Design Study Research Articles

Experimental study of design and manufacture for CFRP bamboo rat tooth bionic drill bit

Experimental study of design and manufacture for CFRP bamboo rat tooth bionic drill bit

The Ecology of Human Sleep (EcoSleep) Cohort Study: Protocol for a longitudinal repeated measurement burst design study to assess the relationship between sleep determinants and outcomes under real-world conditions across time of year.

The interplay of daily life factors, including mood, physical activity, or light exposure, influences sleep architecture and quality. Laboratory-based studies often isolate these determinants to establish causality, thereby sacrificing ecological validity. Furthermore, little is known about time-of-year changes in sleep and circadian-related variables at high resolution, including the magnitude of individual change across time of year under real-world conditions. The Ecology of Human Sleep (EcoSleep) cohort study will investigate the combined impact of sleep determinants on individuals' daily sleep episodes to elucidate which waking events modify sleep patterns. A second goal is to describe high-resolution individual sleep and circadian-related changes across the year to understand intra- and inter-individual variability. This study is a prospective cohort study with a measurement-burst design. Healthy adults aged 18-35 years (N = 12) will be enrolled for 12 months. Participants will continuously wear actimeters and pendant-attached light loggers. A subgroup will also measure interstitial fluid glucose levels (six paticipants). Every 4 weeks, all participants will undergo three consecutive measurement days of four ecological momentary assessments each day ('bursts') to sample sleep determinants during wake. Participants will also continuously wear temperature loggers (iButtons) during the bursts. Body weight will be captured before and after the bursts in the laboratory. The bursts will be separated by two at-home electroencephalogram recordings each night. Circadian phase and amplitude will be estimated during the bursts from hair follicles, and habitual melatonin onset will be derived through saliva sampling. Environmental parameters (bedroom temperature, humidity, and air pressure) will be recorded continuously.

Design, Synthesis, Biological and Docking Studies of Novel 6-fluorobenzothiazole Substituted 1,2,4-Triazole Analogues as Prospective Anti-inflammatory Agents.

Design, Synthesis, Biological and Docking Studies of Novel 6-fluorobenzothiazole Substituted 1,2,4-Triazole Analogues as Prospective Anti-inflammatory Agents.

(In)forming the new building envelope: A pedagogical study in generative design with precedents and multimodal large language models

(In)forming the new building envelope: A pedagogical study in generative design with precedents and multimodal large language models

Design, Synthesis, and Theoretical Studies on the Benzoxadiazole and Thienopyrrole Containing Conjugated Random Copolymers for Organic Solar Cell Applications.

In this study, six different donor-π-acceptor1-π-donor-acceptor2 type random co-polymers containing benzodithiophene as a donor, benzooxadiazole (BO), and thieno[3,4-c]pyrrole-4,6-dione (TPD) as acceptor, have been synthesized and characterized. In addition to the acceptor core ratio at different values, the effect of aromatic bridge structures on the optical, electronic, and photovoltaic properties of six different random co-polymers is investigated by using thiophene and selenophene structures as aromatic bridge units. To investigate how the acceptor unit ratio and replacement of aromatic bridge units impact the structural, electronic, and optical properties of the polymers, density functional theory (DFT) calculations are carried out for the tetramer models. The open-circuit voltage (VOC), which is strongly correlated with the HOMO levels of the donor material, is enhanced with the increasing ratio of the TPD moiety. On the other hand, the short-circuit current (JSC), which is associated with the absorption ability of the donor material, is improved by the increasing ratio of BO moiety with the π-bridges. BO moiety dominant selenophene π-bridged co-polymer (P4) showed the best performance with a power conversion efficiency (PCE) of 6.26%, a JSC of 11.44mAcm2, a VOC of 0.80V, and a fill factor (FF) of 68.81%.

Mathematics Learning Centers – Not Just for the Elementary Classroom

Given the recent trajectory of secondary mathematics performance in the United States, as compared to international counterparts, this design and development case study aimed to explore the varied pedagogical practice and its impact on mathematics proficiency. This study sought to improve mathematics proficiency through varied instructional practices. During one algebra unit, two instructional modalities were employed, by the same instructor, to two separate groups of students. Quantitative measures were captured through the descriptive statistics of Pre-test, Post-test, and Reaction Survey results. The Kirkpatrick Model (Level I and II) was also employed. In addition, qualitative data were obtained through Researcher Notes, Researcher Experience Journal, and Participant Journals. Findings suggested the effectiveness of a learning center pedagogical design, including peer collaboration, technology, and small group, as it yielded higher proficiency than traditional direct instruction. Pre- to Post-Test scores revealed a 1.727 higher mean growth in the experimental group over the control group (Culleny, 2021).

Cyclophosphamide and horse anti-thymocyte globulin versus fludarabine, reduced cyclophosphamide and rabbit anti-thymocyte globulin conditioning regimen for allogeneic hematopoietic stem cell transplantation from matched sibling donors in patients with acquired aplastic anemia

ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for acquired aplastic anemia (acquired AA) in young patients. The objective of the study was to compare patient outcomes after Cyclophosphamide and horse antithymocyte globulin (Cy-hATG) versus Fludarabine-cyclophosphamide and rabbit ATG (Flu-Cy-rATG) as part of conditioning regimen in allo-HSCT for acquired AA. Research design and methods Descriptive retrospective study conducted on patients with acquired AA who received allo-HSCT from HLA-matched sibling donors between January 2008 and August 2022 after conditioning regimen with Cy-hATG or Flu-Cy-rATG. Results A total of 121 patients were enrolled. Cumulative incidence of graft failure was 11.2% in Cy-hATG and 5.3% Flu-Cy-rATG group. There were no significant differences between the two groups in terms of acute GVHD, chronic GVHD and transplant related mortality. Flu-Cy-rATG group was associated with significantly higher CMV and EBV reactivation(s) compared to Cy-hATG group (p = 0.008 and 0.035, respectively). After a median follow-up of 58 months, estimated overall survival, event-free survival and graft rejection-free survival were not statistically different between the two groups. Conclusions In high-risk population, Flu-Cy-rATG is associated with comparable outcomes to Cy-hATG in allo-HSCT from MSD. However, it seems to be associated with significant risk of viral infections.

Design, Synthesis, Cytotoxicity Profiling, Molecular Docking and ADMET Studies of Novel Functionalized Coumarin-Pyrazole-Thiazole Hybrids: Cyclization of Chromonyl Thiazolyl Pyrazolyl Thiosemicarbazone with α-Halocarbonyl Reagents

Abstract: A simple synthetic method was performed to design a novel series of polycyclic systems consisting of a coumarin-pyrazole-thiazole skeleton linked with a completed thiazole ring via hydrazone linkage. The methodology depended on the cyclization of the active precursor 2-[(3-(2-oxo-2H-chromen-3-yl)-1-(4- phenylthiazol-2-yl)-1H-pyrazol-4-yl)methy-lene]hydrazine-1-carbothioamide (2) by its reaction with a series of α-halocarbonyl reagents under Hantzsch reaction conditions. The spectral and analytical data confirmed the structures of all the synthesized compounds. The target compounds were screened for their in vitro anticancer activity. The cytotoxic effects of obtained compound were screened against cancer cell lines (MCF-7, HepG2, and HCT116) using the standard SRB method. Furthermore, products 4, 5, and 7b were the most active against all cancer cell lines, compared with Doxorubicin. These bioactive products effectively suppress the growth of cancer cells by activating the cell death program through late apoptosis. In addition, products 4 and 5 arrested the cell cycle at the S and G2 phases, while product 7b has the ability to arrest the cell cycle at the G2 phase against all three cancer cells. The molecular docking of the products 4, 5, and 7b showed good binding affinities with Cyclin-dependent kinase 8 (CDK-8), while the ADMET prediction supported that these bioactive products can be promising anticancer agents.

Multi-Physics Coupling in IGBT Modules: A Review

Abstract Since insulated gate bipolar transistor (IGBT) is a core component for power conversion in a power electronic system, guaranteeing the safety of IGBT becomes a crucial task for the maintenance of the power system. However, the mechanism of IGBT failure is a considerably complicated process related to the dynamic process, involving electric, thermal, and force. Hence, understanding the behaviors of IGBT under multi-physics field coupling plays an important role in the design and reliability studies of IGBT. In this paper, we review the multi-physics coupling effects, namely, electric-thermal coupling, thermal-force coupling, and force-electric coupling, inside IGBT devices. The basic principles of each coupling, coupling models, application occasions as well as key issues and development trends are discussed in detail, respectively.

Cold tones for sincerity and warm tones for excitement: interactive effects of color tone and brand personality on brand evaluation

ABSTRACT The interior design of hospitality settings is crucial for distinguishing a brand from its competitors. Drawing on color marketing and brand personality theories, this paper posits that aligning interior color tones with the brand personality of the hospitality and tourism brand can heighten tourists’ perceptual fluency and thus their brand evaluation. Three studies support this proposition. The initial archival data analysis discovered a correlation between cold – warm interior tones and sincere – exciting brand personality in real-world hotel interior designs (Study 1). Study 2 revealed that cold tones evoke brand perceptions of sincerity, whereas warm tones elicit brand perceptions of excitement. Study 3 confirmed the effects of matching cold – warm tones with brand personality on brand evaluations and the mediating role of perceived fluency. The present research holds significant practical implications for hospitality and tourism suppliers in terms of interior design, brand personality identification, online platform promotional design, and brand marketing strategy development.

Innovative spoke design for non-pneumatic tyres with enhanced load-bearing capacity and customizability for all vehicles

For over a century, pneumatic tyres have been a crucial part of automobiles. Recently, non-pneumatic (airless) tyres have emerged, offering innovation but facing challenges in complexity, vehicle safety, adaptability, and load-bearing capacity. This research introduces a new spoke design for non-pneumatic tyres that outperforms conventional honeycomb and diamond spokes tyres in load-bearing capacity, while being less complex and customizable for various vehicles, including public transport. The study is structured into two phases. In Phase 1, the spoke design is selected from various CAD models using SolidWorks. This involves comparing the parabola design against prior design studies and honeycomb and diamond spokes concerning total deformation, maximum shear stress, equivalent (von Mises) stress, and maximum principal elastic strain with the help of FEA software Ansys. Results show that the Parabola design surpasses the pneumatic tyres in terms of load-bearing capacity, The parabola spoke design shows a consistent vertical stiffness under varying loads, ranging from 1500 N to 4500 N, with no sudden spikes or drops indicating structural instability. The objective is to identify the spoke design that best meets the performance objectives for phase 2 analysis. In Phase 2, the material selection and analysis are conducted. The goal is to determine the optimal polyurethane durometer rating for bus tyres. In this phase, the insights from Phase 1 are applied to scale up the design and choose suitable materials, showcasing the design’s adaptability from car tyres to bus tyres. Ansys will be used for analysing the total deformation of the tyre under a force of 40,000N, simulating the extreme operating conditions for bus tyres. This paper provides valuable data on non-pneumatic tyre spoke design, material selection, deformation analysis, design optimization, and standardization, enhancing vehicle safety and performance in public transport.

Dietary free L-glutamate contributes to maintaining a low sodium intake among Vietnamese.

The World Health Organization (WHO) and the Food and Agriculture Organization (FAO) recommend the consumption of less than 2,000 mg of sodium/day to reduce blood pressure and the risk of conditions such as cardiovascular disease and coronary heart disease. The sodium intake among Vietnamese was reported to be 7,200 mg/d or more. Free L-glutamate enhances flavor when it is added to food and improves the taste of sodium-reduced foods. This study aims to investigate whether the intake of free L-glutamate-rich seasonings contributes to maintaining a low sodium intake in a cross-over study. From a total of 145 subjects, 42 participants were screened for participation in the cross-over design study. Subjects were randomly allocated to the Low free L-glutamate group (Low free L-Gl) and the Normal free L-glutamate group (Normal free L-Gl). Both received a direct educational guideline to reduce sodium intake. The Low free L-Gl group started with a restriction in the variety of free L-glutamate-rich seasonings, and the Normal free L-Gl group had no restriction in the variety of seasonings. Blood pressure was measured at week 0 (baseline), week 2, week 4, and week 6, while body weight, height, urine sodium and potassium excretion, chromogranin-A (CgA pmol/mg protein) from saliva, and free L-glutamate from food were measured at week 0, week 3, and week 6. In Low free L-Gl, the amount of free L-glutamate in food decreased significantly from baseline to week 6 (p < 0.00), while it did not change in the Normal free L-Gl (p > 0.05). However, the reduction of sodium excretion at week 6 was 22% in Low free L-Gl (5,875 mg/d vs. 4,603 mg/d, p < 0.01) and 46% in Normal free L-Gl (6,107 mg/d vs. 3,277 mg/d, p < 0.00), both lower than the baseline. CgA (pmol/mg protein) did not show any difference between the two groups. The group with Normal free L-Gl intake showed a 46% reduction in sodium excretion by week 6 compared to the baseline. This suggests that the consumption of L-glutamate-rich seasonings when complemented with direct educational guidelines, can contribute to maintaining a low sodium intake.

High performance power handling in the absence of an H-mode edge in negative triangularity DIII-D plasmas

Experiments performed during strongly-shaped high-power diverted negative triangularity (NT) experiments in DIII-D achieved detached divertor conditions and a transient-free edge, showcasing the potential for application of NT to a core-edge integrated reactor-like scenario and providing the first characterization of the parametric dependencies for detachment onset. Detached divertor conditions will be required in future devices to mitigate divertor heat fluxes. Access to dissipative divertor conditions was investigated via an increase in upstream density. Detachment onset at the outer strike point was achieved with H-mode level confinement H98−y2∼1 and reactor-relevant normalized pressures βN∼2 . Confinement degradation was observed with deeper detachment, associated with the loss of an electron temperature pedestal. Differences in geometry, radial transport, impact of cross field drifts are discussed to explain differences in access to detachment in NT discharges. Higher normalized densities, with respect to equivalent discharges in positive triangularity, were necessary to achieve detachment, partially explained by the shorter parallel connection length to the targets. The effect of cross-field particle drifts (E×B, B ×∇ B) on access to detachment was demonstrated by the lower upstream density needed to access detachment with ion B ×∇ B drift directed outside of the active divertor (Greenwald fraction fGw∼ 0.9–1.0 vs fGw∼ 1.3). The upstream density at detachment onset was observed to increase linearly with plasma current with ion B ×∇ B drift into the divertor, consistent with the observed narrowing of the scrape-off layer heat flux width λ q . Edge fluid simulations capture separatrix densities needed to achieve detachment in NT plasma and their dependence on drift direction. The ability to reproduce detachment dynamics in NT plasma increases the confidence in future design studies for NT divertors.

Design and Experimental Study of Banana Bunch Transportation Device with Lifting Mechanism and Automatic Bottom-Fixing Fruit Shaft

In addressing the challenges of high labor intensity, cost, and potential mechanical damage to banana fruit in orchards, this study presents the design of a banana bunch transport device featuring a lifting mechanism and an automatic fruit shaft bottom-fixing system. The device is tailored to the planting and morphological characteristics of banana bunches, aiming for efficient, low-loss, and labor-saving mechanized transport. Key design considerations included the anti-overturning mechanism and the lifting system based on transportation conditions and the physical dimensions of banana bunches. A dynamic simulation was conducted to analyze the angular velocity and acceleration during the initial conveying stages, forming the basis for the fruit shaft bottom-fixation mechanism. A novel horizontal multi-point scanning method was developed to accurately identify and secure the fruit shaft bottom, complemented by an automated control system. Experimental results showed a 95.83% success rate in identification and fixation, validated by field trials that confirmed the necessity and stability of the fixation mechanism. To enhance the durability of the fruit shaft bottom-fixation mechanism, a multi-factor test was conducted, optimizing the device’s maximum travel speed and minimizing the banana bunch’s oscillation angle. Field tests showed an oscillation angle of 8.961°, closely matching the simulated result of 9.526°, demonstrating the reliability of the response surface analysis model. This study offers a practical and efficient solution for banana bunch transport in orchards, showcasing significant practical value and potential for wider adoption.

Barbiturate-sulfonate hybrids as potent cholinesterase inhibitors: design, synthesis and molecular modeling studies.

Aim: Design and synthesis of a series of 5-benzylidene(thio)barbiturates 3a-r. Methodology: Evaluation of the inhibitory activity of the new chemical entities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) using Donepezil as the standard reference. Results & Conclusion: Compound 3r emerged as the most potent AChE inhibitor (IC50=9.12μM), while compound 3q exhibited the highest inhibitory activity against BChE (IC50=19.43μM). Toxicological bioassays confirmed the absence of cytotoxicity for the most potent compounds at the tested doses. Molecular docking analysis demonstrated that the tested derivatives effectively bind to the active sites of both enzymes. Overall, this study sheds light on the potential of barbiturate-sulfonate conjugates as promising drug candidates.

Development and Validation of Psychoeducational Module for Empowering B40 Youth’s Resilience and Family Functioning

This research aims to develop a psychoeducational module to empower B40 youth’s resilience and family functioning. There were three phases implemented in this study: (1) needs analysis, (2) module design and development study and (3) experimental pre-and-post design for module evaluation. First, the Brief Psychological Well-being Scale (PWB), the Malaysian Family Functioning Scale (MFFS), and the Resilience Scale (RS) were used to collect data from 315 youths from the B40 families in various settings such as schools, higher education institutions and PPR/PPRT flats/communities. Results revealed the need for a psychoeducational module to empower youth’s resilience and family functioning. The development of the psychoeducational module adopted Sidek’s model, a Malaysian-based framework for module content development. The module prototype was sent to 11 experts to validate its content. Results showed that the psychoeducational module scored a high content validity value of 89.87%. Finally, the psychoeducational module was implemented and evaluated for its effectiveness before and after a 2-day-1-night programme on youth empowerment. Results revealed that the module effectively empowers the youth's resilience and family functioning. Implications of research for counselling practices are included in the discussion.

The Impact of Serums Calcium 25-Hydroxy Vitamin D, Ferritin, Uric Acid, and Sleeping Disorders on Benign Paroxysmal Positional Vertigo Patients.

This study's objective was to identify the factors and impact of serums calcium 25-Hydroxy vitamin D, ferritin, uric acid, and sleeping disorders on benign paroxysmal positional vertigo (BPPV) patients. This is a case and control design study. The consecutive patients' visits (age, older than 25 years) with idiopathic BPPV were recruited in the present study. For each patient, 3:1 sex and age-matched healthy people were assigned as the control. The study comprised 177 patients with BPPV and 656 controls. The study included biochemical, clinical, physical examinations, PSQI sleep quality, supine roll test, and Dix-Hallpike test for the diagnosis of all patients, and pure-tone audiometry (PTA) was used to assess hearing. Univariate and multivariate stepwise regression analyses were used for statistical analysis. The study comprised 833 patients with 295 males (35.4%) and 538 females (64.6%) who were between 25 and 70 years old. Of a total of 833 participants, 177 were BPPV patients, and 656 subject were normal. The results shown that there were significant differences between the BPPV and the normal group in terms of BMI (p = 0.039), physical activity (p = 0.003), cigarette smoking (p = 0.035), nargile-waterpipe use (p < 0.001), diabetes (p < 0.001), hypertension (p < 0.001), congestive heart failure (CHF) (p < 0.001), neurology (p < 0.001), tinnitus (p < 0.001), dizziness (p < 0.001), headache (p < 0.001), vitamin D (p = 0.004), calcium (p = 0.004), magnesium (p < 0.001), potassium (p = 0.019), phosphorus (p < 0.001), haemoglobin (p < 0.001), serum glucose (p < 0.001), HbA1c (p < 0.001), triglyceride (p < 0.001), systolic BP (p = 0.004), diastolic BP (p = 0.008), and microalbuminuria (p = 0.005); ATP III metabolic syndrome (p = 0.038), IDF metabolic syndrome (p = 0.034), and poor sleep (p = 0.033). In terms of the type of BPPV, the posterior canal was the most commonly affected (n = 126, 71.2%), followed by the horizontal (n = 43, 24.3%) and anterior canal (n = 8, 4.5%). The analysis indicated that serum ferritin (p < 0.001), uric acid (p < 0.001), blood pressure (p < 0.001), dizziness (p < 0.001), cigarette-water-pipe smokers (p = 0.004), headaches/migraines (p = 0.005), calcium (p = 0.007), vitamin D deficiency (p = 0.008), sleepiness (p = 0.016), physical activity (p = 0.022), CHF (p = 0.024), and tinnitus (p = 0.025) were considered as risk predictors for BPPV. The results revealed that the serum levels of vitamin D, ferritin, uric acid, and calcium are low among the study population and supplementation could be considered as prevention in BPPV patients.

Augmenting clinicians' analytical workflow through task-based integration of data visualizations and algorithmic insights: a user-centered design study.

To understand healthcare providers' experiences of using GlucoGuide, a mockup tool that integrates visual data analysis with algorithmic insights to support clinicians' use of patientgenerated data from Type 1 diabetes devices. This qualitative study was conducted in three phases. In Phase 1, 11 clinicians reviewed data using commercial diabetes platforms in a think-aloud data walkthrough activity followed by semistructured interviews. In Phase 2, GlucoGuide was developed. In Phase 3, the same clinicians reviewed data using GlucoGuide in a think-aloud activity followed by semistructured interviews. Inductive thematic analysis was used to analyze transcripts of Phase 1 and Phase 3 think-aloud activity and interview. 3 high level tasks, 8 sub-tasks, and 4 challenges were identified in Phase 1. In Phase 2, 3 requirements for GlucoGuide were identified. Phase 3 results suggested that clinicians found GlucoGuide easier to use and experienced a lower cognitive burden as compared to the commercial diabetes data reports that were used in Phase 1. Additionally, GlucoGuide addressed the challenges experienced in Phase 1. The study suggests that the knowledge of analytical tasks and task-specific visualization strategies in implementing features of data interfaces can result in tools that lower the perceived burden of engaging with data. Additionally, supporting clinicians in contextualizing algorithmic insights by visual analysis of relevant data can positively influence clinicians' willingness to leverage algorithmic support. Task-aligned tools that combine multiple data-driven approaches, such as visualization strategies and algorithmic insights, can improve clinicians' experience in reviewing device data.

A network analysis of self-compassion and burnout in a sample of nurses.

In the nursing profession, the concept of self-compassion has been associated with burnout. However, to date, the fine-grained relationships between different dimensions of self-compassion and symptoms of burnout have not been investigated. Network analysis provides a new avenue for exploring the fine-grained correlation paths of two related variables. To analyse the nuanced associations between self-compassion and burnout using network analysis in a large cohort of Chinese nurses. A cross-sectional multi-centre survey design study. Participants were recruited from 30 hospitals in China between April and May 2022. These nurses completed the Chinese Maslach Burnout Inventory-General Survey (C-MBI-GS) and Self-Compassion Scale-Short Form (SCS-SF). Network analysis was performed to illustrate the complex nuanced relationships between self-compassion and burnout. A total of 1467 nurses (age 32.2 [18-56] years; 89.9% were female) participated in the study. Nodes Mindfulness and Isolation had the highest centralities measured by strength. Nodes Mindfulness, reduced personal accomplishment and Isolation were the most negative and positive influential nodes that bridged self-compassion and burnout. There were no differences in terms of gender, age, professional title and job tenure in the structure or connectivity of the self-compassion and burnout network. Different components of self-compassion were specifically associated with different dimensions of burnout in registered nurses. Among these, Mindfulness, Isolation and Reduced personal accomplishment were the three most important components of self-compassion for burnout symptoms. No patient or public contribution. Understanding the intricate connections between self-compassion and burnout will allow hospital administrators to prioritize the elements of Mindfulness and Isolation within self-compassion and the dimension of Reduced personal accomplishment within burnout when designing preventative measures and interventions aimed at reducing nurse burnout.

Design, synthesis and molecular docking study of novel bis-oxazolone derivatives as potent antioxidant and antibacterial agents

Design, synthesis and molecular docking study of novel bis-oxazolone derivatives as potent antioxidant and antibacterial agents