AbstractThe remarkable ability of geckos to climb and run rapidly on walls and ceilings has recently received considerable interest from many researchers. Significant progress has been made in understanding the attachment and detachment mechanisms and the fabrication of articulated gecko-inspired adhesives and structured surfaces. This article reviews the direct experiments that have investigated the properties of gecko hierarchical structures, i.e., the feet, toes, setae, and spatulae, and the corresponding models to ascertain the mechanical principles involved. Included in this review are reports on gecko-inspired surfaces and structures with strong adhesion forces, high ratios of adhesion and friction forces, anisotropic hierarchical structures that give rise to directional adhesion and friction, and “intelligent” attachment and detachment motions.