Strong Hydrogen-bonding Interactions Research Articles

Structural Studies of Monounsaturated and ω-3 Polyunsaturated Free Fatty Acids in Solution with the Combined Use οf NMR and DFT Calculations-Comparison with the Liquid State.

Molecular structures, in chloroform and DMSO solution, of the free fatty acids (FFAs) caproleic acid, oleic acid, α-linolenic acid, eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) are reported with the combined use of NMR and DFT calculations. Variable temperature and concentration chemical shifts of the COOH protons, transient 1D NOE experiments and DFT calculations demonstrate the major contribution of low molecular weight aggregates of dimerized fatty acids through intermolecular hydrogen bond interactions of the carboxylic groups, with parallel and antiparallel interdigitated structures even at the low concentration of 20 mM in CDCl3. For the dimeric DHA, a structural model of an intermolecular hydrogen bond through carboxylic groups and an intermolecular hydrogen bond between the carboxylic group of one molecule and the ω-3 double bond of a second molecule is shown to play a role. In DMSO-d6 solution, NMR and DFT studies show that the carboxylic groups form strong intermolecular hydrogen bond interactions with a single discrete solvation molecule of DMSO. These solvation species form parallel and antiparallel interdigitated structures of low molecular weight, as in chloroform solution. This structural motif, therefore, is an intrinsic property of the FFAs, which is not strongly affected by the length and degree of unsaturation of the chain and the hydrogen bond ability of the solvent.

Roles of specific hydrogen-bonding interactions in the crystallization kinetics of polymers

Polyamides hold specific hydrogen-bonding interactions as the hierarchical thermodynamic driving forces for crystallization. Their roles in crystallization kinetics are worthy of further investigation. We performed dynamic Monte Carlo simulations to compare crystallization kinetics among 16-mer melts holding hydrogen-bonding interactions with variable strengths specifically assigned to 2, 4 and 8 monomers on the chain, respectively. The results demonstrate higher densities and strengths of hydrogen-bonding interactions generally accelerating the cooling and isothermal crystallization as well as the lateral growth of lamellar crystals, consistent with the experimental observations of polyamide crystallization. Too strong hydrogen-bonding interactions will slow down polymer diffusion and thus bring retardation to crystallization kinetics. Furthermore, hydrogen-bonding interactions at the central 8–9 monomers make higher crystal growth rates than those at the evenly distributed 5–12 monomers, demonstrating the dominant roles of specific interactions in the hierarchical parallel packing of polymer chains at the lateral growth front of lamellar crystals.

Effects of non-specific and specific solvation on structure of tripropylammonium-based protic ionic liquids: Insight from computational modeling

To explore the structure of three protic ionic liquids based on tripropylammonium cation and anions of strong acids – methanesulfonic, sulfuric, and triflic acids – we employed different computational methods, including quantum chemical calculations and molecular dynamics simulations. Solvation effects (non-specific and specific) were considered in order to evaluate the applicability of the methods used for the description of the ionic liquid’s structure. In each of the ionic liquids, we identified the cation–anion pair where a strong hydrogen bond and coulombic interactions kept the ions together. The results of both gas phase and implicit solvation calculations show an increase in the strength of the hydrogen bond and the magnitude of the ion-ion interaction energy in the ion pairs with tripropylammonium cation in the order of anions: triflate < hydrogen sulfate < mesylate, but the absolute values become smaller when going from the gas phase to the continuum medium. The molecular dynamics simulations reveal that the cation–anion pairs are preserved in the bulk phase of these liquids, but besides this, the formation of hydrogen bonds between anions in the tripropylammonium hydrogen sulfate is also possible.

Coordination Polymers with a Pyrazine-2,5-diyldimethanol Linker: Supramolecular Networks through Hydrogen and Halogen Bonds

In this paper, the synthesis and crystal structure of pyrazine-2,5-diyldimethanol (pyzdmH2, C6H8N2O2), a new symmetric water-soluble N,O-chelating tetra-dentate organic ligand, is reported and an environmentally friendly method is used to synthesize coordination compounds in water under ambient conditions, from the reaction of pyzdmH2 with the halide salts of Cu(II), Zn(II), Hg(II) and Cd(II): {[Cu(pyzdmH2)0.5(µ-Br)(Br)(H2O)]·H2O}n 1, {[Zn2(pyzdmH2)(µ-Cl)(Cl)3(H2O)]·H2O}n 2, [Hg2(pyzdmH2)0.5(µ-Cl)2(Cl)2]n 3, {[Cd2(pyzdmH2)(µ-Cl)4]·H2O}n 4, and {[Cd2(pyzdmH2)(µ-Br)4]·H2O}n 5. Single-crystal X-ray diffraction analysis reveals that 1–3 are 1D coordination polymers and 4 and 5 are 3D coordination networks, all constructed by bridging pyrazine-2,5-diyldimethanol and halogen ions. The hydroxyl groups in the organic linker extend the 1D chains to non-covalent 3D networks. In all non-covalent and covalent 3D networks, water molecules are trapped by strong hydrogen bond interactions. Supramolecular analysis reveals strong O-H···O, O-H···N, O-H···X, and weak C-H···O, C-H···X (X = Cl, Br) hydrogen bonds, as well as π-π(pyrazine ring), metal-halogen···π(pyrazine ring), and O-H···ring(5-membered chelate ring) interactions. In addition, X···O weak halogen bonds are present in 1–5 (X = Cl and Br).

Molecular Dynamics Studies of Mixtures of a Deep Eutectic Solvent and Cosolvents

All-atom molecular dynamics simulations have been performed on mixtures of tetrabutylammonium chloride-based deep eutectic solvent and two cosolvents — methanol and acetonitrile. Water, a highly polar protic solvent, strongly interacts with the DES components. Herein, we have chosen methanol, a protic solvent but less polar than water, and acetonitrile, an aprotic solvent, to investigate the structural modifications in DES and new interactions arising after the addition of cosolvent based on both polarity and the presence or absence of labile hydrogen. Of the two cosolvents, methanol is found to affect the interactions present in DES significantly. Strong hydrogen bond interaction occurs between the chloride anion and methanol, leading to changes in the behavior of the mixture at the microscopic level. The self-diffusivity of components of the DES increases with the addition of methanol and acetonitrile; however, the increase is relatively more significant in the latter due to fewer average numbers of H-bonds. The amplitudes of the peaks of the structure factor decrease with an increase in the cosolvent concentration, thereby confirming that cosolvent affects the long-range correlations.

Robust, waterproof, and degradable cellulose-based polyimine vitrimer for plastic replacement

The increasing application of non-degradable petroleum-based plastics has resulted in serious environmental pollution. Renewable and degradable cellulose-based materials are attractive candidates to replace petroleum-based plastics. However, the strong hydrogen bond (H-bond) interactions of cellulose result in its poor plastic formability such as thermoforming. Herein, a novel and effective thermoforming method of cellulose was developed by modifying cellulose into cellulose-based polyimine vitrimer (Cel-PI) via introducing dynamic imine bonds between cellulose molecular chains using Schiff-base reaction. The presence of dynamic imine bonds enables the heat-induced dynamic exchange and stress relaxation behavior of Cel-PI networks, making the excellent thermo-processability of Cel-PI. The as-synthesized Cel-PI powders can be easily thermoformed into Cel-PI film via heat-pressing approach without adding any plasticizers. The resulting Cel-PI film exhibits high Young’s modulus (2.9 GPa), high strength (46.3 MPa), good self-healing ability, excellent waterproof capability and organic solvent stability, and high thermal stability. Moreover, it can be chemically degraded, biodegraded, and recycled. Therefore, Cel-PI represents a promising and sustainable petroleum-based plastic replacement.

Choline Fluoride-Ethylene glycol deep eutectic solvent mixture – Synthesis and physicochemical properties

A critical factor in achieving tunability in DESs is varying the type of hydrogen bond acceptors (HBAs) and donors (HBDs). Choline halides (ChX), such as ChCl and ChBr, have been studied to investigate the effect of the choline anion on DESs. However, ChF-based DESs have been underrepresented in scientific research. ChF has excellent potential, such as high electron affinity, ionization potential, and strong hydrogen bond interactions. Moreover, ChF-based DES can lead to a deeper understanding of DESs due to the NMR-active 19F nuclear spin nature. We report the first synthesis and characterization of choline fluoride-EG (1:2, ChF:EG) DES, which we named “EthalineF.” We studied this mixture using various spectroscopic techniques, including NMR, FT-IR, Raman, and UV–vis spectroscopies. Polarity, density, viscosity, and conductivity measurements were collected as well. Transient absorption spectroscopy (TAS) was used to study the solvation dynamics of EthalineF. 19F NMR indicated that some fluoride anions (∼15%) are coordinated to the choline cation. In EthalineF, the new type of observed fluoride anions is proposed to be a tight-binding choline-fluoride ion pair. Further, EthalineF has a larger solvodynamic radius than Ethaline. This can explain the lower conductivity for EthalineF compared to Ethaline despite the higher fluidity and solvation dynamics for EthalineF.

Degradable Waterborne Polyurethane with Flame Retardancy and High Mechanical Strength via Synergy of Hydrogen Bonds

Waterborne polyurethane (WPU) with degradability is critical to the environment. Especially, degradable WPU with high mechanical strength and flame retardancy features various important industrial applications, while the increased flame retardancy often leads to reduced mechanical strength. Herein, we report the simultaneous realization of degradability, flame retardancy, and high mechanical strength into one design. The tensile strength of degradable WPU is up to 39 MPa and can be tuned by the ratio of soft segments. The strong synergistic hydrogen bond interactions of different components confirmed by FTIR and XPS as well as molecular dynamics simulation are responsible for the excellent mechanical strength. Moreover, WPU achieves the highest “V0” level of flame retardancy. The simultaneous realization of the stress of 35 MPa and a limiting oxygen index of 27.55% is obtained by changing the flame retardant contents. Importantly, WPU possesses degradability with a mass loss rate of 37% after natural burial in soil for 3 months. The dense WPU coatings can be adhered to different substrates and also have good anticorrosion ability. This work provides a promising strategy for high-performance biodegradable materials and expands the industrial application of polyurethane.

Discovery of phosphonate derivatives containing different substituted 1,2,3-triazole motif as promising tobacco mosaic virus (TMV) helicase inhibitors for controlling plant viral diseases.

The discovery and identification of targets is of far-reaching significance for developing novel pesticide candidates and increasing the probability of success. To explore and identify highly effective tobacco mosaic virus (TMV) helicase-targeted lead structures, a series of novel phosphonate derivatives containing a 1,2,3-triazole motif were rationally engineered and their antiviral activity was assessed. Bioassay results showed that the optimized B17 exhibited more potent curative activity (EC50 = 271.5 μg mL-1 ) against TMV in vivo, which was superior to that of commercial Ribavirin (EC50 = 689.3 μg mL-1 ). B17 presented a stronger binding capacity through binding analysis with helicase, affording a corresponding value of 12.7 μM. Enzyme activity assay showed B17 exhibited excellent inhibitory activity on TMV helicase (39.2% at 300 μM). Furthermore, molecular docking simulations demonstrated that B17 displayed strong hydrogen-bond interactions (2.1, 2.1, 2.2, and 3.2 Å) with Ala-33, Gly-10, Gly-8, and Glu-217 of TMV helicase. Encouragingly, transmission electron microscopy analysis revealed that B17 could remarkably disrupt surface morphology and inhibit TMV proliferation. Additionally, these compounds also displayed potential anti-CMV (cucumber mosaic virus) and antipathogens (Xanthomonas oryzae pv. oryzae and Xanthomonas axonopodis pv. citri) by expanding their applications in agriculture. Current research demonstrated that B17 could be considered as a potential antiviral agent alternative though targeting TMV helicase. © 2023 Society of Chemical Industry.

Natural deep eutectic solvent—A novel green solvent for protein stabilization

Natural deep eutectic solvents (NADESs) have been explored to provide a favorable environment for protein stabilization. In this context, NADESs were prepared with the molar ratio of trehalose to betaine ranging from 1:3 to 1:9 (NADES 1-3 to NADES 1-9). There was a strong hydrogen bond interaction between trehalose and betaine, and the interaction weakened with the reduction of trehalose. The NADES 1-7 had good thermal stability (−60–100 °C), low viscosity, and suitable pH (around 7). Trypsin had the highest relative enzyme activity in 50 % (v/v) NADES 1-7 under different temperatures, pH, and storage time. Furthermore, the changes in kinetic parameters indicated that the hydrogen bond environment of 50 % NADES 1-7 increased the contact between the substrate and the trypsin, speeding up the enzymatic reaction rate. This stabilizing effect mainly derived from the virtue of NADES 1-7 itself rather than the superposition of individual components. Additionally, spectral analysis revealed that the NADES 1-7 promoted trypsin conformational folding, effectively protecting the natural structure of trypsin. Importantly, the NADES 1-7 had good biocompatibility, further expanding its application.

Effectively recovering catechin compounds in the removal of caffeine from tea polyphenol extract by using hydrophobically modified collagen fiber

Previous research had proved that collagen fiber can be used as separation material for removing caffeine from tea polyphenol extract effectively. But the recovery rate of catechin compounds from collagen fiber column was quite low by using water and ethanol as eluent because of excessively strong hydrogen bond interaction between collagen fiber and polyphenols. To solve the problem, collagen fiber was hydrophobically modified in this work by using silane coupling agents with alkyl chains (butyl, octyl, dodecyl and octadecyl). FT-IR, DSC, SEM and EDS Mapping proved the successful grafting of alkyl chains on collagen fiber, leading to the significantly enhanced hydrophobicity of collagen fiber. Static adsorption showed that the adsorption capacity of EGCG decreased when the grafted alkyl chain length increased mainly relying on the weakened hydrogen bond interaction. Dynamic adsorption and elution behavior also indicated less retention capacity of EGCG on collagen fiber with higher hydrophobicity. In column separation of simulated tea polyphenol extract containing caffeine and catechin compounds, the collagen fiber grafted with octadecyls (CF(C18)) presented excellent separation efficiency for caffeine and catechin compounds, and simultaneously the catechin compounds were highly recovered. The recovery rates of EGC and EGCG were 2–7 times higher than those separated by pristine collagen fiber column and glutaradehyde crosslinked collagen fiber column developed in our previous work. In the reusing round of CF(C18) column, the chromatogram was almost the same as the first round, showing excellent reusability. In fact, the separation performance of CF(C18) to caffeine and catechin compounds was comprehensively superior to Sephadex LH-20, presenting great practical application potential in effectively removing caffeine from tea polyphenol extract and recovering catechin compounds.

Effect of different types of nanocellulose on the structure and properties of gelatin films

The use of nanocellulose to enhance the performance of biopolymer films is a recent trend in food packaging. This current study aims to investigate the impact of incorporating different morphologies of nanocellulose, namely cellulose nanofibrils (CNFs), cellulose nanospheres (CNSs), and cellulose nanocrystals (CNCs), on the structures and properties of gelatin film. The FTIR confirmed the formation of triple helix structures among CNF and CNC groups due to more hydrogen bonds generated between cellulose and gelatin molecules compared to CNSs. SEM analysis revealed a uniform distribution of CNCs in gelatin but aggregated with an increase in CNC contents, while CNF and CNS groups exhibited aggregation of cellulose upon the surface of gelatin because the vast surface area of nanospheres along with the nanofibrils structure led to irregular dispersion of cellulose (especially CNSs). In comparison to the CNF5% and CNS groups, CNC and CNF2% (w/w) groups greatly improved the mechanical characteristics of the gelatin films to 131.27% EAB and 20.71 MPa TS due to strong hydrogen bond interaction, more triple helix structures, and the relatively thorough dispersion of cellulose in the gelatin film. The incorporation of nanocellulose reduced the solubility and transparency of the gelatin films. Of all the films, CNC2% film exhibited a significant reduction of water vapor permeability due to the facile and even dispersion of CNCs in the gelatin network structure. Adding nanocellulose had little impact on the gelatin films’ heat stability. Therefore, the current work may be a new viable strategy for the construction of a novel molecular network system for enhancing the effectiveness of gelatin film containing lower content of CNCs.

The mimicked cell penetration peptides of chitosan derivates with low molecular weight for transdermal enhancement studies

The biomimetic chitosan derivatives synthesized by chemical coupling of L-arginine onto chitosan with low molecular weight, named Arg-CS, which was prepared by mimicking the arginine-rich peptides, to achieve the permeability performance of Cell-penetrating peptides (CPPs). The physicochemical properties of the Arg-CSs were characterized via Attenuated total reflection Fourier transform infrared (ATR-FTIR) and 1H-nuclear magnetic resonance spectroscopy (1H NMR), and high-performance liquid chromatography (HPLC). The thermal stability of Arg-CS was improved by approximately 80 °C, compared to the pure chitosan. The maximum cumulative amounts of aspirin for Arg-CS 4.7 k, Arg-CS 5.2 k, and Arg-CS 6.3 k were 32.85 µg/cm2, 22.98 µg/cm2, and 17.51 µg/cm2 at 8 h, respectively, presenting a phenomenon of increasing of aspirin permeation with decreasing molecular weight of Arg-CS. Arg-CS with low molecular weight was more conducive to improve the penetration of aspirin by changing the secondary structure of keratin from β-sheets to random coil. The molecular docking also suggested that Arg-CS had stronger affinity to keratin by strong hydrogen bond interactions. These results indicated that the nonirritant and thermally stable Arg-CS with lower molecular weight can be used to enhance the permeation of aspirin and applied in the field of transdermal drug delivery.

Identification of lignans as ATP citrate lyase (ACLY) inhibitors from the roots of Pouzolzia zeylanica

A new lignan, named pouzolignan P (1), together with 14 known ones (2 − 15) were isolated from the roots of Pouzolzia zeylanica (L.) Benn. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates were evaluated for their inhibitory activities toward the ATP citrate lyase (ACLY). Among them, four lignans, isopouzolignan K (3), gnemontanins E (5), gnetuhainin I (6), and styraxlignolide D (15) showed excellent ACLY inhibitory effect with IC50 values of 9.06, 0.59, 2.63, and 7.62 μM, respectively. These compounds were further evaluated for their cholesterol-lowing effects on ox-LDL-induced high-cholesterol HepG2 cells. Compound 15 emerges as the most potent ACLY inhibitor, which significantly decreased the TC level in a dose-dependent manner. In addition, molecular docking simulations elucidated that 15 formed a strong hydrogen-bond interaction with Glu599 of ACLY, which was an important site responsible for the enzyme catalytic activity.

Improved Stability and Catalytic Efficiency of ω-Transaminase in Aqueous Mixture of Deep Eutectic Solvents.

The efficient biosynthesis of chiral amines at an industrial scale to meet the high demand from industries that require chiral amines as precursors is challenging due to the poor stability and low catalytic efficiency of ω-transaminases (ω-TAs). Herein, this study adopted a green and efficient solvent engineering method to explore the effects of various aqueous solutions of deep eutectic solvents (DESs) as cosolvents on the catalytic efficiency and stability of ω-TA. Binary- and ternary-based DESs were used as cosolvents in enhancing the catalytic activity and stability of a ω-TA variant from Aspergillus terreus (E133A). The enzyme exhibited a higher catalytic activity in a ternary-based DES that was 2.4-fold higher than in conventional buffer. Moreover, the thermal stability was enhanced by a magnitude of 2.7, with an improvement in storage stability. Molecular docking studies illustrated that the most potent DES established strong hydrogen bond interactions with the enzyme's amino acid, which enhanced the catalytic efficiency and improved the stability of the ω-TA. Molecular docking is essential in designing DESs for a specific enzyme.

Endohedral doping of Ca12O12-X (X = Zn, Cd, and Hg) as hydrogen storage materials

The emergence of hydrogen storage materials has drawn a lot of insurmountable attention in the scientific community due to the burgeoning demand for energy. As hydrogen not only performs well in various processes but can also be used as a source of alternative energy when paired with a cell technology like a fuel cell, it has gained increased significance. Herein, efforts are being undertaken to create effective hydrogen storage materials based on Ca12O12 nanocages that have been endohedrally encapsulated with transition metals (TMs) (zinc, cadmium, and mercury). The synthesis of endohedrally doped Ca12O12 is a complex process that involves solid-state reaction and diffusion of the modelled dopant atoms (zinc, cadmium, and mercury) into the internal cage. Thus, DFT calculations herein provide valuable insights into the underlying mechanisms and properties of the resulting doped materials. For all the systems under study, quantum chemical calculations were carried out using density functional theory (DFT) and time-dependent DFT at the PBE0/def2SVP level of theory. The adsorption energies of 10H2@ Ca12O12, 10H2@ZndopCa12O12, 10H2@CddopCa12O12, and 10H2@HgdopCa12O12 systems were obtained in the range of −34.47 to 130.86 kcal/mol respectively and portrayed the efficient adsorption of H2 on the metal-encapsulated systems. Also, considerable stabilization of the systems was obtained with higher charge separation which evidently correlates with the adsorption energy parametric values. Strong hydrogen bond and van der waals interaction was observed as the dominant interactions with a considerable binding energy of −9.72 kcal/mol. The proposed designed H2-adsorbed metal-encapsulated Ca12O12 systems are effective systems for designing time-ahead hydrogen storage materials, according to the results of all investigations and global descriptions of reactivity.

Preparation of Polyoxometalate-Based Composite by Solidification of Highly Active Cobalt-Containing Polytungstate on Polymeric Ionic Liquid for the Efficient Isolation of Proteinase K.

A novel porous polyoxometalate (POM)-based composite (Co4PW-PDDVAC) was prepared via the solidification of water-soluble polytungstate (Co4PW) on the polymeric ionic liquid dimethyldodecyl-4-polyethylene benzyl ammonium chloride (PDDVAC) via a cation-exchange reaction. The solidification was confirmed by EDS, SEM, FT-IR, TGA, and so on. The strong covalent coordination and hydrogen-bonding interaction between the highly active Co2+ of the Co4PW and the aspartic acid residues of proteinase K endowed the obtained Co4PW-PDDVAC composite with excellent proteinase K adsorption properties. Thermodynamic investigations indicate that the adsorption behavior of proteinase K was consistent with the linear Langmuir isothermal model, giving an adsorption capacity as high as 1428 mg g-1. The Co4PW-PDDVAC composite was applied in the selective isolation of highly active proteinase K from Tritirachium album Limber crude enzyme fluid.

CuF2/MeOH-Catalyzed N3-Selective Chan-Lam Coupling of Hydantoins: Method and Mechanistic Insight.

An efficient and practical N-arylation of hydantoins with substituted aryl/heteroaryl boronic acids has been established, assisted by CuF2/MeOH under the base and ligand-free conditions at room temperature and open air. The protocol is general, and various N-arylated hydantoins have been prepared in excellent yields with exclusive regioselectivity. The CuF2/MeOH combination was explored further to furnish selective N3-arylation of 5-fluorouracil nucleosides. The efficiency of the protocol was also demonstrated with the gram-scale synthesis of the marketed drug, Nilutamide. A mechanistic study based on density functional theory calculations revealed that both hydantoin and MeOH are crucial for the generation of catalytically active copper species in the reaction process, in addition to their role as a reactant and solvent, respectively. The proposed reaction mechanism indicated that selective N3-arylation of hydantoin is favorable in MeOH, which helps initiate the catalytic cycle by forming a square-planner Cu(II) complex where strong hydrogen-bond interactions are observed. This study is expected to improve the understanding of Cu(II)-catalyzed oxidative N-arylation reactions and for the de novo design and development of Cu-catalyzed coupling reactions.

Efficient Europium Sensitization via Low-Level Doping in a 2-D Bismuth-Organic Coordination Polymer.

A new bismuth-organic compound containing 1,10-phenanthroline (phen) and 2,5-pyridinedicarboxylic acid (PDC) was synthesized and structurally characterized by single-crystal X-ray diffraction. The structure consists of 2-D {Bi(phen)(HPDC)(PDC)}n sheets wherein the PDC ligands bridge metal centers via three unique bonding modes. The 2-D sheets are further connected through strong hydrogen-bonding interactions to form a 3-D supramolecular network. The parent compound displayed yellow photoluminescence in the solid state at room temperature. Doping studies were undertaken to incorporate Eu3+ into the structure, statistically replacing Bi3+ in small quantities (1, 5, and 10 mol % Eu3+ relative to Bi3+). All three compounds displayed characteristic Eu3+ emission, with total quantum yields as high as 16.0% and sensitization efficiencies between 0.21 and 0.37 depending on the Eu3+ doping percentage.

Strong yet tough cross-linked oligosiloxane elastomer with impact-resistant and antifouling properties

Polyurea with strong hydrogen bond interactions has excellent mechanical strength, toughness, and strain-rate-dependent behavior. However, the too fast polymerization and lack of functions limit its applications. In this study, a high-strength polyurea elastomer with impact resistance and antifouling function was prepared with secondary amine–oligosiloxane nanoclusters and a diisocyanate-terminated polytetrahydrofuran (PTMG)-based prepolymer, where the nanoclusters provide mechanical strength and antifouling ability while the urea segments give elasticity and toughness. Due to the lower reaction activity of secondary amine groups, the polymerization rate decreases, so that the operation time can be extended to more than 60 min without gelation. The polyurea elastomers exhibit excellent tensile strength (7.7–28.2 MPa) and strain rate sensitivity (10.8–16.6 MPa). The dynamic mechanical tests demonstrate that it has good energy dissipation capacity (tan δ ＞ 0.3 at 25–30 ℃). Bioassays show that the polyurea elastomers exhibit excellent protein resistance and can effectively inhibit the adhesion of microorganisms (bacteria S. aureus, E. coli, and Pseudomonas sp., as well as diatom N. incerta). The polyurea elastomers exhibit good versatility and can be combined with Kevlar fabric through a simple dip-coating process to form a composite with puncture resistance force as high as 108.8 N, 10 times higher than that of the one-layer Kevlar fabric. The prepared polyurea elastomers are expected to find applications in flexible wear protection, marine antifouling, and biomedical engineering.