Study Of IgA Nephropathy Research Articles

Study of IgA nephropathy in transplanted kidney

Study of IgA nephropathy in transplanted kidney

An immunohistological study of IgA nephropathy and a report of its incidence in Ireland.

We report an incidence of IgA neph ropathy of 14.9% encountered in a total of 562 renal biopsies examined over a period of three years. Reference is made to the incidence reported in other countries. Details of light and fluorescence microscopical findings are correlated with clinical presentation and renal function in an effort to establish prognostic parameters. The results suggest that the presence of IgM deposits with extensions into capillary loops are associated with the more severe histological patterns. In contrast, the finding of classical IgA-IgG nephropathy and the occurrence of the lesion in younger patients is associated with less extensive structural damage.

Estimation of polymeric IgA in human serum: an assay based on binding of radiolabeled human secretory component with applications in the study of IgA nephropathy, IgA monoclonal gammopathy, and liver disease.

Binding of 125I-human secretory component (SC) to human polymeric immunoglobulin A (pIgA) was employed to measure quantitatively the pIgA present in human sera. Interference by IgM in some sera was prevented by removal of IgM with glutaraldehyde polymerized anti-IgM antibodies. 125I-SC complexed to pIgA was measured by precipitation with anti-IgA antibodies and the quantity of pIgA in human serum was estimated by comparing the quantity of 125I-SC bound by several dilutions of human serum to that bound by standard quantities of human monoclonal pIgA proteins. The assay was specific for pIgA because heat-aggregated monomeric IgA or hypogammaglobulinemic serum did not bind 125I-SC greater than a precipitate formed with human monoclonal IgG and anti-IgG. Moreover, analysis of a series of IgA myeloma sera indicated no correlation between the IgA content of the serum and the quantity of pIgA measured. The quantity of pIgA found in 30 normal human sera was 0.13 +/- 0.08 mg/ml (1S.D.), which consisted of 11.3 +/- 5.3% (1 SD) of the total IgA. Patients with IgA monoclonal gammopathy were most often found to have predominantly monomeric IgA. Patients with IgA nephropathy also showed an elevation of pIgA, but this appeared to be a consequence of an overt IgA elevation. IgA nephropathy patients with elevated serum IgA in fact showed a significant elevation of monomeric IgA. Selective elevation of pIgA was observed in patients with primary biliary cirrhosis and alcoholic liver disease. A comparison of this assay with other assays to measure pIgA is discussed.

A Study of IgA Nephropathy : Immunopathology and Clinicopathology in a Comparison with Glomerulonephritis Giving the Similar Lesions

A Study of IgA Nephropathy : Immunopathology and Clinicopathology in a Comparison with Glomerulonephritis Giving the Similar Lesions

Immunologic studies in IgA nephropathy

Circulating immune complexes (CIC) were detected in 43.6% of 78 patients with primary IgA nephropathy by the solid-phase Clq radioimmunoassay. The IC were intermediate (9 to 17S) in size and contained IgA, IgG, and less commonly IgM. CIC were often present intermittently, correlating with episodes of macroscopic hematuria. Elevated serum IgA concentrations (38.7%) did not correlate with the detection of CIC. Similar findings were observed in sera samples from patients with Henoch Schonlein purpura and in IgA glomerulonephritis associated with alcoholic cirrhosis and/or portal systemic shunts. The factors responsible for the mesangial localization of the IC are not clear, but elevations in serum antibody titers to respiratory pathogens (mycoplasma pneumoniae, herpes virus, influenza), gut flora (E. coli 07), and bovine serum albumin suggest that common exogenous antigens may be involved in the pathogenesis. Primary defects in either mucosal antigen exclusion or reticuloendothelial IC sequestration are proposed to account for these findings.

A Study of Ig-A Nephropathy in Children and Adults with Chance Proteinuria and/or Hematuria

A Study of Ig-A Nephropathy in Children and Adults with Chance Proteinuria and/or Hematuria