Overall, African Americans, Hispanics, and Native Americans have higher stroke risks, stroke occurrence at an earlier age, and for some people of color possibly more severe strokes than non-Hispanic whites. Native Americans make up approximately 6.5% of the population of Montana—equating to around 78,000 people. A focused objective of the Mission: Lifeline Stroke Montana initiative was to specifically engage with Native Americans through public awareness campaigns to improve stroke outcomes in Montana. Method: In 2021 a survey was deployed to Native Americans in Montana to evaluate knowledge, awareness, and understanding of stroke risk factors, signs and symptoms, and what to do in the event of a stroke. Surveys were collected from eight tribal nations. The results of this survey guided message development to create a tailored public awareness campaign. Results: Analysis of the 398 surveys collected showed a representative sampling of respondents by age, gender, education, and geographic area. The key findings were:· Less than 38% of respondents reported having ever talked with a healthcare provider about their risk of stroke, with men being less likely than women to have discussed their stroke risk.· Nearly 94% of respondents said they knew high blood pressure was a risk factor for stroke but have not discussed their personal risk with a healthcare provider.· When asked what action they would take in the event of a possible stroke, over 75% of respondents said they would call 911. Less than half of the respondents indicated the best mode of transportation, in the event of a possible stroke, was an ambulance. Conclusion: Based on survey findings, specific engagement strategies were centered around two main messages:-Know the risk factors for stroke and talk with a healthcare provider about your risk. -Stroke is a medical emergency that requires immediate attention. Call 9-1-1 at the first sign of stroke to access treatment through Montana’s Stroke System of Care. A post-campaign survey will be deployed in the fall of 2023. This survey will aim to assess the effectiveness of these tailored campaign initiatives.