Nanoparticles have great potential for the application in new energy and aerospace fields. The distribution of nanoparticle sizes is a critical determinant of material properties and serves as a significant parameter in defining the characteristics of zero-dimensional nanomaterials. In this study, we proposed HRU2-Net†, an enhancement of the U2-Net† model, featuring multi-level semantic information fusion. This approach exhibits strong competitiveness and refined segmentation capabilities for nanoparticle segmentation. It achieves a Mean intersection over union (MIoU) of 87.31%, with an accuracy rate exceeding 97.31%, leading to a significant improvement in segmentation effectiveness and precision. The results show that the deep learning-based method significantly enhances the efficacy of nanomaterial research, which holds substantial significance for the advancement of nanomaterial science.
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