Structured Analysis Research Articles

Population structure of ALS-inhibiting herbicide-resistant Sonchus oleraceus in South Australia.

Annual sowthistle is a weed that is difficult to control in lentil crops in southern Australia due to a lack of herbicide options, widespread herbicide resistance and prolific production of highly mobile seed. This study investigates herbicide resistance in annual sowthistle in the Mid-North (MN) and Yorke Peninsula (YP) regions of South Australia, identifies and characterizes the mechanisms of acetolactate-synthase (ALS)-inhibitor resistance in this amphidiploid species, and combines this with analyses of population structure and gene flow. ALS-inhibitor-resistant annual sowthistle is widespread across the YP and MN of South Australia and is associated with a variety of Proline-197 mutations of the ALS gene, including leucine, alanine, arginine, serine, threonine and histidine. These mutations were found in different combinations on either of the two copies of the ALS gene. An additional 200 tissue samples were collected from across a single field on the YP and the ALS gene was sequenced for all these individuals. Different ALS-inhibitor resistance profiles were evident between mutation combinations and within mutation combinations, possibly mediated by differing subgenome assortment of the mutations, or altered gene experession of the two ALS homeologs. Population genetics analysis showed evidence of long-distance dispersal, resulting in highly mobile resistance genes, and multiple instances of resistance mutation evolution. Continuing selection of Sonchus oleraceus populations with ALS-inhibiting herbicides has resulted in the accumulation of additional mutations within the ALS gene. New practices to control herbicide-resistant S. oleraceus should be examined, and control should focus on reducing seed set and dispersal to prevent the spread of emerging cases of resistance. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

DETERMINANTS OF FRAUDULENT FINANCIAL REPORTING IN MINING COMPANIES: PENTAGON THEORY FRAUD PERSPECTIVE

The purpose of this research is to find empirical evidence the influence of the fraud pentagon which consists of pressure, opportunity, rationalization, competence and arrogance on Fraudulent Financial Statements. The research method used in this study is multivariate analysis using the Generalized Structured Component Analysis tool. The research population is manufacturing companies in the mining sector listed on the Indonesia Stock Exchange for the 2017-2021 period with a total sample of 60 companies. This study shows that pressure, opportunity and competence have a significant effect on fraudulent financial statements, while rationalization and arrogance have no significant effect on fraudulent financial statements.

Analyzing the influence of decision making and effective employee communication on human resource agility in commercial banks: A mediation role for job satisfaction

The Middle East has witnessed global crises that have prompted substantial shifts in the enterprises’ competition. In today’s highly competitive marketplaces, businesses have recognized that HR agility is crucial to their success in the Middle East. However, there is a shortage of research on this topic, particularly in the Middle East context. This study aims to fill this gap by investigating the relationship between job satisfaction, effective employee communication, decision-making, and human resource agility in Jordanian commercial banks. Utilizing 460 questionnaires, this study used structured equation analysis to evaluate the data. Results confirmed that job satisfaction, effective employee communication, and decision-making positively correlate with HR agility. Furthermore, this analysis revealed that decision-making and effective employee communication positively impacted human resources agility via job satisfaction. This research is among the first to emphasize the key drivers of human resource agility in the Middle East context. Organizations can develop more effective HR strategies by understanding these factors critical to their continued success in the rapidly changing business environment. Consequently, this study recommends that other aspects of empowerment practice be used in future studies to expand the proposed framework and disclose their impacts on the variables, where more important results may be discovered.

Synthesis of poly (L-cysteine)/g-C3N4 modified glassy carbon electrodes for electrochemical detection of methotrexate as a medicine for treatment of breast cancer in pharmaceutical fluid samples

Analyzing the levels of anticancer medications in biological samples and body fluids reveals important details on the course and effects of chemotherapy. p (L-Cys)/graphitic-carbon nitride (g-C3N4)/GCE, a modified glassy carbon electrode, was created for the current study's electrochemical detection of methotrexate (MTX), a drug used to treat breast cancer, in pharmaceutical fluid samples. l-Cysteine was electro-polymerized on the surface of the g-C3N4/GCE after the g-C3N4 was first modified to prepare the p (L-Cys)/g-C3N4/GCE. Analyses of morphology and structure showed that well-crystalline p (L-Cys) on g-C3N4/GCE was successfully electropolymerized. Studying the electrochemical characteristics of p (L-Cys)/g-C3N4/GCE using CV and DPV techniques revealed a synergistic impact between g-C3N4 and l-cysteine that improved the stability and selectivity of the electrochemical oxidation of MTX while enhancing the electrochemical signal. Results showed that 7.5–780 μM was the linear range, and that 0.11841 μA/μM and 6 nM, respectively, were the sensitivity and limit of detection. The applicability of the suggested sensors was assessed using real pharmaceutical preparations, and the results showed that p (L-Cys)/g-C3N4/GCE had a high degree of precision. Five breast cancer patients who volunteered and provided prepared blood serum samples between the ages of 35 and 50 were used to examine the validity and accuracy of the proposed sensor in the current work for the determination of MTX. The results showed good recovery values (greater than 97.20%), appropriate accuracy (RSD less than 5.11%), and good agreement between the ELISA and DPV analysis results. These findings showed that p (L-Cys)/g-C3N4/GCE can be applied as a trustworthy MTX sensor for MTX level monitoring in blood samples and pharmaceutical samples.

Whole-genome resequencing to unveil genetic characteristics and selection signatures of specific pathogen-free ducks

Specific pathogen-free ducks are important high-grade laboratory animals, with a key role in research related to poultry biosecurity, production, and breeding. However, the genetic characteristics of experimental duck varieties remain poorly explored. Herein we performed whole-genome resequencing to construct a single nucleotide polymorphism genetic map of the genomes of 3 experimental duck varieties [Jinding ducks (JD), Shaoxing ducks (SX), and Fujian Shanma ducks (SM)] to determine their genetic characteristics and identify selection signatures. Subsequent analyses of population structure and genetic diversity revealed that each duck variety formed a monophyletic group, with SM showing richer genetic diversity than JD and SX. Further, on exploring shared selection signatures, we found 2 overlapping genomic regions on chromosome Z of all experimental ducks, which comprised immune response-related genes (IL7R and IL6ST). Moreover, growth and skeletal development (IGF1R and GDF5), meat quality (FoxO1), and stress resistance (HSP90B1 and Gpx8-b) candidate gene loci were identified in strongly selected signatures specific to JD, SM, and SX, respectively. Our results identified the population genetic basis of experimental ducks at the whole-genome level, providing a framework for future molecular investigations of genetic variations and phenotypic changes. We believe that such studies will eventually contribute to the management of experimental animal resources.

East Timor as an important source of cashew (Anacardium occidentale L.) genetic diversity.

Cashew (Anacardium occidentale L.) is a crop currently grown in several tropical countries because of the economic importance of cashew nuts. Despite its enormous economic worth, limited research has been conducted on the molecular diversity of cashew genetic resources. In this study, a wide comprehensive assessment of the genetic diversity of cashew trees in East Timor was performed using microsatellites (SSRs) to evaluate intraspecific diversity and population structuring. A total of 207 individual cashew trees, including trees from East Timor (11), and outgroup populations from Indonesia (one) and Mozambique (two), were analyzed with 16 cashew-specific SSRs. A comprehensive sampling of cashew trees within East Timor was performed, covering the distribution of cashew orchards in the country. Genetic diversity indices were calculated, and population structuring was determined using three different approaches: genetic distances (UPGMA and NJ), AMOVA, and individual-based clustering methods through Bayesian (STRUCTURE) and multivariate (DAPC) analyses. The population structuring analysis revealed that the genetic diversity of cashew populations in East Timor was higher in this study than previously reported for cashew trees. A higher allelic richness was found within cashew populations in East Timor compared with the outgroup populations (Mozambique and Indonesia), reinforced by the presence of private alleles. Moreover, our study showed that cashew populations in East Timor are grouped into two dissimilar genetic groups, which may suggest multiple cashew introductions over time. These new cashew genetic resources could be explored for future crop improvement. Crop diversity underpins the productivity, resilience, and adaptive capacity of agriculture. Therefore, this study provides useful information regarding genetic diversity and population structure that can be harnessed to improve cashew production in East Timor. This data is also important to creating a country-specific genetic cashew signature to increase cashew market value.

PENGARUH MOTIVASI TERHADAP KINERJA PEGAWAI DINAS KOPERASI DAN UKM KABUPATEN SAMPANG DENGAN KEMAMPUAN MANAJERIAL SEBAGAI VARIABEL MEDIASI

The type of research is explanatory research using a quantitative approach, the research sample is 35 respondents (the sampling technique uses the saturated sample method), the data analysis uses GeSCA (Generalized Structured Component Analysis) analysis. The objectives of this study are: 1) To examine and analyze the effect of motivation on managerial ability in the Department of Cooperatives and SMEs in Sampang Regency. 2) To test and analyze the effect of managerial ability on the performance of the employees of the Cooperatives and SMEs Office of Sampang Regency. 3) To examine and analyze the effect of motivation on the performance of the employees of the Cooperatives and SMEs Office of Sampang Regency. 4).To examine and analyze the effect of motivation on the performance of the employees of the Cooperatives and SMEs Office of Sampang Regency which is mediated by managerial ability. The results showed that: 1) Motivation had a significant negative effect on managerial ability in the Department of Cooperatives and SMEs in Sampang Regency with a CR value of -0.38; 2) Managerial ability has a significant effect on employee performance at the Cooperatives and SMEs Office of Sampang Regency with a CR value of 2.33; 3) Motivation has a significant effect on employee performance at the Cooperatives and SMEs Service Office of Sampang Regency with a CR value of 4.87; 4) Motivation has a significant effect on employee performance which is mediated by managerial ability with a CR value of 11.40.

A proposal of hazard analysis method using structured system theoretical process analysis

System Theoretic Process Analysis (STPA) is a method for analyzing hazards caused by interactions between components of an industrial product. STPA is applied in the upper stream stages of industrial product development, STPA detects hazards while referring to the whole configuration of the industrial product. Therefore, STPA generally does not deal with detailed information about the industrial product. Since the information on the industrial product is insufficient, it is difficult to clarify the factors of hazards, the occurrence order of factors, and the conditions that occur the hazard by STPA. Therefore, the following methods were added to the conventional STPA; the method of describing the components of industrial products in hierarchical detail, the method of clearly defining the behaviour of each component, and the method of tracking the structured CSD to clarify the causes of the hazard. By adding those methods, it became possible to conduct a hazard analysis of the industrial product in detail. As a result of applying the proposed method to the existing railroad crossing control system, it was confirmed that the proposed method could detect more factors of hazards and create adequate scenarios from the occurrence of hazard causes to the occurrence of the hazard.

A novel allelic donkey β-lactoglobulin I protein isoform generated by a non-AUG translation initiation codon is associated with a nonsynonymous SNP

β-Lactoglobulin I (β-LG I) is one of the most important whey proteins in donkey milk. However, to our knowledge, there has been no study focusing on the full nucleotide sequences of this gene (BLG I). Current investigation of donkey BLG I gene is very limited with only 2 variants (A and B) characterized so far at the protein level. Recently, a new β-LG I variant, with a significantly higher mass (+1,915 Da) than known variants has been detected. In this study, we report the whole nucleotide sequence of the BLG I gene from 2 donkeys, whose milk samples are characterized by the β-LG I SDS-PAGE band with a normal electrophoretic mobility (18,514.25 Da, β-LG I B1 form) the first, and by the presence of a unique β-LG I band with a higher electrophoretic mobility (20,428.5 Da, β-LG I D form) the latter. A high genetic variability was found all over the 2 sequenced BLG I alleles. In particular, 16 polymorphic sites were found in introns, one in the 5' flanking region, 3 SNPs in the 5' untranslated region and one SNP in the coding region (g.458G > A) located at the 40th nucleotide of exon 2 and responsible for the AA substitutions p.Asp28 > Asn in the mature protein. Two SNPs (g.920-922CAC > TGT and g.1871G/A) were genotyped in 93 donkeys of 2 Italian breeds (60 Ragusana and 33 Amiatina, respectively) and the overall frequencies of g.920-922CAC and g.1871A were 0.3065 and 0.043, respectively. Only the rare allele g.1871A was observed to be associated with the slower migrating β-LG I. Considering this genetic diversity and those found in the database, it was possible to deduce at least 5 different alleles (BLG I A, B, B1, C, D) responsible for 4 potential β-LG I translations. Among these alleles, B1 and D are those characterized in the present research, with the D allele of real novel identification. Haplotype data analysis suggests an evolutionary pathway of donkey BLG I gene and a possible phylogenetic map is proposed. Analyses of mRNA secondary structure showed relevant changes in the structures, as consequence of the g.1871G > A polymorphism, that might be responsible for the recognition of an alternative initiation site providing an additional signal peptide. The extension of 19 AA sequence to the mature protein, corresponding to the canonical signal peptide with an additional alanine residue, is sufficient to provide the observed molecular weight of the slower migrating β-LG I encoded by the BLG I D allele.

It takes two to tango: A taxonomy of franchise success determinants

PurposeThe authors conduct a structured analysis of the literature on the determinants of economic and financial franchise performance and develop an integrative framework that unifies the literature from franchisor as well as franchisee perspectives.Design/methodology/approach53 relevant research articles on economic and financial franchise success published between 1976 and 2020 were identified. After providing an overview of the empirical methods and theoretical perspectives found in the literature, an original classification system of franchise success determinants was developed.FindingsMore than 50 different variables impacting economic or financial franchise success were identified and grouped into ten distinct categories. The most impactful categories are the franchise relationship, franchisee characteristics and capabilities, franchisor variables and the franchise environment. The study’s integrative framework illustrates not only the impact of these factors on franchise success, but also reveals which areas require more attention.Research limitations/implicationsAs the study focused on understanding the determinants of franchise success, any measures related to franchise failure were excluded. Also, the role of venture capital and stock market listing as growth strategies in the franchise sector were excluded.Practical implicationsThe study’s framework shows how the management of franchise success is complex and that franchise relationship, franchisee and franchisor variables as well as the franchise context need to be taken into account. It illustrates that there is a hierarchy with which these determinants should be prioritized.Originality/valueThe article proposes the first systematic review of the literature on the determinants of economic and financial franchise success. The contribution offers both, researchers and practitioners, new and useful insights for future knowledge development in the field.

Continuing Challenges in the Definitive Diagnosis of Cushing's Disease: A Structured Review Focusing on Molecular Imaging and a Proposal for Diagnostic Work-Up.

The definitive diagnosis of Cushing's disease (CD) in the presence of pituitary microadenoma remains a continuous challenge. Novel available pituitary imaging techniques are emerging. This study aimed to provide a structured analysis of the diagnostic accuracy as well as the clinical use of molecular imaging in patients with ACTH-dependent Cushing's syndrome (CS). We also discuss the role of multidisciplinary counseling in decision making. Additionally, we propose a complementary diagnostic algorithm for both de novo and recurrent or persistent CD. A structured literature search was conducted and two illustrative CD cases discussed at our Pituitary Center are presented. A total of 14 CD (n = 201) and 30 ectopic CS (n = 301) articles were included. MRI was negative or inconclusive in a quarter of CD patients. 11C-Met showed higher pituitary adenoma detection than 18F-FDG PET-CT (87% versus 49%). Up to 100% detection rates were found for 18F-FET, 68Ga-DOTA-TATE, and 68Ga-DOTA-CRH, but were based on single studies. The use of molecular imaging modalities in the detection of pituitary microadenoma in ACTH-dependent CS is of added and complementary value, serving as one of the available tools in the diagnostic work-up. In selected CD cases, it seems justified to even refrain from IPSS.

PENGARUH PENDIDIKAN, PELATIHAN DAN KOMPETENSI SDM TERHADAP KINERJA PEGAWAI DENGAN MOTIVASI SEBAGAI VARIABEL MEDIASI PADA BADAN PENDAPATAN, PENGELOLAAN KEUANGAN DAN ASET DAERAH KABUPATEN SUMENEP

This research is to analysis the education, training and HR competence variables on employee performance with motivation as a mediating variable (study on the Regional Revenue, Financial and Asset Management Agency of Sumenep Regency). This type of research is explanatory research, the research approach uses a quantitative approach, and the data analysis technique uses Generalized Structured Component Analysis (GeSCA). The research sample was 86 people. The results showed education variable has a good internal reliability consistency because it is greater than 0.6. The results of data analysis using the GeSCA method show that the alpha value obtained is 0.7909, which means that the training variable has a good internal reliability consistency because it is greater than 0.6. The results of data analysis using the GeSCA method show that the alpha value obtained is 0.695, which means that the HR competency variable has a good internal reliability consistency because it is greater than 0.6. The results of data analysis using the GeSCA method show that the alpha value obtained is 0.9071, which means that the motivation variable has a good internal reliability consistency because it is greater than 0.6. The results of data analysis using the GeSCA method show that the alpha value obtained is 0.9082, which means that the employee performance variable has a good internal reliability consistency because it is greater than 0.6.

Limitations of hypothesis-testing in defining management units for continuously distributed species

Estimating the risk to wildlife populations resulting from human-induced mortality relies on adequately defining population structure. For marine populations, including cetaceans, identifying population boundaries is difficult because most species have large continuous distributions with no obvious barriers to dispersal. For many species, the extreme ends of the range differ in morphology, indicating that population structure exists. However, the lack of distributional hiatuses often makes this structure difficult to detect. A common method of defining structure in such situations is to use genetic differentiation as a proxy for limited movement between areas. Genetic analyses of population structure usually take the form of hypothesis testing, which requires the a priori definition of hypothesised units and testing for significant genetic differentiation between them. Simulations are used to examine the performance of hypothesis testing to correctly define population structure. Results show that hypothesis testing is likely to lead the researcher to define fewer management units than are necessary to adequately protect local populations from over-exploitation. The need for the development of new methods of defining management units and for rigorous performance testing of all methods applied in a management context is highlighted.

Dynamic behavior and power flow analyses of a cylindrical shell structure embedded with acoustic black holes

Vibrational energy flow model of ABH cylindrical shells with arbitrary profile and general boundary conditions is established using Rayleigh-Ritz method in conjunction with improved Fourier series expansion. Energy equation based on Love’s shell theory is formulated, while the ABH cylindrical shells including any type of indentation profile can be considered uniformly and invariantly expanded into Fourier series accordingly. The vibrational displacements are expanded with the modified version of Fourier series. The proposed model is validated through the comparisons with experimental results and those calculated from finite element method, and excellent agreement can be observed. The power flow analysis illustrates that the vibrational energy flow into ABH indentations is intensified and absorbed by damping materials compared with that of the uniform one for nearly all the frequency ranges. However, the energy absorption loses efficacy in certain low frequencies, which are coincided with its overall mode shapes. This work can shed some new light on the vibration behavior study of ABH cylindrical shell from the viewpoint of energy transmission, and can provide an efficient analysis tool for the vibration characteristics study and its optimal design of such complex structural system embedded with Acoustic Black Holes.

SOCIAL CAPITAL, CORPORATE RESILIENCE AND COMPETITIVENESS DURING PANDEMIC: INDONESIA’S MARINE TRANSPORTATION SERVICES COMPANIES CASE STUDY

Corporate resilience and competitiveness during a pandemic are largely determined by how the company manages its resource capital. This study examined how corporate resilience and competitiveness of marine transportation service companies that rely on social capital with a review point of view from the theory of dynamic capabilities and the resource base-view theory. Using an online method survey with a sample of 446 marine transportation service companies throughout Indonesia. The data were analyzed using multivariate analysis with GSCA application (generalized structured component analysis) and multigroup analysis to examine company age and company size as variable control. The results showed that social capital was associated with corporate resilience and competitiveness as well. The result also showed that corporate resilience was not associated with competitiveness. Meanwhile, in terms of company size, it was associated with a small company. On the contrary, competitiveness was associated with corporate resilience. This study contributes a new empirical finding to the dynamic capability theory and resource base view-based (RBV) competitiveness theory. This study also contributes to the practical implication that social capital in the form of the strength of relations with external is useful for competitiveness and in maintaining the sustainability of the company.

Effect of pore structure on shear resistance and chloride transport of macro-synthetic fiber reinforced concrete

This study proposes a method for the quantitative characterization of the complexity and uniformity of pore structure, and explores the effect of macro-synthetic fiber inclusion on the shear resistance and chloride transport of concrete from the perspective of pore structure. First, the shear capacity and chloride migration coefficient of normal concrete and macro-synthetic fiber reinforced concrete with fiber content of 3, 4.5, 6, and 9 kg/m3 were tested. Next, the porosity and pore size distribution were determined using the Rapidair 457 pore structure analyzer. The complexity of the pore structure was quantified using the fractal dimension calculated from the pore structure scans. The uniformity of spatial distribution of pores was quantified by the standard deviation of pore frequency. The results showed that increasing the fiber content increased the shear resistance and chloride transport of concrete while increasing the complexity and uniformity of pore structure. High-fidelity correlations between shear resistance and pore structure uniformity, chloride transport and pore structure complexity were established. This study will promote the fundamental understanding of concrete pore structure and properties for the development of high-performance fiber reinforced concrete.

Social Innovation Perspective of Community-Based Climate Change Adaptation: A Framework-Based Study of Ladakh, India

Indigenous knowledge of local environments is crucial for developing innovative and contextual climate change adaptation strategies. Although the significance of community-led efforts based on this knowledge has been well acknowledged, they have not been effectively incorporated into mainstream development processes. The mountainous region of Ladakh presents a novel case of water storage in the form of ice reservoirs as an adaptive strategy against intensified water scarcity. This study aims to assess community-based innovations in climate change adaptation strategies and find solutions for their effective integration. This study theorizes a framework for Social Innovation in Climate Change Adaptation (SICCA) for a structured analysis of the situation in Ladakh. This research was conducted through interviews, surveys, Geographic Information System-based mapping, and field observations to analyze the use of ice reservoirs as a solution to water scarcity issues. The results demonstrate the wide recognition of these techniques’ effectiveness and the role of the community in the planning, execution, and operation of the initiatives. The findings highlight the challenges in their scaling up and diffusion. The research emphasizes the need to recognize and value community-based adaptation strategies to address the challenges posed by climate change. It offers recommendations for integrating them into the mainstream development process, and the framework serves as a significant outcome to guide policymakers and civil society actors for practical implementation.

The role of competitiveness as mediating effect of environmental uncertainty on performance of fisheries companies

Current research purpose to analyze and explain the influence of environmental uncertainty on competitiveness and fishery company performance, then also aims to examine the mediating role of competitiveness. This research uses a quantitative approach, with data collection using questionnaires. The sampling in this study was determined based on criteria represented by 3 people at the management level of 19 fishing companies (i.e. directors, operational managers, and supervisors), thus a total sample of 57 managers in the fisheries company. Data analysis and hypothesis testing in this current research using generalized Structured Component Analysis (GSCA). Research findings indicate a positive and significant influence between environmental uncertainty on competitiveness and fishery company performance. Similarly, the competitiveness has a positive and significant effect on fishery company performance. Lasty, competitiveness has a role as partial mediation of the influence environmental uncertainty toward fishery company performance. The practical implications of the results of this study are the importance of fishing companies to adapt to environmental uncertainties in order to create competitiveness and improve company performance.

Influence of two-phase displacement characteristics on the storage efficiency and security of geological carbon storage

In the mitigation of greenhouse gas emissions, the storage efficiency and security of geological carbon storage (GCS) are the focus of attention, and both of them are closely related to the displacement behavior between immiscible two phases. In this study, CO2-water two-phase displacement experiments were conducted on six samples with various pore structures using nuclear magnetic resonance and magnetic resonance imaging technology to characterize the fluid distribution and determine displacement patterns. The displacement property was found to be closely related to the heterogeneity and anisotropy of pore structure. The two-phase displacement instability gradually evolved from tonguing (logCa > −2.94) to capillary fingering (logCa < −2.03), and then further evolved into viscous fingering (logCa > −2.03). Nevertheless, rocks with good connectivity and high permeability will restrain the occurrence of unstable displacement even if logCa is in the favorable range. Combined analyses of displacement patterns and pore structure can provide effective means for the evaluation of reservoir and caprock. For rocks dominated by micropores, their displacement pattern is more likely to correspond to time-consuming piston-like displacement. Their high sealing efficiency is characterized by high capillary displacement pressure and low effective gas permeability, which allow them to be considered as caprocks. For rocks with lower capillary displacement pressure and higher effective gas permeability, their lower residual water saturation makes them more suitable as favorable reservoirs for GCS. Reservoir rocks with stable piston-like displacement exhibit the highest displacement efficiency, while the difference of displacement rates in pores with diverse sizes caused by the fingering or tonguing phenomena weakens the displacement efficiency.

Риск-ориентированный и процессный подходы — основа актуальной системы управления охраной труда в организации

Information is provided on the legislative documents of the Russian Federation regulating the activities of organizations in the field of occupational safety. The relevance and expediency of the application of risk-oriented and process approaches at the stage of the development and implementation of the occupational safety management system on the basis of the legislative documents containing mandatory requirements, compliance with which is mandatory in the development of the occupational safety management system. The methodological substantiation of the process approach to the development of an occupational health and safety management system in an organization, based on a systematic approach using the well-known PDCA principle, is given, the basic issues of its applicability are considered. A matrix of processes and sub-processes was compiled in accordance with the typology of processes according to ISO (ISO/TC 176/SC 2/N 544R3), the organization management processes, the processes of measurement, analysis and improvement, the main processes and processes of resource management are given, the processes are ranked by levels. The model was developed for creating an occupational health and safety management system based on risk-oriented and process approaches, the technique of structural analysis and design SADT (Structured Analysis and Design Technique), and functional modeling methodology IDEF0. The development was carried out concerning the main context diagram of the process of creating an occupational health and safety management system in the IDEF0 notation. The decomposition of processes of the second and third levels is presented, and all their functional relationships are described. It is demonstrated that the risk-oriented and process approaches used in the design of the occupational health and safety management system make it possible to structure the composition of processes, clearly define the input and output parameters of processes, process participants, resources, and ensure control and adjustment of processes.