The epitaxial La0.7Sr0.3MnO3/BaTiO3 bilayers were deposited on (001), (110) and (111) LaAlO3 substrates by pulsed laser deposition technique. All of the bilayers presented coherent ferromagnetic and ferroelectric properties. Furthermore, a strong magnetoelectric (ME) effect at room temperature was approved, which strongly correlated to the film orientation. The ME voltage coefficients for (001), (110) and (111) oriented bilayers were around 140mV/cmOe, 105mV/cmOe, and 120mV/cmOe, respectively. These values were at least one order of magnitude higher than previous reported results, which mainly related to the good interface quality of La0.7Sr0.3MnO3/BaTiO3 bilayers and the small dielectric constant of BaTiO3 film.