Background : This paper outlines ten rules of thumb, or heuristics, for conducting good research in the context of human centered design. The subject matter is situated in design education within the structure of the School of Design at Carnegie Mellon University. To further set context, a process common to the School is framed in terms of Exploratory, Generative, and Evaluative research and design. Methods : The ten rules of thumb were extracted from several years of research and design projects conducted by students and faculty in the School of Design. A common example of the rules of thumb employed through the research and design process is exhibited in projects executed in the graduate Master of Design course, Research Methods for Design. This course is linked to a Studio project course, such that methods are taught “just in time” for application in a full semester long, team-based client project. Students are prompted with an open-ended design brief that varies each year. Results : The ten heuristics are, to Set boundaries; Immerse yourself; Engage your stakeholders; Work in context; Work in teams; Be creative; Integrate research and design; Use both sides of your brain; Triangulate; and Be credible. Examples of research methods and approaches ideally suited to fulfilling each rule of thumb are used to illustrate the heuristics and provide practical guidance for design applications. The paper is concluded with a sample project from the School of Design, highlighting the process framework, rules of thumb, and application of various research and design methods. Conclusion : Although not comprehensive, the ten rules of thumb, each presented with a brief definition, justification, and sample methods, are intended to guide a valid, productive, and enjoyable human centered research and design process, with a goal of achieving excellence in design outcomes through a well bounded, immersive and engaging, contextual, team-based, creative, integrated rational and intuitive process utilizing a triangulated set of credible research methods.