Structure Of Occupational Diseases Research Articles

Occupational diseases of chemical etiology at the enterprises in the Russian Arctic

Chemicals are among the most common harmful production factors causing occupational pathology among workers in various industries. The purpose of the study was to investigate the conditions of development, prevalence and structure of occupational diseases of chemical etiology among employees of enterprises in the Russian Arctic. Materials and methods. The analysis included results of the monitoring study «Working conditions and occupational morbidity» of the population of the Arctic zone of Russia in 2007–2018. Results. It was established that in 2007–2018, at the enterprises in the Arctic, the share of chemicals in the structure of harmful production factors was 8.0 %, and their impact was associated with the development of 7.7 % of cases of occupational pathology mainly among metallurgists of nickel and miners of mining enterprises. The risk of contact with harmful chemicals in 2007 was higher than in 2018: RR = 1.40; CI 1.38–1.43; p < 0.0001. Most often, the development of occupational diseases was caused by water-insoluble nickel compounds (40.6 %) and nickel hydroaerosols (27.2 %). The structure of the pathology of chemical etiology was dominated by chronic bronchitis (43.2 %), intoxication with metals and gases (19.3 %) and bronchial asthma (19.0 %). Acute forms of intoxication occurred mainly in miners exposed to carbon oxides (84.6 %), and chronic ones when in metallurgists exposed to nickel compounds (88.2 %). In 2007–2018, there was a decrease in the number of occupational diseases of chemical etiology. The risk of their development in 2007–2009 was higher than in 2016–2018: RR = 1.49; CI 1.21–1.83; χ2 = 14.7; p = 0.0001. Conclusion. To reduce the risk of occupational intoxications, first of all, it is necessary to reduce exposure to nickel compounds and carbon oxides by means of the technical modernization of production and use of modern personal protective equipment for workers.

Gender features of occupational pathology in the Russian Arctic

Introduction. An interest in studying the gender characteristics of occupational pathology is determined by increasing economic activity in the Arctic and the upcoming expansion of women’s access to occupations with harmful working conditions.The purpose of the study was to carry out a comparative investigation of working conditions and occupational pathology among male and female workers at enterprises in the Arctic.Material and methods. The data of socio-hygienic monitoring “Working conditions and occupational morbidity” of the population of the Russian Arctic in 2007-2018 were studied.Results and discussion. 92.6% of occupational diseases have been established to occur in men due to more harmful working conditions (fibrogenic aerosols, noise, whole-body, and hand-arm vibration, the severity of labor). The risk of their occurrence in 2018 was higher than in 2007 (RR = 1.71; CI 1.51-1.93) and higher than in women (RR = 9.45; CI 7.19-12.4). Unlike men, 48.8% of women worked at facilities of the first group of sanitary and epidemiological welfare (satisfactory conditions) and they had in 2007-2018 a relatively stable number of newly diagnosed occupational diseases. The risk of occupational pathology in women in 2018 and 2007 did not change significantly (RR = 1.07; CI 0.73-1.59). In the structure of occupational diseases in men, the first places are occupied by vibration disease (24.2%), sensorineural hearing loss (20.3%) and radiculopathy (20.1%), and in women - myofibrosis of the forearms (21.2%), radiculopathy(13.7%) and chronic bronchitis (13.4%).Conclusion. Reducing exposure to physical overloads, fibrogenic aerosols, noise, vibration, and chemical factors should be a priority preventive direction at enterprises in the Arctic, especially among male workers whose occupational morbidity rate tends to increase.

Clinical and experimental studies of immunо-infl ammatory mechanisms of anthracosilicosis formation

Introduction. In the structure of occupational diseases of employees of the main professions of the coal industry, respiratory diseases are widespread, in the process of formation of which the key role belongs to the immune system of the body. Early manifestations of the development of professional pathology, as a rule, remain unnoticed, and therefore there is a need to study the pathogenetic mechanisms underlying its formation, not only in clinical, but also in experimental conditions, allowing to assess the premorbid state of the body for timely diagnosis and treatment and prevention.The aim of the study is to study the immune-infl ammatory mechanisms of anthracosilicosis formation on the basis of clinical and experimental studies.Materials and methods. We examined 204 miners working in underground conditions with a signifi cant dustiness of workplaces exceeding the maximum permissible concentration by 10 or more times. Th e main group consisted of 115 workers with a previously established diagnosis of “anthracosilicosis”. Th e comparison group was formed from 89 miners without a diagnosis of respiratory pathology, working in similar sanitary conditions. To assess the dynamics of immuno-infl ammatory mechanisms in the experiment, modeling of dust pathology of the lungs was performed on 310 white male laboratory rats (220-experimental and 90 — control).Results. In patients with anthracosilicosis, the development of immune failure of humoral immunity mechanisms was revealed, which was manifested by a signifi cant decrease in the level of serum IgG against the background of an increase in the absolute and relative number of B-lymphocytes. Th e formation of anthracosilicosis is characterized by the active development of the immuno-infl ammatory process (an increase in the level of pro-infl ammatory cytokines and proteins of the acute phase of infl ammation), the severity of which increases when the disease is complicated by respiratory failure. Activation of the synthesis of anti-infl ammatory IL-4, which is a powerful inhibitor of macrophage infl ammation and slows down the processes of fi brosis in the bronchopulmonary system, acts as a protective mechanism that prevents the formation of respiratory failure in miners with anthracosilicosis. Experimental modeling of anthracosilicosis revealed phase changes in the immune response. In the early period of exposure to dust factor was observed activation of humoral (increased level of all classes of immunoglobulins) and the subsequent development of the inflammatory process (increased concentrations of acute phase proteins of inflammation) in the background of the balance between subpopulations of T-lymphocytes to ensure proper development of protective immune response. Long-term intake of antigen was characterized by violations of humoral immunity, the predominance of cell-type reactions and the chronization of the infl ammatory process.Conclusions. Th e study of immuno-infl ammatory mechanisms of anthracosilicosis formation in clinical and experimental conditions indicates the activation of urgent adaptation and maintenance of compensatory and adaptive reactions of the body in the early period of contact with dust antigen. Th e chronic form of anthracosilicosis is characterized by an imbalance of regulatory mechanisms, ineffi ciency of local immunity and the intensive development of generalized immune infl ammation, which increases with the addition of infection and complication of respiratory failure.

Occupational pathology of respiratory organs in health care workers: issues of timely diagnosis

Introduction. In the structure of occupational diseases of medical workers, respiratory pathology occupies a leading place, accounting for 60% in the Republic of Tatarstan. The most common are diseases from exposure to infectious agents in the form of various forms of respiratory tuberculosis. Most often, an infiltrative form is diagnosed, accompanied in 48.6% of cases by bacilli discharge.The aim of the study is to explore the structure of occupational respiratory diseases in workers of the healthcare industry of the Republic of Tatarstan, to identify factors that affect their early diagnosis during medical examinations.Materials and methods. A retrospective analysis of cases of occupational respiratory diseases in health care workers according to the office of Rospotrebnadzor of the Republic of Tatarstan and the register of patients of the Republican Center of Occupational Pathology.Results. In the structure of occupational diseases of the respiratory system, the leading place is occupied by pulmonary tuberculosis, amounting to 86%, followed by bronchial asthma–8%, chronic toxic bronchitis–4% and subatrophic rhinopharyngolaryngitis–2%. Analysis of cases of occupational respiratory pathology showed that only tuberculosis was detected during periodic medical examinations. Other respiratory diseases were diagnosed by applying for medical care, when there was a pronounced negative trend and when the disease was initially associated with the profession, we had to talk about sending it to the Bureau of medical and social expertise.Conclusions. Early diagnosis of occupational respiratory diseases of allergic etiology and toxic respiratory lesions in medical workers at periodic medical examinations can be achieved by the quality of a special assessment of working conditions due to the mandatory assessment of the chemical factor-contact with allergens, antitumor drugs, hormones, enzymes of microbial origin, narcotic analgesics, regardless of the concentration of harmful substances in the air of the working area. It is also necessary to take into account the presence of substances with an acute irritant effect.

To the question of occupational pathology developing under acceptable working conditions (on the example of workers of enterprises in the Russian Arctic)

The purpose of the study is to investigate occupational pathology that develops under acceptable levels of harmful production factors. Results. It has been found that 0.77% of all cases of occupational diseases in 2007-2018 developed under acceptable working conditions in the enterprises of the Arctic (66 out of 8609 diseases). Their features were: 1) shortened length of service of the sick people (20.2 ± 1.5 years); 2) younger age (47.8 ± 1.2 years); 3) larger proportion of women among the sick people; 4) greater role of chemical factors and severity of work in the development of health disorders; 5) more frequent development of diseases among workers of certain professions; 6) different structure of classes and nosological forms of occupational diseases; 7) increased proportion of acute industrial poisoning in the structure of occupational diseases. Exposure to harmful production factors with exposure levels not exceeding hygiene standards became possible more often due to design flaws in machines, mechanisms and other equipment (54.5%). Detection of most occupational diseases in people working in acceptable working conditions took place because they sought medical help themselves due to deterioration of health (in 66.7% of cases). 59.9-66.2% of diseases in people working in harmful and dangerous working conditions were diagnosed according to the results of periodic medical examinations. Conclusion. There is a need for a deeper understanding of the causes and preventive methods of occupational health disorders that develop under acceptable working conditions.

The prevalence of diseases of non-occupational genesis in persons with diagnosis of occupational disease

The data on prevalence of diseases of non-occupational genesis in persons with occupational diseases that have stopped their labor activity are presented. The purpose of the study was to analyze prevalence of diseases of non-occupational genesis in persons with diagnose of occupational disease working at enterprises and organizations served by health care institutions of the FMBA of Russia. The study uses data from "The Industrial Register of persons with occupational diseases". In the structure of occupational diseases of persons who stopped working the first three places are for "Injury, poisoning and certain other consequences of external causes S00-T98", "Diseases of the respiratory system J00-J99" and "Mental and behavioral disorders F00-F99". The most common were diseases of circulatory system, digestive system and musculoskeletal system with variations in groups of occupational diseases. The high value of "The Industrial Register of persons with occupational diseases" was confirmed. This information permits to to assess health of persons with occupational diseases.

OCCUPATIONAL PATHOLOGY IN THE IRON MINING IN THE KOLA ARCTIC

Introduction. Working conditions at mining enterprises, including iron ore mining, combined with the climatic conditions of the Arctic, create an increased risk of occupational diseases (OD) among miners. The aim of the study was to investigate the risks, circumstances of the development, structure, and prevalence of OD in miners engaged in the extraction of iron ore in the Kola Polar Region. Material and methods. The data of social and hygienic monitoring in the section “Working conditions and occupational morbidity” of the population of the Murmansk region in 2007-2017 were studied. Results. The development of the OD in this category of miners was established to be mainly associated with the whole-body vibration (42.5%) and the severity of labor (33.2%) due to the imperfection of workplaces (66.4%). In the structure of the OD, the largest share belongs to injuries, poisoning and some other consequences of external causes (46.9%), while diseases of the musculoskeletal system occupy the second place (27.0%). The most common nosological form of OD was vibration disease (38.5%). The annual number of workers diagnosed with OD varied over a wide range from 3 to 29 people. In 2007-2015, there was a tendency towards an increase in occupational morbidity rates, and in 2016-2017, there was a sharp decrease to 7.39 cases per 10,000 workers, which cannot be explained by improved working conditions and health promoting activities. Conclusion. To preserve the health of miners engaged in the extraction of iron ore in the Kola Arctic, it is necessary, first of all, to reduce the levels of whole-body vibration and severity of labor processes in combination with the introduction of medical methods to increase the body’s resistance to harmful industrial and climatic factors.

Hygienic assessment of working conditions and health of the workers of mining and processing enterprises

In the article there are presented results of studies on the hygienic assessment of working conditions and health status of 1200 workers of mining and processing enterprises (MPE) developing deposits of iron ores of the Kursk Magnetic Anomaly: Lebedinskiy MPE, Mikhaylovskiy MPE, Stoylenskiy MPE. There were revealed the differences in the character and intensity of adverse occupational factors, there was made the quantitation of the occupational risk level to the health workers of MPE both factories and quarries. The structure of occupational diseases in MPE factories is formed by dust lung diseases and the occupational pathology of the organ of hearing. In the structure of professional pathology in quarries workers vibration disease (61.5%) prevails. The obtained results indicate to the need of the development of the system of measures for the reduction in general and occupational morbidity rate of workers, the creation of safe working conditions, improving the early diagnosis of occupational and common diseases at the stage of preliminary and periodic medical examinations.

OCCUPATIONAL PATHOLOGY AT THE ENTERPRISES OF THE NENETS AUTONOMOUS DISTRICT: RISK FACTORS, STRUCTURE, PREVALENCE

Background. Human labor in the Arctic area is carried out in extreme climatic conditions creating an increased risk of developing health problems, including occupational diseases (OD). The purpose of the study was to investigate the working conditions, the structure and prevalence of OD in the population of the Nenets Autonomous District (NAD), the basis of the which economy is oil and gas production. Material and methods. The data of social and hygienic monitoring in the section “Working conditions and occupational morbidity” of the population of the NAD in 2008-2017 was studied. Results. The most significant harmful production factors at NAD enterprises have been established to be non-ionizing electromagnetic fields and radiations, unfavorable microclimate of workplaces, noise, intensity, and the hardness of the labor process. More than half of all district employees are involved in enterprises with satisfactory working conditions. In the NAD working population, occupational pathology is diagnosed mainly in the flight personnel of civil aviation (88% of cases) in the form of sensorineural hearing loss (96% of cases). The risk of OD development among air transport workers was higher than that of the entire population of the district (RR = 4.42; CI 2.95-6.62) and those employed in oil and gas producing enterprises (RR = 23.2; CI 8.32 - 64.4). Additional occupational health risks associated with the extraction of hydrocarbons in Arctic have not been established. Conclusion. The priority direction in the prevention of occupational pathology (mainly sensorineural hearing loss) should be the reduction of the level of industrial noise among air transport workers.

Indicators of the relationship between heart rate variability and levels of glycemia and cholesterol in vibration pathology

Introduction. Vibration disease (VD) is one of the leaders in the structure of occupational diseases among workers in the coal mining industry. The occurrence of disorders at the systemic level (primarily in the nervous and vascular systems) leads to suppression of heart rate variability (HRV) in vibration pathology as a result of damage to vegetative fi bers, centers, ganglia. The study of metabolic disorders in relation to HRV indicators, including nonlinear ones, is of interest for understanding the mechanisms of the VD, and is also important for fi nding non-invasive and less expensive methods of dynamic control.The aim of the studywas to study the parameters of heart rate variability, total cholesterol and blood glucose levels in patients with vibration disease, to identify the relationship between them.Materials and methods. 75 patients of the Clinic of the Research Institute for Complex Problems of Hygiene and Occupational Diseases subjected to industrial vibration for 10 years or more (the main group) and 20 people of the control group who never had contact with industrial vibration were examined. Th e age of the subjects was 40–60 years. Fasting blood glucose and total cholesterol levels were studied, heart rate variability was studied. Frequency and nonlinear phenomena of heart rate variability were analyzed. Spearman correlation coeffi cient was determined to assess the strength of the relationship between blood and heart rate variability.Results. Glucose and cholesterol levels were statistically higher in the group of patients with vibration disease. Spectral parameters of high — and low-frequency heart rate variability in the main group signifi cantly decreased. In patients with vibration pathology of the approximated entropy was signifi cantly lower, whereas deranty fl uctuation analysis increased. Th ese changes of heart rate variability indicate the involvement of all departments of vegetative nervous system, the development of relative sympathicotonia. Correlations of average strength between heart rate variability and levels of glycemia and cholesterol were revealed.Conclusion.Under the infl uence of industrial vibration in workers’ blood cholesterol and glucose levels increase, heart rate variability is suppressed and correlated with an increase in metabolic disorders.

THE HEALTH OF WORKERS OF CONCENTRATING MILLS BY MODERN TECHNOLOGIES OF CONCENTRATION OF MINERALS AND PREVENTION MEASURES

The article presents the results of study of factors of occupational risk for health of workers of ore-dressing factories. At ore-dressing factories, despite of implementing new technological processes and modern equipment, leading role of noise factor and pollution of air of working zone with aerosols predominantly of fibrogenic effect is preserved. for workers of ore-dressing factories a high degree of industrial conditioning of diseases of blood circulation organs, respiratory organs, bone muscular system, INT organs is specific. The structure of occupational diseases is formed by dust diseases of lungs and occupational pathology of organ of hearing. The complex of preventive measures is developed and ways of their implementation are proposed targeted to supporting health of workers opf ore-dressing factories and preventing development of occupational and occupationally conditioned diseases.

Possibilities of Application of Modern Neurophysiological Methods in Diagnosis of Vibration Disease

Vibration disease is one of the leading in the structure of occupational diseases. A more detailed study of the pathogenesis, expanding the possibilities of diagnosis of vibration disease, is necessary. The aim of the study is to determine the diagnostic value of stabilometry, quantitative sensory testing and neuroenergocarting in vibration disease associated with the combined effects of local and general vibration. Materials and methods. Two groups of patients were examined: with the diagnosis of vibration disease associated with the combined effect of local and general vibration – 50 people (age 48.7 ± 3.1 years), not in contact with vibration – 30 people (age 49.1 ± 2.8 years). The study of the equilibrium function, the determination of the level of the constant potential of the brain by 12 standard leads and the determination of temperature and pain sensitivity. Statistical processing of the results was carried out using the software package “Statistica 6.0” (StatSoft Inc., USA). Differences were considered statistically significant at p < 0.05. Results. In vibration disease, the vertical stance of patients is more unstable than in patients with no contact with vibration. In patients with vibration disease, there is a decrease in the threshold of cold sensitivity and an increase in the threshold of thermal sensitivity and thermal pain compared to the control group. According to our data, the increased level of permanent potential in patients with vibration disease is observed in the central (22.7 (12.6; 30.7) mV) and right central (20.4 (11.5; 27.1) mV), also the average level of permanent capacity in this group is increased – 17.1 (8.4; 25.8) mV.Conclusion. The results obtained indicate the involvement of the neurosensory complex united by single thalamic and cortical centers in the pathological process and confirm the diagnostic value of the methods used.

Clinical and pathogenic aspects of vibrational disease and comorbid pathologies.

Despite the tendency to decrease in the level of vibrational disease morbidity, this pathology is third in the structure of occupational diseases in Ukraine. According to research design, we have examined 178 vibrational disease patients of I and II degree due to local vibration. They have been divided into 3 groups: first — 66 patients with vibrational disease and chronic obstructive pulmonary disease; second — 60 patients with vibrational disease and arterial hypertension of II degree, and group of comparison – 52 patients with isolated course of vibrational disease. We have used clinical and physiological, ELISA methods to estimate cytokines levels in these patients. We have found that clinical signs of vibrational disease depend on vibrational disease progressing and comorbid pathologies. Overlay of chronic obstructive pulmonary disease to vibra­tional disease significantly worsens disease course, manifested by augmenting of clinical symptoms, neurovascular and trophic violations. Comorbid course of vibrational disease and arterial hypertension leads to respective worsening of cardio-vascular pathology. One of the mechanisms of development and progressing of vibrational disease is imbalance of cytokine chain of immunity — increase of the amount of inflammatory cytokine TNF-α and decrease of anti-inflammatory — IL-10. Overlay of chronic obstructive pulmonary disease enhances this trend. In patients with comorbid course of vibrational disease and arterial hypertension we have observed development of secondary dysregulatory state of immunocompetent system. This is proved by increased levels of inflammatory cytokines (TNF-α by 62.5 % and IL-8 by 46.5 %), and decreased activity of melatonin by 35.0 % in comparison with group of patients with isolated vibrational disease.

ФАКТОРИ РИЗИКУ ПРОФЕСІЙНИХ ЗАХВОРЮВАНЬ МЕДИЧНИХ ПРАЦІВНИКІВ (ОГЛЯД ЛІТЕРАТУРИ)

The study of the risk factors of occupational diseases is a medical and social issue from a view point of practice and sociology, it is a theoretical basis for the development of methods for their prevention. The official statistical reports prove that in Ukraine, more than 60 % of 1.1 million health workers undergo harmful exposure and danger, and occupational disease occurrence among them is recorded at the level of 0.71 per 100 thousand working population. In the structure of occupational diseases, tuberculosis is first (80–100 %, on average – 87.7 %), diseases of musculoskeletal system are second (1.3–6.7 %, on average – 3.1 %), allergic diseases are third – 1.0–5.1 % (on average – 2.3 %).The aim of the study – to learn and summarize the causes of professional diseases of medical workers in Ukraine.Materials and Methods. Occupational morbidity of medical staff is caused by the influence of risk factors: mechanical, physical, chemical, biological, nervous-emotional. Medical workers under static work conditions are exposed to negative mechanical influences. The harmful effects of physical factor are considerably increased at present due to a widespread implementation of equipment with light, electromagnetic and radioactive radiation into medical and diagnostic processes. Due to the rapid development of chemical and pharmaceutical industries, the number of chemicals that cause not only the therapeutic effect on a patient but also have a negative impact on healthcare workers in cases of their systematic use has increased significantly.Results and Discussion. A group of occupational diseases caused by pathogens of tuberculosis, toxoplasmosis, viral hepatitis, skin mycoses, syphilis, and HIV infection is an urgent matter of health care in Ukraine. The risk of HIV infection is about 0.3 % and reaches 10 % in cases of hepatitis C virus, and 30 % in hepatitis B virus. In Ukraine, according to the Ministry of Health, every year 30.0–50.0 thousand patients are diagnosed with this illness (84.1 per 100 thousand population). Manifestations of the emotional affection as a symptom complex of “professional burnout” have been revealed in almost 80 % of psychiatrists, psychotherapists, narcologists, in 61.8 % of dentists, and 60.6 % of medical nurses of oncology departments.Conclusion. The analyses of occupational diseases cases among healthcare workers of various medical facilities of Ukraine in 2011–2017 has proved that the highest number of occupational diseases is registered in TB facilities – 70.1–95.5 %. 3.0–6.4 % of all occupational diseases in the healthcare have been registered in community hospitals, 1.5–10.2 – in psychoneurological hospitals, 1.9–3.0 % – in the Bureau of Forensic Medicine and 2.6–3.0 % – in research institutions.

INFORMATIVITY OF THE DIFFERENTIATED ACCOUNT OF SIZES OF SOLID PARTICLES IN THE AIR ENVIRONMENT FOR THE PROTECTION OF THE HEALTH OF EMPLOYEES OF DUST PROFESSIONS AND THE POPULATION (REVIEW OF THE LITERATURE DATA)

Harmful effects of the increased dust content in the air on working sites and the population are one of the current problems of the current time and demand realization of more effective measures of the prevention of risks to health. Professional pathology of respiratory organs of employees of dust professions still remains the main in the structure of occupational diseases. The research conducted by us at one of large iron and steel plant of the country have shown the high professional risk to the health of workers exposed to aerosols (17.19%oo). 75% of all cases of professional pathology fell to the share of occupational diseases of respiratory organs. Data of the analysis of the morbidity with temporary disability records testified about very high (WiΔ> 3) or high (WiΔ = 2.0-3.0) direct epidemiological risk of exacerbations of chronic diseases of the lungs and pneumonia noted in shops with the primary influence of aerosols of condensation. Whereas in production with prevalence in the soaring dust of aerosols of disintegration WiΔ = 1.0-2.0 recently the increasing relevance is acquired by fine particles, including - the nanoparticles differing in special physical and chemical characteristics and impact on biological structures including the human body. For the assessment of the potential danger of the aerosol particles to health working and the population there isn’t enough knowledge of dispersing composition of the dust soaring in air, and it is necessary to know the inhaled fraction, i.e. a mass fraction of all weighed particles in air which are inhaled through a nose or a mouth and also -the major area of their sedimentation in airways of the person. In our country, there are performed numerous epidemiological investigations devoted to the studying of the influence of the weighed particles (PM2.5 and PM10) on the population that has formed the basis for the development of domestic hygienic standards and control methods. The recommendations focused on the separate accounting of mass of the soaring and inhaled particles for more effective protection of the health of workers of dust professions are proved.

FORECASTING THE DEVELOPMENT OF ACUTE TOXIC EFFECTS IN PROFESSIONAL CONTINGENTS AFTER COMBINED PESTICIDES APPLICATION FOR AGRICULTURAL CROPS PROTECTION

In the overall structure of occupational diseases the large proportion is acute pesticide poisoning (mainly group cases). In recent decades in the structure of agricultural workers’ occupational diseases chemicals poisoning was 14,7-43,5 %. That is why the purpose of the work was to predict the possibility of acute toxic effects on agricultural workers when working with combined formulations. Methods. In order to assess the effects of the aforementioned substances on the workers’ organism the coefficient of possible inhalation poisoning (CIPP), the coefficient of pesticide effect selectivity at inhalation effect (CPESinhal.) and at dermal application (CPESderm.) were used. Results. According to the "Hygienic Classification of Pesticides by Degree of Danger", all studied compounds, as well as combined preparations based on them, are pertained to 4th hazard according to this criterion (CIPP <0,5). Calculated CPESinhal. (103,4-4701,2) and CPESderm. (237,4-12345,7) values for all investigated a.i. were more than 100, which indicates a rather high selectivity of their action. Discussion. Thus, the obtained results allow to predict the possible negative influence of pesticides of different classes on the initial stages of registration tests of pesticide formulations containing studied active substances Conclusion. The importance of observance of the established regulations for formulations application (norms and rates of application) and the obligatory use of the recommended individual protecting means for the respiratory and skin protection by agricultural workers during the application of studied pesticides are shown

Hygienic assessment of occupational diseases in the coal industry of Kuzbass

Integrated hygienic assessment of the sanitary and epidemiological situation with occupational diseases in the coal industry of Kuzbass allowed: to establish quantitative parameters improve levels of occupational diseases in 2008–2015; determine the structure of occupational diseases in their nosological forms, length of service and age to occur; find quantitative depending on the length of service before the emergence of occupational diseases from grade 3 class working conditions; rank the causes and circumstances of occupational diseases; give miners hygienic characteristics professions and sections of workers, contributing most to the occupational diseases.

Study of otoacoustic emissions in workers of various professional groups of the coal industry.

Noise influence takes one of the leading roles in the development of sensorineural hearing loss (SHL) . At the same time professional deafness steadily occupies the 5th place in the structure of occupational diseases in Ukraine over the past few years. Of special importance is the problem of pre-clinical and early diagnosis of occupational hearing deterioration, in sense of timely prophylactic and rehabilitation measures in “risk group” workers. The objective research methods play an important role in the diagnosis of auditory analyzer state. Many scientific studies have shown the diagnostic effectiveness of method of otoacoustic emissions recording in the early diagnosis of lesions of receptor part of auditory analyzer. It is known that SHL of noise genesis largely affects the receptor part of the auditory analyzer, for which the OAE method has great practical diagnos tic significance. Objective: to study informativity indicators of otoacoustic emission for the diagnosis of sensorineural hearing loss in various occupational groups of coal workers in Ukrainian mines. Materials and Methods: Auditory function of 87 workers of the coal industry (drifters, miners and longwall miners) with different levels of industrial noise and hygienic conditions in their workplaces was: 28 studied drifters (group 1), 25 miners (group 2) and 34 longwall miners (group 3). Work experience in noise in these groups was 17,9±1,0; 23,1±1,0 and 22,2±2,0 accordingly. Noise ratio in drifters was 93,6±4,9 dBA, in miners – 92,9±5,5 dBA and in longwall miners – 86,5±6,04 dBA accordingly, while the maximum permitted level is 80 dBA. The research was conducted on the analyzing system Eclipse Interacoustics (Denmark). All patients underwent registratiov of the caused OAE at frequency distortion product (DPOAE) at frequencies 1-6 kHz. The results were rated using variation statistics Student's test. Results: The most prominent violation of the receptor part of the auditory analyzer according to the OAE among all the examined workers of different professional groups of the coal industry was found in drifters, miners had less pronounced violations and the least significant ones were in longwall miners. At the same time in 42,9% drifters caused OAE at frequency distortion products was not recorded on any of the investigated frequencies. Received averages of OAE amplitude in the studied frequencies differed significantly in drifters not only from the norm , but also from that in the group of longwall miners in the 4-6 kHz region . The most prominent disorders according to the speech and above-threshold audiometry were found in drifters and miners, testifying to violations in the receptor part of the auditory analyzer. Conclusions: In all occupational groups of coal industry workers according to OAE data, more pronounced violations were found in the frequency distortion products in the 4-6 kHz. This is evidenced by significant decrease of OAE amplitudes averages, especially pronounced in 4 and 6 kHz, where they significantly differ from the norm and from the indicators in the group of longwall miners; and OAE registration was absent in the drifters. The identified differences in OAE indicators and dysfunction severity in the receptor structures of the auditory analyzer , obviously, could be explained by the nature of industrial noise and hygienic working conditions in the workplaces of the studied workers of coal industry.

Многолетняя динамика и структура профессиональной заболеваемости в Республике Татарстан

Многолетняя динамика и структура профессиональной заболеваемости в Республике Татарстан

Rational approaches to diagnosis and treatment of pneumoconiosis

Dust-related lung diseases still occupy a significant place among other forms of occupational pathology, accounting for about 30% in the structure of occupational diseases in our country. Pneumoconiosis continues to be one of the priority problems of occupational medicine worldwide, and for many developing countries - one of the most important: at various production facilities the number of patients with silicosis reaches 54.6% of the number of workers. In Canada, 283 cases of silicosis have been reported among 68,000 people working in dust-exposed environments; in the United States, about 3 million people have significant occupational exposure to silica dust.