This paper investigates the blast response and protection level of a new blast-resistance wall panels made of Recycled Tyre Fibres Concrete (RTFC) as an exterior protective layer compositely connected to a concrete wall through experiments and numerical modelling. RTFC is a novel sustainable cement-based versatile composite, made with recycled non-biodegradable material (tyre rubber particles) in the form of composite fibres in a cement matrix, with applications in blast and ballistic protection that features high dynamic properties. Three composite wall panels were constructed and subjected to blast loads generated by Advanced Blast Simulator (ABS). Three different loading scenarios, each with an intensity capable of causing complete structural failure, were applied. The blast wave characteristics, such as the imposed overpressure and impulse, were measured alongside the deflection of the specimens. The wall specimens could withstand the blast loads with minimal damage. No cracks were observed in the RTFC layer, with only minor cracks appearing on the concrete side of the wall. The protection performance of the wall specimens was examined following UFC guidelines, revealing their outstanding resistance to blast loads. Moreover, in line with these guidelines, the composite wall panel is eligible for a High Level of Protection (HLoP) classification. Finally, a Single Degree of Freedom (SDOF) analytical model was developed for the wall panel to determine the Dynamic Increase Factor (DIF) of RTFC. The analysis resulted in a DIF value of 1.5, which was then incorporated into the numerical models of the walls. The accuracy of the DIF was validated by comparing the numerical results with experimental data, confirming its reliability.