Strong Mediator Research Articles

Does management support drive sustained agile usage? a serial mediation model and cIPMA perspective.

Agile software development is immensely popular in the industry, but most teams struggle to sustain its use. Human factors like management support, agile training, agile mindset, and team resilience are often neglected, hindering long-term success. However, research has not explored their underlying mechanisms in depth. Therefore, this study examines if management support impacts the sustained usage of agile methodologies within software development teams. It subsequently investigates the individual and serial mediating effects of agile training, the agile mindset, and team resilience on this relationship. Additionally, it compares the importance and performance of management support, agile training, the agile mindset, and team resilience in infusing agile practices. Finally, it determines these antecedents' necessity for the enduring success of agile application. Data collected from 391 agile software development professionals using a structured questionnaire. Partial-least-squares structural equation modelling, importance-performance map analysis and necessary condition analysis were used to investigate relationships. The findings underscore the pivotal role of management support in infusing agile practices. Agile training, mindset, and team resilience emerge as critical mediators, with a strong serial mediation effect. While management support is paramount, its practical implementation falls short within teams. All four antecedents are found to be necessary for optimal agile sustainment. Thus, this study significantly advances theoretical understanding by introducing a serial mediation model that elucidates their mechanisms in impacting agile infusion. It extends prior organisational-level findings to the team-level. The study's quantitative verification of qualitative findings strengthens their generalisability to a broader spectrum of teams. It pioneers in expounding the constructs' relative importance, performance and necessity, to offer actionable insights for agile practitioners. Finally, it provides methodological guidance to apply importance performance map analysis and necessary condition analysis in agile software development research.

Metabolites and lipid species mediate the associations of adiposity in childhood and early adulthood with mammographic breast density in premenopausal women

BackgroundMammographic breast density (MBD), a strong predictor of breast cancer, is highly influenced by body mass index (BMI) in childhood and early adulthood, but the mechanisms underlying these associations are not fully understood. Our goal is to identify biomarkers that mediate the associations of BMI at ages 10 and 18 with MBD in premenopausal women.MethodsThis study consists of 705 premenopausal women who had their screening mammogram at Washington University in St. Louis, MO, and provided a fasting blood sample. Our comprehensive metabolomic and lipidomic profiling yielded complete data for 828 metabolites and 857 lipid species after imputation. We used Volpara to determine volumetric measures of MBD. We performed high dimensional mediation analysis using the HIMA R package, adjusted for confounders, to determine whether lipid species and metabolites mediate the associations of BMI at 10 and 18 with MBD. We applied a false discovery rate (FDR) p-value < 0.1.ResultsFour metabolites (glutamate, β-cryptoxanthin, cortolone glucuronide (1), phytanate) significantly mediated the association of BMI at 10 with volumetric percent density (VPD), and two (glutamate, β-cryptoxanthin) mediated the association of BMI at 18 with VPD. Glutamate was the strongest mediator across time points. Glutamate mediated 6.7% (FDR p-value = 0.06) and 9.3% (FDR p-value = 0.008) of the association between BMI at age 10 and 18, respectively. Four lipid species (CER(18:0), LCER(14:0), LPC(18:1), PC(18:1/18:1)), mediated the association of BMI at 10 with VPD, while five lipid species (CER(18:0), LCER(14:0), PC(18:1/18:1), TAG56:5-FA22:5, TAG52:2-FA16:0) mediated the association of BMI at 18 with VPD. The strongest mediator was PC(18:1/18:1), which mediated 9.7%, (FDR-p = 0.009) and 7.7%, (FDR-p = 0.04) of the association of BMI at age 10 and 18 with VPD, respectively.ConclusionsMetabolites in amino acid, lipid, cofactor/vitamin, and xenobiotic super-pathways as well as lipid species across the phospholipid, neutral complex lipid and sphingolipid super-pathways mediated the associations of BMI in early-life and MBD in premenopausal women. This study offers insight into the biological mechanisms underlying the link between early-life adiposity and MBD, which can support future research into breast cancer prevention.

Teacher competency and work engagement among secondary school physical education teachers: the multiple mediating roles of occupational stress, emotional exhaustion, and professional achievement

ObjectiveThis study examined the relationships between teacher competency, occupational stress, emotional exhaustion, sense of professional achievement, and work engagement among secondary school physical education teachers. It also investigated demographic differences in these variables and tested the structural invariance of the proposed model across genders.MethodA total of 1,347 secondary school physical education teachers participated in the study, completing validated scales to measure the key constructs and providing demographic information such as gender, age, education level, professional title, and school location. Data were analyzed using descriptive statistics, t-tests, one-way ANOVA, correlation analysis, and structural equation modeling (SEM). Mediation effects were assessed through bootstrapping, and structural invariance was tested using multigroup SEM.ResultsDemographic analyses revealed significant differences. Male teachers reported higher competency, professional achievement, and engagement, while female teachers experienced slightly greater emotional exhaustion. Younger teachers and those with lower professional titles reported higher occupational stress and emotional exhaustion. Rural and urban teachers exhibited comparable levels of most variables, except for urban teachers reporting slightly higher emotional exhaustion. Teacher competency directly influenced work engagement (28.27% of the total effect) and indirectly through occupational stress, emotional exhaustion, and professional achievement, with professional achievement being the strongest mediator (25.97% of the total effect). Sequential mediation pathways involving these factors were significant but weaker in magnitude. Structural invariance analysis confirmed that the model was consistent across genders, demonstrating robust applicability across male and female teacher populations.ConclusionTeacher competency is a key driver of work engagement, operating through both direct and indirect mechanisms, particularly by alleviating occupational stress and enhancing professional achievement. These findings underscore the importance of interventions aimed at fostering teacher well-being, including stress management programs and professional development opportunities, while addressing demographic-specific needs. Future research should employ longitudinal designs and consider additional contextual factors to extend these findings.

Patient Engagement’s Influence On Brand Image As A Mediator To Strengthen Revisit Intention

The transformation of medical services in Indonesia from a disease-centered model to a patient-centered model has created intense competition among medical institutions. At one of the Maternal and Child Hospitals in Jakarta, a decline in visits from Non-BPJS patients indicates the need for a deeper understanding of the factors influencing patients' intentions to revisit. This study aims to analyze the influence of patient involvement and patient experience on the intention to revisit the hospital, with the mediation of the hospital's brand image. A quantitative approach with a cross-sectional design was used in this study. Data were collected through questionnaires from 119 Non-BPJS patients in the Outpatient Unit. Data analysis was conducted using PLS-SEM with the Smart-PLS program. The results showed that patient involvement and patient experience significantly influenced the intention to revisit, with the hospital's brand image serving as a strong mediator. Enhancing patient involvement, positive experiences, and a strong brand image can significantly increase patients' intention to return to the Maternal and Child Hospital in Jakarta.

P2 purinergic receptors at the heart of pathological left ventricular remodeling following acute myocardial infarction.

Pathological left ventricular remodeling is a complex process following an acute myocardial infarction, leading to architectural disorganization of the cardiac tissue. This phenomenon is characterized by sterile inflammation and the exaggerated development of fibrotic tissue, which is non-contractile and poorly conductive, responsible for organ dysfunction and heart failure. At present, specific therapies are lacking for both prevention and treatment of this condition, and no biomarkers are currently validated to identify at-risk patients. Physiopathological understanding of this process is limited, probably due to the combination of the multi-cellular responses involved that are initially necessary for tissue healing but may be detrimental on longer term. Current research focuses on understanding and modulating the inflammatory response, a key aspect of the tissue healing process. Inflammation is triggered by the release of inflammatory mediators from cardiomyocytes undergoing cell death in the context of ischemia-reperfusion injury. Among them, extracellular ATP is a strong mediator of inflammation through the activation of P2 purinergic receptors, regulating the behavior of all the cellular actors of the post-myocardial infarction response and impacting organ function and recovery. Rather than considering each cellular protagonist independently, this review provides an integrated overview of the inflammatory and tissue response to myocardial infarction by members of the P2 receptor family. Finally, it explores the possibility of reducing pathological left ventricular remodeling through the modulation of these receptors and their associated signaling pathways.

The mediating role of cultural capital between internet use and happiness among Chinese adults

ABSTRACT In China, with over 1.067 billion online users, the Internet use (IU)’s role in happiness is complex. This study examined how cultural capital (CC) influences the link between IU and happiness in China. Both institutionalised cultural capital (ICC) and embodied cultural capital (ECC) were found to significantly mediate IU’s effect on happiness, with ECC being the stronger mediator. Differing education levels within ICC showed varied mediating effects. These findings underscored the importance of equitable internet access and inclusive cultural programmes for well-being. This study indicates that social workers may contribute to clients’ happiness by addressing both their IU and CC.

Radiant living: embarking on a journey to well-being through wellness tourism experience, dived by tourist satisfaction and fear of missing out

ABSTRACT This study examines the influence of wellness tourism experiences on tourists well-being, focusing on the mediating roles of tourist satisfaction and fear of missing out (FoMO). This is the first model to measure the mediating effects of tourist satisfaction and FoMO in the context of wellness tourism. Using a purposive sampling technique, data were collected from 348 respondents who had participated in wellness tourism in Ubud, Bali. A structured questionnaire was administered to gather responses. The proposed model was validated using Partial Least Squares Structural Equation Modeling (PLS-SEM) which was analysed with SmartPLS 4. Wellness tourism experiences have a significant positive impact on tourist well-being, both directly and indirectly through the mediating roles of tourists’ satisfaction and FoMO. Tourist satisfaction was identified as a stronger mediator than FoMO. The present study demonstrates that tourist satisfaction positively influences well-being during wellness tourism. FoMO also contributed positively, thus indicating a distinct role. The results of this research hold theoretical and practical implications for increasing the understanding of tourist well-being and augmenting the wellness tourism experience.

Analyzing Extension and Advisory Service Delivery Dynamics in Nepal through Social Network Analysis Lens: A Comparative Study

Aims: Amid the changes in extension and advisory service delivery after federalism in Nepal. The existing players and new players in the network influence the flow and accessibility of services, providing both opportunities and challenges. However, very few studies have been carried out. So, this research was designed to analyze the perception and diffusion flow dynamics/pattern (mediators) of public extension and advisory services at the local/municipal level in Nepal. Study Design: A cross-sectional research approach with a convergent parallel mixed-method research design was used. Methodology: A field survey was carried out by selecting 200 stakeholders using a simple random sampling method, 22 key informant interviews, and 4 focus group discussions at Chandragiri and Dakshinkali municipalities. Results: The five-point Likert Scale (13 constructs), social network analysis, and community network map revealed that the EAS network with progressive farmers (CB= 2384.94), agriculture section (CB= 1134.8), input suppliers (CB= 855.21), farmers group (CB= 511.7), and social actors (CB= 452.58) as strong mediators, had a poor perception toward current public extension and advisory services. The EAS network with agriculture section (CB= 2292), farmers group (CB= 2199.5), input suppliers (CB= 584.32,) and progressive farmers (CB= 481.9) as their strong mediators in the EAS network perceive the public EAS slightly positively. Conclusion: The research concludes that the stakeholders often neglected by government institutions but perceived strong mediators in the EAS network must be identified and prioritized for effective service delivery. The study could be a basis for the stakeholders' identification and management in the service delivery framework of public extension and advisory service delivery at the municipal/local level.

Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes

BackgroundAdipose tissue distribution plays a crucial role in the development of cardiovascular complications. In particular, visceral adipose tissue (VAT) has been linked to insulin resistance (IR) and cardiovascular disease (CVD). However, the relationship between VAT, cardiac dysfunction and the meditation capacity of VAT related to IR has not been fully characterized.MethodsThis cross-sectional study included adults living with type 2 diabetes (T2D). VAT was measured using electrical bioimpedance and also estimated with the Metabolic Score for Visceral Fat (METS-VF). LV function was assessed using left ventricular global longitudinal strain (LV-GLS) by speckle tracking echocardiography analysis. Spearman correlation coefficients, adjusted linear regression models guided by direct acyclic diagrams and causal mediation analysis were performed.ResultsAmong 195 adults living with T2D (median age: 57, IQR: 49–64, women: 63%), VAT showed a positive association with LV-GLS (β = 0.482, 95% CI: 0.060–0.904, p = 0.039) after adjusting for relevant confounders. The effect was strongly replicated using METS-VF as a surrogate for VAT. The mediation analysis revealed that VAT accounted for 60.9% (95% CI: 15.82–171) of the total effect between IR and LV-GLS.ConclusionThis study demonstrated a positive association between VAT and LV-GLS. This relationship was consistently observed using the clinical surrogate METS-VF. Visceral adiposity was identified as a strong mediator in the relationship between IR and LV-GLS, underscoring its role in the pathophysiology of cardiovascular disease in patients with T2D.Graphical abstractSummary of the main results of the study. Abbreviations: T2D: Type 2 diabetes, LV-GLS, Left-ventricular global longitudinal strain; VAT: Visceral adipose tissue; METS-VF, Metabolic Score for Visceral Fat.

DIGITAL HEALTH AND OLDER ADULT WELL-BEING: THE MEDIATING ROLE OF SOCIAL TECHNOLOGY USE

Abstract Older adults engage in digital health use (DHU) and social technology use (STU) to connect with health care providers and loved ones. DHU has expanded as an accessible health care option, though its effects on well-being are underexplored. Meanwhile, STU is known to improve quality of life for older adults. This study investigates the association between DHU and well-being and determines whether STU mediates this association. Data from the 2022 National Health and Aging Trends Study were analyzed, with a sample of 5,773 U.S. Medicare beneficiaries, ages 65 and older. The sample was primarily White (64%), female (58%), 65-79-years-old (52%), and urban-living (84%). Structural equation modeling captured the complex relationships of the latent constructs of DHU (e.g., telehealth visit, sending portal messages), STU (e.g., video chat, texting, social media), and well-being (e.g., belief in one’s life purpose, self-determination, confidence). Confirmatory factor analyses with sufficient fit indices established validity of the measurement models. In the full model, DHU was negatively associated with well-being (β=-0.22, p&amp;lt;.001); however, a mediation analysis revealed a strong partial mediation (β=0.32 (CI 0.24-0.46), SE=0.055, z=6.163, p&amp;lt;.001) with acceptable model fit. Adding STU as a mediator reversed the direction and increased the magnitude of the association between DHU and well-being. The significant negative path between DHU and well-being may indicate that DHU is not a preferred option for older adults, but the partial mediation suggests that STU offers familiarity with communication technology that strengthens the association towards well-being. Future research should clarify the reasons underlying these significant associations.

Online fashion consumerism among women: The interplay of digital experiences and decision-making – a mediated moderated analysis

This research examines how digital experiences on social media influence women’s buying behavior towards online fashion. Furthermore, it examines how challenges moderate these purchase decisions, and how attitudes mediate these purchase decisions. The research executed in Southern Karnataka state of India obtained the responses from 800 women employed through a formal questionnaire and a systematic method of selection. The measurement models and structural models were examined using AMOS 23. The study indicates that when women engage with social media and gain easy access to information and feedback through reviews, they develop a stronger positive outlook on buying fashion. These favourable opinions lead directly to consumer buying choices and additionally shape the relationship between the digital experience and their purchasing patterns on online sites. The issues regarding online shopping discourage the transformation of positive views into real transactions. The results reveal that ease of use, exemplified by intuitive navigation (β = 0.188) and easy access to product information, positively affect consumer attitudes. Electronic word-of-mouth (E-WOM), including reviews and recommendations (β = 0.456), also significantly boosts trust, leading to higher purchase intentions. Attitude acts as a strong mediator, with its effect on buying behavior showing a β coefficient of 0.609. However, challenges like concerns over data privacy and difficulties in verifying review authenticity negatively affect the attitude-behavior relationship, with a moderating effect of β = -0.092. The findings show the necessity for more robust data protection laws and better accessibility of online reviews to minimize seen threats and enhance shopper trust in digital clothing shopping.

The Mediation of Financial Behavior to Financial Literacy and Spending Habits of Gen Z: An Exploratory Factor Analysis

The study aims to explain the relationship of financial literacy with spending habits and behavior. Financial behavior is a mediator of Generation Z. Financial literacy is a very important dimension in making financial decisions, and this research highlighted the direct and indirect impacts that financial literacy exerts on spending behavior. Data is collected from 317 respondents using a structured questionnaire measuring financial literacy, financial behavior, and spending behavior. Correlation, regression, mediation analysis, and Structural Equation Modeling have been used in evaluating these relationships. Financial literacy directly reflects a strong relationship with spending behavior, and its coefficient is 1.167. Financial behavior, therefore, exercises a strong mediation effect on this relationship with a mediation coefficient of 0.797, thus indicating that financial behavior is an essential tool in successfully translating financial knowledge into responsible spending. From these findings, greater financial literacy and responsible financial behavior may increase the aggregate financial efficacy of Generation Z. Although the current study heavily focuses on the fact that financial literacy and behavior are highly associated with financial well-being, it shows that targeted financial literacy education programs on either behavior or financial literacy enhance healthier spending behavior. The scope of future studies involves considering the role of income and personality characteristics as well as an elongation of the time horizon to uncover the impact of financial literacy on shifts in the individual's financial well-being.

THE EFFECT OF TOURISM MARKETING MIX AND SERVICE QUALITY ON INTEREST IN RETURNING VISITORS THROUGH TOURIST SATISFACTION AS AN INTERVENING VARIABLE

This study aims to analyze the influence of tourism marketing mix and service quality on interest in returning visitors through tourist satisfaction as an intervening variable. The research was conducted in tourist destinations in Luwu Regency using a survey method of 100 respondents. The results of the study show that the marketing mix and service quality have a significant positive influence on tourist satisfaction, which in turn increases the interest of tourists to return. In addition, tourist satisfaction proved to be a strong mediator in the relationship between marketing mix and service quality with interest in returning. These findings indicate the importance of effective marketing strategies and high-quality services in increasing tourist loyalty and the competitiveness of tourist destinations. Based on these findings, it is recommended that tourist destination managers focus on strengthening elements of the marketing mix and improving service quality to achieve higher tourist satisfaction and loyalty.

The Role of Psychological Capital and Job Securities Factors on Shaping Readiness to Change

This study investigates the challenges construction sector companies face due to market disruptions and the lack of innovation, with a specific focus on PT Wijaya Karya (WIKA), a leading Indonesian construction firm. Drawing on Kodak's failure as a cautionary example of the risks of neglecting technological advancements, the research underscores the critical need for companies to remain adaptable and ready to innovate to address evolving customer demands. In response to a significant financial loss of IDR 7.13 trillion in 2023, WIKA implemented cost-saving measures, including workforce restructuring and halting recruitment. Despite these setbacks, the company showcased resilience by initiating innovative projects, such as electric motorcycles and precast concrete technologies, contributing to its recovery. The research emphasizes WIKA's initiatives to cultivate employee readiness for change through programs like Wikasatrian and technology skills development. Utilizing a descriptive quantitative approach, the study surveyed 233 managers and directors from government-owned construction firms (BUMN), employing instruments to measure readiness for change, psychological capital, and job security. Data analysis using Structural Equation Modeling (SEM) confirmed that psychological capital plays a critical mediating role between job security and readiness to change. Findings reveal that job security significantly impacts readiness to change, with psychological capital acting as a strong mediator. The study highlights the importance of investing in psychological resources to foster adaptability, particularly in sectors undergoing technological and organizational transformations. The model demonstrated strong validity, with fit indices including GFI (0.90), CFI (0.98), TLI (0.97), NFI (0.97), and RMSEA (0.09), affirming its robustness and providing valuable insights into the public construction sector, an area often underexplored in previous research.

The effect of corporate venturing on knowledge acquisition and performance in small and medium-sized firms in Germany

Although corporate venturing (CV) is associated with acquiring new skills and competencies and with achieving corporate vitalization, there are limited insights as to how CV activities in small and medium sized enterprises (SMEs) relate to knowledge acquisition and performance. To address these, we utilize survey data of 570 organizational members, up to the top management level, of SMEs in Germany. The results indicate that CV positively affects knowledge acquisition and performance. Additionally, we found positive moderation effects of transformational leadership and technological turbulence on the CV-performance relationship. Further analysis confirmed a strong mediation effect of knowledge acquisition (KA) on the CV-performance relationship. The results also suggest that firms practicing CV in high technology dynamism related industries face a triangle of tensions where high technology turbulence supports exploitation of existing competitive advantages, but the former dampens the exploration of future competitive advantages through new knowledge.

Fostering links, building trust, and facilitating change: connectivity helps sustain longitudinal integrated clerkships in small rural and remote communities

BackgroundMaldistribution of medical professionals presents a significant challenge globally and leads to inequitable healthcare access, particularly in remote areas. Longitudinal integrated clerkships (LICs) in rural areas can improve workforce distribution and may be an innovative contributor to solving maldistribution issues. However, to align with healthcare needs, LICs must be sustainable in small communities, which often have a limited medical workforce. This study investigates the key elements underpinning LIC sustainability in small communities.MethodsThis study adopted a constructivist research paradigm in which participants’ constructions of their experiences supporting LICs in small rural communities were explored. Participants were conveniently sampled from the LIC community of practice attending the 2021 virtual annual conference of the Consortium of Longitudinal Integrated Clerkships. Data were collected through video recording and thematically analysed to identify barriers and enablers to running sustainable LIC programmes.ResultsEleven participants fulfilling key roles within LICs, including clinical school directors, program coordinators, and clinical educators, were recruited for the study. Thematic analysis indicated that it is Connectivity, expressed through three subthemes, Fostering Links, Building Trust, and Facilitating Change, which underpins sustainable LICs in small communities.ConclusionsConnectivity is a strong mediator for sustainability of LICs and may be the central defining theme of LICs. Increasing connectivity through prioritizing community engagement, trust-building, and strategic investment enhances the sustainability of rural LICs, ensuring their continued positive contribution to medical workforce distribution in underserved areas.

A psychospiritual theory of general factor p

ABSTRACT Research points to a single factor known as general factor p that can account for people’s liability to psychopathology, comorbidity among psychopathologies and the severity of psychopathology. Here, we speculate that this common psychopathology factor is an insufficient understanding of the way the human psychospiritual system (or HPS) works. We first describe the Principles 1 that we posit account for the operation of the HPS. Then we propose a process from an insufficient understanding of the way the HPS works to psychopathology. Finally, we present a study that tests our theory of factor p with 851 participants with varying levels of understanding of the way the HPS works. The findings support our theory of p. The mediation analyses show that the level of understanding of the way the HPS works significantly mediates the relationship between maladaptive repetitive thought and psychopathology, and between maladaptive repetitive thought and mental health. Also, as predicted in both relationships, the level of understanding of innate mental health is an even stronger mediator than the level of understanding of the Principle of Thought. The application of these findings to psychopathology prevention and treatment is discussed.

Abstract 4134900: Cellular Crosstalk in Endocardial Fibroelastosis: NRG Signaling Dysregulation Contributes to Fibrosis and Myocardial Dysfunction in Hypoplastic Left Heart Complex

Background: Endocardial fibroelastosis (EFE) is marked by a thickened fibro-elastic layer derived by endothelial-to-mesenchymal transition (EndMT), leading to restrictive myocardial function and poor cardiac growth, complicating biventricular repair in hypoplastic left heart complex (HLHC) patients. Neuregulin (NRG) signaling, crucial in EndMT and myocardial development, is implicated in various cardiomyopathies and heart failure, and its dysregulation may drive EFE pathogenesis. Hypothesis: NRG signaling dysregulation influences the cellular and molecular mechanisms of EFE. Methods: Single nucleus RNA sequencing (snRNA-seq) was conducted on human left ventricular (LV) tissue resected from 7 EFE patients (0.4-15 years) and 4 non-congenital heart disease (CHD) postmortem human controls (0.02-16 years). Differential gene expression was analyzed using the Wilcoxon Rank Sum test. We used CellChat, a computational tool for analyzing intercellular communication networks, to identify signaling changes via quantitative contrasts and joint manifold learning. Results: We identified 11 cell types in 64,963 nuclei. In EFE samples compared to non-CHD samples, NRG1-expressing fibroblasts increased from 3.4% to 21.2% (P&lt;0.0001), and NRG2-expressing cardiomyocytes from 11.9% to 45.9% (P&lt;0.001). CellChat analysis revealed a denser NRG signaling network in EFE, with enhanced interactions among cardiomyocytes, endocardial cells, fibroblasts, mast cells, and smooth muscle cells (Fig. 1A-B). Cardiomyocytes emerged as significant senders of NRG signaling in EFE, while endocardial cells, though still key senders, showed reduced influence. Fibroblasts became strong mediators, receivers, and influencers, smooth muscle cells emerged as prominent receivers, and mast cells gained roles as mediators and influencers (Fig. 1 C-D). These changes indicate a complex NRG signaling network in EFE, highlighting altered cellular interactions driving disease progression. Conclusion: Dysregulated NRG signaling in EFE contributes to pathological cellular crosstalk, fibrosis, and myocardial dysfunction, potentially hindering successful biventricular repair in HLHC patients. Targeting NRG pathways could represent a novel therapeutic approach. These findings offer promising implications for affected patients, potentially improving outcomes. Future research should explore additional molecular pathways involved in EFE and assess the therapeutic efficacy of targeting NRG signaling.

Reductive Photocatalytic Proton-Coupled Electron Transfer by a Zirconium-Based Molecular Platform.

Reductive proton-coupled electron transfer (PCET) has important energetic implications in numerous synthetic and natural redox processes. The development of catalytic systems that can mediate such transformations has become an attractive target, especially when light is used to generate the reactive species towards solar-to-chemicals conversion. However, such approach becomes challenged by kinetic competition with H2 evolution. Here we describe the excited state reactivity of a molecular Zr-based platform under visible light irradiation for the efficient reduction of multiple bonds. Mechanistic investigations shine light on a charge separation process that colocalizes an excited electron and an acidic proton to promote selective PCET. We further leveraged this reactivity for the photocatalytic reduction of a variety of organic substrates. Our results demonstrate the promise of this molecular platform to design strong photocatalytic PCET mediators for reductive transformations. More broadly, we also show the potential relevance of PCET mechanisms in the (photo)redox chemistry of Zr-based molecular materials.

Reductive Photocatalytic Proton‐Coupled Electron Transfer by a Zirconium‐Based Molecular Platform

AbstractReductive proton‐coupled electron transfer (PCET) has important energetic implications in numerous synthetic and natural redox processes. The development of catalytic systems that can mediate such transformations has become an attractive target, especially when light is used to generate the reactive species towards solar‐to‐chemicals conversion. However, such approach becomes challenged by kinetic competition with H2 evolution. Here we describe the excited state reactivity of a molecular Zr‐based platform under visible light irradiation for the efficient reduction of multiple bonds. Mechanistic investigations shine light on a charge separation process that colocalizes an excited electron and an acidic proton to promote selective PCET. We further leveraged this reactivity for the photocatalytic reduction of a variety of organic substrates. Our results demonstrate the promise of this molecular platform to design strong photocatalytic PCET mediators for reductive transformations. More broadly, we also show the potential relevance of PCET mechanisms in the (photo)redox chemistry of Zr‐based molecular materials.