Wall Structure Research Articles

Separation methods for food protein purification and analysis

The extraction, separation, and purification of dietary proteins from a variety of food sources are crucial for their targeted use in food applications. To achieve this, proteins should be effectively separated from non-protein components such as cell wall structures, polysaccharides, and lipids. Traditional protein purification methods can be time-consuming, highlighting the need for automated, cost-effective, and sustainable alternatives. This comprehensive review critically assesses various protein purification instruments from an analytical perspective, weighing their advantages and disadvantages. The methods under evaluation include ultrafiltration, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), fast protein liquid chromatography (FPLC), high-performance liquid chromatography (HPLC), ultra performance liquid chromatography (UPLC), and microfluidic chips. Among these, FPLC stands out as an affordable and efficient technique that allows for high protein recovery. However, HPLC and UPLC provide faster results but may denature proteins, leading to lower recovery rates. Ultrafiltration is a cost-effective and straightforward method that doesn’t require complex equipment. Microchip-based approaches are emerging as innovative techniques for rapidly analyzing small samples. While SDS-PAGE is user-friendly, it denatures proteins, particularly those linked to other biomolecules. The choice of the most appropriate instrument depends on factors such as cost, energy efficiency, processing time, the characteristics of the target protein, desired outcomes, protein recovery, and resource availability. By critically examining these analytical instruments for protein purification, this review aims to assist researchers and practitioners in selecting the most suitable method for their specific needs, ultimately promoting efficient and successful protein purification endeavors in the field of food science and technology.

Fabrication of superior flame-retardant phosphorylated chitosan biobased porous composites reinforced by superhydrophobic silicone interpenetrating crosslinking networks

Chitosan-based porous materials have potential to develop into a new generation of high performance sustainable thermal insulation materials. In this study, hydrophobic and enhanced phosphorylated porous materials (PCSM) were constructed by the in-situ crosslinking of methytrimethoxylsilane (MTMS), and modified SiO2 nanoparticles (H-SiO2) were further incorporated into the crosslinking networks to fabricate superhydrophobic and reinforced PCSM-H-SiO2 porous composites. The morphology of PCSM-H-SiO2 porous materials exhibited special micro-nanoscale “pearl string-like” rough and interpenetrating pore wall structure, which endowed them superhydrophobicity and self-cleaning ability. The water contact angles (WCAs) of PCSM-H-SiO2 porous composites achieved up to 150o, and the compressive and specific moduli of PCSM2-H-SiO2–2 porous composite significantly increased to 11.0 MPa and 89.6 m2·s−2, 5.39 and 1.74 times higher than those of PCS porous material, respectively. The limited oxygen index (LOI) values of PCSM2-H-SiO2–2 porous composite were above 80 %. The cone calorimeter test result demonstrated the peak heat release rate and total heat release rate values of PCSM-H-SiO2–2 porous composite were lower than those of PCS porous material. The ultra-high flame-retardant PCSM-H-SiO2–2 porous composite with superhydrophobicity and excellent compressive property is a promising biodegradable thermal-insulation material as replacement of petroleum-based material.

A novel dynamic predictive control model for variable air volume air conditioning systems using deep learning

Model-based predictive control has proven effective for managing indoor temperature and humidity in variable air volume (VAV) air conditioning systems. However, delays in temperature and humidity adjustments in response to changes in internal and external environmental conditions can impede high-performance operation. This study introduces a dynamic predictive control model for the multi-zone indoor temperature and humidity of VAV systems, designed to predict and control these parameters in real-time. Utilizing the RC network two-node wall structure method and backward finite difference scheme, a multi-zone building model is developed. Coupled with a deep fuzzy cognitive map (DFCM) for temperature and humidity prediction, and controlled by a PID controller, the model dynamically regulates the opening degrees of terminal air dampers and chilled water valves. Implemented on a networked control platform in a large commercial building, the model consistently maintained indoor temperature and humidity within ±0.5 °C and ±0.1 g/(kg dry air) of the target values under varying conditions, demonstrating substantial improvements in stability and operational efficiency. The research enhances the predictability and control of HVAC systems through advanced algorithmic integration, improving real-time indoor climate management in complex building environments. This method offers a practical improvement in HVAC control technologies, which could be beneficial for applications in commercial building management systems, providing a useful tool for supporting energy efficiency and sustainability in modern infrastructures.

Wave trapping by porous breakwater near a rigid wall under the influence of ocean current

The present work investigates the water wave interaction with bottom-standing thick porous trapezoidal-shaped structures and shore-side vertical rigid wall in the presence of uniform ocean currents. This study has been done to understand the impact of different physical parameters like friction, porosity, and ocean currents along with different structural parameters (width and height) on different phenomena like wave energy reflection, wave forces, wave energy dissipation, etc. The quadratic boundary element method-based numerical technique has been used to solve the boundary value problem. The structural porosity is modeled using Sollitt and Cross’s model of water wave interaction with thick porous structures. Several results associated with the wave energy reflection and energy dissipation have been analyzed. Also, the wave force exerted by the incoming waves has been investigated to check the stability and sustainability of the right vertical rigid wall and porous structure. The Doppler-shift effect is observed in wave transformation characteristics due to the presence of ocean currents. The impact of following and opposing ocean currents can be seen in the graph of wave energy reflection, dissipation, and wave forces. The periodic patterns can be observed clearly in wave characteristics like wave energy reflection, dissipation, and wave forces when plotted against the non-dimensional separation gap between the porous breakwater and shore-side rigid seawall.

Three-Dimensional Printing of Cuttlebone-Inspired Porous Ceramic Materials.

Lightweight and strong ceramic materials are attractive for tissue engineering, aerospace, armor systems, and many high-temperature applications. Cuttlebone, primarily composed of bioceramics, features a unique S-shaped wall structure that contributes significantly to its remarkable mechanical properties. Here, we explore the hierarchical structure and components of the cuttlebone and reveal the high ceramic content in S-shaped walls. Inspired by the design of the cuttlebone, we developed a high ceramic loading slurry for three-dimensional printing cuttlebone-like structures. As shown in the compression test, the fabricated bioinspired ceramics exhibit excellent mechanical properties and can withstand 1.07 million times their own weight, outperforming traditional ceramic foams. The specific strength and modulus are 59.5 and 785.6 MPa/(g cm-3), 9 and 36 times that of the natural cuttlebone. The failure mechanisms are also systematically studied on the basis of tuning the structural parameters. These findings provide effective solutions and inspiration in fabricating high-performance ceramic structural materials.

Numerical Modeling of Cantilever Retaining Wall Using EPS Geofoam

Earth retaining wall structures are common civil engineering structures. Estimation of magnitude and distribution of earth pressure on retaining structures under different surcharge loading conditions is essential as they influence the design and overall economy of retaining structures. Numerical modeling using finite element code PLAXIS is used static analysis. 7 m height of non-yielding cantilever retaining wall with and without EPS geofoam structure is studied and 20 m backfill width was considered. In the present study backfill was modeled as Mohr-Coulomb yield criteria and EPS geofoam and wall were modeled as Linear-elastic. EPS geofoam densities namely 12 kg/m3 and 15 kg/m3 and two different geofoam thicknesses 0.107H and 0.143H were used for static analysis. Three different surcharge loading namely 10 kPa,30kPa and 50kPa which were kept at a distance of 2.0 m away from the wall face. In the static analysis earth pressure distribution for wall with and without geofoam were analyzed. Approximately 50% isolation efficiency was reported. At lower surcharge loads the effectiveness of EPS is more as compare to higher surcharge load and with increase in surcharge load, isolation efficiency gradually decreases and isolation efficiency decreases with increase in buffer modulus. Apart from these serviceability criteria was also checked. Serviceability criteria comprise of lateral deformation of EPS geofoam at sand-geofoam interface and backfill surface settlement were studied. Lower EPS geofoam density and higher EPS geofoam thickness reduces higher magnitude of earth pressure but in this combination the backfill surface settlement was coming very high.

The Effect of Systemic Endotoxinemia on the Structure of the Brachiocephal Arteries Wall or a Potential Clinical Model for Assessing the Efficacy of Anti-Aging Measures

Integrated indicators of systemic endotoxemia (SEE): the level of endotoxin (ET) and the concentration of antibodies to the hydrophobic (AT-LPS-FOB) and hydrophilic (AT-LPS-PIL) forms of the lipopolysaccharide (LPS) molecule in the general circulation can be used to determine the risk category of atherosclerosis development and progression, which dynamics is an objective marker of aging rate. The comparison of images the structure of brachycephalic arteries wall in dynamics with changes in blood parameters is one of the most successful models for monitoring the atherosclerotic process in a clinical setting. 42 people were examined without the presence of recognized risk factors for the progression of atherosclerosis at baseline and after 1.5-2 years. It was found that lipid profile indicators, such as the concentration of total cholesterol, low and high density lipoproteins, triglycerides, atherogenic index had no prognostic value. Whereas in the group with the progression of damage to the arterial wall, an increase in the concentration of ET was noted with a decrease in the concentration of AT-LPS-FOB and AT-LPS-PIL. In the group with regression of atherosclerotic changes, on the contrary, against the background of a decrease in the concentration of ET, an increase in AT was noted. A prospective study revealed an extremely important fact of a decrease in the concentration of LPS in the blood of patients with positive dynamics of morphological manifestations of atherosclerosis, indicating both the reversibility of the atherosclerotic process and the participation of ET in atherogenesis, which is a real way for extending the life of an individual and indicates the direction to achieve this goal – “antiendotoxin therapy”.

Antibacterial activities of Adina rubella extract enhanced by fermentation and its application in packaging films

Food spoilage caused by pathogens pose great threat to food safety and human health. Plastarch-based packaging films with antibacterial activities provide an effective way to control foodborne pathogens. In this study, microbial fermentation dominated by yeast was used for the first time to increase the antibacterial activity of Adina rubella extract (ARE). The best antimicrobial effect of ARE was observed by fermentation for 9 days. The minimum inhibitory concentration of ARE against Listeria monocytogenes was 3.125 mg/mL. ARE destroyed the structure of the cell wall, increased the permeability of the cell membrane, led to the leakage of nucleic acids, and induced the change of ROS level, which caused cell death of Listeria monocytogenes. ARE-based biodegradable films were prepared and their performance in pork packaging application was evaluated. The films showed effective antimicrobial properties and showed great potential for the development of safe and sustainable food packaging films.

Comparison of Seed Morphology and Seed Coat Chemistry in Ophrys (Orchidaceae) Species.

Orchidaceae is the largest flowering plant family in the world and holds significant importance in terms of biological diversity. Many of the species are found in endemic regions, serving as important indicators for the conservation of biological diversity. Therefore, research on the morphology, seed and embryo structures, chemical composition, and taxonomy of orchids is crucial for species conservation, habitat restoration, and the sustainability of natural habitats. This research involves comparing the morphometric and chemical contents of seeds belonging to certain Ophrys L. species and examining interspecies relationships. The micromorphological features of the seeds were analyzed by using light microscopy and scanning electron microscopy (SEM), while their chemical contents were compared by using Fourier transform infrared spectroscopy (FT-IR) analysis. Seed and embryo morphology, morphometric analysis, and seed coat chemistry hold diagnostic significance. In species of the Ophrys genus, features like anticlinal wall structure and periclinal wall reticulation are considered weak taxonomic characters. FT-IR analysis identifies specific chemical groups in orchid samples, revealing significant differences in absorbance values and chemical compositions among the different orchid species. Particularly, Ophrys lycia (Lycian Kaş Orchid) shows distinct separation from closely related species at peak points such as 2917 and 2850, 1743, 1515, 1240, and 1031 cm-1. Common peak points in the fingerprint region (1200- 700 cm-1) indicate similarity between O. apifera and O. reinholdii subsp. reinholdii. O. ferrum-equinum, O. mammosa subsp. mammosa, O. fusca subsp. leucadica, O. reinholdii subsp. reinholdii, and O. iricolor exhibit similar absorbance values in the range of 1500-1000 cm-1. These results provide valuable preliminary information about the structure of orchid seed coats, reticulation presence and pattern, chemical profiles, distribution, and dormancy-germination processes.

Research on flexural mechanical properties and mechanism of green ecological coir fiber foamed concrete (CFFC)

To explore the effect and mechanism of coir fiber on the performance of foamed concrete, the flexural performance test, pore characteristics and microstructure test of coir fiber foamed concrete with different content were carried out. First, Image-Pro Plus (image processing software) was used to study the pore morphology, porosity, average pore diameter, and pore roundness of CFFC with various fibers dosage (0, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%) by binarization processing method. Then, a total of eighteen specimens, divided into six groups, were used to investigate the effect of CF dosage on flexural strength, toughness, energy absorption, and failure patterns of FC through a three-point flexural test. Furthermore, the microscopic properties of coir fiber foamed concrete (CFFC) were observed by scanning electron microscope (SEM) and energy dispersive X-ray detector (XRD) to explain the influence mechanism of CF on FC flexural properties. According to the research, CF can affect the pore characteristics of CFFC and improve its flexural performance. When CF content is 1.5–2.0%, the porosity, diameter and roundness of CFFC have lower values of 68.6%, 1.96 mm and 1.29. After the fiber dosage reaches 1.5%, the CFFC failure mode changed to plastic damage, the flexural strength increased from 0.33 to 0.73 MPa, and the toughness energy absorption value was increased from 0.05 to 1.4 J. The optimum dosage of coir fiber is 2.0% for improving the flexural mechanical properties of FC. CF affects the process of hydration reaction of CFFC, but does not change the type of hydration product. However, the flexural performance of FC would decrease with excessive dosage of CF (> 2.0%) due to accelerating the formation of Ca(OH)2. CFFC can solve problems such as brittleness and easy cracking existing in traditional foamed concrete, and it can be used in the field of pavement engineering, foundation backfill and lightweight wall structure with CF dosage of 15–2.0%.

Steel truss reinforced concrete composite walls: Numerical investigation and design consideration

Conventional design practices for reinforced concrete (RC) structural walls in the lower stories of super high-rise buildings involve employing large thickness and dense reinforcement to ensure satisfactory seismic performance. This is necessary to withstand the considerable gravity and seismic forces caused by the superstructure. However, this approach brings a design challenge in engineering practice because excessively thick RC walls not only occupy useable space but also magnify earthquake forces due to the increased self-weight. For this reason, steel truss RC (STRC) composite walls have been developed to address the above-mentioned shortcomings of conventional designs. This paper elucidates the working mechanism of STRC walls under cyclic loading, indicating that these two diagonal embedded steel elements mainly exhibit truss behavior. The working mechanism is further verified through computational models developed in OpenSees with high accuracy and efficiency. Moreover, the design provisions in the current specification are evaluated in terms of the flexural strength and shear strength of STRC walls. Results show that the flexural strength of the design equations for STRC walls in the current specification is underestimated because the contribution of steel trusses is not considered. The findings of this study offer valuable insights into the engineering application of STRC walls.

Polystyrene nanoplastics induce cell type-dependent secondary wall reinforcement in rice (Oryza sativa) roots and reduce root hydraulic conductivity

Nanoplastics (NPs) have been demonstrated the ability to penetrate plant roots and cause stress. However, the extent of NPs penetration into various root tissues and the corresponding plant defense mechanisms remain unclear. This study examined the penetration and accumulation patterns of polystyrene nanoplastics (PS-NPs) in different cell types within rice roots, and explored how the roots quickly modify their cell wall structure in response. The findings showed that fully developed sclerenchyma cells in rice roots effectively prevented the invasion of PS-NPs. Meanwhile, PS-NPs triggered the accumulation of lignin and suberin in specific cells such as the exodermis, sclerenchyma, and xylem vessels. PS-NPs at a concentration of 50 mg L−1 increased cell wall thickness by 18.6 %, 21.1 %, and 22.4 % in epidermis, exodermis, and sclerenchyma cells, respectively, and decreased root hydraulic conductivity by 14.8 %. qPCR analysis revealed that PS-NPs influenced the cell wall synthesis pathway, promoting the deposition of lignin and suberin monomers on the secondary wall through the up-regulation of genes such as OsLAC and OsABCG. These results demonstrate that PS-NPs can induce cell type-specific strengthening of secondary walls and barrier formation in rice roots, suggesting the potential role of plant secondary wall development in mitigating NPs contamination risks in crops.

Multichannel GPR and multi-depth electromagnetic surveys for the study of Villa Eucheria and Aquinum at Castrocielo (Frosinone, Central Italy)

The municipality of Castrocielo (Frosinone, Italy) is a historically significant center which includes several centers of great archaeological importance, including part of the archaeological site of the ancient Roman city of Aquinum. In this work, we show the results of geophysical surveys performed in two different areas: the first area is close to the Monacato of Santa Maria al Palazzolo, built on the foundation slab of a Roman villa dating back to the 1st-2nd century BCE; the second area is close to the charging station Casilina Est, where several burials, dating back to different periods from 4th century BCE to 4th century CE, were found. The aims of geophysical investigations is to identify structures linked to the ancient Roman villa (Villa Eucheria) in Area 1, and to identify the tombs of the necropolis in Area 2. The two areas were investigated in two different days, on 27th and 28 th March 2023 respectively, through a multi-channel georadar system (GPR). In the second area, an electro-magnetometric survey was also performed. This choise is to address the heavy rain developed during the night before the acquisition. Infact the GPR survey performed during the second day of the geophysical campaign did not provide good results.Based on the geophysical results, the archaeological excavation in Area 1 confirmed the detected anomalies, documenting a section of wall and other structures and elements brought to light over a length of approximately 9 m. The results obtained in Area 2 confirmed the cropmarks visible in the aerial photo, highlighting the traces of buried structures.

Numerical Simulation of Cluster-Connected Shear Wall Structures under Seismic Loading

The reinforced part at the bottom of high-rise assembled monolithic concrete shear wall structures generally uses cast-in-place concrete due to high elastic–plastic deformation capacity requirements, which limits the advantages of prefabricated shear wall structures. This study investigates the feasibility of using cluster connections to assemble integral shear wall structures at the bottom by modifying the vertical reinforcement of the cluster connection. Numerical simulations using ABAQUS (Version 2019) were validated with laboratory test results. The seismic performance of prefabricated shear walls with cluster connections was examined under varying axial compression ratios. Results indicate that the prefabricated shear wall demonstrates higher bearing and deformation capacity compared to cast-in-place shear walls. The degradation of strength and equivalent stiffness in prefabricated walls is slower, showing better seismic performance under higher axial compression ratios. The cluster connection ensures effective force transmission, maintaining wall integrity. After optimization, the prefabricated shear wall with cluster connection meets the expected seismic performance, providing a basis for its application in reinforced bottom sections.

Candida tropicalis PMT2 Is a Dispensable Gene for Viability but Required for Proper Interaction with the Host.

Candidemia is an opportunistic mycosis with high morbidity and mortality rates. Even though Candida albicans is the main causative agent, other Candida species, such as Candida tropicalis, are relevant etiological agents of candidiasis and candidemia. Compared with C. albicans, there is currently limited information about C. tropicalis' biological aspects, including those related to the cell wall and the interaction with the host. Currently, it is known that its cell wall contains O-linked mannans, and the contribution of these structures to cell fitness has previously been addressed using cells subjected to chemical treatments or in mutants where O-linked mannans and other wall components are affected. Here, we generated a C. tropicalis pmt2∆ null mutant, which was affected in the first step of the O-linked mannosylation pathway. The null mutant was viable, contrasting with C. albicans where this gene is essential. The phenotypical characterization showed that O-linked mannans were required for filamentation; proper cell wall integrity and organization; biofilm formation; protein secretion; and adhesion to extracellular matrix components, in particular to fibronectin; and type I and type II collagen. When interacting with human innate immune cells, it was found that this cell wall structure is dispensable for cytokine production, but mutant cells were more phagocytosed by monocyte-derived macrophages. Furthermore, the null mutant cells showed virulence attenuation in Galleria mellonella larvae. Thus, O-linked mannans are minor components of the cell wall that are involved in different aspects of C. tropicalis' biology.

Shared genetic etiology of vessel diseases: A genome-wide multi-traits association analysis

BackgroundThe comorbidity among vascular diseases has been widely reported, however, the contribution of shared genetic components remains ambiguous. MethodsBased on genome-wide association study summary statistics, we employed statistical genetics methodologies to explore the shared genetic basis of eight vascular diseases: coronary artery disease, abdominal aortic aneurysm, ischemic stroke, peripheral artery disease, thoracic aortic aneurysm, phlebitis, varicose veins, and venous thromboembolism. We assessed global and local genetic correlations among these disorders by linkage disequilibrium score regression, high-definition likelihood, and local analysis of variant association. Cross-trait analyses conducted with CPASSOC identified pleiotropic variants and loci. Further, biological pathways at the multi-omics level were explored using multimarker analysis of genomic annotation, transcriptome-wide and proteome-wide association studies. Causal associations among the vascular diseases were evaluated by mendelian randomization and latent causal variable to assess vertical pleiotropic effects. ResultsWe found significant global genetic associations in 18 pairs of vascular diseases. Additionally, we discovered 317 unique genomic regions where at least one pair of traits demonstrated significant correlation. Multi-trait association analysis identified 19,361 significant potential pleiotropic variants in 274 independent pleiotropic loci. Multi-trait colocalization analysis revealed 56 colocalized loci in specific disease sets. Gene-based analysis identified 700 potential pleiotropic genes, which were subsequently validated at both transcriptome and protein levels. Gene-set enrichment analysis supports the role of biological pathways such as vessel wall structure, coagulation and lipid transport in vascular disease. Additionally, 7 pairs of vascular diseases have a causal relationship. ConclusionsOur study indicates a shared genetic basis and the presence of common risk genes among vascular diseases. These findings offer novel insights into potential mechanisms underlying the association between vascular diseases, as well as provide guidance for interventions and treatments of multi-vascular conditions.

Reverse-Mode Polymer-Stabilized Liquid Crystal Films with Enhanced Peel Strength and Electro-Optical Performance Based on Photoreactive Self-Assembly Alignment Layers and Patterned Polymer Walls.

Polymer-stabilized liquid crystal (PSLC) is a promising material toward the practical application of serving as energy-saving reverse-mode smart windows owing to its superior electro-optical (E-O) properties, simple and efficient processability, and compatibility to most practical circumstances. However, its feeble peel strength originated from low polymer content and poor adhesion between polymer networks and substrates inhibited its large-scale flexible film production. It is still a challenging task to derive good mechanical properties and superior E-O performance for PSLCs at the same time. In this study, a highly durable liquid crystal/polymer composite film showing enhanced peel strength and excellent E-O properties was attained by simultaneously building photoreactive self-assemble alignment layers through an efficient one-step method and the sculpture of a patterned polymer wall structure. This film has comprehensive ascendant E-O properties of lower driving voltages, faster response times, and higher contrast ratio, together with an over 30 times lift of the peel strength. The effectuation mechanisms of the alignment, E-O properties, peel-strength, microstructures, and cyclic durability of the films have been systematically studied. This novel liquid crystal/polymer composite film demonstrates advantages in every aspect of performance compared to traditional PSLC devices, which hoards promising applications in smart windows for cars and buildings.

Effects of grass species and harvest date on cell wall components and feed efficiency of dairy cows

There is a balance between DM yield and feed value when choosing types of grasses on a farm depending on the acreages of farmland and types of ruminants to be fed. Therefore, optimisation of the harvest strategy for grass silage is important for profitable dairy farming. Tall fescue has high DM yield and can replace traditional grasses, such as timothy, in Northern Europe in a changing climate as it has been shown to be more drought tolerant. As differences in climate responses previously have been related to differences in cell wall structure between grass species and, consequently, in digestibility, it is highly relevant to compare these species at similar maturity stages and to investigate if a very early harvest date will diminish potential differences between the species. This study evaluated the effects of harvest date and forage species on the concentration of hydroxycinnamic acids in silages and its relationship to feed efficiency of dairy cows. Tall fescue and timothy were harvested at very early date on May 25 or at early date on May 31 in the spring growth cycle. Forty lactating dairy cows were used in a block design. Cows received 1 of 4 treatments: (1) tall fescue harvested at very early date, (2) timothy harvested at very early date, (3) tall fescue harvested at early date, and (4) timothy harvested at early date. Diets were formulated to have the same forage-to-concentrate ratio (49:51 on DM basis). Tall fescue silages showed greater concentrations of DM, ash, and CP than timothy silages. Grasses harvested at early date showed greater concentrations of NDF, ADL, and cell wall than grasses harvested at very early date. Tall fescue silages showed greater concentration of p-coumaric acid and lower in vitro organic matter digestibility (IVOMD) compared to timothy silages. Milk production and composition were not affected by treatments but cows fed tall fescue-based diets showed lower milk protein yield and greater milk urea nitrogen than when timothy-based diets were fed. Furthermore, cows receiving timothy-based diets showed greater feed efficiency compared to cows receiving tall fescue-based diets. Thus, the lower concentration of p-coumaric acid and the higher IVOMD was associated with greater feed efficiency of cows fed timothy-based diets compared to tall fescue-based diets.

Load-bearing furniture modules for fast deployable and reusable systems

The urgent need to reduce carbon emissions in the construction sector has driven the exploration of circular economy practices in the built environment. Nevertheless, the implementation of circular economy principles in projects remains limited. This research contributes to bridging this gap by introducing a project proposal that establishes a typology of modular systems designed for easy assembly, disassembly, and reuse. Specifically, the proposal focuses on load-bearing wood furniture modules (FMs) as an intermediate solution between planar and volumetric modules. These FMs expand the structural wall’s volume, facilitating the integration of services, storage, and appliances. This addresses scenarios where swift building deployment is required. The proposed modular dimension enhances transportation efficiency compared to volumetric solutions and simplifies construction by eliminating the need for temporary stabilization, as seen in planar systems. Standardization and “separability” of each component within the FM allows for easy integration and maintenance. Special attention is paid to the timber connection systems within and between FMs facilitating easy assembly, and disassembly for future reuse. The adaptability of the FM concept is demonstrated through versatile compositions and layouts, facilitating space reconfiguration. While the technical feasibility of the FM-based system is demonstrated, further research is needed to address regional and cultural variations and customize the system to different contexts. The study emphasizes the potential of FMs as a solution for buildings aligned with circular economy principles and highlights the importance of continued research and development in this field.

Pain management after thoracotomy with dexamethasone and bupivacaine through a peripleural cather: a randomized controlled trial

IntroductionThoracotomy procedures can result in significant pain and cause nausea/vomiting. Glucocorticoids have anti-emetic and analgesic effects due to their anti-inflammatory and nerve-blocking properties. This study investigates the additive effect of local dexamethasone with bupivacaine as sole analgesic medication through a peripleural catheter after thoracotomy.MethodThe study was conducted as a randomized control trial on 82 patients. Participants were allocated to receive either 2.5 mg/kg of bupivacaine plus 0.2 mg/kg of dexamethasone or 2.5 mg/kg of bupivacaine plus the same amount of normal saline as placebo through a 6 French peripleural catheter implemented above the parietal pleura and beneath the musculoskeletal structure of the chest wall. The primary outcome was the severity of pain 24 h after the operation in the visual analogue scale (VAS) score. Secondary outcomes were the incidence of nausea/vomiting, opioid consumption for pain control, and incidence of any adverse effects.Results: A total of 50 participants were randomized to each group, and the baseline characteristics were similar between the groups. Median of VAS score (6 (3-8) vs. 8 (6-9), p < 0.001), postoperative opioid consumption (9 (36%) vs. 17 (68%) patients, p=0.024), and median length of hospital stay (4 (3-8) vs. 6 (3-12) days, p < 0.001) were significantly lower in the dexamethasone group. However, postoperative nausea/vomiting (p=0.26 for nausea and p=0.71 for vomiting) and surgical site infection (p = 0.55) were similar between the two groups. ConclusionIn thoracotomy patients, administering local dexamethasone + bupivacaine through a peripleural catheter can reduce postoperative pain, analgesic consumption, and length of hospital stay.Trial RegistrationIranian Registry of Clinical Trials (IRCT20220309054226N1, registration date: 3/21/2022.