Structural Modifications Research Articles

“All in one” lipid-polymer nanodelivery system for gene therapy of ischemic diseases

Gene therapy offers a promising avenue for treating ischemic diseases, yet its clinical efficacy is hindered by the limitations of single gene therapy and the high oxidative stress microenvironment characteristic of such conditions. Lipid-polymer hybrid vectors represent a novel approach to enhance the effectiveness of gene therapy by harnessing the combined advantages of lipids and polymers. In this study, we engineered lipid-polymer hybrid nanocarriers with tailored structural modifications to create a versatile membrane fusion lipid-nuclear targeted polymer nanodelivery system (FLNPs) optimized for gene delivery. Our results demonstrate that FLNPs facilitate efficient cellular uptake and gene transfection via membrane fusion, lysosome avoidance, and nuclear targeting mechanisms. Upon encapsulating Hepatocyte Growth Factor plasmid (pHGF) and Catalase plasmid (pCAT), HGF/CAT-FLNPs were prepared, which significantly enhanced the resistance of C2C12 cells to H2O2-induced injury in vitro. In vivo studies further revealed that HGF/CAT-FLNPs effectively alleviated hindlimb ischemia-induced gangrene, restored motor function, and promoted blood perfusion recovery in mice. Metabolomics analysis indicated that FLNPs didn't induce metabolic disturbances during gene transfection. In conclusion, FLNPs represent a versatile platform for multi-dimensional assisted gene delivery, significantly improving the efficiency of gene delivery and holding promise for effective synergistic treatment of lower limb ischemia using pHGF and pCAT.

Patterning damage mechanisms for two-dimensional crystalline polymers and evaluation for a conjugated imine-based polymer

High-quality patterning determines the properties of patterned emerging two-dimensional (2D) conjugated polymers and is essential for potential applications in future electronic nanodevices. However, the most suitable patterning method for 2D polymers has yet to be determined because we still do not have a comprehensive understanding of their damage mechanisms by visualizing the structural modification that occurs during the patterning process. Here, the damage mechanisms during patterning of 2D polymers, induced by various patterning methods, are unveiled based on a systematic study of structural damage and edge morphology in an imine-based 2D polymer (polyimine). Patterning using a focused electron beam, focused ion beam (FIB) and mechanical carving is evaluated. The focused electron beam successively introduces a sputtering effect, knock-on displacement damage and massive radiolysis with increasing electron dose from9.46×107electrons nm-2to1.14×1010electrons nm-2. Successful patterning is enabled by knock-on damage but impeded by carbon contamination beyond a critical sample thickness. A FIB creates current-dependent edge morphologies and extensive damage from ion implantation caused by the tail of the unfocused beam. A precisely controlled tip can tear the polyimine film through grain boundaries and hence create a patterning edge with suitable edge roughness for certain application scenarios when beam damage is avoided. Taking structural damage and the resulting quantitative edge roughness into consideration, this study provides a detailed instruction on the proper patterning techniques for 2D crystalline polymers and paves the way for tailored intrinsic properties and device fabrication using these novel materials.

Investigating the role of solvents in modulating glass transition and dynamic mechanical characteristics of polystyrene film

This study investigates how different solvents impact the glass transition and dynamic mechanical properties of polystyrene (PS) films. Using FTIR spectroscopy, it analyzes solvent-induced variations in molecular vibrations, particularly in the phenyl ring region. Results show solvent-specific effects on the 750 cm-1 peak, associated with the "meta-substituted aromatic ring," influencing phenyl ring vibrations. DSC analysis highlights solvent effects on the glass transition temperature (Tg), revealing complexities in PS films prepared with chloroform, tetrahydrofuran (THF), and toluene. Varied Tg behavior suggests solvent-driven structural modifications and gradual solvent removal. Dynamic Mechanical Analysis (DMA) demonstrates solvent-dependent changes in storage modulus, loss modulus, and tan δ, indicating solvent polarity role in polymer chain dynamics. Toluene-induced plasticization reduces Tg and increases creep compliance, revealing PS film sensitivity to solvents. These findings stress solvent selection importance in tailoring thermal and mechanical properties of polymer films for specific applications.

Natural and Synthetic Capsaicin Analogues: A Comprehensive Review of Biological Effects and Synthetic Pathways.

Capsaicin analogs, whether sourced from natural origins or synthesized de novo, have garnered significant attention across diverse scientific disciplines. This comprehensive investigation explores the expansive domain of medicinal chemistry and pharmacology, focusing on capsaicin and its analogs. Notably, these analogs exhibit a wideranging pharmacological spectrum, with a particular emphasis on their potent antitumor properties. Researchers frequently explore structural modifications, particularly in region C, consistently enhancing their pharmacological activities. A highlighted finding is that analogs with alterations in both regions A and C manifest a diverse array of effects, spanning from anti-obesity to protection against ischemia. They also demonstrate anti- Alzheimer's, anti-fibrotic, anti-inflammatory, anti-diabetic, antimalarial, and anti-epileptic properties. This underscores the potential of structural adaptations in these regions, expanding the therapeutic applications of capsaicin-like compounds. Additionally, manipulations in regions B and C result in compounds that possess antioxidant and anti-obesity properties, providing valuable insights for the development of novel compounds. The therapeutic potential of capsaicin analogs opens innovative avenues for drug design and development, promising to address a broad spectrum of diseases and enhance global quality of life. Moreover, this article meticulously examines various synthetic methodologies for synthesizing capsaicin analogs, complementing the main review. These methodologies distinguish themselves through their simplicity, mild reaction conditions, and reliance on readily available commercial reagents. The accessible synthesis pathways enable researchers from diverse backgrounds to explore these compounds, fostering investigations and potential therapeutic applications.

Metallo-Supramolecular Helicates as Surface-Enhanced Raman Scattering (SERS) Substrates with High Tailorability.

The exploration of novel functionalized supramolecular coordination complexes (SCCs) can enable new applications in domains that include purification and sensing. In this study, employing a coordination-driven self-assembly strategy, we designed and prepared a series of benzochalcogenodiazole-based metallohelicates as high-efficiency charge transfer surface-enhanced Raman scattering (SERS) substrates, expanding the range of applications for these metallohelicates. Through structural modifications, including the substitution of single heteroatoms on ligands, replacement of coordinating metals, and alteration of ligand framework linkages, the Raman performance of these metallohelicates as substrates were systematically optimized. Notably, the SERS enhancement factors (EFs) of the metallohelicate-based SERS substrates were significantly enhanced to levels as high as 1.03 × 107, which rivals the EFs of noble metals devoid of "hot spots". Additionally, the underlying Raman enhancement mechanisms of these metallohelicates have been investigated through a combination of control experiments and theoretical calculations. This study not only demonstrates the utility of metallohelicates as SERS substrates but also offers insights and materials for the development of high-efficiency new charge transfer SERS substrates.

Advancing protein hydrolysis and phytosterol encapsulation: Emerging trends and innovations in protein-based microencapsulation techniques – A comprehensive review

Phytosterols represent a diverse and complex category of lipophilic bioactive compounds, exhibiting excellent pro-healthy properties. However, their consumption in daily diets is insufficient, and their application in food production is hindered by challenges such as low water solubility, high reactivity, and rapid degradation. The adoption of different protein or their structural modification as hydrolysates as wall material into microencapsulation techniques can be associated with improved solubility, enhanced bioaccessibility, increased bioavailability, and an extension of shelf life.This contribution provides an overview of advancements in modifying functional properties through various protein isolation methods and structural changes resulting from enzymatic hydrolysis. Additionally, the paper considers the state of the art in the utilization of various techniques and the composition of wall material in the encapsulation of phytosterols and other common lipophilic phytochemicals incorporated into delivery systems.Protein isolates obtained through novel methods of extraction may be characterized by an enhancement of their functional properties, which is crucial for the microencapsulation process. It entails not only recognizing their role as protective barriers for core materials against environmental conditions but also acknowledging their potential health-promoting attributes. These attributes encompass antioxidant properties and enhanced functional characteristics compared to native proteins. Moreover, the exploration of protein hydrolysates as versatile wall materials holds significant promise. These hydrolysates offer exceptional protective features for core materials, extending beyond mere environmental shielding. The envisioned impact extends beyond conventional delivery systems, offering transformative potential for the future of drug delivery and nutraceutical formulations.

Metallo‐Supramolecular Helicates as Surface‐Enhanced Raman Scattering (SERS) Substrates with High Tailorability

The exploration of novel functionalized supramolecular coordination complexes (SCCs) can enable new applications in domains that include purification and sensing. In this study, employing a coordination‐driven self‐assembly strategy, we designed and prepared a series of benzochalcogenodiazole‐based metallohelicates as high‐efficiency charge transfer surface‐enhanced Raman scattering (SERS) substrates, expanding the range of applications for these metallohelicates. Through structural modifications, including the substitution of single heteroatoms on ligands, replacement of coordinating metals, and alteration of ligand framework linkages, the Raman performance of these metallohelicates as substrates were systematically optimized. Notably, the SERS enhancement factors (EFs) of the metallohelicate‐based SERS substrates were significantly enhanced to levels as high as 1.03 × 107, which rivals the EFs of noble metals devoid of "hot spots". Additionally, the underlying Raman enhancement mechanisms of these metallohelicates have been investigated through a combination of control experiments and theoretical calculations. This study not only demonstrates the utility of metallohelicates as SERS substrates but also offers insights and materials for the development of high‐efficiency new charge transfer SERS substrates.

Stretchable Metamaterials with Tunable Infrared Emissivity for Dynamic Thermal Management.

Manipulation of infrared emissivity, which is closely related to surface structure and optical parameters of materials, is a crucial approach for realizing dynamic thermal management. In this study, we design a metamaterial consisting of an array of aluminum disks embedded on a surface of a stretchable elastomeric substrate. Mechanical stretching-induced deformation allows dynamic modification of the surface structure and equivalent optical parameters, thus enabling dynamic control of the emissivity. By utilizing the elastomer polydimethylsiloxane (PDMS) as the substrate, the microstructure interdisk gap can be altered by stretching the PDMS. Through theoretical calculations, the plausibility of this approach is explained by the excitation of plasmon resonance and the variation in the exposed area of highly absorbent PDMS, and the optimal structures for tuning the infrared emissivity are revealed to be 6 μm in diameter and 100 nm in height. Based on this design, we prepare samples with periods of 7 and 7.9 μm and experimentally demonstrate that a change in the period can cause a change in the emissivity and thus tunability in thermal control performance. The temperature difference between the two samples reaches 44.1 °C at a heating power of 0.28 W/cm2 for both samples. Furthermore, we construct a stretching platform that enables in situ mechanical stretching to realize dynamic changes in emissivity. The integral infrared emissivity of the sample increases from 0.32 to 0.5 at a biaxial tensile strain of 13%, achieving a 56% modulation rate of the integral infrared emissivity. The material is expected to enable dynamic thermal management.

Larger grains in high-Tc superconductors synthesized by the solid-state reaction route

Solid-state synthesis is widely used in exploratory research to study various structural modifications that affect the properties (critical temperature, critical current density, irreversibility field, etc.) of superconductors. The popularity of this method is due to its relative simplicity and availability of the necessary equipment. Combining solid-state synthesis and top-seeded melt growth allows us to increase the grain size in a Tm- and Nd-based 1-2-3 superconductor. Samples with a grain size up to 0.1 mm have been obtained. X-ray diffraction, scanning electron microscopy and magnetization measurements have been used for investigating this superconducting material. The magnetization width ΔM has increased significantly in the synthesized samples. However the temperature dependence of the intragrain critical current density and the pinning force scaling give evidences that the pinning mechanism in the obtained superconductor is essentially the same as in polycrystalline superconductors synthesized by standard solid-state technology. The increase in grain size in the synthesized samples is the main reason for the high values of ΔM.

Fe/Li Co-doped CuO: enhanced photosensing and conductivity correlated with structural modifications

Fe/Li Co-doped CuO: enhanced photosensing and conductivity correlated with structural modifications

Comparative stem and wood anatomy of Ipomoea eriocarpa R.Br. (Convolvulaceae) growing in the arid zone and tropical deciduous forest

Family Convolvulaceae is dominated by climbing species and in most of the members, radial growth is achieved by forming vascular variants. The present study compares stem anatomy and structural modifications in the secondary xylem of Ipomoea eriocarpa R.Br. (Convolvulaceae) growing at Banni (Kachchh, arid zone) and at Toranmal (Tropical dry deciduous forest). Individuals growing at both biogeographic zones showed similar ontogeny for the development of successive cambia, inter-and intraxylary phloem, intraxylary cambium, and non-lignified axial (and radial) parenchyma wedges. However, as plants grew older, stems of individuals growing at Banni became lobbed in outline and showed the development of successive cambia and bidirectional intraxylary cambium. The thickest stems of samples from Banni possessed three successive cambial rings, vessels mostly solitary and relatively narrow in diameter with a greater number of non-lignified axial parenchyma wedges. In contrast, samples collected from Toranmal showed two successive cambial rings with relatively few numbers of non-lignified axial parenchyma wedges, intraxylary cambium was unifacial and exclusively produced intraxylary phloem. The secondary xylem was diffuse-porous, vessels usually in tangential multiples or clusters. Though, the time of seed germination and establishment of seedlings remained the same; in Banni samples, initiation of successive cambia, intraxylary cambium and its derivatives (i.e. xylem and phloem) began before the individuals growing at Toranmal. Samples from both locations showed the presence of inverse cambia on the inner margin of the xylem produced by the first successive cambium. These alterations in the behaviour may be correlated with the ephemeral lifecycle of Banni plants.

GaAs quantum transport: Scrutinizing the effects of pressure, temperature and Rashba-Dresselhaus spin-orbit interactions for next-generation spintronic devices

This research investigates the spin-dependent transmission attributes and associated Giant Magnetoresistance (GMR) effect emerging from spin-polarized electron tunneling in a GaAs quantum well superlattice (QWS). The influence of Rashba and Dresselhaus spin-orbit interactions (SOIs) on transport properties is analyzed under the framework of the scattering matrix method. Our quantitative findings revealed that these spin-orbit couplings (SOCs) introduce inherent spin-filtering mechanisms, significantly influencing transmission probabilities. Furthermore, numerical estimations proved that external perturbations including pressure, temperature and structural modifications considerably impact the quantum transport characteristics of the scrutinized system. Additionally, major outcomes suggest that precise manipulation of spin-dependent transport in GaAs QWS holds promise for advancing spintronics technology. It is found that with well-tuned parameter values, the SOCs behave as a spin-dependent barrier modifying the band shape and its anisotropy. This study offers novel insights into the fundamental physics governing spin-dependent transport within quantum superlattices with promising implications for the development of advanced spintronic devices.

A circularly polarized graphene based wideband 1 × 2 array antenna for terahertz spectrum applications

A graphene-based 1 × 2 array antenna with circular polarization for terahertz applications is prescribed in this article. Initially, a novel concept of a folded quarter wave impedance transformer is utilized in the design process of a single element for minimizing the overall antenna size. The opposite corners of the patches have been truncated and structural modifications are performed with the insertion of four flower-shaped slots along with an additional circular slot for achieving a much-improved reflection coefficient and better impedance bandwidth. It also shows a much wider 3 dB axial ratio bandwidth, confirming circular polarization due to the suggested modifications in its geometry. Then, an array antenna has been formed to provide better gain. The configured patches are fed by a magic-T power divider to attain the required impedance matching. The results of the CP antenna array have been analyzed using the HFSS and CST simulators. The propounded 1 × 2 array antenna shows circular polarization with a 3 dB AR bandwidth of 205 GHz (2.345–2.55 THz) and wide spectral coverage of 210 GHz (2.345 − 2.555 THz) along with a maximum gain of 8.65 dB and 99.8 % radiation efficiency with a total size of 53.5 × 102 × 1.56 μm3. It could be utilized for high-speed data transmission, material characterization, terahertz spectroscopy, terahertz imaging, etc. applications.

How Advanced are Nanocarriers for Effective Subretinal Injection?

Subretinal injection (SR injection) is a commonly used method of ocular drug delivery and has been mainly applied for the treatment of neovascular age-associated macular degeneration (nAMD) and sub-macular hemorrhage (SMH) caused by nAMD, as well as various types of hereditary retinopathies (IRD) such as Stargardt's disease (STGD), retinitis pigmentosa (RP), and a series of fundus diseases such as Leber's congenital dark haze (LCA), choroidal defects, etc. The commonly used carriers of SR injection are mainly divided into viral and non-viral vectors. Leber's congenital amaurosis (LCA), choroidal agenesis, and a series of other fundus diseases are also commonly treated using SR injection. The commonly used vectors for SR injection are divided into two categories: viral vectors and non-viral vectors. Viral vectors are a traditional class of SR injection drug carriers that have been extensively studied in clinical treatment, but they still have many limitations that cannot be ignored, such as poor reproduction efficiency, small loading genes, and triggering of immune reactions. With the rapid development of nanotechnology in the treatment of ocular diseases, nanovectors have become a research hotspot in the field of non-viral vectors. Nanocarriers have numerous attractive properties such as low immunogenicity, robust loading capacity, stable structure, and easy modification. These valuable features imply greater safety, improved therapeutic efficacy, longer duration, and more flexible indications. In recent years, there has been a growing interest in nanocarriers, which has led to significant advancements in the treatment of ocular diseases. Nanocarriers have not only successfully addressed clinical problems that viral vectors have failed to overcome but have also introduced new therapeutic possibilities for certain classical disease types. Nanocarriers offer undeniable advantages over viral vectors. This review discusses the advantages of subretinal (SR) injection, the current status of research, and the research hotspots of gene therapy with viral vectors. It focuses on the latest progress of nanocarriers in SR injection and enumerates the limitations and future perspectives of nanocarriers in the treatment of fundus lesions. Furthermore, this review also covers the research progress of nanocarriers in the field of subretinal injection and highlights the value of nanocarrier-mediated SR injection in the treatment of fundus disorders. Overall, it provides a theoretical basis for the application of nanocarriers in SR injection.

Cracking the Pericellular Matrix Code: Exploring how MMP-2, -3, and -7 influence matrix breakdown and biomechanical properties

IntroductionThe intricate process of articular cartilage remodeling, pivotal for both physiological functions and osteoarthritis (OA) progression, is orchestrated through a balance of matrix synthesis and breakdown, which is mediated by matrix metalloproteinase enzymes (MMPs). At the heart of this remodeling lies the pericellular matrix (PCM), a specialized microenvironment encapsulating each chondrocyte and composed mainly of collagen type VI and perlecan. The aim of this study was to assess the impact of MMP-2, -3, and -7 on the structural integrity and biomechanical attributes of the PCM. MethodsHuman articular cartilage explants (N=10 patients) were incubated with activated MMP-2, -3, or -7, individually or in combination. Structural alterations in the PCM were evaluated by immunolabeling. The biomechanical properties of the PCM were measured using atomic force microscopy (AFM). ResultsCollagen type VI structural integrity and fluorescence intensity uniformly decreased across all enzyme groups, while perlecan was selectively affected by MMP-3 and -7. AFM measurements demonstrated decreased PCM stiffness after incubation with individual MMPs, leading to an overall ~31 % reduction in elastic modulus for each enzyme. Combinations of enzymes induced comparable significant biomechanical alterations (~35 %), except for MMP-2+MMP-7. DiscussionThis study highlights the significant influence of MMP-induced alterations in PCM composition on biomechanical properties, mirroring characteristics observed in early OA. Each MMP showed specificity in breaking down PCM, and an intriguing interplay, especially between MMP-2 and -7, indicated reduced efficacy in lowering PCM stiffness. Overall, MMP-2, -3, and -7 directly induce functional and structural PCM modifications.

The Effect Of Changes In Lifestyle Measures On Weight And Body Mass Index Among Adult Pre-Hypertensive Patients In A Tertiary Hospital In North Central Nigeria

Background: Results from several clinical trials show that comprehensive behavioral intervention programs improve lifestyle behaviors and lower weight and BMI. The study was undertaken to determine the effect of structured changes in lifestyle measures on weight and BMI among pre-hypertensive adults presenting it the GOPC of JUTH. Study Design/Setting: The study was a randomized controlled experimental study involving pre-hypertensive adults aged 18 years and above presenting in GOPC of JUTH. Methods: Participants were consecutively selected and randomized to a control and an intervention group. The intervention group was offered a structured lifestyle modification counseling while routine advice only was offered to the control group. Data was collected about patients’socio-demographic, medical and lifestyle habits that included dietary and exercise history. Physical examination was done to include height, weight and BMI. Participants were followed up monthly for twelve weeks during which physical examination was routinely carried out and changes in their lifestyle habits reported. The outcome measures were reduction in weight and BMI. The difference in the means of the outcome measures at pre- and post-intervention were determined using the independent and paired student t-tests at 95% confidence interval. Data were analyzed on an intention to treat basis. A p-value of ≤ 0.05 was considered statistically significant in all analyses. Results: On completing the study, independent t-test showed that the mean weight difference between the two study groups was 0.17kg (p=0.96; -5.77, 6.12, 95% CI) and the mean BMI difference was 0.32kg/m2 (p=0.79; - 2.07, 2.71, 95% CI). These were not statistically significant. However, significant improvement in healthy lifestyle habits were notably more in the intervention group. Desirable changes in the mean weight and BMI were more evident among participants of the intervention group after the 12 weeks study, although there were no statistically significant differences in the two groups. Conclusion: Findings from the study showed that although individuals with pre-hypertension can make and sustain, during a period of 12 weeks, multiple lifestyle modifications which can significantly control or reduce weight and BMI, structured changes on lifestyle measures may not be better than routine verbal advice only among pre-hypertensives in the study setting. There is a need for improved lifestyle intervention programs, including those appropriate for delivery in the clinical setting, that enable individuals at risk for hypertension to adopt long-term healthier lifestyles

MnFe Prussian Blue Analogue Open Cages for Sodium-Ion Batteries: Simultaneous Evolution of Structure, Morphology, and Energy Storage Properties.

Prussian blue analogues (PBAs) exhibiting hollow morphologies have garnered considerable attention owing to their remarkable electrochemical properties. In this study, a one-pot strategy is proposed for the synthesis of MnFe PBA open cages. The materials are subsequently employed as cathode electrode in sodium-ion batteries (SIBs). The simultaneous evolution of structure, morphology, and performance during the synthesis process is investigated. The findings reveal substantial structural modifications as the reaction time is prolonged. The manganese content in the samples diminishes considerably, while the potassium content experiences an increase. This compositional variation is accompanied by a significant change in the spin state of the transition metal ions. These structural transformations trigger the occurrence of the Kirkendall effect and Oswald ripening, culminating in a profound alteration of the morphology of MnFe PBA. Moreover, the shifts in spin states give rise to distinct changes in their charge-discharge profiles and redox potentials. Furthermore, an exploration of the formation conditions of the samples and their variations before and after cycling is conducted. This study offers valuable insights into the intricate relationship between the structure, morphology, and electrochemical performance of MnFe PBA, paving the way for further optimizations in this promising class of materials for energy storage applications.

Intensifying interfacial oscillations in falling film flows over rectangular corrugations

Unsteady film flows play an important role in intensifying heat and mass transfer processes, with applications, e.g., in falling film absorbers or reactors. In this context, the influence of surface structure modification on the wave dynamics of falling film flows is experimentally investigated based on localized film thickness time series data. Arrays of rectangular ridges oriented perpendicular to the main flow direction are considered, and an optimum ridge distance is identified, at which particularly strong interfacial oscillations are induced in the falling film. These potentially result from the interaction of the flow with a statically deformed base film under resonance-like conditions. The transient destabilization is amplified in the case of narrow ridge sizes, where inertia-driven flow features are particularly pronounced. With regard to mass transfer applications, the structure-induced increase in gas–liquid interfacial area may be of secondary importance compared to changes in internal flow conditions.

Habitat Inventory, Diversity and Structural Modification of Hill-Stream Fishes of Noa Dihing River, Eastern Himalayan Hotspot, Arunachal Pradesh, Northeast India

Habitat Inventory, Diversity and Structural Modification of Hill-Stream Fishes of Noa Dihing River, Eastern Himalayan Hotspot, Arunachal Pradesh, Northeast India

New Quinoline Derivatives and their Antimicrobial Potential Against Candida Albicans and Staphylococcus Aureus

AbstractAntimicrobial resistance is a pressing global health concern, demanding the development of novel antimicrobial agents. Quinoline derivatives emerge as promising candidates with their diverse chemical structures and recognized bioactive properties. This study aimed to investigate the antimicrobial potency of newly synthesized quinoline derivatives against Candida albicans and five bacterial strains, which are responsible for various infections and have exhibited varying degrees of antibiotic resistance. A series of quinoline derivatives were synthesized through simple structural modifications, such as the inclusion of nitro, amino, and hydrazino groups, or using the molecular hybridization strategy, involving the combination of quinoline and 1,2,3‐triazoles. None of the compounds showed promising activity against the bacterial strains. However, a promising fungistatic effect was observed against C. albicans. In this test, two of the compounds showed lower MIC values than fluconazole (25 μg/mL). In addition, the most promising compounds showed high affinity for the enzyme lanosterol 14 alpha demethylase, due to the low energy values found (−7.6 and −8.2 kcal/mol). Our study offers new avenues for future drug development in the fight against antimicrobial resistance.