Strong Bonds Research Articles

Self-Reinforcing Ionogel Bioadhesive Interface for Robust Integration and Monitoring of Bioelectronic Devices with Hard Tissues.

Integrating bioelectronic devices with hard tissues, such as bones and teeth, is essential for advancing diagnostic and therapeutic technologies. However, stable and durable adhesion in dynamic, moist environments remains challenging. Traditional bioadhesives often fail to maintain strong bonds, especially when interfacing with metal electrodes and hard tissues. This study introduces a self-reinforcing ionogel bioadhesive interface (IGBI) combining silk fibroin and calcium ions, designed to provide robust and conductive integration of bioelectronic devices with hard tissues. The IGBI exhibits strong adhesion (up to 186Jm-2) and undergoes mechanical self-reinforcement through a structural transition in silk fibroin under physiological conditions. In vivo experiments demonstrate the IGBI's effectiveness in repairing bone defects and reimplanting teeth, with the added capability of wireless, real-time monitoring of bone healing. This approach allows for continuous tracking of tissue regeneration without a second invasive surgery for device removal. The IGBI represents a significant advancement in bioelectronic integration, offering a durable and versatile solution for challenging environments. Such unique self-reinforcing properties make the IGBI a promising material for biomedical applications where traditional adhesives are insufficient.

Computational investigation of naturally occurring anticancer agents in regulating Hedgehog pathway proteins.

Embryonic development in humans is controlled by the Hedgehog pathway, which becomes inactive in mature tissues. Except for tissue maintenance and healing, activation of this pathway results in tumorigenesis with only a few exceptions. The drugs currently in use have shown no effectiveness in blocking the key proteins responsible for tumorigenesis. Therefore, it is crucial to find new inhibitors that can stop the abnormal activation of the pathway. A preliminary Insilco screening of naturally occurring compounds was carried out to identify potential inhibitors of the pathway. Docking of seventeen naturally occurring antitumorigenic compounds against the four key proteins of the regulatory proteins of the Hedgehog pathway using AutoDock v4.2.6 software was carried out. Liriodenine exhibited the strongest binding affinity towards three out of the four regulatory proteins (-7.61 kcal/mol with Smoothened, -8.14 kcal/mol with Patched-I, and -6.15 kcal/mol with Gli-II) of the Hedgehog pathway, whereas 2',4-dihydroxy-3-methoxychalcone displayed the highest binding affinity of -7.04 kcal/mol with the Sonic Hedgehog protein. Additional molecular dynamic simulation was conducted using Gromacs with Liriodenine and 2',4-dihydroxy-3-methoxy chalcone. Every protein-ligand complex underwent simulation using v5.1.4 software for a duration of 100 nanoseconds. The findings from the simulation indicate that Liriodenine and 2',4-dihydroxy-3-methoxy chalcone form a strong bond with their corresponding protein. Our findings show that the two aforementioned molecules have potential as new inhibitors of the pathway and should be further investigated in both invitro and in vivo experiments.

The design and preparation of PDI modified NH2-MIL-101(Fe) for high efficiency removal of dimethoate in peroxymonosulfate system: Performance, mechanism, pathway and toxicity assessment

The widespread use of organophosphorus pesticide dimethoate (DMT) in agriculture poses a threat to human health. In this work, the perylene tetracarboxylic diimide (PDI) modified NH2-MIL-101(Fe) (PDI/MIL) with strong covalent bond C(=O)–N were designed and prepared by a step solvothermal method. The synergistic effect between photocatalytic and peroxymonosulfate (PMS) activation for the DMT elimination over PDI/MIL was gained. Interestingly, PDI/MIL(1:10)/PMS showed boosting degradation efficiency (95.6%) for DMT under 18 min simulated sunlight irradiation. Its apparent reaction rate constant was 24.7 times higher than that of NH2-MIL-101(Fe)/PMS. Moreover, its reusability, stability and mineralization ability were evaluated, and a remarkable mineralization rate of 95.3% with 90 min was achieved. The enhanced activity were attributed to the formation of amide bond that exhibited superior charger transport ability and amount of produced active species. Combined the results obtained from the HPLC-MS and molecular structure characteristics of DMT analyzed by Fukui index, the degradation pathways were proposed. The toxicity of intermediates were predicted by Ecological Structure Activity Relationship (ECOSAR), Toxicity Estimation Software Tool (T.E.S.T.), and Vibrio fischeri experiments. Our work provided deep insights into the mechanisms of DMT degradation via photocatalysis-activated PMS over organic semiconductor modified metal organic frameworks.

Optimized strategy for induction cladding of diamond/Ni-based wear-resistant coatings

Diamond/Ni-based wear-resistant coatings were fabricated on 45 steel using induction cladding, followed by laser remelting of the gradient coatings. The microstructure, phase composition, hardness, and friction properties of the coatings were examined. Results revealed that the surfaces of the composite and gradient coatings primarily consisted of a hard γ-Ni matrix and phases such as diamond, Cr7C3, and Cr23C6. High-temperature diffusion results in a strong metallurgical bond between the coating and the substrate. The gradient coating design significantly reduce the physical property mismatch between the 45 steel substrate and the composite coating. While laser remelting increased chromium aggregation and achieved a more uniform distribution of Fe, Ni, and Si. XRD analysis indicated that the Ni2Si diffraction peaks disappeared. Concurrently, the surface roughness and wear loss of the coating decreased, while the microhardness of the surface layer increased to 1030.74 HV, enhancing surface wear and corrosion resistance performance.

Explorasi Dinamika Psikologis Dampak Celebrity Worship pada Remaja yang Memiliki Fan-Account

The rapid development of technology and easy access to social media platforms have strengthened the relationship between fans and celebrities, creating a strong emotional bond, known as the phenomenon of celebrity worship. This study aims to identify the impact of celebrity worship on adolescents who have fan accounts on social media, using qualitative survey methods and mixed-method analysis. Data were obtained from 123 adolescent participants (12-18 years old) who actively idolize celebrities and have fan accounts. This study provides different results from previous literature studies on the impact of celebrity worship. The results showed that the majority of participants reported positive impacts, such as increased motivation, positive emotions, and self-improvement in the affective and behavioral dimensions. On the other hand, negative impacts were also found, such as decreased emotional regulation, decreased self-control, and tendencies towards violence on the internet. Cognitive impacts showed increased mental resilience and emotional regulation in most fans. Although celebrity worship can have a positive influence in terms of motivation and self-quality, this phenomenon can also be at risk of reducing mental health and triggering conflict between fans.

Dewetting dynamics of metal/metallic coated ceramic systems at high temperatures

This work focuses on kinetic analysis of high-temperature dewetting at metal/ceramic interfaces. Metal films were deposited on ceramics via magnetron sputtering, followed by wetting tests with tin, aluminum, and copper droplets. Results revealed asymmetric wetting-dewetting, indicating strong chemical bonds instead of reversible physical ones at high temperatures, deviating from traditional model predictions. Current room-temperature dewetting models (including hydrodynamic model, molecular kinetic theory and the combined model) fail to accurately describe high-temperature dewetting dynamics on metallized ceramics. Dewetting is governed by the metal film diffusion in droplets or the decomposition reaction kinetic at triple line, seen in diffusion-limited model in Sn/Ag-Ti on ZrO2 and Sn/FeCoNiCrCu coated h-BN, and decomposition reaction model in Cu/FeCoNiCrCu on sapphire. These insights are crucial for designing stable high-temperature metallurgical interfaces.

Low carbon footprint lightweight GPM production: Optimization of carbon fiber and hydrogen peroxide

This study examines the effects of using Carbon Fiber (CF) and Hydrogen Peroxide (H2O2) on the mechanical and thermal properties of ground Raw Perlite (RP) based Geopolymer Mortar (GPM). It focuses on determining the optimal dosages of CF and H2O2. This study aims to make perlite-based GPMs that form strong bonds with alkali activators lightweight, while also improving their compressive, tensile, flexural, and thermal properties. Sodium Silicate (Na2SiO3) and Sodium Hydroxide (NaOH) were used as alkali activators, while H2O2 served as the foaming agent. The NaOH solution was 13 M, and Na2SiO3 was used with a 2-module specification. In this context, a reference GPM was prepared using RP and Crushed Sand (CS). CF was chosen for its advantages, such as low density, high Young's modulus and tensile strength. Various amounts of CF and H2O2 were used to determine the optimal dosage to achieve a durable and lightweight mortar. The results showed that the best performance was achieved with 1 % CF and 1 % H2O2. Compressive strength increased to around 3.5 MPa with the addition of 2 % H2O2 and 2 % CF. It was found that the use of CF provided significant protection in compressive and flexural strength, but increasing the fiber weight or volume ratio beyond a certain dosage could decrease strength efficiency. These findings support the use of 6 mm CF as a reinforcing material in GPMs within the construction industry while emphasizing the need to avoid exceeding a 2 % H2O2 ratio. The results of this research can be considered an important step toward developing environmentally friendly and durable building materials.

Experimental studies on the physical and mechanical properties of modified silica/graphene reinforced polyamide6/copolyester elastomer blend nanocomposites

AbstractCompatibility of epoxy extrusion and injection molding was used to create a series of polyamide6 (PA6)/ copolyester elastomer (CoPe)/nano‐silica (nS) and graphene nanoplatelets (nG) composites. The impact of surface‐modified nanofillers and loading on the composites' physical and mechanical properties were investigated. As a consequence, PA6/CoPe blend with silane‐treated nS and nG composites had a slight drop in elongation but a significant gain in strength and modulus than PA6/CoPe blend. The interlaminar shear strength of the nG‐filled PA6/CoPe blend was increased by up to 33.5%, a maximum of 37.55 MPa, with a 1.5 wt% nG loading. With the 1.5 wt% nG loading on the blend surface, the ep resin compatibilizer assisted in interfacial bonding between the matrix and nanoparticles. The impact strength of the PA6/CoPe blend was found to be greater due to the existence of a tougher PA6 matrix, which was subsequently increased by the addition of nS filler reinforcement in the PA6/CoPe/nS composite. The addition of 1.5 wt% of nG in PA6/CoPe blend improved the tensile strength and elastic modulus by 15.8% and 15.1% compared to PA6/CoPe blend, respectively. Scanning electron microscopic studies revealed that the composite had a continuous PA6 phase and a dispersed CoPe phase. The nS and nG particles were embedded in the PA6/CoPe blend exclusively at 1.5 wt% loading. Microstructure analysis reveals a strong contact between the silane‐treated nS and nG and the polar PA molecules, and it may be responsible for the increased mechanical properties.Highlights 1.5 wt% nanoplatelets (nG) boosted tensile strength by 15.8% in polyamide6/copolyester elastomer blend. nG addition increased elastic modulus by 15.1% in the composite. Nano‐silica reinforcement enhanced impact strength with tough polyamide6 matrix. Silane‐treated nano‐silica and nG improved mechanical properties via strong bonds. Slight reduction in elongation observed with nanofiller addition.

Unraveling the mechanistic effects of oxidation and ionization on polydopamine-Pb(Ⅱ) interaction: MD and DFT study

Polydopamine (PDA), recognized for its straightforward synthesis and multifunctional groups, serves as an effective adsorbent for lead ions (Pb(II)). The structures of PDA are affected by different oxidation and ionization degrees, consequently influencing the adsorption performance for Pb(Ⅱ). Despite its extensive use, the detailed microscopic mechanisms by which these modifications affect Pb(II) adsorption remain poorly understood. In this study, all-atom molecular dynamics (AAMD) and density functional theory (DFT) simulations were employed to elucidate the interactions between PDA and Pb(II) under varying conditions of PDA’s ionization and oxidation. Enhancing PDA's ionization and oxidation degrees can effectively boost Pb(II)'s adsorption capacity. Specifically, heightened ionization significantly amplifies adsorption, as evidenced by the transfer of PDA monomer to the 6p vacant orbital of Pb(II), fostering strong coordination bonds through increased electron density. Meanwhile, escalated oxidation levels of PDA facilitate enhanced aggregation among polydopamine monomers, forming a more porous structure. Furthermore, oxidation activates inner orbital electrons within the polydopamine monomer, elevating electron transfer efficiency between PDA and Pb(II). These insights clarify the role of ionization and oxidation in optimizing PDA's performance as a Pb(II) adsorbent and provide valuable guidance for the design of advanced materials for heavy metal removal.

Global trends in sports programs to improve family health and resilience: a systematic review as an effort to achieve well-being

Lack of physical activity in daily life can lead to serious health problems, such as obesity, heart disease, and mental health disorders that negatively impact family resilience. Therefore, exercise is important to improve the health of family members, reduce the risk of disease, and strengthen social relationships, all of which contribute to better family resilience and well-being. Given the importance of exercise for health, this study focuses on How exercise programs can holistically improve family health and well-being. This study explored the relationship between exercise programs and their impact on family health, resilience, and well-being. The method used is a systematic literature review (SLR), which includes the selection of literature from various academic databases, Scopus, PubMed, Semantic Scholar, and Google Scholar, by setting clear inclusion and exclusion criteria to ensure the relevance and quality of the research and obtaining data that is worthy of being analysed as many as 23 scientific articles. Data analysis using the help of biblioshiny and NVivo. The results of this review indicate that participation in exercise programs improves individuals' physical and mental health and strengthens emotional and social relationships within the family, resulting in stronger bonds between family members. These findings highlight the importance of policies supporting family participation in physical activity and developing inclusive and flexible sports programs to address the challenges families face. Recommendations for future research include exploring the accessibility of sports programs for all population segments and paying attention to the potential negative impacts of involvement in organized sports. This study provides valuable insights into the vital role of sport in creating healthy and resilient families in a changing era.

Synthesis and multifaceted evaluation of novel AgCZ nanocomposite for targeted anti-angiogenic cancer therapy

Angiogenesis is the formation of blood vessels from the existing vasculature, which is important in the tumor growth where the metastatic spread, of cancer cells depends on an adequate supply of oxygen and nutrients and the removal of waste products. Targeting angiogenesis has emerged as a promising therapeutic strategy for cancer treatment. This study presents the synthesis and evaluation of a novel Ag-CeO2-ZnO (AgCZ) nanocomposite designed to specifically inhibit angiogenesis for effective cancer therapy. The nanocomposite was synthesized via a glycine-assisted combustion method, and its physicochemical properties were meticulously characterized using advanced analytical techniques. The anti-angiogenesis potential of the AgCZ nanocomposite was vigorously explored through an assortment of in vitro investigations, with a particular interest in inhibiting agents like vascular endothelial growth factor (VEGF). In silico data from molecular docking studies were instrumental in elucidating the nanocomposite’s primary reported mechanism of action, i.e., its strong VEGF target bond. Notably, the nanocomposite had selective cytotoxicity with different types of cancer cells and no sign of serious influence onto normal cells, reflecting great promise of the targeted cancer therapy. Not and importantly, nanocomposite was implemented in vitro studies to measure its anti-angiogenic as well as anti-tumor effect in biological models additionally. Our study highlights emerging developments in medicine and draws possible future paths. The use of AgCZ composite nanoparticle is one of the potential anticancer drug and alternative to the conventional medicine which appears to be safer and more effectual, but further research is needed to overcome current limitations in clinical translation.

Implications of incorporating CrFeNiTiZn high-entropy alloy on the tribomechanical and microstructure morphology behaviour of A356 composites processed by friction stir processing

Abstract This study investigated the impact of incorporating a CrFeNiTiZn High Entropy Alloy (HEA) into the A356 aluminum matrix through the friction stir processing (FSP) technique. The CrFeNiTiZn HEA, renowned for its compositional complexity and high-performance potential, was incorporated into the A356 alloy with different weight percent combinations to enhance its mechanical and tribological characteristics. The results revealed a refined microstructure characterized by solid solution phases and potential intermetallic compound formation due to the HEA addition for A356/2 %Cr2 %Fe2 %Ni2 %Ti2 %Zn composition. Strong interfacial bond strength was also observed among the matrix and reinforcement particles for the A356/2 %Cr2 %Fe2 %Ni2 %Ti2 %Zn composition. The number of grains was found to be about 1820.34 (average grain size is 686 µm) for A356/2 %Cr2 %Fe2 %Ni2 %Ti2 %Zn processed composite with FSP per square inch at 500 magnifications. The A356/2 %Cr2 %Fe2 %Ni2 %Ti2 %Zn composite exhibited improved tensile strength (35.70 %) and hardness (63.33 %) after the addition of 2 %Cr2 %Fe2 %Ni2 %Ti2 %Zn into A356 alloy, attributed to the strengthening effect of HEA particles. Furthermore, wear resistance is notably enhanced, likely due to the synergistic effects of the HEA’s inherent hardness and the modified microstructure.

Synergistic effects of interstitial and substitutional doping on the thermoelectric properties of PbS

Lead sulfide (PbS) is widely recognized as a promising n-type thermoelectric material for use in the middle-temperature range. Although it already exhibits favorable electronic and thermal properties, its thermoelectric performance could be further enhanced by addressing the disparity between the light and heavy bands in the conduction band, thereby optimizing electrical transport, and by modifying the strength of its chemical bonds to reduce lattice thermal conductivity. In this study, we demonstrate that introducing just small amounts of antimony (Sb) into PbS generates a unique combination of interstitial and substitutional doping that leads to a significant improvement in both directions. Substitutional doping enhances the degeneracy between the light and heavy bands, increasing carrier mobility. At the same time, interstitial doping introduces a new resonance state near the Fermi level, providing an additional channel for electron transport while boosting carrier concentration. These synergistic effects lead to a marked increase in the power factor of PbS, achieving an average power factor (PFavg) of 1.07 mW m−1 K−2 across the temperature range of 320–873 K. Moreover, Sb substitution for Pb induces a shift in the surrounding S atoms toward Sb, weakening their bonds with neighboring Pb atoms. This shift results in a coexistence of strong and weak chemical bonds, which effectively reduces lattice thermal conductivity. Additionally, the defect structures introduced by Sb doping effectively scatter phonons, further lowering lattice thermal conductivity. As a result, PbS doped with 0.5% Sb exhibits a figure of merit (ZT) of 0.73 at 873 K, which is approximately three times higher than that of undoped PbS.

Strong Bonding of Lattice N Activates Metal Ni to Achieve Efficient Water Splitting.

Developing efficient and robust free-standing electrocatalysts for overall water splitting is a promising but challenging task. Herein, the N-incorporated Ni nanosheets non-fully encapsulated by N-doped carbon (NC) layer are fabricated (N─Ni©NC). The introduction of N not only regulates the size of nanosheets in N─Ni©NC but also promotes the electrochemical activity of metal Ni. Experimental and theoretical results reveal that strong bonding of the lattice N activates the inert metal Ni by promoting charge transfer between Ni and N. In addition, the upward shift of the d-band center induced by lattice N enhances the adsorption of intermediates, thereby making Ni as a new OER active site together with C. This strategy of generating Ni and C dual active sites by introducing lattice N greatly accelerates oxygen evolution reaction (OER) kinetics, resulting in excellent electrocatalytic performance of N─Ni©NC. At the current density of 10mA cm-2, the overpotentials of hydrogen evolution reaction (HER) and OER are 27 and 206mV, respectively, and the cell voltage for overall water splitting only needs 1.47V. This work offers a unique heteroatom activation approach for designing free-standing electrodes with high activity.

Lignocellulose-Mediated Functionalization of Liquid Metals toward the Frontiers of Multifunctional Materials.

Lignocellulose-mediated liquid metal (LM) composites, as emerging functional materials, show tremendous potential for a variety of applications. The abundant hydroxyl, carboxyl, and other polar groups in lignocellulose facilitate the formation of strong chemical bonds with LM surfaces, enhancing wettability and adhesion for improved interface compatibility. Beyond serving as a supportive matrix, lignocellulose can be tailored to optimize the microstructure of the composites, adapting them for diverse applications. This review comprehensively summarizes the fundamental principles and recent advancements in lignocellulose-mediated LM composites, highlighting the advantages of lignocellulose in composite fabrication, including facile synthesis, versatile interactions, and inherent functionalities. Key modulation strategies for LMs and innovative synthesis methods for functionalized lignocellulose composites are discussed. Furthermore, the roles and structure-performance relationships of these composites in electromagnetic shielding, flexible sensors, and energy storage devices are systematically summarized. Finally, the obstacles and prospective advancements pertaining to lignocellulose-mediated LM composites are thoroughly scrutinized and deliberated upon. This review is expected to provide basic guidance for researchers to boost the popularity of LMs in diverse applications and provide useful references for design strategies of state-of-the-art LMs.

Hexafluorophosphate-Triggered Hydrogen Isotope Exchange (HIE) in Fluorinated Environments: A Platform for the Deuteration of Aromatic Compounds via Strong Bond Activation.

There is a perpetual need for efficient and mild methods to integrate deuterium atoms into carbon frameworks through late-stage modifications. We have developed a simple and highly effective synthetic route for hydrogen isotope exchange (HIE) in aromatic compounds under ambient conditions. This method utilizes catalytic amounts of hexafluorophosphate (PF6-) in deuterated 1,1,1,3,3,3-hexafluoroisopropanol (HFIP-d1) and D2O. Phenols, anilines, anisoles, and heterocyclic compounds were converted with high yields and excellent deuterium incorporations, which allows for the synthesis of a wide range of deuterated aromatic compounds. Spectroscopic and theoretical studies show that an interactive H-bonding network triggered by HFIP-d1 activates the typically inert P-F bond in PF6- for D2O addition. The thus in-situ formed DPO2F2 triggers then HIE, offering a new way to deuterated building blocks, drugs, and natural-product derivatives with high deuterium incorporation via the activation of strong bonds.

Microcrystal Growth Pathways Investigated with Machine Learning Segmentation and Classification in Scanning Electron Microscopy.

Advances in electron microscopy have revolutionized material characterization on the nano- and microscales, providing important insights into local ordering, structure, and size and quality distributions. While shape and size can be rigorously quantified through microscopy, it is often limited to local structure analysis and fails to describe bulk sample quality. Herein, a flexible machine learning (ML) tool is described that can segment and classify faceted crystals in scanning electron microscopy (SEM) micrographs to determine sample quality through the crystal size and product distribution. As a case study, this tool was applied to investigate crystal growth pathways (classical nucleation and growth compared to nonclassical growth) in DNA-mediated nanoparticle assembly through size and product (single crystal, fused crystal, or noncrystal) distribution of samples containing over 13000 colloidal crystal products. Strong DNA bond strengths (controlled by DNA sequence) lead to fast nucleation that exhausts the monomer concentration, resulting in smaller colloidal crystals. Alternatively, increased thermal energy and crystallization time lead to nonclassical crystallization pathways (coalescence) that result in larger colloidal crystals. This tool is useful since experimental conditions can now be deliberately identified to control colloidal crystal size and size distribution, important considerations for researchers interested in designing and synthesizing colloidal crystal metamaterials.

Late-Stage Functionalization Using a Popular Titrating Agent: Aryl-Chlorides and -Fluorides Activation by the Diphenylacetic Acid Dianion.

Aryl-chlorides and -fluorides are common building blocks, but their use in synthesis is limited by the high stability of their Ar-X bonds. The generation of aryl radicals via activation of strong Ar-X bonds is possible through the irradiation of tailor-made organic anions, which become reductants stronger than lithium metal. We report that the combination of visible light with the cheap diphenylacetic acid dianion is an even better tool, showing excellent activity across a variety of complex substrates and providing opportunities for late-stage drug modification. Ar-X bonds are chemoselectively activated in the presence of more easily reducible functions, such as Alk-Cl ones and carbonyl groups. These results pave the way to original synthetic strategies that would be otherwise considered impossible.

A Base-Free Two-Coordinate Oxoborane.

Oxoboranes (R-BO) are transient species that rapidly trimerise to form boroxines. To date, the only method used to stabilise oxoboranes is to add a Lewis base, but this forms a three-coordinate at boron oxoborane that has a different bonding/reactivity profile. Herein we report a base-free, two-coordinate oxoborane that is isolated as a Lewis adduct with AlCl3. This species, Mes*BO-AlCl3 (Mes* = 2,4,6-tBu-C6H2), has a ν11ΒΟ stretching frequency of 1843 cm-1, indicating a strong BO bond. Computational analysis indicates this is due to a highly polarised BO bonding interaction combined with modest BO multiple bond character. While the polarisation of the BO bond on AlCl3 coordination enhances the Lewis acidity at boron it also reduces the basicity at oxygen and the latter is key to accessing a base-free oxoborane. Finally, this oxoborane reacts with PhN3 in a unique way to form an unprecedented boron heterocycle.

Coupling [Bmim]PF6 and Pd NPs Modulated MOF-Based Material for Synergetic Regulating Electrocatalytic CO2 Reduction.

Metal-organic frameworks (MOFs) with a large number of active sites and high porosity are considered to be good platforms for the carbon dioxide electroreduction reaction (CO2RR) but with confined low conductivity or low efficiency. Here, Pd-[Bmim]PF6/Cu-BTC with exceptional selectivity and electron-transfer ability is elaborately designed by introducing ionic liquids (ILs) into the MOFs. ILs favor promoting the overall current density of the catalysts, and the introduction of Pd atoms combined with O atoms on the catalyst surface reconfigures into strong Pd-O bonds, improving the desorption efficiency of *CO. The unique structure of the catalyst Pd-[Bmim]PF6/Cu-BTC leads to a significant improvement of the C1 product with a high Faraday efficiency (FE) of 99.36%, especially for carbon monoxide (CO) with an FE of 93.18% (-1.1 VRHE). The exceptional performance of the catalyst is verified by density functional theory (DFT) calculations, and the reduction of the free energy required by *HOCO as a key intermediate for CO production was only 0.12 eV, providing new insights to improve the electrocatalytic performance of MOF-based materials for the CO2RR. In this research, an effective and promising strategy that configures active sites by larger current density is proposed to enhance the efficiency of the CO2RR.