Structure-activity Relationships For Inhibition Research Articles

Additions and Corrections - Quantitative Structure-Inhibitory Activity Relationships of Phenols and Fatty Acids for Bacilus subtillis Spore Germination.

Additions and Corrections - Quantitative Structure-Inhibitory Activity Relationships of Phenols and Fatty Acids for Bacilus subtillis Spore Germination.

ChemInform Abstract: Quantitative Structure‐Inhibitory Activity Relationships of Phenols and Fatty Acids for Bacillus subtilis Spore Germination.

Chemischer InformationsdienstVolume 13, Issue 33 Other Subjects ChemInform Abstract: Quantitative Structure-Inhibitory Activity Relationships of Phenols and Fatty Acids for Bacillus subtilis Spore Germination. Y. YASUDA, Y. YASUDASearch for more papers by this authorK. TOSHIKUBO, K. TOSHIKUBOSearch for more papers by this authorY. HACHISUKA, Y. HACHISUKASearch for more papers by this authorH. TOMIDA, H. TOMIDASearch for more papers by this authorK. IKEDA, K. IKEDASearch for more papers by this author Y. YASUDA, Y. YASUDASearch for more papers by this authorK. TOSHIKUBO, K. TOSHIKUBOSearch for more papers by this authorY. HACHISUKA, Y. HACHISUKASearch for more papers by this authorH. TOMIDA, H. TOMIDASearch for more papers by this authorK. IKEDA, K. IKEDASearch for more papers by this author First published: August 17, 1982 https://doi.org/10.1002/chin.198233330AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume13, Issue33August 17, 1982 RelatedInformation

Quantitative structure-inhibitory activity relationships of phenols and fatty acids for Bacillus subtilis spore germination.

Phenols and fatty acids were found to inhibit L-alanine-initiated germination of Bacillus subtilis spores without altering their heat resistance. Inhibitory effect was defined as the concentration necessary to cause 50% inhibition of the germination rate. The quantitative structure-inhibitory activity relationships for 39 phenols and 7 fatty acids were analyzed. The pH dependency of inhibition showed that the nonionized form of the molecule was responsible for inhibition. Hydrophobicity, which was expressed by the partition coefficient or the distribution coefficient of the compounds, was important for inhibition. In addition to hydrophobicity, the electronic effect, which was expressed by the dissociation constant, played a partial role in phenols. The correlation equation of the fatty acids was similar to those of the alcohols and other hydrophobic compounds, which had been reported earlier. That of the phenols, however, appeared to be different, indicating a different and more complex mechanism of inhibition. The type of inhibition by both compounds was mixed rather than competitive or noncompetitive.

Structure-activity relationships of inhibition of hepatic monodeiodination of thyroxine to 3,5,3'-triiodothyronine by thiouracil and related compounds.

We have compared the relative potencies of various thiouracils (TUs) and related compounds in inhibition of 5′-monodeiodination of T4 to T3 by rat liver homogenate. T4 (2.5 (μM) was incubated with 0.13 geq liver homogenate in 0.1 M Tris buffer (pH 7.4) for 30 min in the presence or absence of various test agents, and the amount of T3 produced was quantitated by a specific RIA. Thiourea, thiobarbiturate (2-thiobarbituric acid), imidazoles and imidazolines (2-thiohydantoin, 2,4-dihydroxy-5- thiohydantoin, and 2-mercaptoimidazole), and thiopyrimidines (4-mercaptopyrimidine and 2,4-hydroxy-5-thiopyrimidine) had 3% or less of the activity of 2-TU. Among TU derivatives, 5-iodo-2-TU was the most active agent, with about a 30-fold greater inhibiting activity (on a molar basis) than 2-TU. 6-N-propyl TU (PTU) exhibited 2.5 times the inhibiting activity of TU, whereas 6-carbethoxy-2-TU had 1.4 times the activity, and others followed in descending order: 5-N-butyl-6-methyl-TU (1.3 times), 4-hydroxy-6-methyl-TU (0.4 t...

Catechol O-methyltransferase. 8. Structure-activity relationships for inhibtion by 8-hydroxyquinolines.

A series of 5- and 7-substituted 8-hydroxyquinolines was evaluated as inhibitors of catechol O-methyltransferase (COMT, E.C. 2.1.1.6). The electronic character of the substituents in the 5 position appeared to have only a small effect if any on the inhibitory activity of these compounds. A significant factor which contributes to the inhibitory activity of these compounds appears to be the nature of the 7-substituent. The structure-activity relationship for this series of inhibitors is discussed relative to the nature of the enzymatic binding site.

Catechol O-methyltransferase. 5. Structure-activity relationships for inhibition by flavonoids.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatechol O-methyltransferase. 5. Structure-activity relations for inhibition by flavonoidsRonald T. Borchardt and Joan A. HuberCite this: J. Med. Chem. 1975, 18, 1, 120–122Publication Date (Print):January 1, 1975Publication History Published online1 May 2002Published inissue 1 January 1975https://doi.org/10.1021/jm00235a030RIGHTS & PERMISSIONSArticle Views558Altmetric-Citations109LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (372 KB) Get e-Alerts Get e-Alerts