Stress can contribute to or influence the development of psychological disorders like depression and anxiety, as well as physiological issues like high blood pressure and slow wound healing. Objectives: To find out the prevalence of stress and its oral and physical manifestations in medical, dental, and engineering students of Pakistan. Methods: This cross-sectional questionnaire-based study was carried out in Rashid Latif Medical Complex and Clapp trust Lahore, Pakistan. The study included 326 male and female students from medical, dentistry, and engineering universities. Results: The majority of them were females 68.7% as compared to males 31.3%. The mean age of the students was 21.9±4.17 years. The persistent headache had the highest frequency among physical problems due to stress with 84.5% of the participants responding. In a comparative analysis, the t-test showed gender to be significant for disturbed sleep, difficulty breathing persistent headaches, and muscular pains while the ANOVA test showed a significant association of age with weight gain, pain in TMJ, and ulcers in the oral cavity. Regression analysis showed a significant relationship between weight gain and age. Conclusions: This study demonstrated that the stress of studying is making students more susceptible to problems with their physical and oral health, which is lowering their quality of life.