Stromal Calcification Research Articles

Histopathology of Silicone Oil Keratopathy in Humans

Corneal endothelial decompensation is a frequent complication when silicone oil is used as a tamponade following vitrectomy for treatment of proliferative vitreoretinopathy in an aphakic eye. We evaluated the clinical, histopathological, and ultrastructural features of silicone oil-induced keratopathy in 10 patients who developed corneal complications requiring penetrating keratoplasty. Clinically, some cases showed corneal edema, corneal hypesthesia, endothelial opacification, band keratopathy, and peripheral corneal vascularization. Histopathologically, retrocorneal membranes were present, and different degrees of stromal hypercellularity, superficial stromal calcification, and vascularization were noted. The ultrastructural features of endothelial cell loss and retrocorneal membrane formation are consistent with changes previously reported in rabbits and cats receiving intracameral silicone oil injections.

Histopathology of Silicone Oil Keratopathy in Humans

Corneal endothelial decompensation is a frequent complication when silicone oil is used as a tamponade following vitrectomy for treatment of proliferative vitreoretinopathy in an aphakic eye. We evaluated the clinical, histopathological, and ultrastructural features of silicone oil-induced keratopathy in 10 patients who developed corneal complications requiring penetrating keratoplasty. Clinically, some cases showed corneal edema, corneal hypesthesia, endothelial opacification, band keratopathy, and peripheral corneal vascularization. Histopathologically, retrocorneal membranes were present, and different degrees of stromal hypercellularity, superficial stromal calcification, and vascularization were noted. The ultrastructural features of endothelial cell loss and retrocorneal membrane formation are consistent with changes previously reported in rabbits and cats receiving intracameral silicone oil injections.

Psammomatous-like calcification in a Brenner tumour of the ovary

Radiographic demonstration of psammomatous calcification in the female abdomen is almost invariably associated with an ovarian papillary cystadenoma or papillary cystadenocarcinoma (Lingley, 1942; Castro & Klein, 1962). However, identical calcifications have been reported in an ovarian thecoma (Mecca et al, 1974) and a virilising lipid-cell tumour of the ovary (Scully et al, 1982). Ovarian gonadoblastomas may show a similar pattern of calcification (Seymour et al, 1976). We present what we believe is the first description of typical radiographic psammomatous calcification produced by stromal dystrophic calcification in a benign Brenner tumour of the ovary. A 54-year-old black female presented with a 2—3 month history of weakness, decreased appetite, and 15 pounds weight loss. Pelvic examination revealed a 10—12 cm firm, irregular, left adnexal mass.

Ultrastructure of stromal calcification in mucoepidermoid carcinoma.

A case of mucoepidermoid carcinoma with calcified bodies in the stroma which appeared in a 24-year-old woman was studied ultrastructurally and electron-microanalytically. In this neoplasm, two types of abnormal epithelial secretions-flowing out type and basal secretion type-were observed. Calcified round bodies were noticed in the stromal tissues of this neoplasm. We discussed the relationship between the abnormal epithelial secretion into the stromal tissues and this calcification.

Retroperitoneal synovial sarcoma. A report of four cases.

Synovial sarcoma most commonly affects the extremities, especially the lower thigh and knee region; other primary sites, in contrast, have been only infrequently reported. Therefore, we undertook this study of four synovial sarcomas arising in the retroperitoneum. This group, whose ages ranged from 17-57 years (mean, 36 years), comprised three males and one female. The nonspecific clinical presentations consisted of pain and/or a mass; diverse preoperative radiographic procedures merely served to reinforce the impression of a retroperitoneal mass. Histologically, all four examples revealed a typical biphasic pattern. Two cases showed a predominant spindle cell component; two others disclosed a more even distribution of the spindle-cell and epithelioid-cell elements, one of these containing, in addition, broad areas of stromal calcification. Follow-up data, obtained for two patients, indicated that both died as a direct result of peritoneal sarcomatosis. The differential diagnosis of selected spindle-cell and biphasic neoplasms known to arise in the retroperitoneum will be discussed.

The Brenner tumour of the ovary. A clinicopathological study of 54 cases.

SummaryThe clinical and pathological features of 54 cases of Brenner tumour of the ovary have been reviewed. One tumour was considered to be malignant and one to be of the “proliferative” type; the remainder showed the characteristic features of Brenner tumours and many were of microscopic size only. Cystic change, mucinous metaplasia, stromal calcification, stronial hyalinosis and thecosis were common histological features. Thirteen of the tumours were in combination with mucinous or serous tumours or with a benign cystic teratoma. Three were bilateral.A very high proportion of the tumours were asymptomatic and were incidental findings during the investigation or treatment of some other condition. Abdominal symptoms or abnormal vaginal bleeding occur as symptoms of a small proportion of cases of Brenner tumour and there is an association of this tumour with cystic hyperplasia of the endometrium; the degree of endometrial hyperplasia is usually mild and rarely produces symptoms. A small proportion of Brenner tumours are presumed to be oestrogenic but it has not proved possible to correlate any morphological features of the tumour with presumed hormonal activity.