Existing scholarship extensively explores the dynamics, determinants, and consequences of urban expansion, yet there is scant literature examining the impact of regional cooperation upon the directions and spatial forms of urban expansion amidst the fast-urbanizing process. This study focuses on the Guangdong-Hong Kong-Macao Greater Bay Area (GBA), a developed megacity-region in southern China, to probe whether the notable urban expansion observed in contemporary China has been profoundly influenced by collaborative efforts among jurisdictions. Through the spatial metrics and panel data regression spanning the period from 2010 to 2018, this study unveils that regional cooperation has extended from coastal cities towards hinterland cities within the GBA. Consequently, urban land in most cities has undergone expansion in diverse directions. Furthermore, in contrast to economic and social cooperation, regional institutional cooperation emerges as the most influential factor driving external urban expansion. Additionally, heterogeneous results reveal that regional cooperation drives the external expansion of ordinary cities towards core cities. In contrast, the inertia within the urban system demonstrates strong path dependence on the pattern of adjacent expansion, contrasting with the external expansion facilitated by regional cooperation. In summary, this study illuminates the genesis and dynamics of urban expansion amid the city-regionalization process, going beyond interpretations confined to the municipal scale.