Abstract Clinically relevant examples are needed to support knowledge application of Immunology teaching content within undergraduate Medical Sciences Education frameworks. The appropriate contextualisation of these Immunology teaching examples is essential, particularly when presenting health related issues that are of significance and relevance to Māori and Pacific population groups living in New Zealand (NZ) and the Pacific Region. Acute Rheumatic Fever (ARF) is an autoimmune condition that results from untreated Group A Streptococcal (GAS) infection of the throat (and skin). Repeated or severe episodes of ARF that remain untreated can lead to Rheumatic Heart Disease (RHD) or permanent heart damage. Māori, Pacific and Indigenous Aboriginal population groups are affected disproportionately by ARF and RHD. This work involved Immunologically related ARF and RHD teaching examples were presented to 4th year undergraduate Medical Science Education students that were contextualized, and relevant to current health priorities for Māori and Pacific population groups. Sound understanding was demonstrated by students participating in these classes. Strong interest in Immunologically related ARF/RHD research and teaching examples with positive feedback expressed by students within written and verbal teaching feedback platforms. A subset of students were motivated to undertake research placements to contribute to the NZ based ARF and RHD related Penicillin reformulation work. Overall, the contextualisation of the Immunologically related ARF/RHD research and teaching examples supported knowledge application and helped raise awareness of health issues for Māori and Pacific population groups living in NZ and the Pacific Region.