Structural Connectivity Strength Research Articles

Adolescent impatience decreases with increased frontostriatal connectivity

Adolescence is a developmental period associated with an increase in impulsivity. Impulsivity is a multidimensional construct, and in this study we focus on one of the underlying components: impatience. Impatience can result from (i) disregard of future outcomes and/or (ii) oversensitivity to immediate rewards, but it is not known which of these evaluative processes underlie developmental changes. To distinguish between these two causes, we investigated developmental changes in the structural and functional connectivity of different frontostriatal tracts. We report that adolescents were more impatient on an intertemporal choice task and reported less future orientation, but not more present hedonism, than young adults. Developmental increases in structural connectivity strength in the right dorsolateral prefrontal tract were related to increased negative functional coupling with the striatum and an age-related decrease in discount rates. Our results suggest that mainly increased control, and the integration of future-oriented thought, drives the reduction in impatience across adolescence.

Identification of Pivotal Causes and Spreaders in the Time-Varying Fault Propagation Model to Improve the Decision Making under Abnormal Situation

Under abnormal conditions, timely and effective decisions of system recovery and protective measures are of great significance for safety-critical systems. The knowledge of the roles that network nodes play in the spreading process is crucial for developing efficient maintenance decisions; for singling out and preferential control, the ‘pivotal spreaders’ may be a way to maximize the chances to timely hinder the fault pervasion. Inspired by the inhomogeneous topological nature of a complex fault propagation network, this study is devoted to exploring the spreading capabilities of nodes regarding both structural connectivity and causal influence strength, so as to provide decisions of preferential recovery actions under specific fault scenarios. Specifically, the dynamic betweenness centrality and nonsymmetrical entropy are incorporated to adaptively measure the system-wide fault diffusion risk of a set of controllable fault events. In order to model the dynamics and uncertainties involved in the complex fault spreading process, we introduce the model of a dynamic uncertain causality graph, based on which solutions of time-varying structure decomposition and causality reduction are adopted to improve the reasoning efficiency. Verification experiments consisting of simulated calculation cases and generator faults of a nuclear power plant show empirically the effectiveness and applicability of this method in large-scale engineering practice. Copyright © 2014 John Wiley & Sons, Ltd.

Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity

It is commonly assumed that functional brain connectivity reflects structural brain connectivity. The exact relationship between structure and function, however, might not be straightforward. In this review we aim to examine how our understanding of the relationship between structure and function in the 'resting' brain has advanced over the last several years. We discuss eight articles that directly compare resting-state functional connectivity with structural connectivity and three clinical case studies of patients with limited white matter connections between the cerebral hemispheres. All studies examined show largely convergent results: the strength of resting-state functional connectivity is positively correlated with structural connectivity strength. However, functional connectivity is also observed between regions where there is little or no structural connectivity, which most likely indicates functional correlations mediated by indirect structural connections (i.e. via a third region). As the methodologies for measuring structural and functional connectivity continue to improve and their complementary strengths are applied in parallel, we can expect important advances in our diagnostic and prognostic capacities in diseases like Alzheimer's, multiple sclerosis, and stroke.