Fluid-induced vibration (FIV) features of the semi-submerged flexible pipe in an oncoming flow are experimentally investigated in this paper. The flexible pipe is towed to simulate the equivalent uniform oncoming flow with a Froude number (Fr) ranging from 0.2 to 2.5. The overtopping states are determined and divided into three regions by the Fr numbers, including non-overtopping, intermitting overtopping, and continuous overtopping regions. Through the displacement reconstruction and wavelet transform methods, the displacement response, frequency, trajectory, and the chaotic characteristics of the semi-submerged pipe are studied. The results show that the FIV displacement responses are evidently affected by the intensity of the overtopping phenomenon. A significant mean displacement in the cross flow (CF) direction can be seen and a maximum value of 0.88D can be reached. The unexpectedly larger FIVs with standard deviation values of around 0.52D can be witnessed in the in-line (IL) direction than those for a fully submerged pipe. Moreover, the FIV frequency response in the IL direction is found to be consistent with that in the CF direction under intermitting overtopping and continuous overtopping state, and the corresponding Strouhal numbers are 0.24 and 0.28, respectively. The FIV response is found to be chaotic in non-overtopping states, while it behaves periodic and quasiperiodic features as overtopping occurs. The “O” shape of the motion trajectory is observed at such overtopping regions. The present work improves the basic understanding of the FIV features of the semi-submerged flexible pipe in the oncoming flow and can provide useful references for designing the relevant marine structures.