The growth of structural reliability theory and applications, along with a recognition of its role in guiding the structural engineering profession in addressing some of the most important issues in design of the built environment, represents one of the key engineering achievements during the past five decades. Structural reliability provides a unifying framework for managing uncertainties affecting performance of structures and a quantitative link between the practice of structural engineering and its social consequences. Such links perhaps are most obvious in probability-based codified design and performance evaluation but there are numerous other applications, which are summarized in this special issue. As the field has matured, researchers in reliability have worked with structural engineers to elevate both the practice of structural engineering and the quality of research to levels that otherwise would not have been possible. The Joint Committee on Structural Safety has played a central role in this historic development and it will inspire future opportunities for the reliability community to build upon past successes to improve structural engineering and construction practices. This paper surveys the key theoretical developments and milestones that enable these opportunities.