The current digital transformation has become a global trend, and the Party building in colleges and universities is facing new opportunities and challenges in the digital age. Starting from the significance of the integration of red culture into the Party building work in colleges and universities in the digital age, this paper aims at solving the problems faced by the Party building work in colleges and universities, such as the lack of understanding and cognition of red culture among grass-roots student Party members, the lack of ways and means of integrating red culture into Party building system and brand characteristics. This paper puts forward some measures, such as strengthening the propaganda and learning of red culture at the grass-roots level, innovating the way of integrating red culture, establishing and perfecting the digital party building work system, and strengthening the construction of ideological and political course teachers, which provide some reference and guidance for the integration of party building work and red culture in colleges and universities in the digital era.