Objective To evaluate the feasibility and efficacy of subfascial endoscopic perforator surgery in treating varicose ulcer after great saphenous vein stripping. Methods Between July 2008 and July 2013, 152 limbs of venous ulceration after great saphenous vein stripping were divided into two groups(conservative therapy and subfascial endoscopic perforator surgery therapy) and followed up at least for 2 years, respectively compared symptoms and signs improvement, ulcer healing time, ulcer healing and ulcer recurrence rate after healing for 6, 12, 24 months. Results No patient underwent the surgery occured pulmonary embolism or death, 2 limbs appeared hematoma. Conservative and subfascial endoscopic perforator surgery group′s symptoms and signs improvement rates were 81.9%(59/72) and 86.3%(69/80)(not significant, P=0.528), while the ulcer healing time, ulcer healing and ulcer recurrence rate respectively were 65.3%(47/72) and 78.8%(63/80), (73±15.7) d and (41±12.6) d, 34.0%(16/47) and 14.3%(9/63) (significantly different, P<0.05). According to the three time-points′ (6, 12, 24 months) follow-up, the non-recurrence rate were 89.4%(42/47) and 96.8%(61/63), P=0.135; 72.3%(34/47) and 92.1%(58/63), P=0.006; 66.0%(31/47) and 85.7%(54/63), P=0.014. Conclusions Subfascial endoscopic perforator surgery is a reliable, safe and minimally invasive surgery, and has a long-term effect in treating varicose ulcer after great saphenous vein stripping. Key words: Venous insufficiency; Surgical procedures, minimally invasive; Varicose ulcer