The COVID-19 pandemic underlines the importance of targeting the groups with the highest risk of vaccine hesitancy, understanding their fears, and alleviating them. As the pandemic situation is very dynamic due to the appearance of new SARS-CoV-2 variants, concerns might also change over time. This is the first study to evaluate the vaccination rate and state of knowledge among medical students in Poland, comparing English and Polish divisions. We collected the data in 2 months. A total of 1,521 surveys were collected as follows: 273 students from the English division and 1,248 students from the Polish division answered the survey. The questionnaire was aimed at investigating students' awareness, knowledge, and apprehensions toward the COVID-19 pandemic and vaccines. The results were obtained for the following statements: good knowledge about ways of transmission is not statistically significant in determining if a student is vaccinated. Moreover, a year of study is not statistically significant in determining if a student knows all ways of COVID-19 transmission. Interestingly, the correlation between the statement “Keeping up to date with the upcoming vaccines is important for my role as a future health care worker” and being vaccinated against SARS-CoV-2 showed that 45.5% of unvaccinated students did not update their information about the vaccines and rated 1 out of 5 for this statement (p < 0.001). Even though the pandemic will not last forever, the obtained knowledge about the role of individual interests can be applied in many different life situations as this feature is statistically significant.