Strong Link Research Articles

Religious coping and delinquent behaviors: Moderated mediation roles of religion affiliation and prosocial moral reasoning.

Religion has been shown to have a positive impact for developing adolescents; however, the processes underlying this relation are not well known. In his almighty prosocial theory, Anazonwu (Conceptualizing and testing almighty prosociality theory for a more peaceful world, SCOA Heritage Nigeria, 2017) proposed that the activation of learnt prosocial moral reasoning through religion enabled performance of prosocial peace behavior that will benefit society. Thus, religion coping enhances the development of prosocial reasoning which in turn propagate prosocial acts while reducing delinquent behaviors. Similarly, developmental system theory (Lerner, Developmental science, developmental systems, and contemporary theories of human development, John Wiley & Sons, 2006) assumed that in every individual three mechanisms: plasticity (potential to change), context (environment), and developmental regulation (learnable principles) interact to describe the direction of the transactions between individuals and their various embedded sociocultural context of development which will also determine other developmental outcomes. Based on these two theoretical assumptions, the present study examined whether prosocial moral reasoning (developmental regulation) was the mechanism in the negative correlation between religious coping (plasticity) and delinquent behaviors (outcome), and if religious affiliation(context) (Christianity and Islam) moderated these paths. We hypothesized that the link from prosocial moral reasoning to lower delinquent behaviors would be stronger for Muslim compared with Christian youth. These questions were tested among Nigerian adolescence, an important sample because of high interreligious and interethnic tension among youth in the country. 298 adolescents (Mean age = 15.03 years, SD = 1.76; male = 176, female = 122; 46.3% Muslim, 53.7% Christian) were sampled using questionnaires in senior secondary schools in Nigeria. Moderated mediation result shows that greater religious coping was linked with higher prosocial moral reasoning, which in turn predicted fewer delinquent behaviors. Religious coping interacted with religion affiliation to influence delinquent behavior; there was a stronger link between these two constructs for Muslim compared to Christian youth. Thus, interventions aiming to reduce youth delinquent behaviors should consider promoting prosocial moral reasoning, particularly among the various religions (i.e., Christian/Muslim) communities.

Fluctuations in emotion regulation as a mechanism linking stress and internalizing psychopathology among adolescents: An intensive longitudinal study

Stressful life events (SLEs) are tightly coupled with the emergence of anxiety and depression symptoms among adolescents, but the mechanisms underlying this relationship remain poorly understood. We investigated within-person fluctuations in emotion regulation as a mechanism linking SLEs and internalizing psychopathology in an intensive longitudinal study. We examined how monthly fluctuations in SLEs were related to engagement in three emotion regulation strategies—acceptance, reappraisal, and rumination—and whether these strategies were associated with changes in internalizing symptoms in adolescents followed for one year (N = 30; n = 355 monthly observations). Bayesian hierarchical models revealed that on months when adolescents experienced more SLEs than was typical for them, they also engaged in more rumination, which, in turn, was associated with higher anxiety and depression symptoms and mediated the prospective relationship between SLEs and internalizing symptoms. In contrast, greater use of acceptance and reappraisal selectively moderated the association between stressors and internalizing symptoms, resulting in stronger links between SLEs and symptoms. These results suggest that emotion regulation strategies play different roles in the stress-psychopathology relationship. Understanding how changes in emotion regulation contribute to increases in internalizing symptoms following experiences of stress may provide novel targets for interventions aimed at reducing stress-related psychopathology.

Failure Sensitivity in Perfectionism and Procrastination: Fear of Failure and Overgeneralization of Failure as Mediators of Traits and Cognitions

The current study investigated perfectionism and procrastination from the trait and cognitive perspectives and addressed how they relate to components of a personal orientation toward failure. A sample of 327 undergraduate students completed three perfectionism measures (i.e., Frost Multidimensional Perfectionism Scale, Hewitt–Flett Multidimensional Perfectionism Scale, and Perfectionism Cognitions Inventory), two procrastination measures (i.e., Lay Procrastination Scale and Procrastinatory Cognitions Inventory), and measures of fear of failure and overgeneralizing failure. Correlational analyses showed that the composite trait dimension of perfectionistic concerns and the cognitive dimension of perfectionistic automatic thoughts had modest links with trait procrastination but much stronger links with the cognitive measure of procrastinatory automatic thoughts. All perfectionism and procrastination measures were significantly correlated with fear of failure and overgeneralization of failure. More extensive analyses showed that fear of failure mediated trait and cognitive pathways between perfectionism and procrastination, and the overgeneralization of failure mediated most pathways. Other evidence supported a sequential mediation between perfectionism and procrastination (i.e., fear of failure followed by the overgeneralization of failure). Overall, the results suggest that procrastinating perfectionists have a cognitive hypersensitivity to failure and a potentially debilitating form of perfectionistic reactivity characterized by overgeneralizing failures to the self. The theoretical and practical implications are discussed.

Two Characteristic Patterns of the Summer Indian Ocean Dipole

Abstract This study identifies two distinct patterns of the summer Indian Ocean Dipole (IOD) — the coastal IOD and the offshore IOD — named based on the proximity of their eastern pole to Sumatra. Their spatial characteristics, evolutionary mechanisms, relationships with ENSO, impacts on precipitation, and the factors controlling the simulation performances of climate models are discussed. The coastal IOD shares the same eastern pole as the conventional IOD off Sumatra, but its western pole is located in the central southern tropical Indian Ocean (TIO). The offshore IOD shares the conventional western pole off Somalia, but its eastern pole is located in the central southern TIO. Regarding their evolutions, while they initially develop similarly, their later evolutions differ due to their distinct pole locations: the offshore IOD peaks in summer, while the coastal IOD can be sustained into autumn. The coastal IOD correlates to preceding and late ENSO states, but the offshore IOD does not, making it an independent internal mode of TIO. The two IODs affect climate differently, with only the coastal IOD affecting Australian rainfall. Climate models exhibit varied levels of performance in simulating the two IODs. Specifically, a stronger link between spring TIO rainfall and ENSO, as well as stronger southeasterly monsoonal winds in the southern TIO, can enhance the coastal IOD modeling, while a stronger summer Somali jet benefits the simulation of the offshore IOD. Distinguishing these two IODs has implications for accurate diagnosis and prediction of the summer climate surrounding the TIO.

Exploring the relationship between paternal co‐parenting behaviors and cyberbullying perpetration in Chinese adolescents: The moderating roles of psychological entitlement and gender

AbstractThis study examined the relationships between paternal co‐parenting dimensions (including integrity, consistency, conflict, and bias) and adolescent cyberbullying perpetration, delving into potential moderating mechanisms. A sample of 795 Chinese adolescents (Mage = 14.79 years, SD = 1.67) completed questionnaires assessing parental co‐parenting, cyberbullying perpetration, and psychological entitlement. Results showed a positive association only between paternal co‐parenting bias and cyberbullying perpetration. The study identified a moderating role of psychological entitlement, indicating a stronger link between paternal co‐parenting bias and cyberbullying perpetration for adolescents with higher psychological entitlement than for those with lower psychological entitlement. Notably, the significant association between paternal co‐parenting bias and cyberbullying perpetration only existed among boys. The study provides new insights into the roles of paternal co‐parenting and adolescent psychological entitlement in cyberbullying perpetration among adolescent boys, emphasizing the importance of mitigating paternal co‐parenting bias and reducing adolescent psychological entitlement to prevent cyberbullying perpetration.

The relative contribution of PM2.5 components to the obstructive ventilatory dysfunction—insights from a large ventilatory function examination of 305,022 workers in southern China

BackgroundThe new round of WHO/ILO Joint Estimates of the Work-related Burden of Disease assessment requires futher research to provide more evidence, especially on the health impact of ambient air pollution around the workplace. However, the evidence linking obstructive ventilatory dysfunction (OVD) to fine particulate matter (PM2.5) and its chemical components in workers is very limited. Evidence is even more scarce on the interactive effects between occupational factors and particle exposures. We aimed to fill these gaps based on a large ventilatory function examination of workers in southern China. MethodsWe conducted a cross-sectional study among 363,788 workers in southern China in 2020. The annual average concentration of PM2.5 and its components were evaluated around the workplace through validated spatiotemporal models. We used mixed-effect models to evaluate the risk of OVD related to PM2.5 and its components. Results were further stratified by basic characteristics and occupational factors. FindingsAmong the 305,022 workers, 119,936 were observed with OVD. We found for each interquartile range (IQR) increase in PM2.5 concentration, the risk of OVD increased by 27.8 (95 % confidence interval (CI): 26.5–29.2 %). The estimates were 10.9 % (95 %CI: 9.7–12.1 %), 15.8 % (95 %CI: 14.5–17.2 %), 2.6 % (95 %CI: 1.4–3.8 %), 17.1 % (95 %CI: 15.9–18.4 %), and 11 % (95 %CI: 9.9–12.2 %), respectively, for each IQR increment in sulfate, nitrate, ammonium salt, organic matter and black carbon. We observed greater effect estimates among females, younger workers, workers with a length of service of 24–45 months, and professional skill workers. Furthermore, it is particularly noteworthy that the noise-exposed workers, high-temperature-exposed workers, and less-dust-exposed workers were at a 5.7–68.2 % greater risk than others. InterpretationPM2.5 and its components were significantly associated with an increased risk of OVD, with stronger links among certain vulnerable subgroups.

Adolescent nonmedical use of prescription pain relievers: an examination of primary socialization theory

ABSTRACT Objective The purpose of the present study was to examine the links between primary socialization sources and the past year non-medical use of prescription pain relievers among adolescents. Methods The data for the study came from the National Survey on Drug Use and Health (NSDUH) (2016–2019). Specifically, self-reported past year non-medical use of prescription pain relievers, Primary Socialization Theory (PST) constructs, and control measures was used. Results The results from binomial complex survey logistic regression indicated poor parental bonds, poor school bonds, and associating with substance using peers had links with past year non-medical use of prescription pain relievers. Conclusion Further, the results indicated associating with substance using peers had the strongest link with past year non-medical use of prescription pain relievers hypothesized by the theory. The limitations and implications for future research are noted.

“This is how I'm going to do it, but this is not how you're going to do it”: the expectation gap between student paramedics and mentors in East and Central Scotland

BackgroundThe role of paramedics has expanded significantly over the past two decades, requiring advanced skills and education to meet the demands of diverse healthcare settings. In 2021, the academic requirements for paramedics were raised to a bachelor’s degree to align with other registered professions. The limited evidence on effective paramedic practice education necessitates a novel or new examination of unique learning methods, emphasising the need to establish effective learning relationships between mentors and learners to enhance professional respect and support achieving learning outcomes. This study aimed to investigate expectations between student paramedics and their mentors, focusing on the learning dynamics within paramedic education.MethodsThis qualitative study used purposive sampling to recruit participants from two distinct cohorts: student paramedics from the University of Stirling and Practice Educator Mentors from the Scottish Ambulance Service. Focus groups were conducted to illuminate comprehensive insights into participants' expectations regarding practice education and their respective roles in the learning process. Codebook thematic analysis was used to assess the alignment of these expectations.ResultsFindings illustrate important challenges within practice placement across learning paradigms and highlight the attitudes surrounding the integration of higher education and expectations of practice placements. These challenges encompass systemic barriers, including the support provided to mentors as they assume increased responsibilities and barriers that deter qualified staff from initially undertaking this role.ConclusionThe study aimed to assess expectations between practice educators and students within the paramedic profession in Scotland. The methodology effectively identified key themes from comprehensive data, marking the first primary research in this field. There are disparities in learning styles, expectation measurement, and attitudes toward higher education during practice placements, which could significantly impact the teaching and assessment processes. The findings suggest increased support for practice educators, educational programs addressing challenges of mentorship, and stronger links between higher education institutes and the Scottish Ambulance Service. Further research is needed to understand the extent of the expectation gap, how expectations evolve, and to develop strategies to address disparities.

From memory to motivation: Probing the relationship between episodic simulation, empathy, and helping intentions.

Research has documented a strong link between constructing episodic simulations-vivid imaginations of specific events-and empathy. To date, most studies have used episodic simulations of helping someone to facilitate affective empathy and promote helping intentions, but have not studied how episodic simulations of another's distressing situation affect empathy. Moreover, affective empathy encompasses both personal distress (i.e., an egocentric experience of distress in response to another's circumstances) and empathic concern (i.e., compassion for another), but we do not know how episodic simulations affect each component. To address these questions, we ran three experiments testing how different episodic simulations influenced personal distress and empathic concern, and thereby willingness to help. In Experiment 1 (N = 216), we found that participants who constructed episodic simulations of another's situation reported increased personal distress (but not empathic concern) and increased helping intentions compared to a control group; additional analyses revealed that personal distress mediated the simulation effect on helping. Furthermore, in Experiment 2 (N = 213), we contrasted episodic simulation of helping versus the distressing scenario; we found no differences in personal distress or helping intentions, but simulating helping led to higher empathic concern. Experiment 3 (N = 571) included both simulation conditions and a control condition; we fully replicated our findings, additionally showing that simulating a helping interaction increased personal distress, empathic concern, and helping intentions relative to the control condition, which consisted of prior work. Taken together, our work illustrates how distinct forms of episodic simulation differentially guide empathic responding and highlights the importance of personal distress in motivating helping. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

An Action Research to Enhance Students’ Classroom Engagement through Group Tasks among 8th Graders

This study investigated the effect of employing group tasks to improve student engagement in a classroom at the level of Grade VIII. Engaging students in the learning process presents a significant challenge for educators. This study examined how several group tasks affect student engagement in Grade 8th (A). The study incorporated a single-group pre-post experimental quantitative design; quantitative data was collected over ten weeks. Quantitative data encompassed the observation rating scale. The sample was based on 40 students who were selected through purposive technique from Government Boys High School Bagrian, Lahore. Descriptive and inferential data analysis techniques were used. Findings suggested a strong link between the implementation of group tasks and increased student engagement. Students who participated in group tasks showed active involvement and deeper engagement in the learning process. The analysis revealed the positive effect of group tasks on student engagement within the one grade and classroom. This research contributed by highlighting the importance of group tasks in creating an effective learning environment through engagement for Grade 8th students. The implications extend beyond academic performance to include the holistic development of adolescents, nurturing both cognitive and social skills.

Predictive modeling of burnout based on organizational culture perceptions among health systems employees: a comparative study using correlation, decision tree, and Bayesian analyses

Burnout is a significant concern, particularly within the healthcare field, affecting both nurses and physicians. It is a common issue in health systems, which encompass a range of healthcare facilities, such as hospitals, physician practices, ambulatory sites, and administrative offices like finance. Despite this, there has not been an extensive exploration of burnout in employees working directly with patients versus those in non-patient-facing roles within these health systems. It is important to note that organizational culture plays a crucial role in influencing various aspects of employees' work-life balance and their experiences of burnout. This study adopts a cross-sectional design, involving the distribution of a 57-question Likert scale survey to employees in health systems. These employees serve in various roles, both patient-facing and non-patient-facing, within jointly owned healthcare organizations, which encompass hospitals, ambulatory sites, and administrative offices. The survey was disseminated through trade organizations and employees at the managerial level and above within these health systems. Data was collected between October 2022 and January 2023, resulting in a total of 67 responses. The study employs correlation analysis to explore the connection between organizational culture and burnout. Furthermore, a decision tree model is constructed to predict burnout scores based on survey responses, specifically the question regarding the perceived positivity of the organizational culture. The decision tree models indicate that perceiving organizational culture as positive, safety-oriented, and supportive predicts various outcomes for individuals, including job retention, positive experiences with patients, increased callousness, and stimulation while working with colleagues. Bayesian analysis, considering the small sample size, reinforces these findings and provides a different perspective, incorporating prior knowledge and credible intervals. An association test suggests a strong link between a positive organizational culture and burnout symptoms, while another test supports a connection with engagement signs. Similar to nurses and physicians, administrative health systems’ personnel are susceptible to burnout. Organizational culture can affect burnout. Therefore, health systems’ leaders should cultivate an organizational culture that protects against burnout.

Dermatological patients with itch report more stress, stigmatization experience, anxiety and depression compared to patients without itch: Results from a European multi-centre study.

Itch as the most common symptom in dermatology has been shown to be related to psychological factors such as stress, anxiety and depression. Moreover, associations were found between perceived stigmatization and itch. However, studies investigating the differences between patients with dermatoses with and without itch regarding perceived stress, stigmatization, anxiety and depression are missing. Therefore, one of the aims of the second study of the European Society for Dermatology and Psychiatry (ESDaP study II) was to investigate these relationships in a large cohort of patients with different itchy dermatoses. 3399 patients with 14 different itchy dermatoses were recruited at 22 centres in 17 European countries. They filled in questionnaires to assess perceived stigmatization, stress, signs of clinically relevant anxiety or depression, itch-related quality of life, the overall health status, itch duration, frequency and intensity. The most significant association between the severity of itching and the perception of stress was observed among individuals with rosacea (correlation coefficient r = 0.314). Similarly, the strongest links between itch intensity and experiences of stigmatization, anxiety, and depression were found in patients with seborrheic dermatitis (correlation coefficients r = 0.317, r = 0.356, and r = 0.400, respectively). Utilizing a stepwise linear regression analysis, it was determined that within the entire patient cohort, 9.3% of the variation in itch intensity could be accounted for by factors including gender, levels of anxiety, depression, and perceived stigmatization. Females and individuals with elevated anxiety, depression, and perceived stigmatization scores reported more pronounced itch intensities compared to those with contrary attributes. This study underscores the connection between experiencing itch and its intensity and the psychological strain it places on individuals. Consequently, psychological interventions should encompass both addressing the itch itself and the interconnected psychological factors. In specific cases, it becomes imperative for dermatologists to direct individuals towards suitable healthcare resources to undergo further psychological assessment.

The olfactory bulb: A neuroendocrine spotlight on feeding and metabolism.

Olfaction is the most ancient sense and is needed for food-seeking, danger protection, mating and survival. It is often the first sensory modality to perceive changes in the external environment, before sight, taste or sound. Odour molecules activate olfactory sensory neurons that reside on the olfactory epithelium in the nasal cavity, which transmits this odour-specific information to the olfactory bulb (OB), where it is relayed to higher brain regions involved in olfactory perception and behaviour. Besides odour processing, recent studies suggest that the OB extends its function into the regulation of food intake and energy balance. Furthermore, numerous hormone receptors associated with appetite and metabolism are expressed within the OB, suggesting a neuroendocrine role outside the hypothalamus. Olfactory cues are important to promote food preparatory behaviours and consumption, such as enhancing appetite and salivation. In addition, altered metabolism or energy state (fasting, satiety and overnutrition) can change olfactory processing and perception. Similarly, various animal models and human pathologies indicate a strong link between olfactory impairment and metabolic dysfunction. Therefore, understanding the nature of this reciprocal relationship is critical to understand how olfactory or metabolic disorders arise. This present review elaborates on the connection between olfaction, feeding behaviour and metabolism and will shed light on the neuroendocrine role of the OB as an interface between the external and internal environments. Elucidating the specific mechanisms by which olfactory signals are integrated and translated into metabolic responses holds promise for the development of targeted therapeutic strategies and interventions aimed at modulating appetite and promoting metabolic health.

The Eurovision song contest and the potential of unintended events and public diplomacy: how exposure to an international mega-event shapes external views of the EU

ABSTRACT This article focuses on the Eurovision Song Contest (ESC) as a potential tool for EU public diplomacy. Institutionally, the ESC, a pan-European international mega-event that forms images of Europe, is not related to the EU. Yet, given the strong link between the ESC and the notion of Europe, the article suggests that the ESC might have unintentionally become a public diplomacy tool for the EU. This argument is supported by showing how public views of the EU in a nonmember country, Israel, changed following its hosting of the ESC in 2019. A longitudinal survey was used to examine the impact of the ESC on Israelis’ sympathy for the EU six months before the 2019 ESC and immediately after hosting the contest. The findings indicated that watching the ESC final increased sympathy for the EU. This demonstrates the positive influence of exposure to the ESC on the views of the EU, highlighting the potential role of the ESC as a tool of public diplomacy for the EU. The findings also illustrate a broader potential for understanding public diplomacy consequences from real-life events.

Technology-Supported Guidance Models to Stimulate Nursing Students' Self-Efficacy in Clinical Practice: Scoping Review.

In nursing education, bridging the gap between theoretical knowledge and practical skills is crucial for developing competence in clinical practice. Nursing students encounter challenges in acquiring these essential skills, making self-efficacy a critical component in their professional development. Self-efficacy pertains to individual's belief in their ability to perform tasks and overcome challenges, with significant implications for clinical skills acquisition and academic success. Previous research has underscored the strong link between nursing students' self-efficacy and their clinical competence. Technology has emerged as a promising tool to enhance self-efficacy by enabling personalized learning experiences and in-depth discussions. However, there is a need for a comprehensive literature review to assess the existing body of knowledge and identify research gaps. The aim of this study is to systematically map and identify gaps in published studies on the use of technology-supported guidance models to stimulate nursing students' self-efficacy in clinical practice. This scoping review followed the framework of Arksey and O'Malley and was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR). A systematic, comprehensive literature search was conducted in ERIC, CINAHL, MEDLINE, Embase, PsycINFO, and Web of Science for studies published between January 2011 and April 2023. The reference lists of the included papers were manually searched to identify additional studies. Pairs of authors screened the papers, assessed eligibility, and extracted the data. The data were thematically organized. A total of 8 studies were included and four thematic groups were identified: (1) technological solutions for learning support, (2) learning focus in clinical practice, (3) teaching strategies and theoretical approaches for self-efficacy, and (4) assessment of self-efficacy and complementary outcomes. Various technological solutions were adopted in the guidance models to stimulate the self-efficacy of nursing students in clinical practice, leading to positive findings. A total of 7 out of 8 studies presented results that were not statistically significant, highlighting the need for further refinement of the applied interventions. Nurse educators play a pivotal role in applying learning strategies and theoretical approaches to enhance nursing students' self-efficacy, but the contributions of nurse preceptors and peers should not be overlooked. Future studies should consider involving users in the intervention process and using validated instruments tailored to the studies' intervention objectives, ensuring relevance and enabling comparisons across studies.

Innovation in technology: A game changer for renewable energy in the European Union?

AbstractAs environmental solutions emerge, technological innovations are driving the global transition from fossil fuels to renewable energy. These innovations are game changers in transforming the energy sector and are driving the rapid expansion of renewable energy. Hence, we analyze the nexus between technological innovations and renewable energy in the European Union. The results reveal that technology has a meaningful impact on renewable energy in one‐third of countries. This influence is driven by advancements in energy generation, storage, infrastructure, supportive policies, and incentives, which are crucial in promoting technology innovation and adoption, accelerating the growth of renewable energy. On the other hand, renewable energy is causing technological innovation in one‐third of countries due to the development of renewable energy, which promotes targeted technological innovation to exploit resources, enhance integration, and increase efficiency. A balanced approach works for countries lacking a strong link between the two factors.

Vocabulary learning strategies in extramural English gaming and their relationship with vocabulary knowledge

Research has shown that students learning English as a foreign language can enhance their vocabulary knowledge through exposure to the target language outside of school. However, little is known about whether certain extramural activities have stronger links with vocabulary acquisition than others, and more crucially, the extent to which the vocabulary learning strategies that learners employ during extramural English encounters affect vocabulary learning outcomes. The study reported in this article investigated the relationship between the vocabulary learning strategies employed by 116 students in a Norwegian secondary school when gaming extramurally in English, their gaming frequency, engagement in other EE activities besides gaming, and their receptive and productive English vocabulary knowledge. The findings revealed that inferencing, using language references, and notetaking when gaming statistically significantly correlated with participants’ productive vocabulary knowledge, whereas only inferencing predicted their receptive vocabulary knowledge. Moreover, a negative link was discovered between playing driving games and receptive vocabulary knowledge.

Causal role of immune cells in obstructive sleep apnea hypopnea syndrome: Mendelian randomization study

BACKGROUND Despite being one of the most prevalent sleep disorders, obstructive sleep apnea hypoventilation syndrome (OSAHS) has limited information on its immunologic foundation. The immunological underpinnings of certain major psychiatric diseases have been uncovered in recent years thanks to the extensive use of genome-wide association studies (GWAS) and genotyping techniques using high-density genetic markers (e.g. , SNP or CNVs). But this tactic hasn't yet been applied to OSAHS. Using a Mendelian randomization analysis, we analyzed the causal link between immune cells and the illness in order to comprehend the immunological bases of OSAHS. AIM To investigate the immune cells' association with OSAHS via genetic methods, guiding future clinical research. METHODS A comprehensive two-sample mendelian randomization study was conducted to investigate the causal relationship between immune cell characteristics and OSAHS. Summary statistics for each immune cell feature were obtained from the GWAS catalog. Information on 731 immune cell properties, such as morphologic parameters, median fluorescence intensity, absolute cellular, and relative cellular, was compiled using publicly available genetic databases. The results' robustness, heterogeneity, and horizontal pleiotropy were confirmed using extensive sensitivity examination. RESULTS Following false discovery rate (FDR) correction, no statistically significant effect of OSAHS on immunophenotypes was observed. However, two lymphocyte subsets were found to have a significant association with the risk of OSAHS: Basophil %CD33dim HLA DR- CD66b- (OR = 1.03, 95%CI = 1.01-1.03, P < 0.001); CD38 on IgD+ CD24- B cell (OR = 1.04, 95%CI = 1.02-1.04, P = 0.019). CONCLUSION This study shows a strong link between immune cells and OSAHS through a gene approach, thus offering direction for potential future medical research.

The relationship of pain intensity and opioid craving with delayed methadone dose: A preliminary study of individuals with opioid use disorder.

Despite a strong theoretical link between opioid craving and pain, little is known about the temporal relationship between pain and craving and the acute experience of pain in the context of methadone treatment. Using a cross-over design, the current study evaluated the time course of pain and craving and objective experience of pain as a function of the last methadone dose. Participants (n = 20) presented for the study in the morning and either received methadone dose as scheduled or delayed dose until the afternoon. During the 4-h study visit, participants completed a series of tasks, including repeated assessment of pain and craving at 0, +40, +70, +130, +160 and +240 min and a cold pressor test (CPT) at +15 and +220 min. Separate mixed model results demonstrated no effect of dosing condition on craving; however, there was a significant dosing condition by time interaction (F(5,209) = 3.38, P = .006) such that pain increased over time in the delayed methadone condition but decreased in time in the scheduled methadone condition. A mixed model predicting self-reported pain revealed a three-way interaction between dosing condition, craving and time (F(5,197) = 2.39, P = .039) explained by a positive association between craving and pain at each time point (except 240 min) in delayed condition (P-range = .004-.0001). A separate mixed model on CPT data indicated a significant condition by time interaction such that pain threshold decreased in the delayed, but not scheduled, condition (F(1,57) = 4.01, P = .050). These preliminary findings highlight the potential for increased risks after even a short delay in receiving a methadone dose.

A new macroeconomic measure of human capital exploiting PISA and PIAAC: linking education policies to productivity

ABSTRACT This paper develops a new measure of human capital, calculated as a cohort-weighted average of the quality of education (PISA scores) and the quantity of education (mean years of schooling). Contrary to the existing studies, the relative weights of quality and quantity are estimated (and not calibrated). The quality of education is estimated to be three to four times more important for education than the quantity of education. The new measure has a strong link to productivity, which materialises with long lags. Productivity gains are much greater from improvements in the quality than quantity component of human capital.