In accordance with results of analysis of state-of-the-art theoretical and experimental research works, analysis and synthesis of data on the impact of extreme impacts on structures of existing nuclear power plants (including NPP "Fukushima-1", Japan), and other unique objects, the existing regulations, corresponding design codes and procedures do not fully take into account the specific definition of extreme (special) external loads and impacts on the main building of NPP, and, therefore, require clarification and development. The distinctive paper is devoted to advanced methods of analysis, choice of appropriate and correct methods and software application packages for numerical simulation of external loads and impacts on the basic structures of nuclear power plants (wind hurricane, tornado, plane crash, the impact of the shock wave, seismic and tsunami effect). Results of development, adaptation and verification (with the use of universal software application packages) within representative number of sample problems, dealing with advanced methods of analysis, definition of loads and impacts on the basic structures of nuclear power plants are presented. The results of analysis showed correctness and effectiveness of the developed numerical methods of advanced analysis and definition of extreme external loads and impacts on NPP structures of a new generation.