Strong Effect Research Articles

Camel FGF21 Protein Enhances FGF21 Signaling and its Targeted Compounds Screening.

The hormone Fibroblast Growth Factor 21 (FGF21), as a novel glucose and lipid metabolism regulator, has become a promising therapeutic target for metabolic disorders. Camel, the characteristic species adapted to arid and semi-arid desert climates, has shown exceptional ability for the regulation of lipid reserve and utilization. This study found camel FGF21 to have a stronger regulatory effect for downstream signaling compared to human and mouse through sequence analysis and FGF21 signal downstream markers detection. FGF21 protein has been found to have one potential drug-binding pocket, which has been predicted using the CavityPlus online platform. Four small compounds, resorcinol monoacetate, tropisetron, nylidrin, and stiripentol, targeting FGF21 protein have been screened by molecular docking using the UCSF DOCK6 program. The inhibitory concentration 50% (IC50) values of the four small compounds have been determined by MTT assay and the values have been simulated by the software GraphPad Prism. The biological effect testing has indicated the four compounds to be involved in the regulation of the FGF21 signaling pathway and serve as agonists for FGF21 signaling transduction. While the blocking experiment of compound and protein cotreatment has indicated the four small compounds to not inhibit FGF21-induced pathway activation. Even, resorcinol monoacetate and stiripentol have shown to synergistically activate downstream signaling pathways with the FGF21 protein. This study has provided new ideas for developing therapeutic strategies based on FGF21 protein modification and exploring novel disease treatment strategies based on the compounds-protein combination.

A dynamic bidirectional system of stress processes: Feedback loops between stressors, psychological distress, and physical symptoms.

Stress processes have long been of interest to researchers. A growing body of research explores the bidirectional relations between stressors, psychological and physical states. However, research on stress processes and their individual differences from a dynamic systems perspective is still lacking. This study examined dynamic feedback loops between stressors, psychological distress, and physical symptoms simultaneously using ecological momentary assessment. Three hundred and fifty-six participants completed five momentary assessments on stressors, psychological distress, and physical symptoms per day for 7 days in 2023. They also completed measures of their Big Five personality traits, depressive symptoms, and anxiety symptoms. Dynamic structural equation models showed positive cross-lagged and feedback effects of stressors with psychological distress and physical symptoms, suggesting their self-perpetuating loops. Agreeableness and conscientiousness were protective factors, and neuroticism was a risk factor for the stressor-psychological loop. Individuals with depressive and/or anxiety symptoms were characterized by (a) greater inertia of psychological distress and physical symptoms, (b) stronger reverse effects of psychological distress and physical symptoms on subsequent stressors, (c) significant reciprocal effects between psychological distress and physical symptoms, and (d) stronger self-perpetuating loops of stressors with psychological distress and physical symptoms. Our findings highlight the importance of analyzing feedback loops to understand bidirectional relations and individual differences in dynamic stress processes, providing insights for relevant personalized interventions. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

The Power of Storytelling in Influencing Social Crowdfunding Intention: A Case of a Non-Profit Organization in Indonesia

ABSTRACT This study examines the effectiveness of storytelling in enhancing social crowdfunding donations for nonprofit organizations. Using a sample of 708 respondents, partial least squares structural equation modeling (PLS-SEM) is employed to analyze the relationships between storytelling, prosocial motivations, trust in a social crowdfunding platform, and social crowdfunding donation intentions. The findings demonstrate that storytelling positively influences pleasure-based (desire to help) and pressure-based (sense of obligation) prosocial motivations, ultimately driving intentions to donate to social crowdfunding. Interestingly, pressure-based motivation exerts a stronger effect on the intention to donate. Additionally, this study highlights the crucial mediating role of trust in the social crowdfunding platform, suggesting the importance of the platform’s credibility in connecting pleasure and pressure-based prosocial motivation on the intention to donate to social crowdfunding. This is the first study to investigate social crowdfunding through the lens of consumer storytelling theory and pleasure and pressure-based prosocial motivation theory.

Herbivore regulation of savanna vegetation: Structural complexity, diversity, and the complexity–diversity relationship

AbstractLarge mammalian herbivores exert strong top‐down control on plants, which in turn influence most ecological processes. Accordingly, the decline, displacement, or extinction of wild large herbivores in African savannas is expected to alter the physical structure of vegetation, the diversity of plant communities, and downstream ecosystem functions. However, herbivore impacts on vegetation comprise both direct and indirect effects and often depend on herbivore body size and plant type. Understanding how herbivores affect savanna vegetation requires disaggregating the effects of different herbivores and the responses of different plants, as well as accounting for both the structural complexity and composition of plant assemblages. We combined high‐resolution Light Detection and Ranging (LiDAR) with field measurements from size‐selective herbivore exclosures in Kenya to determine how herbivores affect the diversity and physical structure of vegetation, how these impacts vary with body size and plant type, and whether there are predictable associations between plant diversity and structural complexity. Herbivores generally reduced the diversity and abundance of both overstory and understory plants, though the magnitude of these impacts varied substantially as a function of body size and plant type: only megaherbivores (elephants and giraffes) affected tree cover, whereas medium‐ and small‐bodied herbivores had stronger effects on herbaceous diversity and abundance. We also found evidence that herbivores altered the strength and direction of interactions between trees and herbaceous plants, with signatures of facilitation in the presence of herbivores and of competition in their absence. While megaherbivores uniquely affected tree structure, medium‐ and small‐bodied species had stronger (and complementary) effects on metrics of herbaceous vegetation structure. Plant structural responses to herbivore exclusion were species‐specific: of five dominant tree species, just three exhibited significant individual morphological variation across exclosure treatments, and the size class of herbivores responsible for these effects varied across species. Irrespective of exclosure treatment, more species‐rich plant communities were more structurally complex. We conclude that the diversity and architecture of savanna vegetation depend on consumptive and nonconsumptive plant–herbivore interactions; the roles of herbivore diversity, body size, and plant traits in mediating those interactions; and a positive feedback between plant diversity and structural complexity.

Spatiotemporal dynamics of irrigated cropland water use efficiency and driving factors in northwest China’s Hexi Corridor

BackgroundAgricultural irrigation is an important practice to safeguard crops against drought and enhance grain yield in arid regions. The Hexi Corridor, known as a classic arid region, faces significant pressure on agricultural production and food security due to the scarcity of water resources. There is an urgent need to investigate agricultural water use of the irrigated regions. Water use efficiency (WUE), defined as the ratio of gross primary productivity (GPP) to actual evapotranspiration (ET), serves as a valuable indicator linking carbon assimilation and water loss. It enables the quantification of areas where water can be utilized more effectively. However, the long-term spatiotemporal dynamics of WUE and driving mechanism in the irrigated areas of the Hexi Corridor remain unclear.ResultsThis study used GPP calculated by a light use efficiency model (EF-LUE), ET estimated by an ETMonitor model and irrigated cropland maps across China (IrriMap_CN) to examine the spatiotemporal dynamics of irrigated cropland WUE and its controlling factors in the Hexi Corridor from 2001 to 2018. The results are as following: (1) The average annual WUE was approximately 1.34 ± 0.38 g C kg−1 H2O yr−1, with an increasing trend of 0.012 g C kg−1 H2O yr−1, and faster growth observed during 2011–2018 compared to 2001–2010. (2) The contribution of GPP to WUE trends and WUE interannual variability (IAV) was greater than that of ET. (3) The dominant climatic factors of WUE IAV in the Hexi Corridor were SPEI, precipitation, and soil moisture. (4) The standardized Structural Equation Model (SEM), incorporating the relationship between WUE and factors such as water, energy, NDVI, and water-saving irrigation, explained 81% of the variation in irrigated cropland WUE. Here, biological factors (GPP and NDVI) were the primary factors influencing WUE variability, and water-saving irrigation had a stronger indirect effect than climate factors (water and energy) on variation in WUE.ConclusionsOur findings offer valuable theoretical insights into the mechanisms governing the interaction between the carbon and water of irrigated cropland, guiding the management of water resources and land in agricultural practices within the Hexi Corridor.

Activity of Common Thyme (Thymus vulgaris L.), Greek Oregano (Origanum vulgare L. ssp. hirtum), and Common Oregano (Origanum vulgare L. ssp. vulgare) Essential Oils against Selected Phytopathogens

The aim of this study was to determine the activity of common thyme (Thymus vulgare L.), Greek oregano (Origanum vulgare L. ssp. hirtum), and common oregano (Origanum vulgare L. ssp. vulgare) essential oils (EOs) against selected phytopathogenic microorganisms in relation to their chemical profile. The EOs were obtained from the herbs of 2-year-old plants cultivated in the organic farming system in a temperate climate in Central Europe. The EOs’ composition was determined by GC/MS and GC/FID. The investigated species were represented by the following three chemotypes: ‘thymol’ for common thyme, ‘carvacrol’ for Greek oregano, and mixed ‘caryophyllene oxide + β-caryophyllene’ for common oregano. The antimicrobial activity of the EOs was assessed based on minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) values. The plant pathogenic bacteria Pseudomonas syringae, Xanthomonas hortorum, Erwinia carotovora, and fungi: Fusarium culmorum, Alternaria alternata, Botrytis cinerea, Epicoccum purpurascens, Cladosporium cladosporioides, Phoma strasseri, and Pythium debaryanum were tested. The EOs revealed a stronger inhibitory effect against fungal growth in comparison to bacterial growth (MIC: 0.016–2 µL/mL for fungi and 0.125–4 µL/mL for bacteria). Common thyme and Greek oregano EOs indicated stronger antimicrobial power than common oregano EO. These results were associated with the chemical profile of the analysed EOs. The growth of examined bacteria and fungi strains (in particular, X. hortorum, F. culmorum, and P. debaryanum) were negatively correlated with the content of phenolic monoterpenes and monoterpene hydrocarbons. Among the tested strains, P. strasseri turned out to be the most sensitive (MIC 0.016 µL/mL) and E. carotovora the most resistant (MIC 0.250–4 µL/mL) to all investigated EOs.

In the gray zone: How representational deficit moderates the effect of openness on protest participation

This article investigates how the governmental status quo alters the effect of individuals’ openness as a predisposition for protest participation. We define the governmental status quo as individuals’ standing or position within the political system, contingent upon their party’s current status in government. Based on this, we clasify voters into three groups: Opposition voters, junior coalition partners’ voters (JCPV), and senior coalition partners’ voters (SCPV) or single-party government voters (SPGV). SCPV and SPGV are expected to have lower protest motivation due to their substantial governmental representation, whereas opposition voters, with lacking any governmental representation, are more likely to be motivated to protest. Nevertheless, given their fuzzy position that alleviates the effect of the representational deficit on their protest behavior, we argue that the protest participation of JCPV is more likely to be driven by their basic values belonging to the openness dimension. Statistical analyses based on data from the European Social Survey support our hypothesis, highlighting the stronger effect of stimulation, one of the components of the openness dimensions in Schwart's basic human values, for the JCPV compared to other voter categories.

Does Urban Green Space Pattern Affect Green Space Noise Reduction?

The effect of urban green spaces on traffic noise reduction has been extensively studied at the level of single vegetation, hedges, etc., but there is a lack of corresponding studies at the scale of spatial patterns of urban green spaces. Therefore, this study aims to analyze the relationship between the spatial pattern of urban green space and the change in green space’s noise reduction capacity. Through the morphology spatial pattern analysis method, this analysis divides the urban green space in the Fuzhou high-tech zone into seven types of elements with different ecological definitions and simulates the noise condition of the urban environment with the presence of green space as well as without the presence of green space by computer simulation, calculates the distribution map of the noise reduction produced by the urban green space, and analyzes the correlation between the seven types of green space elements and the noise reduction with the geographically weighted regression modeling analysis. The study finds that (1) Urban green space patterns can significantly affect the net noise reduction of green space. Areas with high green coverage can produce a stronger green space noise reduction effect. (2) More complex green space shapes and more fragmented urban green space can produce higher noise reduction. (3) The green space close to the source of noise can exert a stronger noise reduction effect. Therefore, in the process of planning and design, from the perspective of improving the urban acoustic environment, the configuration of high-quality green spaces in areas with higher levels of noise pollution should be given priority, which may have better noise reduction effects.

Risedronate prevents exercise-induced hypercalcemia but not nausea or vomit in humans: a double blind randomized controlled trial

Reportedly, nausea or vomiting after heavy exercise was associated with post-exercise increased blood calcium (Ca) levels, which was correlated with enhanced bone resorption. We conducted a randomized, double-blind, placebo-controlled trial, enrolling 104 healthy trained male members of the Japan Ground Self-Defense Forces. Risedronate (17.5 mg) or placebo was prescribed 3 and 10 days before heavy exercise lasting approximately 5 h. The primary outcome was the severity of nausea or vomiting assessed by a visual analog scale during or post-exercise. The secondary outcomes included clinical symptoms associated with heat illness, post-exercise serum total Ca (tCa), whole blood ionized Ca (iCa), and serum tartrate-resistant acid phosphatase 5b (TRACP-5b) levels. The mean age was 26 years. The exercise resulted in a 4.5% weight loss. The two groups were comparable in terms of the symptoms, including primary outcome. However, post-exercise tCa and TRACP-5b were significantly lower with risedronate. A similar result was observed for iCa. The post-exercise urinary Ca/Magnesium ratio and the incidence of hypercalcemia (defined as tCa or iCa levels ≥ each median value of all subjects) were significantly lower with risedronate (78.0% vs. 58.5%). A stronger treatment effect of risedronate on blood Ca levels was observed in participants who lost substantial body weight. Post-exercise hypercalcemia is attributed to enhanced bone resorption but not the cause of nausea.

Comparative study of influence of Cu, CuO nanoparticles and Cu2+ on rainbow trout (Oncorhynchus mykiss W.) spermatozoa.

The same elements can yield disparate nanoproducts that may elicit different harmful effects in cells and organisms. This study aimed to compare the effects of copper (Cu NPs) and copper oxide (CuO NPs) nanoparticles and Cu2+ (from CuSO4) on the physico-biochemical variables of rainbow trout spermatozoa. The cell death assay, along with the activation of caspases 8 and 9, the level of reactive oxygen species (ROS), and the percentage of cells exhibiting a high mitochondrial membrane potential (MMP) were quantified over 24-hour incubation. Interestingly, during exposure, all copper products induced cell apoptosis. However, Cu NPs had a stronger effect than CuO NPs, while the impact of the Cu in ionic form was found to be between the other two compounds. The extrinsic and intrinsic apoptotic pathways were activated, as evidenced by the activation of caspases 8 and 9. Initially, caspase activation increased without a corresponding decrease in MMPs but prolonged exposure resulted in a significant decrease in MMP levels. In all treated cells, the ROS levels increased over time. Further studies are needed to confirm the lower CuO NPs' toxicity compared to Cu NPs because their effect on cells also depends on many other parameters such as size or shape.

The Impact of Emotional Factors on L2 Learners Enjoyment and Anxiety in Foreign Languages

In light of the expansion of globalization and the intensification of cross-cultural communication, there is an increasing necessity to learn a second language (L2). However, many L2 learners face emotional challenges throughout the learning process, which affect their learning experience and outcomes. This paper explores the emotional experiences of Chinese learners of English as a L2 and their impact on learning outcomes. Theoretical frameworks from positive psychology and educational psychology are then employed to investigate the roles of foreign language enjoyment and foreign language anxiety, as well as the moderating effects of classroom environment and social support. The results show that foreign language enjoyment has a positive effect on learning outcomes, whereas foreign language anxiety has a detrimental effect. In the case of semantic-prefix incongruence, high-level learners exhibited stronger interference effects, which indicates the complexity of affective information processing. Therefore, the paper not only deepens the comprehension of emotional factors in foreign language learning, but also provides valuable insights into foreign language teaching practices, which indicates that teachers should prioritize students affective experiences, optimize classroom environments, and offer positive social support to promote their affective engagement and learning outcomes. Future research should further explore the differences in students affective experiences in different cultural contexts to achieve more comprehensive and personalized foreign language teaching goals.

Characterisation of potential anti-inflammatory next-generation probiotics resistant to bisphenol A.

The world is witnessing an increasing incidence of chronic non-communicable diseases (NCDs), such as inflammatory bowel disease (IBD), a group of complex gastrointestinal disorders characterised by inflammation. It is believed that environmental factors, such as exposure to pollutants and endocrine-disrupting chemicals (i.e. bisphenol A [BPA]), are playing a role in IBD pathophysiology. New research suggests a potential treatment solution: next-generation probiotic (NGP) strains isolated from human gut microbiota that can biodegrade xenobiotics and thus possibly modulate IBD triggered by these xenobiotics. In this study, we hypothesised that specific BPA-tolerant bacteria would exhibit beneficial, anti-inflammatory properties that could counter the effects of BPA exposure and concomitantly reduce colitis severity. We observed that two such strains, Bacillus sp. AM1 and Paeniclostridium sp., exhibited potential anti-inflammatory properties in vitro and in vivo. First, these bacteria were able to decrease the secretion of interleukin (IL)-8 cytokines by HT-29 cells that had been exposed to the proinflammatory cytokine tumour necrosis factor (TNF)-α. Second, when treated with Bacillus sp. AM1 and Paeniclostridium sp. (this latter had a stronger reducing effect on inflammatory markers), mice with chemically induced colitis displayed lower levels of colon damage, monocyte chemotactic protein 1 (MCP-1), lipocalin-2 (LCN-2), and proinflammatory cytokines (IL-1β and IL-6). Future research should clarify the underlying mechanisms at play and identify potential strategies for counteracting the systemic effects of IBD, including those exacerbated by BPA exposure. Our results suggest that one such strategy could be treatment with BPA-tolerant bacteria that possess anti-inflammatory properties.

In vitro evaluation of the clinical utility of Apitolisib/Vorinostat combination in Apitolisib-resistant H1975 lung adenocarcinoma cells

BackgroundThe PI3K signalling pathway regulates the metabolic activity of cells. Disruption by PI3K inhibitors causes an aerobic/anaerobic imbalance that decreases energy production and cell growth. Cancer cells adapt to PI3K inhibitors in order to reduce their effectiveness. Resistance to Apitolisib could be due to intrinsic factors or acquired adaptation. Oncologists often ask whether to discontinue Apitolisib, increase its dose, or use a drug combination.MethodsWe observed the proliferation of resistant cells in (H1975R+) and out (H1975R−) of Apitolisib treatment, cell cycle pattern, energy phenotyping/reprogramming, and the effects of combining Apitolisib with Vorinostat on the acquired proliferation of H1975R− cells.ResultsThe Proliferation of H1975R− cells increased, while that of H1975R+ cells remained suppressed. Both conditions showed a 5 × decrease in the number of cells at the Go/G1 phase and doubled at S and G2/M phases (p < 0.0001). Both H1975R− and H1975R+ cells exhibited decreased ECAR, with a stronger effect observed in H1975R+ cells (p < 0.0001). Oxygen consumption (OCR) increased significantly in H1975R− compared with that in H1975P (p = 0.02). The resistant cells became energetically active using mitochondrial respiration in drug-free medium; H1975R+ was hypo-energetic and consumed more free fatty acids (p = 0.0001). Ketone bodies in H1975R+ were increased by 40% and 2 × in BOHB and AcAc levels, respectively, compared to that in H1975P and H1975R− (p < 0.0001). H1975R− cell survival was 80% compared with 20% in H975R+ cells treated with 7 μM Vorinostat. Vorinostat effectively controlled acquired hyperproliferation of H1975R− cells.ConclusionIf a tumour becomes unresponsive to Apitolisib, it is advisable to continue the inhibitor and consider a combination with non-tyrosine kinase inhibitors.

Sex-dependent effects of acute stress and alcohol exposure during adolescence on mRNA expression of brain signaling systems involved in reward and stress responses in young adult rats

BackgroundAdolescent stress and alcohol exposure increase the risk of maladaptive behaviors and mental disorders in adulthood, with distinct sex-specific differences. Understanding the mechanisms underlying these early events is crucial for developing targeted prevention and treatment strategies.MethodsMale and female Wistar rats were exposed to acute restraint stress and intermittent alcohol during adolescence. We assessed lasting effects on plasma corticosterone (CORT) and adrenocorticotropic hormone (ACTH) levels, and mRNA expression of genes related to corticotropin releasing hormone (CRH), neuropeptide Y (NPY), corticoid, opioid, and arginine vasopressin systems in the amygdala and hypothalamus.ResultsThe main findings are as follows: (1) blood alcohol concentrations (BAC) increased after the final alcohol administration, but stressed males had lower BAC than non-stressed males; (2) Males gained significantly more weight than females; (3) Stressed females showed higher ACTH levels than non-stressed females, with no changes in males; (4) Stress increased CORT levels in males, while stressed, alcohol-treated females had lower CORT levels than non-stressed females; (5) CRH: Females had lower Crhr1 levels in the amygdala, while alcohol reduced Crhr2 levels in males but not females. Significant interactions among sex, stress, and alcohol were found in the hypothalamus, with distinct patterns between sexes; (6) NPY: In the amygdala, stress reduced Npy and Npy1r levels in males but increased them in females. Alcohol decreased Npy2r levels in males, with varied effects in females. Similar sex-specific patterns were observed in the hypothalamus; (7) Corticoid system: Stress and alcohol had complex, sex-dependent effects on Pomc, Nr3c1, and Nr3c2 in both brain regions; (8) Opioid receptors: Stress and alcohol blunted the elevated expression of Oprm1, Oprd1, and Oprk1 in the amygdala of males and the hypothalamus of females; (8) Vasopressin: Stress and alcohol interacted significantly to affect Avp and Avpr1a expression in the amygdala, with stronger effects in females. In the hypothalamus, alcohol increased Avp levels in females.ConclusionsThis study demonstrates that adolescent acute stress and alcohol exposure induce lasting, sex-specific alterations in systems involved in reward and stress responses. These findings emphasize the importance of considering sex differences in the prevention and management of HPA dysfunction and psychiatric disorders.

Difference in the toxic effects of micro and nano ZnO particles on L. minor - an integrative approach.

The toxicity of nano-sized ZnO particles (nZnO) was evaluated and compared to that of their micro-sized counterparts (mZnO) using an integrative approach to investigate the mechanism of toxicity, utilizing duckweed (Lemna minor) as plant model. Following 7days of exposure to nZnO or mZnO (2.5, 5, 25, and 50mg L-1) growth rate, photosynthesis, oxidative stress, and genotoxicity parameters have been determined in duckweed. Phytotoxicity of both ZnO forms at relatively low concentrations was due to the release of free Zn ions into the nutrient media. However, the accumulation of Zn in plants treated with nZnO was significantly higher than in those treated with mZnO. Both mZnO and nZnO significantly reduced growth rate and impaired the functionality of the photosynthetic apparatus as evidenced by structural changes of chloroplasts, a decline in the efficiency of photosystem II, and chlorophyll a content. Additionally, exposure to mZnO and nZnO resulted in the accumulation of reactive oxygen species (ROS), increased lipid peroxidation, the formation of carbonylated proteins, DNA damage, and alterations in antioxidant defense mechanisms. Overall, nZnO caused significantly stronger toxic effects than mZnO. The mechanism of nZnO toxicity to L. minor, as determined by multivariate statistical analysis, involved the disruption of primary photosynthetic reactions due to a redox imbalance in the cell caused by the enhanced absorption of Zn into plant tissues.

The time dependent influence of curvature and topography of biomaterials in the behavior of corneal endothelial cells

Among the different layers of the cornea, the corneal endothelium, which is composed of corneal endothelial cells (CEC), plays a key role in the maintenance of cornea transparency. Based on the donor shortages and the limitations associated with transplantation, in this work we have developed collagen hydrogels with different patterned structures on the surface to provide topographies in ranges similar to the natural environment that CEC sense. This aimed at stimulating cells to maintain a typical CEC phenotype and provide alternatives to corneal transplantation. In this sense, we have elaborated curved collagen hydrogels (concave and convex) with three different topographies (50, 200 and 300 µm grooves), with the help of 3D printed mold and replicating the mold with the collagen hydrogel, onto which CEC were cultured in order to analyze its behavior. Flat hydrogels were used as controls. Cell morphology, cell circularity and gene expression of ATP1A1 and ZO-1 genes were analyzed after 3 and 6 days. Results showed an effect of the curvature and the topography compared to flat collagen hydrogels, showing higher expression of ZO-1 and ATP1A1 in curved non-patterned hydrogels at day 3. The patterned hydrogels did not have such a significant effect on gene expression compared to flat hydrogels, showing stronger effect of the curvature compared to the topography. The effect was opposite at day 6, showing higher gene expression at days 6 on the patterned hydrogels, especially for the ZO-1 gene. The gene expression results were in accordance with the cell morphology observed at the different time points, showing circularities closer to hexagon like morphology at shorter time points. Overall, this platform can serve as a system to culture cell under proper environment to further be able to transplant a CEC monolayer or to allow transplantation of thin collagen layers with cultured CEC.

Impact of Environmental Regulation on the Resilience of Marine Economy: A Case Study of 11 Coastal Provinces and Cities in China

Enhancing marine economic resilience is a necessary response to both domestic and international shocks, and it is also key to achieving the sustainable development of the marine economy. In recent years, rising uncertainties both domestically and internationally have posed significant challenges to the resilience of China’s marine economy. In response, China has continuously strengthened its environmental regulations, influencing the resilience of its marine economy through various environmental regulations. This paper measures marine economy resilience index using panel data from 11 coastal provinces and municipalities in China from 2010 to 2019. It empirically examines the direct impact, spatial spillover effects, and mediating mechanisms of environmental regulations on marine economy resilience. The results show that: (1) Environmental regulations significantly enhance the resilience of the marine economy. Among the various environmental regulation tools, command-and-control regulations have a stronger effect in promoting marine economic resilience compared to market-incentive regulations. (2) Environmental regulations exhibit spatial spillover effects in enhancing marine economic resilience, and the spatial influence of different regulatory tools is heterogeneous. (3) The optimization of marine industrial structure serves as a crucial avenue for environmental regulations to enhance the resilience of the marine economy. This study offers theoretical support and a scientific basis for the adjustment and optimization of environmental regulations and the enhancement of marine economic resilience, while also contributing to the sustainable development of the marine economy.

Influence of solar thermal radiations and convective boundary on Al2O3/H2O transient model efficiency

Riga plate is a new, sophisticated magnetic field device that may be created by adjusting a group of permanent magnets and a different electrode over a plane surface. The heat transport and fluid movement in such physical setup are of paramount interest and have numerous engineering and industrial application particularly in submarines technologies. Due to the fixed magnetics the field produced which imperatively affect the model dynamics. Keeping in mind the influential applications of such physical setup, the purpose of this study is to introduce a new model based scrutinization of heat transport of stagnation point flow of Al2O3/water along vertically oriented convectively heated Riga surface. The conventional stagnation point flow model extended for nanofluid via radiative heat flux, dissipation effects and the first order thermal slip. The values of thermal conductivity values estimated via Corcione model and achieved the final nanoliquid model. For the results interpretation, the numerical scheme used and portrayed the results using different parametric ranges. The fluid motion is observed very slow due to stronger mixed convection and higher concentration of Al2O3 nanoparticles. The temperature is determined very high against the stronger convection effects and radiation number. However, the fluid layers in the vicinity of Riga surface have high heat transmission ability. Further, thermal slip and viscous dissipation effects also boost the temperature of Al2O3/water. Further, buoyancy number δ resists the fluid movement and thermal boundary region reduces in the presence of buoyancy factor.

Does greater filial piety bring more gender income advantages? Exploring the influence of traditional Chinese filial piety on the gender wage gap

PurposeBased on traditional Chinese filial piety, this article examines the impacts and mechanisms of the two-dimensional filial piety concept “Qinqin – Zunzun” on gender wages in China via China Family Panel Studies (CFPS) conducted in 2014 and 2018.Design/methodology/approachThis article construct regression models to examine the relationship between filial piety concepts and wages. Also, it uses unconditional quantile regression and decomposition to explore the impact of filial piety concepts on the wage gap.FindingsIt is found that: (1) The effects of two-dimensional filial piety are heterogeneous in terms of gender. Specifically, authoritarian filial piety significantly suppresses individual wages and has a stronger suppressive effect on women’s wages, whereas affinity filial piety significantly enhances individual wages without gender heterogeneity; (2) Parents' time support in the intergenerational exchange model is a crucial mechanism by which filial piety affects wages, exhibiting significant gender heterogeneity; (3) Regarding wage distribution, authoritarian filial piety mainly widens the gender income gap in the low and middle income-groups, while affinity filial piety narrows the gender wage gap by “raising the floor”, with its converging effect being most significant in the middle and high-income groups. This article deepens the understanding of the gender wage gap and intergenerational income mobility, providing policy references for better utilizing the social governance function of culture.Originality/valueThe article deepens the understanding and mechanisms of the gender wage gap and inter-generational income mobility, providing policy reference for better utilizing the social governance function of culture.

Breaking boundaries: the influence of social insurance collection system reform on corporate innovation strategies

ABSTRACT This study employs a staggered difference-in-differences (DID) approach to explore the impact of the exogenous shock policy of the Social Insurance Collection System Reform (SICSR) on corporate innovation strategies in China. The findings suggest that SICSR has a significant positive effect on corporate breakthrough innovation, while it does not impact incremental innovation. Moreover, the study finds that the impact is more pronounced among non-state-owned enterprises and enterprises with high-labour-intensity. Additionally, a mechanism analysis reveals that SICSR has a stronger promotional effect in regions characterized by high levels of marketization, while this effect diminishes as the level of corruption increases.