Bulk physical properties, solubility properties, solvatochromic properties, and chromatographic properties (reversed-phase) are presented for six room temperature liquid alkylammonium nitrate and thiocyanate salts. The solvent selectivity measurements indicate that their properties are governed by strong proton donor—acceptor and orientation interactions accompanied by weak dispersive interactions. Individual variations with cation size and anion type are readily apparent within the above general framework. The spectroscopic and solubility data indicates water-like behavior for the nitrate salts and more organic-solvent-like behavior for the thiocyanate salts. Thus, in reversed-phase liquid chromatography water—liquid organic salt mobile phases are weak eluents except for proton donor acceptor solutes. For proton donor—acceptor solutes the solvent strength weighting factors are similar to typical values for organic modifiers in water. The water-like behavior for the alkylammonium nitrate salts suggests that they are suitable for use as strength adjusting solvents in reversed-phase liquid chromatography. In this case a wide range of organic solutes can be eluted from reversed-phase columns. The solvent strength weighting factors for methanol, ethanol, acetonitrile and tetrahydrofuran in the alkylammonium nitrate salts undergo some leveling of their properties compared to their values in water. The solvent strength weighting factors are also salt dependent. The alkylammonium nitrate salts are useful solvents for reversed-phase liquid chromatography. The thiocyanate salts are less useful due to their corrosive action on the chromatographic system.