowest RHIC-BES energy.

Study of resonances in exotic neutron-rich 14Be by the use of isospectral potential

In this work, Hyperspherical Harmonic Expansion (HHE) formalism aided by supersymmetric quantum mechanics is used to study bound and resonant states of 14Be in the three-body (12Be+ n + n) cluster model, and the analysis of the resonant states close to the binding threshold utilizes supersymmetric quantum mechanics (SSQM). GPT nucleon-nucleon potential together with SBB core-nucleon potential is chosen for the solution of three-body Schrödinger equation to get the lowest bound state energy and wave function. In the next stage, energy and wave function of the bound state is used to derive an isospectral potential that exhibit deep well following a strong barrier facilitating confinement (or trapping) of particle inside it at some positive energy (E>0). The trapping probability when plotted against energy shows a prominent peak at the energy of resonance. WKB approximation is used to determine the width of resonance width. Calculated resonance energy and width of resonance are compared with those measured experimentally for the promising neutron halo candidate, the 14Be.

PB1879: OVERALL SURVIVAL OF RELAPSED/REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS TREATED WITH IBRUTINIB IN ALBANIA (2018-2022)

Background: The survival and the outcome of the patients with refractory/relapsed Chronic Lymphocytic Leukemia, in the beginning has been limited and unsatisfactory, but has significantly improved during the last decades, with the discovery of the pathway inhibitors. The overall survival depends mostly on their response to the lines of treatments used and is patient-related and we have to take in consideration also the numbers of chemotherapies applied. The significant benefit of Ibrutinib approved in 2014 as a target therapy for all the patients with Chronic Lymphocytic Leukemia who has been treated previously with at least one line of therapy has been shown across all the risk groups, as demonstrated in the RESONATE study. Aims: Our study aims to evaluate the Overall Survival (OS) of all the refractory/relapsed Chronic Lymphocytic Leukemia patients treated with Ibrutinib in the third line of therapy from 2018 until january 2022 and evaluate the correlation of this survivance with the age subgroups and gender. Methods: We studied all the patients diagnosed in our University Hospital Center “Mother Teresa” in Tirana, Albania with R/R CLL who started the treatment with ibrutinib, in combination or not with immunotherapy from July 2018 until January 2022 from age >18 years old and up. We collected the data from the registries and database of Hematology Clinic. The data were analysed with SPSS variant 25. Results: From July 2018 until January 2022 we have treated with Ibrutinib third line 46 patients diagnosed with R/R CLL, 32 (69.6%) were males and 14 (30.4%) were females with a ratio M/F of about 2:1 with a median age of 63 ± 7.4 (range 43 – 80) years old. The estimated median Overall Survival resulted of 28 ± 4.9 (95%CI range 18- 37) months. Overall survival estimated according to age subgroups was higher in the 50-59 yo subgroup resulting in 38 ± 7.7 (95%CI range 16- 39) months. The differences of overall survival of the patients with R/R CLL treated with ibrutinib in the third line depending on gender were non significant Image:Summary/Conclusion: Chronic Lymphocytic Leukemia is the most common type of leukemia in the western countries and with the median age at the diagnosis of 72 years old and diagnosed more in males than in the females1. In 2013 Byjrd JC et al published in N Engl J Med that the response to Ibrutinib of R/R CLL patients previously treated was independent of clinical and genomic factors with an OS 83% at 26 months. In our study we found a median younger age of the patients at the moment of the diagnostication (median age of 63 years old) compared with the literature and a ratio male:femato 2:1. The median overall survival resulted 28 ± 4.9 (95%CI range 18- 37) months In our study found also that gender does not influence the overall survival of the patients with R/R CLL treated with ibrutinib in the third line.

Electric Field Sensor Based on High Q Fano Resonance of Nano-Patterned Electro-Optic Materials

This paper presents theoretical studies of Fano resonance based electric-field (E-field) sensors. E-field sensor based on two electro-optical (EO) materials i.e., barium titanate (BaTiO3, BTO) nanoparticles and relaxor ferroelectric material Pb(Mg1/3Nb2/3)O3-PbTiO3 (PMN-PT) combined with nanostructure are studied. As for the BTO based E-field sensor, a configuration of filling the BTO nanoparticles into a nano-patterned thin film silicon is proposed. The achieved resonance quality factor (Q) is 11,855 and a resonance induced electric field enhancement factor is of around 105. As for the design of PMN-PT based E-field sensor, a configuration by combining two square lattice air holes in PMN-PT thin film but with one offsetting hole left is chosen. The achieved resonance Q is of 9,273 and an electric field enhancement factor is of around 96. The resonance wavelength shift sensitivity of PMN-PT nanostructured can reach up to 4.768 pm/(V/m), while the BTO based nanostructure has a sensitivity of 0.1213 pm/(V/m). If a spectrum analyzer with 0.1 pm resolution is considered, then the minimum detection of the electric field Emin is 20 mV/m and 0.82 V/m for PMN-PT and BTO based nanostructures, respectively. The nano-patterned E-field sensor studied here are all dielectric, it has therefore the advantage of large measurement bandwidth, high measurement fidelity, high spatial resolution and high sensitivity.

Study of Tunable Single and Coupled EBG Resonators

Study of Tunable Single and Coupled EBG Resonators

Growth and characterization studies of 3-aminobenzene sulfonic acid single crystal for thermal application

We report the growth and characterization of 3-Amino benzene sulfonic acid (3-ABSA) of an organic single crystal for the first time under slow evaporation technique. The presence of characteristics vibrational groups and molecular structure were established by Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) studies. The lower ultraviolet ray absorption edge was found to be 220 nm with a broad transmission window was observed in the visible region. The mechanical strength of grown crystal was assessed, and it belongs to soft material category. However, high thermal stability and other thermodynamic parameters were calculated using thermogravimetric (TGA) and differential thermal analyses (DTA). Therefore, the dielectric behavior of grown crystal was measured at various frequencies and temperature. The Kurtz powder second harmonic generation displays the second harmonic generation behavior of material and its efficiency is 0.55 times that of KDP were discussed in detail.

Supercapacitor applications of 2_aminoisobutyric acid-mediated N-doped graphene

N-doped graphene has been synthesized by the reduction of graphene oxide (GO) using 2-aminoisobutyric acid (AIB) as a reducing agent (N-GrAIB) under mild experimental conditions in aqueous medium. The reduction of GO was indicated by a change in its optical absorption as well as by its Raman spectrum and 13C solid state magic angle spinning (MAS) nuclear magnetic resonance (NMR) studies. The latter two techniques also confirmed the doping of N. N-GrAIB exhibited fairly high conductivity (6.3 S/cm), high specific capacitance (228 F/g at 1 A/g) with good cycling stability for 1000 charge-discharge cycles, high coulombic efficiency (100-101%) and high energy density of 20.26 Wh/kg at a power density of 400 W/kg. The present work shows that this environmental benign N-doped graphene (N-GrAIB) could be a promising electrode material for supercapacitor applications. Copyright © 2016 VBRI Press

Insights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles

BackgroundThis cardiovascular magnetic resonance (CMR) study investigates the impact of trabeculae and papillary muscles (TPM) on diastolic function parameters by differentiation of the time-volume curve. Differentiation causes additional problems, which is overcome by standardization.MethodsCine steady-state free-precession imaging at 1.5 T was performed in 40 healthy volunteers stratified for age (age range 7–78y). LV time-volume curves were assessed by software-assisted delineation of endocardial contours from short axis slices applying two different methods: (1) inclusion of TPM into the myocardium and (2) inclusion of TPM into the LV cavity blood volume. Diastolic function was assessed from the differentiated time-volume curves defining the early and atrial peaks, their filling rates, filling volumes, and further dedicated diastolic measures, respectively.ResultsOnly inclusion of TPM into the myocardium allowed precise assessment of early and atrial peak filling rates (EPFR, APFR) with clear distinction of EPFR and APFR expressed by the minimum between the early and atrial peak (EAmin) (100% vs. 36% for EAmin < 0.8). Prediction of peak filling rate ratios (PFRR) and filling volume ratios (FVR) by age was superior with inclusion of TPM into the myocardium compared to inclusion into the blood pool (r2 = 0.85 vs. r2 = 0.56 and r2 = 0.89 vs. r2 = 0.66). Standardization problems were overcome by the introduction of a third phase (mid-diastole, apart from diastole and systole) and fitting of the early and atrial peaks in the differentiated time-volume curve.ConclusionsOnly LV volumetry with inclusion of TPM into the myocardium allows precise determination of diastolic measures and prevents methodological artifacts.

Study of Resonances Via CDCC Analysis with the Complex-Scaling Method

Study of Resonances Via CDCC Analysis with the Complex-Scaling Method

Cardiac function is normal in most patients recovered from COVID-19

Abstract Background There are conflicting results regarding impaired cardiac function in patients that have recovered from COVID-19. Cardiovascular magnetic resonance (CMR) studies have revealed a very high frequency of cardiac involvement (78%) and ongoing myocardial inflammation (60%) in patients recently recovered from COVID-19. Findings are advocating further investigation of the long-term myocardial consequences of COVID-19 disease. Purpose We aimed to investigate left ventricular (LV) and right ventricular (RV) function by a comprehensive echocardiographic study in patients recovered from COVID-19 infection 3 months after admission to hospital. Methods All patients (n=92) had been hospitalized for COVID-19 and were examined with echocardiography three months after hospitalization. They were 59±13 years, and 43% were women. LV function was assessed by ejection fraction (EF) and global longitudinal strain (GLS) and RV function was measured by fractional area change (FAC), tricuspid annular plane systolic excursion (TAPSE) and RV GLS free wall. Tricuspid regurgitation pressure gradient was measured to estimate pulmonary artery pressure. Results LV EF was 63±6% and LV GLS was −18.6±2.2%. All patients had normal EF &amp;gt;53%, but 10 showed signs of subtle impaired LV function by LV GLS (≥ −16%). Only two of these did not have hypertension, LV hypertrophy, diabetes or other preexisting diagnosis of heart disease explaining subtle LV dysfunction. All had normal RV FAC (48±7%) and TAPSE (2.3±0.3 cm). We found modestly impaired RV longitudinal function (RV GLS free wall &amp;gt;−25%) in 30% patients, but none had RV GLS worse than −20%. One-third of all patients with reduced RV GLS had signs of elevated pulmonary arterial pressures, which might impact the assessment of RV function. Conclusions Traditional echocardiographic parameters showed normal function in all hospitalized COVID-19 patients three months after hospital admittance. Approximately one-third had subtle ventricular dysfunction detected by sensitive echocardiographic methods, but these findings could mostly be explained by systemic or pulmonary hypertension. We cannot, however, exclude that a slight reduction in cardiac function in a minority of our patients was caused by the COVID-19 infection. Funding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): National Clinical Therapy Research in the Specialist Health Services, Norway

2-Methylimidazolium pyridine-2,5-dicarboxylato zinc(II) dihydrate: Synthesis, characterization, DNA interaction, anti-microbial, anti-oxidant and anti-breast cancer studies

2-Methylimidazolium pyridine-2,5-dicarboxylato zinc(II) dihydrate crystal (1) is synthesized and characterized by Fourier transform infrared spectroscopy (FTIR), single crystal X-ray diffraction analysis (SCXRD), thermogravimetric-differential thermal analysis (TG-DTA), scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), powder X-ray diffraction analysis (PXRD), proton nuclear magnetic resonance (1H NMR) studies, electronic absorption studies (UV-VIS) and DNA interaction studies. 1 was then explored for anti-microbial, anti-oxidant and anti-cancer activity. The SCXRD studies show that the compound crystallizes in the triclinic system and exhibits a distorted octahedral geometry with methyl imidazole ion as the cation. An exothermic decomposition at 400 °C implies high temperature stability in TG-DTA. PXRD confirms the phase purity of the sample. 1H NMR and UV-VIS results show that the solution structure of 1 is in agreement with SCXRD data. DNA interactions evaluated by agarose gel electrophoresis method substantiate the intercalative mode of binding. Anti-oxidant analysis shows that it exhibits good scavenging ability against DPPH and NO radicals. Anti-microbial activity suggests that 1 has better activity against Escherichia coli than Staphylococcus aureus. Further, the potential anti-cancer activities of complex indicate that the compound has good activity with a half-maximal inhibition concentration (IC50) value of 21.3 against MCF-7 human breast cancer cell line, suggesting that it may act as an anti-breast cancer drug.

Insight into dual fluorescence effects induced by molecular aggregation occurring in membrane model systems containing 1,3,4-thiadiazole derivatives

This work reports on biophysical insights into the excited state intramolecular proton transfer (ESIPT) processes taking place in three 1,3,4-thiadiazole derivatives that served as model compounds, on which electronic absorption, fluorescence, Fourier-transform infrared spectroscopy (FTIR), surface plasmon resonance (SPR) and electrochemical impedance spectroscopy (EIS) studies were performed. The fluorescence spectra recorded in various solvents revealed an interesting dual fluorescence effect. In molecules in their monomeric form, the effect is associated with the ESIPT phenomenon, and may be further enhanced by aggregation-related effects, such as aggregation-induced emissions. Other spectroscopic studies on the selected molecules in a liposomal medium as a model revealed that, in a biomimetic environment, they can exist in both monomeric and aggregated forms. In both cases, however, the effects observed are closely related to the lipid’s main phase transition temperature and the structure of the molecule. Introduction of specific substituents to the phenyl moiety either allows or prevents proton transfer from occurring in the excited state. The hydrophobicity changes in a lipid environment may result in an emergence of specific molecular forms and therefore either facilitate or hinder ESIPT processes. SPR and EIS confirmed the significant hydrophobicity changes in the model lipid systems, while FTIR measurements revealed a notable influence of 1,3,4-thiadiazoles on the fluidity of liposomal membranes. The results obtained clearly show that the thiadiazole derivatives are very good model molecules for studying hydrophobic-hydrophilic environments, and particularly with polymers or liposomes used as drug delivery systems.

The breakthrough of a quantum chemist by classical dynamics: Martin Karplus and the birth of computer simulations of chemical reactions

1964–1965 was an early, crucial period in Martin Karplus’ research—a time when, rather unexpectedly, he approached the problem of reactive collisions using a quasiclassical approximation with the aid of computer technologies. This marked a substantial departure from the quantum-chemical studies of nuclear magnetic resonance that had, until then, dominated his work. The historical perspective outlined by George Schatz, as well Karplus’ own biography, partly frames the contours of this remarkable period in the history of theoretical chemistry. Yet, the available historical literature is not sufficiently complete to allow us to understand Karplus’ transition from nuclear magnetic resonance to reaction dynamics. In this article, we discuss the intellectual ground on which Karplus operated around 1964, further commenting on the relevance of his quantum and quasiclassical studies and pondering how Karplus’ approach eventually led to his interest in the simulation of complex biomolecules.

Resonance study: Effect of partial triples excitation using complex absorbing potential‐based Fock‐space multi‐reference coupled cluster

AbstractResonances are metastable states with finite lifetime. They play important role in physics, chemistry and biology. The theoretical calculation of resonance state is a challenging problem. In this paper we have studied the shape resonance of Be, Mg, N2 and CO. We have used correlated independent particle approximation to the Fock space multi‐reference coupled cluster singles‐doubles with third‐order triples (CAP‐CIP‐FSMRCCSD(T)) method augmented by complex absorption potential. The resonance energy and decay widths are obtained by solving a non‐Hermitian eigen‐value problem within FSMRCC framework. The effects of the lowest order triples on the resonance energy and decay are studied.

Changes of Metabolic Connectivity in Dementia with Lewy Bodies with Visual Hallucinations: A 18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Study.

Background: Recurrent complex visual hallucinations (VHs) are common in dementia with Lewy bodies (DLB). Previous investigations suggest that VHs are associated with connectivity changes within and between large scale networks involved in visual processing and attention. Aim: To examine more directly whether VH in DLB reflects direct changes in neuronal activity between cortical regions assessing metabolic connectivity with 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/magnetic resonance and graph theory. Methods: Twenty-six patients with probable DLB (13 VHs and 13 no-VHs; mean age: 72.9 ± 6.87 years vs. 70.2 ± 7.96 years) were enrolled. T1-weighted 3T-MR images and FDG-PET data were coacquired using an integrated PET/MR scanner. MR images defined cortical parcels of the Shaefer-Yeo atlas for multiple functional networks. We computed in each parcel the regional standardized-uptake-values (SUV) corrected for partial volume and normalized to the cerebellar cortex. Strength degree, clustering coefficient, characteristic path length, and hubs were analyzed with graph analysis. Results: The mean 18F-FDG-PET SUVr of parcels belonging to the visual and dorsal attention networks (DANs) were significantly lower in the VH group (p = 0.01). Metabolism in the right temporoparietal cortex correlated with VH severity (R = -0.58; p < 0.01). VH patients showed weaker metabolic connectivity in the parietal, temporal, and occipital cortex of the default mode network, DAN, and visual networks, but more robust connectivity in the right insula and orbitofrontal cortex. A lower global efficiency characterized the VH group, except for ventral attention network and limbic network. Conclusions: VHs in DLB correlate with lower glucose metabolism and weaker metabolic connectivity in the parietal-occipital cortex, but stronger connectivity in the limbic system. Impact statement This study shows that application of the graph theory to 18F-fluorodeoxyglucose-positron emission tomography data, commonly acquired during the diagnostic workflow in neurodegenerative diseases, could be used to obtain information of functional connectivity at a group level, with results that are consistent with other data commonly used in brain functional investigation (e.g., electroencephalography or functional magnetic resonance). New network-based methods of metabolic image analyses, such as graph analysis, are a recent area of research with a potential capacity to extract information on alterations of metabolic connectivity that may become pharmacological and neuromodulation targets of the physiopathology of recurrent complex visual hallucinations.

Natural history of right ventricle: longitudinal study in veteran athletes

Abstract Funding Acknowledgements Type of funding sources: None. INTRODUCTION Right ventricular (RV) enlargement is a physiologic adaptation to long lasting athletic training. Its clinical implications for veteran athletes are poorly understood. In recent years, controversial data suggest an association between ultra-endurance exercise and a RV cardiomyopathy similar to arrhythmogenic cardiomyopathy (ACM). In this context, the effects of exercise detraining have not been extensively studied yet. PURPOSE The aim of this study was to assess the morphological and functional RV changes in veteran athletes and to evaluate the effect of a long period of detraining. METHODS This is a longitudinal study including 22 veteran rowers with at least 10 years of competitive career. We evaluated them with an echocardiographic assessment at baseline and after a minimum of 3 years of detraining (age: 23.2 ± 4.4 and 43 ± 7.4 years), by reducing the weekly training volume from 26 ± 0.7 to 3 ± 2 hours. In this second evaluation we also performed an RV strain analysis and a cardiac magnetic resonance (CMR) study. RESULTS RV end diastolic (ED) areas significantly reduced after detraining (31.48 ± 5.8 versus 28.59 ± 6.8; p = 0.001), although remaining larger than normal. RV enlargement was balanced: the ratio between inflow (IT) and outflow tract (OT) (RVIT/RVOT = 1.4 ± 0.1) and the ratio between RV and left ventricle (LV) (RV/LV = 0.81 ± 0.1) were within normal limits. The fractional area change (FAC%) was normal at baseline and increased significantly (41.5 ± 6% versus 45.8 ± 7%; p = 0.011). After detraining, RV longitudinal strain was normal (-19.7 ± 2.7%). CMR assessment showed enlarged RVED volumes (97.9 ± 14 ml/m2) but normal RV ejection fraction (55.5 ± 4.1%). CONCLUSIONS RV enlargement in endurance athletes persists after a long period of detraining. However, detraining results in a significant reduction of RV dimensions. Furthermore, the absence of RV dysfunction or disproportionate RV geometry are reassuring findings that suggest a physiological remodeling of the RV. Significant echo findings. RV ECHO PARAMETERS BASELINE DETRAINING MEAN DIFF. (C.I. 95%) p VALUE RVOT plax (mm) 34.8 ± 4 33.7 ± 14 1.1 (0.18; 2.1) p = 0.011 RVOT psax (mm) 34.9 ± 3.3 33.09 ± 3.5 1.8 (0.9; 2.7) p &amp;lt; 0.001 RV basal diameter (mm) 47.31 ± 5.3 45.86 ± 6.4 1.4 (0.04; 2.8) p = 0.022 RV end-diastolic area (cm&amp;sup2;) 31.48 ± 5.8 28.59 ± 6.8 2.8 (1.1; 4.6) p = 0.001 FAC% 41.5 ± 6 45.8 ± 7 0.04 (-0.07; -0.007) p = 0.011 RV inflow/outflow ratio 1.36 ± 0.1 1.36 ± 0.2 -0.003 (-0.06; 0.06) p = 0.454 RV/LV ratio 0.82 ± 0.07 0.81 ±0.1 0.01 (-0.01; 0.04) p = 0.219 Abstract Figure. Comparison in the same veteran athlete.