Strict Adherence Research Articles

Analysis of Geographical Indications and Its Infringement and Remedies with Case Studies

In the field of Intellectual Property Rights, the Concept of Geographical indications (GIs) are a unique form of intellectual property that protects products originating in a specific geographical region. After the WTO TRIPS’s the concept of GI is mostly implemented in all countries with strict adherence to TRIP’s. This Paper makes an in-depth examination into geographical indications, throwing insight on the nature of infringement and applicable remedies. It is need of hour to check the importance of geographical indications (GIs), the issues associated with infringement, and the legal systems in place to protect the integrity of regional products. By investigating current instances and changes, this study intends to provide insights into the changing landscape of Geographical Indications and the means available to combat infringement. Refereed case studies helpful to find out the solutions on the infringement with the wide reasoning given by the Honorable Judges of the Supreme Court and High Court.

How acceptable is optimal deterrence?

The article examines the social acceptability of optimal deterrence policies. While there is considerable research on intuitions regarding punishment and the counter-intuitive nature of economic reasoning, the problem of whether decisions based on optimal deterrence are acceptable remains inadequately researched. Two studies examined how acceptance rates vary for different decisions implementing optimal deterrence theory. They demonstrate that (1) policies increasing punishment severity are more acceptable than those decreasing it; (2) changes at the level of penal policy are more acceptable than individual court rulings; (3) acceptance rates decrease as the magnitude of change increases; (4) strict adherence to optimal deterrence theory’s recommendations does not significantly affect the acceptability of the decisions. In addition, no optimal deterrence policies were accepted, on average, or by the majority of participants.

The Mediterranean diet, but not time-restricted eating, mediates the effects of nesfatin on beta cell function among overweight, metabolically healthy individuals

Nesfatin concentrations are positively correlated with beta cell function. However, it is unclear whether diet composition mediates this relationship. We recruited 27 overweight individuals who practiced Orthodox fasting (OF), a subset of the Mediterranean diet (MedDiet), for 7 weeks. Fourteen overweight people who practiced 16:8 time-restricted eating served as control group. Anthropometric parameters, biochemical data and adipokine levels were evaluated at baseline and after the end of the diet period (7 weeks from baseline). Subsequently, participants were asked to return to their usual eating plans, and an additional evaluation was performed 5 weeks after the end of the research diets (12 weeks from baseline). We observed a significant and negative correlation between HOMA-B and nesfatin values at 12 weeks, only in the OF group (r = −0.455, p = 0.01). In conclusion, returning to normal eating habits after 7 weeks of strict adherence to MedDiet affects the homeostatic balance between insulin secretion and nesfatin.

Antiretroviral adherence among people living with HIV during the postpartum period: a retrospective cohort study at a PMTCT reference center in Rio de Janeiro before and during the COVID-19 pandemic

ABSTRACT Despite success in achieving viral suppression during pregnancy in people living with HIV (PLWH), postpartum adherence remains a challenge. We aimed to describe rates of adherence at a Prevention of Mother-to-Child HIV Transmission (PMTCT) Center before and during the COVID-19 pandemic. This study was conducted from a cohort of PLWH who received prenatal care and were virally suppressed near delivery. We tracked combined antiretroviral therapy (cART) pickups for 12 months and HIV viral load (VL) from 2 to 12 months after delivery. We defined flexible adherence as a monthly pickup of cART and strict adherence as also having VL < 200 copies/mL and at least one maternal HIV VL between two and twelve months postpartum. Pre-pandemic was defined as delivery from March 2017-February 2019 and pandemic as March 2020-February 2022. During the study, 1119 PLWH were followed, and 965 (86%) were suppressed near delivery. There were 511 pre-pandemic and 290 pandemic participants. Adherence rates were 66/511 (13%) and 38/290 (13%), respectively. During the pandemic, more participants conceived using cART and were undetectable at the start of prenatal care; nevertheless, postpartum adherence was no better than pre-pandemic underscoring the need to improve strategies for adherence specific to this subset of PLWH in the postpartum period.

Efficacy of a Tailored COMET Protocol Combined with Medication on Vibratory Perception and SkinConductance in Diabetic Neuropathy- A Protocol for Randomized Controlled Trial

This research attempts to evaluate the effectiveness of a customized COMET protocol in conjunction with medicine for the treatment of diabetic neuropathy, with vibratory perception and skin conductance being the main focus. Participants will be allocated to either the intervention group, which will get the customized COMET protocol and medicine, or the control group, which will receive standard medication alone, in a randomized controlled trial. Validated measurement instruments will be used in the trial to evaluate variations in skin conductance and vibratory perception both at baseline and during the course of the investigation. Strict adherence to ethical rules will guarantee the safety and well-being of participants. This study intends to provide important insights into the holistic management of diabetic neuropathy by examining the effects of the customized COMET protocol in conjunction with medication on vibratory perception and skin conductance. This could result in better treatment plans and an improvement in the quality of life for those who are affected. CTRI Reference Number CTRI/2023/07/055366,https://ctri.nic.in/Clinicaltrials/rmaindet.php?trialid=89691&amp;EncHid=88073.73654&amp;modid=1&amp;compid=19,20/07/2023

Cattle Reproductive Disorders Documented from Gaushalas of Nepal.

Cow is the national animal of Nepal, yet it is one of the most abused animal species here. Under realized utilities of cow that is nonlactating or pregnant is the reason for demonic cruelty. Since the Vedic period, gaushalas have been caring for cows. At present, most gaushalas have responsibility to rescue, offer refuge, and treat poorly treated or confiscated cattle from smuggling rackets in Nepal. It is no surprise that these abused animals suffer from many health issues and compromised reproductive ability. This study was conducted to know about husbandry practice and to determine prevalence of reproductive disorders in cows of Gaushala from Nepal. Altogether, 27 gaushalas were visited throughout the study period and cows (≥2 years) (n = 2959) were included for the study. From the study, respondents from 14.81% Gaushala admitted indigenous cattle only, 11.11% admitted any breed (indigenous and crossbreed), 44.44% admitted stray animals only, and 29.63% admitted all types (indigenous, crossbreed, and stray animals). The study revealed that among (n = 2959) animals examined, 5.54% (n = 164) were affected by either one or more reproductive problems. The major reproductive disorders identified in study area were repeat breeding 0.47%, cervico-vaginal and uterine prolapse 0.34%, retention of placenta 2.13%, dystocia 0.61%, and abortion 1.66%. Herd size of Gaushala had a significant difference (P < 0.05) on the overall prevalence of reproductive problems in cows of Gaushala. The main issues with gaushalas included a lack of resources like adequate fund, feeds, fodder, and water, shortage of grazing acreage, veterinary services, and difficulties in managing male cattle. To mitigate the issues and welfare related to gaushalas strict adherence to disease surveillance and biosecurity rules, avoidance of unlimited reproduction in cows, and separation of males and females, fund raising and resource management, collaboration with local government and NGOs, veterinary hospital, clinics, research, and innovation with veterinary institution and universities.

Investigating the Influence of Project Initiation Management on Performance of Mega-dam Projects: Empirical Evidence from Kenya

Performance of large projects including mega-dams could be associated with strict adherence to project life cycle (PLC) phases while considering the risks such as displacement of people and natural ecosystem disturbance. Understanding these risks helps project managers and stakeholders make informed decisions thus creating a positive legacy for the project in the long run. The main objective of the research was to determine how project initiation management influences the performance of mega-dam projects in Kenya. This study was guided by positivist research philosophy. A descriptive cross-sectional survey research design was adopted. In this study, the unit of analysis was 18 mega-dam projects launched and completed across Kenya as listed under the Ministry of Water, Sanitation, and Irrigation (MoWSI) while the unit of observation was the respective three officials (project manager, project engineer, geospatial engineer) in the MoWSI. A Census of all mega-dams completed in Kenya was conducted. In addition, the study purposively interviewed 5 key stakeholders including the cabinet secretary, permanent secretary from the MWSI, donor, contractor, and one randomly selected beneficiary from the community with the target mega-dam. This formed a total sample size of 180 respondents. Primary data was collected using the semi-structured questionnaires as well as the Key Informant Interview (KII) guide. Quantitative and qualitative data from multiple sources and perspectives provided a more comprehensive and robust understanding. Pretesting was done by way of pilot testing to ascertain the validity and reliability of the tools. Descriptive and inferential statistics were used to summarize and describe the key characteristics of the data, as well as draw conclusions and make inferences. Correlation findings showed that project initiation management and performance of selected mega-dam projects in Kenya have a strong positive and significant relationship (r= 0.874, p&lt;0.05). In addition, regression findings showed that one-unit rise in project initiation management corresponds to a 0.433 improvement in the performance of these mega-dam projects. Based on the findings, the study concluded that project initiation management positively and significantly influences the performance of selected mega-dam projects in Kenya. This study therefore recommends that project managers should give priority to project initiation management

Band-amplified angle spectrum method for the phase hologram design to achieve high-quality holographic imaging in long distance

The angular spectrum method (ASM) is widely used in the design of computer-generated holograms (CGH) due to its strict adherence to the Helmholtz equations and the potential for accelerated computation using fast Fourier transform (FFT). However, when dealing with long distance propagation conditions, the reduction of effective spectral components and spectral aliasing will introduce significant computation errors, leading to a substantial degradation in holographic imaging quality. To achieve high-quality holographic imaging design in long distance, we introduce a novel angular spectrum computation method, the calculation process is divided into two steps: (1) First propagate a longer distance from the CGH plane to an intermediate plane. (2) Then continue to propagate to the observation plane after incorporating a spread spectrum phase factor to amplify the effective non-aliased bandwidth in the intermediate plane and eliminating the aliasing artifacts. Furthermore, the non-uniform fast Fourier transform (NUFFT) algorithm is adopted which allows for the flexible adjustments of the sampling interval and quantity in the spatial frequency domain, all while maintaining compliance with the Nyquist sampling theorem even in the context of bandwidth amplification. Both simulations and optical experiments are conducted to validate the feasibility and effectiveness of our proposed method.

Organization of storage of various groups of medicines in pharmacy organizations

In the lecture, the significance of organizing the proper storage of various groups of pharmaceutical products in pharmacy institutions is discussed. The key principles and requirements for storing pharmaceutical products are illuminated, including maintaining the necessary temperature conditions, controlling humidity, tracking expiration dates, drug identification, as well as the peculiarities of storing light-sensitive and flammable medications. Special attention is given to the strict adherence to all established standards and procedures to ensure a high level of quality and safety in storing pharmaceutical products, in accordance with legislative requirements. Additionally, the lecture explores practical recommendations and current approaches to organizing the medication storage process to optimize the functioning of pharmacy organizations and to create conditions for safe and high-quality patient service.

Therapy Dogs in the Dialysis Clinic: A Qualitative Study Examining Hemodialysis Patients’ Attitudes Toward an Animal-Assisted Intervention

ABSTRACT Hemodialysis (HD) is a burdensome clinical process that demands frequent and long visits to the clinic every week indefinitely, yet strict adherence to its regimen is paramount to overall health and wellbeing. Effective approaches are needed to not only reduce patients’ rates of missed treatments but also ease the overall burden and stress associated with long-term HD use. The purpose of this qualitative study was to explore HD patients’ attitudes toward a clinic-based animal-assisted intervention (AAI) to build an understanding of its perceived fit within this novel setting, as well as how this intervention could improve their treatment adherence. Patients from four outpatient clinics engaged in one-on-one, in-depth semi-structured interviews that were audio-recorded and transcribed verbatim. Within a framework of iterative thematic analysis, the Matrix Method was utilized in combination with line-by-line coding to thematically analyze data. A total of 20 patients (age M = 57, SD = 7.93) participated. Results are reflected in four main themes: (1) The dread and suffering of endless treatment; (2) Yearning for the presence of therapy dogs at the clinic; (3) Therapy dogs can aid in the internal battle of treatment adherence; (4) The logistics of incorporating therapy dogs into HD care routine. Participants’ narratives collectively illustrate the perceived value of AAI in the HD clinic setting. This study improves not only our understanding of how HD patients perceive clinic-based therapy-dog visits but also offers helpful insights for implementing this intervention in future research. Incorporating therapy dogs into HD patients’ healthcare routine may offer an innovative approach to improving patient outcomes, and the results of this study are a compelling prompt to empirically investigate the role of AAI in HD treatment adherence.

Delving into the Aftermath of a Disease-Associated Near-Extinction Event: A Five-Year Study of a Serpentovirus (Nidovirus) in a Critically Endangered Turtle Population.

Bellinger River virus (BRV) is a serpentovirus (nidovirus) that was likely responsible for the catastrophic mortality of the Australian freshwater turtle Myuchelys georgesi in February 2015. From November 2015 to November 2020, swabs were collected from turtles during repeated river surveys to estimate the prevalence of BRV RNA, identify risk factors associated with BRV infection, and refine sample collection. BRV RNA prevalence at first capture was significantly higher in M. georgesi (10.8%) than in a coexisting turtle, Emydura macquarii (1.0%). For M. georgesi, various risk factors were identified depending on the analysis method, but a positive BRV result was consistently associated with a larger body size. All turtles were asymptomatic when sampled and conjunctival swabs were inferred to be optimal for ongoing monitoring. Although the absence of disease and recent BRV detections suggests a reduced ongoing threat, the potential for the virus to persist in an endemic focus or resurge in cyclical epidemics cannot be excluded. Therefore, BRV is an ongoing potential threat to the conservation of M. georgesi, and strict adherence to biosecurity principles is essential to minimise the risk of reintroduction or spread of BRV or other pathogens.

Paediatric clinical study of 3D printed personalised medicines for rare metabolic disorders

Rare diseases are infrequent, but together they affect up to 6–10 % of the world’s population, mainly children. Patients require precise doses and strict adherence to avoid metabolic or cardiac failure in some cases, which cannot be addressed in a reliable way using pharmaceutical compounding. 3D printing (3DP) is a disruptive technology that allows the real-time personalization of the dose and the modulation of the dosage form to adapt the medicine to the therapeutic needs of each patient. 3D printed chewable medicines containing amino acids (citrulline, isoleucine, valine, and isoleucine and valine combinations) were prepared in a hospital setting, and the efficacy and acceptability were evaluated in comparison to conventional compounded medicines in six children. The inclusion of new flavours (lemon, vanilla and peach) to obtain more information on patient preferences and the implementation of a mobile app to obtain patient feedback in real-time was also used. The 3D printed medicines controlled amino acid levels within target levels as well as the conventional medicines. The deviation of citrulline levels was narrower and closer within the target concentration with the chewable formulations. According to participants’ responses, the chewable formulations were well accepted and can improve adherence and quality of life. For the first time, 3DP enabled two actives to be combined in the same formulation, reducing the number of administrations. This study demonstrated the benefits of preparing 3D printed personalized treatments for children diagnosed with rare metabolic disorders using a novel technology in real clinical practice.

Sensory Symptoms without Structural Pathology in Patients with Gluten Sensitivity.

The patients were selected from the gluten neurology clinic based at the Royal Hallamshire Hospital, Sheffield, UK, on the basis of sensory symptoms but normal neuroaxis imaging and peripheral nerve evaluation. A total of 30 patients were identified with a mean age at presentation of 47 years. The prevalence of enteropathy was 78%. The sensory disturbance was characterised by tingling at 50%, numbness at 27%, pain at 20%, burning at 13% and "buzzing" feeling at 7%. The distribution of the sensory symptoms included hands and feet in 27% of the patients, torso in 27%, legs only in 23%, face in 17% and arms only in 10%. For five patients, the sensory disturbance was migratory and affected different parts of the body at any given time. After the introduction of a gluten-free diet, 77% of patients noted significant improvement in their sensory symptoms. In one-third of the patients, there was a complete resolution of the sensory symptoms. Unexplained sensory symptoms can be seen in patients with gluten sensitivity and respond to strict adherence to a gluten-free diet.

Tailoring fluoride networks to precipitate hexagonal Ln1-yMyF3-y nanocrystals in glass: Towards short-wavelength upconversion PL of lanthanides

The AlF3-MF2-LnF3 (M = Ca; Sr; Ba; Ln = Yb/Tm) based pure fluoride GCs are essentially ideal candidates for the realization of PL in UV and VIS spectral region. However, the pure fluoride glasses are prone to precipitation of undesired nano-crystals while quenching and post annealing due to their poor chemical stability. Therefore, the development of such glass systems requires strict adherence to composition control right from the outset. This research employed extensive molecular dynamics (MD) simulations and incorporated the results into the experimental design to develop an efficient multicomponent fluoride glass system. Vivid simulation of M-F-Ln and M-F-Al nano-cluster formation via MD are observed in the glass matrix. These nano-clusters serve as the structural origins of the precipitated nano-crystals in GCs post heat treatment. Through meticulous manipulation of the Al/M ratio, it became feasible to theoretically forecast the transformation of the glass matrix from a cubic M1-xLnxF2+x to a hexagonal Ln1-yMyF3-y nano-crystal precipitated GCs, which could conceivably be manufactured experimentally. This transformation offers superior luminescent performance for Ln1-yMyF3-y containing GCs enabling short-wavelength PL realisation in near UV (∼361 nm with 8-fold enhancement) and VIS (∼478 nm with 1.7-fold enhancement) from Yb3+/Tm3+ transitions, in comparison to its cubic M1-xLnxF2+x counterpart. Hence, we propose an effective fluoride glass system for short-wavelength upconversion luminescent applications through the integration of MD simulations and experimental research.

Acute Gastroenteritis Outbreak Among Colorado River Rafters and Backpackers in the Grand Canyon, 2022.

From April 1 to May 31, 2022, Grand Canyon National Park received increased acute gastroenteritis reports. Pooled portable toilet specimens identified norovirus genogroups I and II. We sought to determine outbreak transmission contributors and individual risk factors while rafting or backpacking in the park. Grand Canyon rafters and backpackers were surveyed online from June 13-July 8, 2022, and a Cox proportional hazards model was used to identify predictors associated with illness and adjusted for potential confounding factors. Among 762 surveys, 119 cases and 505 well persons submitted complete survey data. Illness among rafters was associated with interaction with ill persons during the trip (adjusted hazard ratio [adjHR] = 3.4 [95%CI 2.3-5.0]) and lack of any hand hygiene (1.2 [0.7-1.9]) or use of only sanitizer or water (1.6 [1.04-2.6]) before snacks. Younger rafters had higher illness rates compared to those ≥60 y (1.5 [1.2-1.8] for ages 40-59 and 2.2 [1.4-3.5] for ages <40 y). Person-to-person transmission likely accounted for the widespread outbreak. Future outbreak mitigation efforts on river trips could focus on symptom screening before the trip starts, prompt separation of ill and well passengers, strict adherence to hand hygiene with soap and water, minimizing social interactions among rafting groups, and widespread outbreak notices and education to all park users.

Fecal calprotectin levels in patients with non-celiac wheat sensitivity: a proof of concept

Some data suggest the existence of intestinal inflammation in patients with non-celiac wheat sensitivity (NCWS). We aimed to verify whether fecal calprotectin (FCP), a marker of intestinal inflammation, could be used to confirm this inflammatory status and to test its diagnostic performance in differentiating NCWS from irritable bowel syndrome/functional dyspepsia (IBS/FD). We conducted a multicenter study, comparing NCWS patients, diagnosed by a double-blind placebo-controlled wheat challenge, with IBS/FD subjects. In the retrospective phase, FCP values were analyzed to define the prevalence of its positivity and its role as a NCWS diagnostic biomarker. In the prospective phase we tested the effects of a strict 6-month wheat-free diet (WFD) on FCP values. 31.3% (n = 63/201) of NCWS patients had above normal FCP values (NCWS FCP +), whereas all IBS/FD patients proved negative (P = 0.0001). FCP using a cut-off value > 41 µg/g showed a 58.6% sensitivity and a 98.0% specificity (AUC 0.755, 95% C.I. 0.702–0.837) in distinguishing NCWS from IBS/FD patients. Of the 63 NCWS FCP+, 65.1% had negative FCP values after ≥ 6 months of WFD, with a significant reduction in FCP values (P < 0.0001). All NCWS FCP- subjects still preserved negative FCP values after ≥ 6 months of WFD. Our study showed that FCP can be a useful but supplementary diagnostic marker for differentiating between NCWS and IBS/FD. Strict WFD adherence reduced FCP values, normalizing them in 65.1% of NCWS FCP + subjects. These data suggest the existence of two NCWS subgroups: NCWS FCP + characterized by a probable predominantly inflammatory/immunologic pattern and NCWS FCP− featuring non-immuno-mediated etiopathogenetic mechanisms. (Registration number NCT01762579).

The Impact of Internet Banking on Bank Fraud in Nigeria

This study investigated the effect of internet banking on bank fraud in Nigeria. Monthly data covering from January 2008 to January 2019 representing 97 observations were utilized. The Auto Regressive Distributed Lag (ARDL) technique was used as the technique of data analysis. The independent variable is internet banking while the dependent variable is bank fraud. The control variables included measures of regulatory quality, bank development and capital market development which have strong correlation with the level of bank fraud in a financial system. Identity theft theory &amp; software vulnerability theory were the theoretical underpinnings in this work. The findings of the study reveal overwhelming evidence of a positive interaction between internet banking and bank fraud in Nigeria which could be attributed to the regulatory quality of the Nigerian banking industry. Internet based transactions had a positive and significant effect on bank fraud in Nigeria Some of the recommendations emanating from the findings of the study are; mainstreaming regulatory sandbox, promoting favorable macroeconomic environment, strengthen AML/CFT regime, strict adherence to fraud disruption measure, biometric authentication, harmonization of industry standards, consumer education awareness.

Antibiotic lock solutions as adjunct therapy for catheter-related blood stream infections in pediatric hemodialysis patients.

The predominant use of intravenous catheters as primary access type in the pediatric hemodialysis population is associated with an increased risk of catheter related blood stream infections. While strict adherence to catheter placement and long-term care guidelines have helped to decrease the incidence of these infections, blood stream infections remain an infection burden in pediatric patients with long term hemodialysis catheters. The formation of biofilms on the surfaces of these catheters has been shown to be a source of microbes causing blood stream infections. One of the strategies for preventing bacterial colonization, inhibiting microbial multiplication, and suppressing the seeding of these microbes from biofilms upon maturation, has been the use of antibiotic-based lock solutions in-between dialysis treatments. Although clinical guidelines for the use of antibiotic lock solutions are yet to be developed, available evidence suggests a beneficial role of antibiotic lock solutions in the management of catheter related blood stream infections. Additionally, a clear understanding of how biofilms are formed and their role in the pathogenesis of catheter related bloodstream infection will facilitate the development of solutions that can prevent biofilm formation and inhibit their multiplication, maturation and seeding into the bloodstream.

Fuzzy‐AHP methodology for ranking of hospitals based on waste management practices: A study of Gwalior City

AbstractWithin the scope of this research, the fuzzy‐analytical hierarchy process (F‐AHP) method is applied to assess the waste management approaches adopted by various hospitals in the city of Gwalior, India. Fuzzy‐AHP, as an alternative to traditional AHP, accommodates uncertainty and imprecision, offering a decision‐making method that is more adaptable and realistic. The F‐AHP methodology, delineated in a seven‐step process, incorporates pairwise comparisons, fuzzy mathematics, and linguistic variables to compute fuzzy weights for waste management criteria, encompassing physical, biological, social, and economic aspects. Hospital 1, with a weight value of 0.406 and strict adherence to the Bio‐medical Waste Management (Amendment), 2018 rules and regulations of the Government of India, emerges as the most promising sustainability hospital based on the F‐AHP analysis findings. Conversely, Hospital 5 exhibits the poorest waste management practices among the surveyed hospitals, earning the lowest possible ranking. While the proposed F‐AHP method provides valuable insights, the study is limited to a specific geographic area (Gwalior) and potential variations based on environmental factors. Additionally, the practical implications extend beyond the general emphasis on continuous monitoring to include specific actions for hospitals to enhance their waste management systems.

Perioperative Antibiotic Prophylaxis.

Postoperative surgical site infections (SSI) account for almost 25% of all nosocomial infections in Germany and are a source of increased morbidity and mortality. This review is based on pertinent publications retrieved by a selective search in PubMed and on national and international guidelines. The individual risk factors for SSI must be assessed before any surgical procedure. A body-mass index above 30 kg/m2 is associated with an unadjusted risk ratio of 1.35 [1.28; 1.41] for SSI, which rises to 3.29 [2.99; 3.62] if the patient is also immunosuppressed. The risk of SSI is also significantly higher with certain types of procedure. Perioperative antibiotic prophylaxis (PAP) is clearly indicated for operations that carry a high risk of SSI (e.g., colorectal surgery) and for those that involve the implantation of alloplastic material (e.g., hip endoprostheses). PAP can usually be administered with basic antibiotics such as cefazoline. The basic principles of PAP are that it should be given by the anesthesia team in the interval from 60 minutes preoperatively up to shortly before the incision, and that its administration should only be for a short period of time, usually as a single shot. Continuing PAP onward into the postoperative period leads to increased toxicity, bacterial superinfections, and antibiotic resistance. The evidence shows that perioperative antibiotic prophylaxis is a component of a bundle of measures that can help prevent SSI. Strict indications and adherence to the basic principles of PAP are essential for therapeutic success.