Study Of Spanish Research Articles

2855 Dementia in elderly individuals with depression: a systematic review and Meta-analysis of longitudinal studies (2013–2024)

Abstract Introduction With population ageing comes challenges like dementia, prompting the urgent identification of risk factors and its associations with other psychiatric disorders. This review aims to explore the connection between depression and the onset of mild cognitive impairment (MCI) or dementia through recent literature analysis. Methods Systematic review and meta-analysis, following PRISMA recommendations, with studies from 2013 onwards. The search strategy ‘Depression’ AND ‘Dementia’ AND ‘Aged’ was employed in the Cochrane, Embase, LILACS, PubMed, Scopus, and Scielo databases. Cohort studies in Portuguese, English, or Spanish were included, while reviews or clinical trials were excluded. The meta-analysis was conducted using RevMan software, employing unadjusted OR effect measures for exposure in the Forest Plot graph. Study heterogeneity was calculated using the I2 statistic, with a cutoff point of >75% indicating high heterogeneity. Results The search strategy identified 3394 articles, screened by title and abstract. Of these, 187 were fully read, and 26 were included in the review. The most used tool for assessing depressive symptoms was the Geriatric Depression Scale (38.4%), while the Mini-Mental State Examination was the most frequently used tool for assessing symptoms of MCI and dementia (26.9%). The quantitative analysis included 14 studies evaluating dementia and 8 studies evaluating MCI. The likelihood of older adults with depression developing dementia was 1.75 times higher than in the non-depressed population (OR = 1.75; 95% CI 1.46–2.11). Additionally, a twofold increase in the likelihood of developing MCI was found in depressed older adults (OR = 2.03; 95% CI 1.44–2.88). All analyses revealed high heterogeneity. Conclusion Depression was found to be associated with higher likelihood of developing MCI or dementia in older adults. Understanding this complex relationship with new studies and reviews is crucial for developing targeted interventions and improving the prognosis for individuals affected by both conditions.

The therapeutic potential of cannabidiol in reducing symptoms of Amiotrophic Lateral Sclerosis: A bibliographic review

Introduction: Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease that results in the gradual loss of muscle control. There is currently no cure for ALS and treatment aims to alleviate symptoms and improve patients' quality of life. In this context, cannabidiol (CBD), a compound found in the cannabis plant, has been studied as a complementary therapy for ALS. Objectives: This study consists of a literature review that aims to analyze the scientific evidence available on the use of CBD in the treatment of ALS. Methodology: This is a bibliographic review based on the PubMed, LILACS, SciELO and Google Scholar platforms. The descriptors used were “treatment” AND “cannabidiol” AND “amyotrophic lateral sclerosis”. Studies in Portuguese, Spanish and English were included, from 2000 to 2024. Results: With progress in neuroscience, cannabidiol emerges as a potential treatment for ALS, presenting anti-inflammatory and neuroprotective effects, in addition to benefits against anxiety and depression. Conclusion: Therefore, the therapeutic potential of cannabidiol in Amyotrophic Lateral Sclerosis highlights that CBD has promising properties in relieving ALS symptoms and improving patients' quality of life. However, more research is essential to establish it as a standard treatment for ALS, including its interaction with other medications and safety as a therapeutic.

Effectiveness of Manual Bronchial Clearance Techniques in the Treatment of Bronchiolitis

Background: Bronchiolitis is a seasonal viral infection of the respiratory tract that causes numerous childhood hospitalizations annually. Treatments vary based on severity, with mild cases requiring fluids and moderate to severe cases involving hospitalization with oxygen therapy, bronchodilators, and chest physiotherapy. Manual bronchial clearance techniques differ between Anglo-Saxon and European schools, and their effectiveness remains a subject of debate. Objective: The aim of this systematic review is to evaluate the effectiveness of manual bronchial clearance techniques in bronchiolitis by assessing clinical outcomes, including improved ventilation, increased oxygen saturation, and enhanced hemodynamic and respiratory stability. Materials and Methods: A systematic review was conducted between 2013 and 2024 using PRISMA guidelines. Databases searched included PubMed, Science Direct, Scopus, Springer, and Google Scholar; the inclusion criteria focused on randomized clinical trials and cohort studies in English, Spanish, and Portuguese. The selection bias was evaluated. The study was registered in Prospero (CRD42023486450). Results: Five articles involving 291 participants diagnosed with mild to moderate bronchiolitis were analyzed. The assessed techniques included Anglo-Saxon school and European School. Heart rate was evaluated in four studies, showing significant reductions in one (p < 0.01), while the significance in the other studies was not specified. Respiratory rate was assessed in three studies, with significant results being seen in two (p < 0.05). SpO2 was examined in all six studies, demonstrating significant improvements in two (p = 0.02 and p < 0.05). The Kristjansson respiratory score showed significant changes in one study (p = 0.005), and the Wang respiratory score indicated significant results in another (p = 0.03). These findings support the efficacy of chest physiotherapy techniques in managing bronchiolitis. Conclusions: While Anglo-Saxon techniques are widely used, their effectiveness remains a subject of debate. In contrast, European techniques indicate promising clinical outcomes, including improved ventilation, increased oxygen saturation, and enhanced respiratory stability; however, additional studies could further validate these findings.

Возможности лингвистического корпуса Corpus del Español М. Дэвиса в рамках преподавания испанского языка

The article deals with the didactic potential of the non-academic corpus of the Spanish language Corpus del Español, created by M. Davis. The purpose is to reveal the scope of options of this corpus for students and teachers in classes of Spanish as a foreign language. Among the four Corpus del Español subcorpora (Género/Histórico; Web/Dialectos; NOW 2012–2019; Google Books n-grams), particular attention is paid to the subcorpus of Internet resources of the national varieties of Spanish: the article points out its advantages over other subcorpora, taking into account the latest functions, as well as presents information search options and describes the procedure in detail. Specific examples demonstrate the principles of using the corpus in intervariant research (studying the frequency, semantic and pragmatic features of separate words as well as their lexical and grammatical collocations in the national varieties of the Spanish language). In addition, the paper suggests assignment ideas for students of different levels (from simple introductory and search exercises to rule formulation), taking into account both advantages and disadvantages of using the corpus in the classroom. A conclusion is drawn about the importance of using this tool for linguodidactic purposes due to the wide scope of its functions and easy access to them, which allows one to stimulate students’ inductive activity, increase their motivation and develop a creative approach to learning activities. The article outlines prospects for further work in the field of corpus research related to the study of Spanish as a multinational language in all its diverse manifestations.

Influence of Perceived Maternal Self-Efficacy on Exclusive Breastfeeding Initiation and Consolidation: A Systematic Review.

Different international organizations recommend exclusive breastfeeding during the neonate's first six months of life; however, figures of around 38% are reported at the global level. One of the reasons for early abandonment is the mothers' perception of supplying insufficient milk to their newborns. The objective of this research is to assess how mothers' perceived level of self-efficacy during breastfeeding affects their ability to breastfeed and the rates of exclusive breastfeeding up to six months postpartum. A systematic review for the 2000-2023 period was conducted in the following databases: Cochrane, Web of Science, Scopus, PubMed, Science Direct, and CINAHL. Original articles, clinical trials, and observational studies in English and Spanish were included. The results comprised 18 articles in the review (2006-2023), with an overall sample of 2004 participants. All studies were conducted with women who wanted to breastfeed, used the Breastfeeding Self-Efficacy Scale or its short version to measure postpartum self-efficacy levels, and breastfeeding rates were assessed up to 6 months postpartum. The present review draws on evidence suggesting that mothers' perceived level of self-efficacy about their ability to breastfeed affects rates of exclusive breastfeeding up to 6 months postpartum. High levels of self-efficacy are positively related to the establishment and maintenance of exclusive breastfeeding; however, these rates decline markedly at 6 months postpartum.

Strategies to Improve Environmental Comfort of Institutionalized Older Adults: A Scoping Review

The demographic trends of an aging global population present significant challenges and opportunities for healthcare, particularly in providing optimal care environments for older adults living in long-term care facilities, with it being imperative to ensure these environments provide basic care and promote overall well-being through enhanced environmental comfort. This scoping review intends to show evidence-based practices enhancing the environmental comfort of institutionalized older people. Following the Joanna Briggs Institute’s methodology, this scoping review’s inclusion criteria included studies in English, Portuguese, or Spanish between 2013 and 2023, focused on institutionalized people over the age of 65 years residing in long-term care settings where nurses implemented strategies or interventions designed to enhance environmental comfort in which older residents themselves directly evaluated, indexed in Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, Psychology and Behavioral Sciences Collection, DART-Europe, or Repositório Científico de Acesso Aberto de Portugal (RCAAP). Out of 497 initially retrieved studies, none of them met the established criteria, leading this study to be an empty review. The absence of studies meeting the inclusion criteria indicates a significant gap in the existing literature, highlighting the need for specialized training programs that equip nurses with the skills and knowledge to implement effective comfort-enhancing interventions, ensuring that the unique and challenging needs of older people are covered.

Electromyographic parameters for treatment of pelvic floor disorders in pregnant and postpartum women: A review protocol.

Electromyography is a widely used instrument in clinical practice to evaluate and treat pelvic floor disorders in pregnant and postpartum women. The objective of this study is to analyze the scientific evidence on the electromyography parameters used for treatment of pelvic floor disorders in pregnant women in any gestational week and postpartum women up to 12 months after delivery. A systematic review of randomized controlled experimental studies (clinical trials) and quasi-experimental studies in English, Portuguese or Spanish, which used electromyography as an intervention for treatment of pelvic floor disorders in pregnant or postpartum women up to 12 months after delivery will be performed in online databases (Scopus, Medline, Pedro, Scielo and Pubmed),. Risk of bias assessment will be performed using Cochrane group tools. The Rob 2.0 tool will be used for experimental studies and the Robins-I tool for non-experimental studies. The protocol was registered in PROSPERO (no.433510). The quality of the evidence will be analyzed using the GRADE System Methodological Guide and the systematic review structure will be performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Can resistance exercise prevent breast cancer–related lymphoedema? A systematic review and metanalysis protocol

IntroductionEvidence shows that resistance training (RT) reduces lymphoedema in patients with breast cancer–related lymphoedema (BRCL), making it a safe and efficient intervention. However, it is uncertain if RT is safe...

Evaluation of Red Blood Cell Biochemical Markers and Coagulation Profiles Following Cell Salvage in Cardiac Surgery: A Systematic Review and Meta-Analysis.

Background: Individuals undergoing cardiac surgery face an increased risk of bleeding, as well as alterations in biochemical and coagulation patterns. Therefore, assessing the effectiveness of systems such as Cell Salvage is necessary to prevent potential surgical complications. Objective: To evaluate the efficacy of Cell Salvage in relation to the biochemical parameters of the red blood series and coagulation, as well as the risk of hemorrhage. Methods: A systematic review, accompanied by a meta-analysis, was executed via an extensive literature exploration encompassing Medline, CINAHL, Scopus, Web of Science, and the Cochrane Library. The inclusion criteria comprised studies in English or Spanish, without year restrictions, conducted in adults and with a randomized controlled trial design. Results: Twenty-six studies were included in the systematic review, involving a total of 2850 patients (experimental group = 1415; control group = 1435). Cell Salvage did not demonstrate superior outcomes compared to allogeneic transfusions in the management of post-surgical hemorrhage, as well as in total blood loss, platelet count, fresh frozen plasma, and fibrinogen. However, Cell Salvage showed a greater effectiveness for hemoglobin (moderate evidence), hematocrit (low evidence), post intervention D-dimer (low evidence), and some coagulation-related parameters (low evidence) compared to allogeneic transfusions. Finally, better results were found in the control group for INR parameters. Conclusions: The use of the Cell Salvage system holds high potential to improve the postoperative levels of biochemical and coagulation parameters. However, the results do not provide definitive evidence regarding its effectiveness for hemorrhage control, platelet count, fresh frozen plasma, and fibrinogen. Therefore, it is recommended to increase the number of studies to assess the impact of the Cell Salvage system on improvements in the red blood cell count and patient coagulation patterns. In addition, protocols should be homogenized, and variables such as the sex of the participants should be taken into account.

Understanding the Dry Eye Disease-Related Symptoms in South America: Prevalence and Associated Factors-A Systematic Review.

Background/Objectives: Dry eye disease is a leading cause of ophthalmologic consultations worldwide and can significantly impact quality of life. While global prevalence rates vary widely, data specific to South America are limited. This systematic review aims to describe and analyze the prevalence and associated factors of dry eye disease-related symptoms in South American populations. Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review was conducted using databases such as PubMed, Web of Science, Scopus, and LILACS. Primary studies in English and Spanish that examined the prevalence of dry eye disease-related symptoms in South American populations and its associated factors were included without date restrictions. Studies were screened and selected based on predefined inclusion and exclusion criteria, resulting in the final inclusion of 16 studies from six South American countries. Results: This review identified significant variability in the prevalence of dry eye disease-related symptoms in South American populations in the region, ranging from 4% to 77.5%, with a mean prevalence of 39.3%. Higher prevalence rates were observed among specific groups, such as university students (58.6%) and administrative workers (57.9%). Factors associated with dry eye disease-related symptoms in South American populations included female sex, older age, prolonged screen time, insufficient sleep, and medical conditions such as hypertension, connective tissue disorders, and the use of medications like antihypertensives and antidepressants. Conclusions: The prevalence of dry eye disease-related symptoms in South American populations is notably higher than global averages, highlighting regional challenges. This study emphasizes the need for standardized diagnostic tools and comprehensive epidemiological research across South America, particularly in underrepresented countries, to inform public health strategies tailored to the specific needs of these populations.

Systematic review of cost-effectiveness studies on cervical cancer screening across Europe

IntroductionCervical cancer (CC) is a type of cancer with poor prognosis when diagnosed in advanced stage with a big socioeconomic burden. The incidence rates have wide variations among European countries depending on the implementation or not of screening, vaccination programs and the human development index (HDI). Most studies on cost-effectiveness of CC screening programs are carried out in countries with a high HDI, however more recent reviews of screening approaches are coming from countries with lower HDI aiming to identify the best screening strategies. Our study aims to identify which are the currently applied and most cost-effective strategies of CC screening in Europe. Materials and methodsThis is a systematic review conducted in three different databases (PubMed, Scopus and ScienceDirect) and reported following the PRISMA guidelines. General key terms for all databases were the following: cost-effectiveness, cervical cancer, screening, Europe. We included studies in English, Italian, Spanish and Bulgarian, published in the last 25 years, reporting data on cost-effectiveness of CC screening, costs and outcome measures. The methodological quality of the articles was evaluated with a standardized tool. ResultsA total of 262 studies were identified and 22 studies were included in the final analysis. In 90.1 % of the economic studies, the new screening strategy was shown to be more cost-effective compared to the current one or compared to no screening. The optimal strategy mostly involved primary HPV testing, combined with cytology or as stand-alone screening technique. Several scenarios differing on starting age and periodicities for CC screening, combination of techniques and triage, were found to be cost-effective and below the willingness to pay (WTP) threshold. The methodology of all included studies was assessed from 10 to 11 on the JBI standardized tool and Drummond 11-point checklist. ConclusionNumerous cost-effective options for CC screening in different European countries were identified in this systematic review. HPV testing, with or without cytology, mainly starting at 30 years of age and repeated every 5 years or more was the most cost-effective technique. Future studies should focus on the most appropriate CC screening approach for each context and setting, also considering HPV vaccination in Europe.

Effect of diet on the management of hypertension and type 2 diabetes mellitus in adults from low-income and middle-income countries: protocol for a systematic review of randomised controlled trials.

Hypertension and type 2 diabetes mellitus (T2DM) are two highly prevalent non-communicable diseases worldwide, both leading to disability and premature mortality in low-and-middle-income countries (LMICs). Nutritional interventions towards a healthier dietary pattern or food and nutrients intake have an important role on the management of this disease. This systematic review aims to evaluate the effect of nutritional interventions on the management of blood pressure and glycaemia in adults with hypertension and T2DM from LMICs. We will conduct a systematic review of randomised controlled trials (RCTs) on the effect of nutritional interventions on blood pressure and glycaemia in adult patients with hypertension and T2DM. Literature search will be conducted in MEDLINE, EMBASE, Scopus, Cochrane and Web of Science databases from anytime until April 2024. Nutritional interventions would have been applied in addition to regular or standard treatment, which is prescribed and/or provided by the healthcare system. Studies in English and Spanish will be selected and reviewed by two independent reviewers. Risk of bias will be assessed using the Cochrane tool for RCTs. Heterogeneity and publication bias will be estimated using the I2 and Egger's test, respectively. Ethics approval was not required for this systematic review, considering there was no direct data collection or participation of patients. The investigators will write a manuscript of the final detailed report with the study development and main findings to be published in a peer- reviewed journal. The main findings may be shared with academia partners and groups working on similar topics in LMICs, in addition to policymakers and authorities in these countries. CRD42023483847.

Risk of Developing Chronic Kidney Disease among Obese Metabolically Free Adults: A Systematic Review/Meta-Analysis

Abstract Background Metabolically healthy obesity (MHO) is a type of obesity characterized by a favorable metabolic picture. Yet, the relationship between chronic kidney disease (CKD) and MHO has not been established. This review investigates the relationship between the metabolic healthy phenotype of obesity and the development or progression of CKD. Objective To determine the risk of development or progression of chronic kidney disease (eGFR <60 ml/min/1.73 m2) in metabolically healthy obese individuals. Methods A literature search was performed in 5 databases using the following search strategies: (” chronic kidney disease” OR “end-stage renal disease” OR “estimated glomerular filtration rate” OR “kidney function”) AND (“obesity” OR “metabolic syndrome” OR “metabolically healthy” OR “metabolically healthy obesity” OR “overweight” OR “metabolically healthy overweight “OR “metabolic parameters” OR “metabolic profile” OR “obesity without metabolic abnormality” OR “healthy obesity”). We included prospective, retrospective cohort studies and case-control studies in English, French, Spanish, and Arabic until December 2022 that investigated the development or progression of CKD in adults > 18 years with a baseline GFR of ≥ 60 ml/min/1.73 m2 exposed to MHO. A total of 12579 studies were retrieved, and 12564 were excluded due to different populations, exposures, or outcomes. Studies with missing data, narrative reviews, systematic reviews, meta-analyses, case reports, case series, and commentaries, along with studies conducted on animals, were also excluded. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) for reporting. Results We included 15 cohort studies with 5,039,394 participants. MHO subjects showed an increased risk for CKD with a pooled risk ratio (RR) of 1.42, 95% CI (1.25–1.61), p < 0.001 using the random effects model. Heterogeneity is high, as indicated by Cochrane Q = 73.35 and I squared (I2) = 81%. Conclusion Metabolic healthy obese adults have a significantly higher risk of the development or progression of CKD.

P9: Preventable adverse events and related outcomes among people with dementia in hospital settings: Scoping review

Background: Hospital-related negative outcomes such as reduced functional ability and mortality are significantly more frequent in people with dementia compared to other groups. Although these can result from preventable adverse events (AE) related to care standards (e.g., in-hospital falls or infection), researchers usually link such outcomes with the dementia itself. To date, it is unclear whether and the extent to which negative outcomes in hospitalised people with dementia are partly or fully due to the occurrence of AE.Aim: To explore the AE endured by people with dementia in hospital settings and to determine whether and the extent to which these are associated with negative outcomes.Methods: A scoping review was undertaken in line with Arksey and O’Malley’s framework in PUBMED, Web of Science, CINAHL, and Scopus in October 2023. Primary studies in English, Spanish, or Portuguese published in peer-reviewed journals were eligible.Results: Of the 1,976 retrieved documents, 16 were included. Considering all studies and AE together, people with dementia had between 2.8 to 5.2 times higher risk of having an AE compared to people without dementia. In non- surgical settings, the most frequently reported AE were falls, delirium, and infections, while in surgical settings, these included postoperative delirium, infections, and other complications. Longer hospital stay, increased healthcare costs, higher risk of discharge to residential care (vs. home), and increased mortality were significantly more frequent in people with dementia. The link between the AE and negative outcomes was explored in three studies: longer hospital stay was linked to having endured a fall, delirium, or pneumonia as AE; higher risk of 90- day readmission was linked to having had delirium, and higher mortality was found in those with a hip fracture due to an in-hospital fall.Conclusions: AE are more common in people with dementia compared to other hospitalised groups and may be largely responsible for the negative outcomes found in this population. However, current evidence is limited and does not allow for this relationship to be confidently established. Future research should further explore such associations with the goal to improve care and safety for people with dementia in hospital settings.

In Silico Characterization of Inflammatory and Anti-Inflammatory Modulation in Diabetic Nephropathy: The Construction of a Genetic Panel

Diabetic Nephropathy (DN) stands as a primary cause of end-stage renal disease and its etiology remains unclear. Thus, this study aims to construct a genetic panel with potential biomarkers linked to the inflammatory pathway of DN associated with the pathology’s susceptibility. Through a systematic review and meta-analysis, we selected observational studies in English, Portuguese, and Spanish, selected from the PubMed, SCOPUS, Virtual Health Library, Web of Science, and EMBASE databases. Additionally, a protein–protein interaction network was constructed to list hub genes, with differential expression analysis by microarray of kidneys with DN from the GSE30529 database to further refine results. Seventy-two articles were included, and 54 polymorphisms in 37 genes were associated with the inflammatory pathway of DN. Meta-analysis indicated a higher risk of complication associated with SNPs 59029 G/A, −511 C/T, VNTR 86 bp, −308 G/A, and −1031 T/C. Bioinformatics analyses identified differentially expressed hub genes, underscoring the scarcity of studies on CCL2 and VEGF-A genes in relation to DN. This study highlighted the intrinsic relationship between inflammatory activity in the etiology and progression of DN, enabling the effective application of precision medicine in diabetic patients for potential prognosis of the complications and contributing to cost reduction in the public health system.

Paleo-species distribution modelling in the marine realm: protocol for a global scoping review

Background Studying the spatial distribution of marine species and its alterations through time is fundamental for understanding how they respond to environmental changes, as well as the changes of marine biodiversity, its geographic patterns, and how to best preserve it. Species distribution models (SDM) and Ecological Niche Models (ENM) are statistical tools widely used to investigate distribution range shifts under future and past climate change. The present work provides a protocol for conducting a scoping review (ScR) to assess the contribution of SDM and ENM to the study of past environmental suitability, its spatial and temporal extent and gaps, as well as to identify methodological challenges. Protocol The ScR follows the Joanna Briggs Institute (JBI) methodology. Two online databases, Web of Science and Scopus, will be used for the bibliographic search. Inclusion criteria will be as follows: studies applying SDM and/or ENM in the marine realms worldwide, with clear methodological details, to identify to what extent they contributed to paleobiology. Both peer-reviewed articles, book chapters and grey literature will be considered for eligibility. No search limitations will be applied regarding publication year, geographic area and source type. Studies in English, Spanish and French will be reviewed. The Covidence software will be used for document selection and data extraction. Conclusions This comprehensive approach will provide a visual representation of the available studies, enhancing the understanding and interpretation of the results focusing on the contribution of SDM and ENM to species potential ancient distribution knowledge, identifying the spatial and temporal extent and the presence of gaps of knowledge in their use.

Antiemetic prophylaxis regimens in haematologic malignancies patients undergoing a hematopoietic stem cell transplantation. Which is the best standard of care? A systematic review.

This systematic review, adhering to PRISMA guidelines, aimed to evaluate the efficacy and safety of antiemetic prophylaxis in haematological patients undergoing high-dose chemotherapy as part of their hematopoietic stem cell transplantation (HSCT) conditioning regimens. We performed a comprehensive search in PubMed, EMBASE, ClinicalTrials.gov and the Cochrane database to identify randomised controlled trials (RCTs) and systematic reviews of antiemetic prophylaxis. Studies in English, French, Italian or Spanish were included. This review is registered with PROSPERO, ID CRD42023406380. Eight RCTs were analysed. The antiemetic regimens evaluated ranged from monotherapy with 5-Hydroxytryptamine Receptor 3 antagonists (5-HT3RAs) to complex combinations including olanzapine, neurokinin-1 receptor antagonists, 5-HT3RAs and corticosteroids. Complete response rates for triplet or quadruple regimens varied between 23.5% and 81.9%. Although no significant adverse effects were observed, minor symptoms such as diarrhoea, constipation, sedation and headaches were reported. Existing evidence on HSCT antiemetic therapy highlights its benefits but fails to provide clear clinical directions. The choice between triplet and quadruplet therapies for different patient scenarios is still uncertain. Until more detailed research is available, healthcare providers must rely on the latest guidelines and their judgement to customise antiemetic care for each patient's specific needs and risks.

OZONIOTHERAPY AS PAIN TREATMENT IN LOWER LIMBS

To evaluate through a systematic review the effectiveness of ozone therapy for the treatment of pain in the lower limbs. Methods: To achieve this objective, the methodology adopted involved a systematic search in the ScienceDirect, PubMed and SciELO databases, using a structured combination of specific keywords. Literature review studies and clinical studies relevant to the theme were included. The inclusion criteria involved the selection of studies in English, Portuguese and Spanish that addressed the application of ozone therapy in the treatment of pain in the lower limbs. We excluded articles that had no direct relationship with the theme, as well as case reports, case series, coursework, theses and dissertations. Conclusion: Chronic pain in the lower limbs is a prevalent condition, often caused by traumatic injuries, degenerative joint diseases, peripheral neuropathies and/or circulatory disorders. In addition to the physical impact, this condition limits mobility and significantly affects people’s quality of life. Conventional treatments, although widely used, often have limited efficacy and potential adverse side effects, driving the search for more effective and safe therapeutic alternatives. Utilizing the oxidative potential of ozone, this therapy is administered in various forms, including topical, subcutaneous, venous and rectal applications.

EHealth early intervention programs to support premature parents transitioning from NICU to home on parental and infant outcomes: a systematic review protocol.

This review will assess the effectiveness of eHealth early intervention programs in supporting premature infants and their parents transition from neonatal intensive care units (NICUs) to home and the impact of such programs on parental and infant outcomes. The literature has shown the benefits of eHealth early intervention programs to support premature infants and their parents after discharge from NICUs. Parents have reported benefits such as enhanced user-friendliness, increased confidence in infant care, satisfaction, and knowledge acquisition. However, the effectiveness of these programs on parental and infant outcomes remains unclear. This review will consider studies that assess any early intervention program using eHealth to support premature infants and their parents after discharge from NICU. The programs may be initiated during hospitalization or within the first month of discharge. The programs will include interventions that use eHealth components (eg, teleconsultation), either alone or in combination with face-to-face interventions (eg, home visits). This review will consider parental outcomes, including stress, anxiety, competence, and satisfaction, as well as infant outcomes, including health service utilization and cognitive, motor, and social development. This review will follow the JBI methodology for systematic reviews of effectiveness. The search strategy will aim to find both published and unpublished quantitative studies in English, Spanish, and Portuguese, without any geographical or cultural limitations. Two reviewers will independently perform study selection, critical appraisal, and data extraction. The results will be accompanied by a narrative synthesis. If possible, a meta-analysis will be conducted and the Summary of Findings will be presented using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. PROSPERO CRD42023444721.

Could Online Education Replace Face-to-Face Education in Diabetes? A Systematic Review.

Diabetes Self-Management Education and Support (DSMES) is a critical component of diabetes care. This study aims to examine the effect of online-based educational interventions on diabetes management compared to face-to-face interventions. A systematic review was conducted by searching three databases for studies in English or Spanish between December 2023 and March 2024. The inclusion criteria were studies that compared face-to-face DSMES with online interventions. The follow-up duration of the trials ranged from 1 to 12months. Multidisciplinary teams delivered online DSMES through various means, including Short Message Service (SMS), telephone calls, video calls, websites, and applications. Online DSMES was found to be comparable to face-to-face interventions in terms of glycated hemoglobin (HbA1c) levels in people with type 1 diabetes (T1D). In contrast, online interventions that focus on weight management in people with type 2 diabetes (T2D) have shown a significant reduction in HbA1c compared to face-to-face interventions. Online DSMES was found to be superior in terms of quality of life and cost-effectiveness in both T1D and T2D. None of the analyzed studies explored the differences between individual and group methodologies. The current evidence indicates that online DSMES services provide at least comparable biomedical benefits to face-to-face interventions, suggesting that online interventions could be incorporated into clinical practice as a complement or reinforcement. However, further research is needed to explore the potential benefits and effectiveness of online group sessions in DSMES.