1551 Background: CCH is the largest health provider for HIV patients in Chicago and has one of the largest HIV outpatient clinics in the United States, the Ruth M. Rothstein CORE Center (CC). Per year, over 5000 HIV + individuals are treated at the CC with over 500 HIV-infected individuals treated at CCH. Most studies of non-AIDS defining (NADC) and AIDS defining cancers (ADC) cover wide areas. Insights into the prevalence, type of cancer, and characteristics of HIV + cancer patients found in the inner city and underserved populations have been under represented in the literature. To this end, we examined all of the malignancies presenting to either the CC or CCH for the past 13 years. Methods: We identified via CCH, CC, and pharmacy databases all HIV infected patients with a cancer ICD9 codes from 1998-2010. HIV characteristics, cancer type, and patient demographics were confirmed by chart review. One-way Anova was used to show statistical significant between the prevalence among the different sub populations. Results: After initial screening, 404 cancers were confirmed, representing 21 malignancies. 56% were ADC, with 104 (25%) non-hodgkins lymphoma (NHL), 111(28%) Kaposi sarcoma, and 11(2.7%) cases of cervical cancer. Of the 104 NHL, the most common were DLBCL 61%, Burkitts (BL) 21%, and primary CNS lymphoma 7.6%. The most frequent NADC was anal cancer (n=30) and Hodgkin lymphoma (n=29). 70% of all cancers were stage III or above. HIV + patients at the CC were 71% African American (AA) and 19% Hispanic (Hsp) (compared to 26% and 23% in the Chicago population, respectively). In our study, AA represents 64% of all HIV cancers with Hsp and Caucasians 17% each. Though Caucasians with HIV and cancer in our cohort have the highest prevalence of cancer, 1.06%, vs. 0.69% AA vs. 0.60 Hsp (P< 0.001). The Male:Female ratio of all HIV malignancies in our cohort are 5.1:1. Conclusions: Our data show a race disparity isolated to AA compared to the general population, and a male predominance. Although the Caucasian-HIV population is the smallest, they have the highest cancer prevalence.