Radiation Stress Research Articles

Along-Slope Bottom Current and Sediment Resuspension and Transport Induced by Internal Tides on a Continental Slope

Abstract Moored observations on a critical continental slope in the northeastern South China Sea (SCS) are presented to reveal along-slope bottom current and sediment resuspension and transport caused by internal tides. During spring tides, the bottom-intensified diurnal internal tides were observed, and their breaking generated an along-slope bottom current toward the southwest direction, with a clear ∼14-day spring–neap cycle and a maximum low-frequency velocity exceeding 0.25 m s−1. The diurnal internal tides and along-slope bottom currents showed the same seasonal variations. There were larger near-bottom along-slope velocities in winter (∼9.0 cm s−1) and summer (∼8.9 cm s−1) than in spring (6.3 cm s−1) and autumn (7.4 cm s−1). The previous theory based on radiation stress caused by wave breaking is used to reproduce the observed along-slope bottom current velocity. Strong bottom flows caused by internal tides on the critical slope inhibit deposition of fine-grained sediments and may erode bottom coarse-grained sediments, leading to the generation of near-bottom nepheloid layer with a thickness H > 130 m, as demonstrated by the fact that seafloor sediments on the critical slope are dominated by coarse-grained sediments (sands). The suspended sediments can be southwest transported by the persistent along-slope bottom current generated by internal tide breaking. It was estimated that approximately three million tons of sediments during the observation were carried along the slope to the south of the SCS. Our observations suggest that internal tide-induced sediment resuspension/deposition and along-slope transport could be important for seafloor sediment distribution of the SCS.

An Updated Review on the Role of Phytoconstituents in Modulating Signalling Pathways to Combat Skin Ageing: Nature’s Own Weapons and Approaches

Abstract: Various geographical areas exhibit varying degrees of prevalence and severity of dermatological issues. The most commonly observed skin issues among adolescents during their growth period on a global scale encompass dry skin, dyspigmentation, wrinkles, fungal infections, as well as benign and malignant tumors. These conditions arise as a consequence of diminished functional capacity and heightened skin susceptibility. The primary manifestation of the whole process of skin ageing is its visual presentation, which encompasses changes in both the structure and function of the skin. The look and function of human skin exhibit particular variations as individuals age, representing a time-dependent phenomenon. This review article primarily examines the discussion surrounding the diverse phytoconstituents and their impact on signalling pathways in cellular metabolism, as well as their interaction with environmental factors and xenobiotic agents that contribute to skin aging. Ultraviolet (UV) light induces the rapid formation and subsequent accumulation of reactive oxygen species (ROS) within skin cells, hence accelerating oxidative stress and the ageing process of the skin. One effective approach to addressing age-related skin disorders entails the utilization of exogenous supplementation through the consumption of dietary antioxidants, as well as the application of antioxidant-based lotions to the skin prior to sun exposure. Several plant species include phenolic components, including ascorbic acid, ellagitannins, and carotenoids, which have the ability to protect the skin from harmful UV radiation, reduce inflammation and oxidative stress, and influence several survival signalling pathways. This comprehensive study elucidated multiple processes by which phytoconstituents exert their effects for intervention purposes. Additionally, it highlighted the ability of these phytoconstituents to modulate the NF-κB signalling pathway, MAPK signalling, Nrf2 signalling, and other pathways, hence demonstrating their potential anti-aging properties.

Baroclinic Effects on Wave-Driven Flows in a Microtidal Bay

Abstract A wave–current coupled numerical model with 3D radiation stress formalism is used to study baroclinic effects, specifically stratification and baroclinic pressure gradient force (BcPGF), on wind-wave-driven flows, separated as vertically sheared flows and vertically homogeneous flows. Numerical experiments are conducted under ideal offshore winds of 8 m s−1. Results show that stratification enhances the two-layer structure of the wave-driven sheared flow, while BcPGF has minimal impact. Stratification and BcPGF have limited influence on the direction of the wave-driven depth-averaged circulation, but they can enhance the total circulation by promoting the upper one. In the upper layer where form drag dominates, the competition between the vertical form drag divergence (FDD) and turbulent stress divergence (TSD) plays a critical role in shaping the wave-driven flow. Stratification reduces vertical eddy viscosity Km, suppressing the growth of TSD associated with the vertical shear of velocity, which facilitates the FDD driving the upper outflow. Likewise, stratification can enhance the effect of FDD curl on the upper horizontal circulation by limiting the growth of TSD curl related to the vertical shear of vorticity. Additionally, low Km reinforces geostrophic effect and therefore enhances the lateral circulation. Baroclinic torque contributes to reducing the vertical variation of vorticity and the growth of TSD curl, indirectly improving the effectiveness of FDD curl in driving the upper circulation. Stratification undergoes fortnightly adjustments due to the spring–neap cycle, leading to the synchronized variation in the strength of wave-driven flow, particularly its vertically sheared component. During neap tides with weak tidal forcing and well-developed stratification, wave-driven sheared flow, horizontal circulation, and lateral circulation are stronger. Significance Statement The aim of this study is to enhance our comprehension of the impact of baroclinic processes on wind-wave-driven flows in wind-dominated regimes. During summer, wave-driven flows exhibit noticeable vertical shearing, which differ from those observed in winter. This is particularly important because during summer, river runoffs generate strong stratification and introduce large quantities of terrigenous materials into coastal oceans. Consequently, wave-driven flows may play a crucial role in bay-shelf exchange, which has been given in few studies. Our findings highlight the influence of baroclinic processes on turbulent stress divergence, which can enhance wave-driven flows, both the vertically sheared and the vertically homogeneous components, especially during neap tides.

Metabolomic Analysis of Elymus sibiricus Exposed to UV-B Radiation Stress.

Plants cultivated on the Qinghai-Tibet Plateau (QTP) are exposed to high ultraviolet radiation intensities, so they require effective mechanisms to adapt to these stress conditions. UV-B radiation is an abiotic stress factor that affects plant growth, development, and environmental adaptation. Elymus sibiricus is a common species in the alpine meadows of the QTP, with high-stress resistance, large biomass, and high nutritional value. This species plays an important role in establishing artificial grasslands and improving degraded grasslands. In this study, UV-B radiation-tolerant and UV-B radiation-sensitive E. sibiricus genotypes were subjected to simulated short-term (5 days, 10 days) and long-term (15 days, 20 days) UV-B radiation stress and the metabolite profiles evaluated to explore the mechanism underlying UV-B radiation resistance in E. sibiricus. A total of 699 metabolites were identified, including 11 primary metabolites such as lipids and lipid-like molecules, phenylpropanoids and polyketides, organic acids and their derivatives, and organic oxygen compounds. Principal component analysis distinctly clustered the samples according to the cultivar, indicating that the two genotypes exhibit distinct response mechanisms to UV-B radiation stress. The results showed that 14 metabolites, including linoleic acid, LPC 18:2, xanthosine, and 23 metabolites, including 2-one heptamethoxyflavone, glycyrrhizin, and caffeic acid were differentially expressed under short-term and long-term UV-B radiation stress, respectively. Therefore, these compounds are potential biomarkers for evaluating E. sibiricus response to UV-B radiation stress. Allantoin specific and consistent expression was up-regulated in the UV-B radiation-tolerant genotype, thereby it can be used to identify varieties resistant to UV-B radiation. Different metabolic profiles and UV-B radiation response mechanisms were observed between the UV-B radiation-tolerant and UV-B radiation-sensitive E. sibiricus genotypes. A model for the metabolic pathways and metabolic profiles was constructed for the two genotypes. This metabolomic study on the E. sibiricus response to UV-B radiation stress provides a reference for the breeding of new UV-B radiation-tolerant E. sibiricus cultivars.

Exogenous Brassinolide Ameliorates the Adverse Effects of Gamma Radiation Stress and Increases the Survival Rate of Rice Seedlings by Modulating Antioxidant Metabolism.

Gamma irradiation-based mutant creation is one of the most important methods for rice plant mutagenesis breeding and molecular biology research. Although median lethal dose irradiation severely damages rice seedlings, applying brassinolide (BR) can increase the survival rate of irradiated seedlings. In this study, we investigated the effects of soaking seeds in solutions containing different BR concentrations (0.001, 0.01, 0.1, 1.0, and 5.0 μmol/L) and then spraying the resulting seedlings twice with 0.1 μmol/L BR. The combined BR treatments markedly decreased the superoxide anion (O2•-), hydrogen peroxide (H2O2), and malondialdehyde contents but increased the chlorophyll content. An appropriate BR treatment of gamma-irradiated samples substantially increased the activities of the antioxidant enzymes superoxide dismutase, peroxidase, and ascorbate peroxidase as well as the proline, ascorbic acid, and glutathione contents in rice seedling shoots. The BR treatment also promoted the growth of seedlings derived from irradiated seeds and increased the shoot and root fresh and dry weights. Most notably, soaking seeds in 0.01 or 0.1 μmol/L BR solutions and then spraying seedlings twice with 0.1 μmol/L BR significantly increased the final seedling survival rate and decreased mutant loss. The study results suggest that exogenous BR treatments can protect rice seedlings from gamma irradiation stress by enhancing antioxidant metabolism.

Photophysiological and Oxidative Responses of the Symbiotic Estuarine Anemone Anthopleura hermaphroditica to the Impact of UV Radiation and Salinity: Field and Laboratory Approaches.

The estuarine anemone Anthopleura hermaphroditica and its symbiont Philozoon anthopleurum are continuously exposed to intense fluctuations in solar radiation and salinity owing to tidal changes. The aim of this study was to evaluate the effects of the tidal cycle, solar radiation, and salinity fluctuations on the photosynthetic and cellular responses (lipid peroxidation, total phenolic compounds, and antioxidant activity) of the symbiont complex over a 24 h period in the Quempillén River Estuary. Additionally, laboratory experiments were conducted to determine the specific photobiological responses to photosynthetically active radiation (PAR), ultraviolet radiation (UVR), and salinity. Our field results showed that the photosynthetic parameters of the symbiont complex decreased with increasing ambient radiation; however, no relationship was observed with changes in salinity. Increased peroxidative damage, total phenolic compound levels, and antioxidant activity were mainly related to increased UVR and, to a lesser extent, PAR. During the dark period, only PAR-exposed organisms returned to the basal levels of photosynthesis and cell damage. Laboratory exposure confirmed the deleterious effects of UVR on the photosynthetic response. The present study suggests that the ability of A. hermaphroditica to acclimate to natural radiation stress is mediated by the concerted action of various physiological mechanisms that occur at different times of the day, under varying levels of environmental stress.

Biological Adaptations in Rhabdomyosarcoma Tumor Cells in lymph nodes: A Case Report of RMS with FUS::TFCP2 translocation

Abstract Introduction/Objective The WHO classification categorizes Rhabdomyosarcoma (RMS) into four main subtypes based on clinicopathological and molecular features. However, TFCP2-rearranged RMS, a rare tumor, does not neatly fit into any of these subtypes. Literature review identified only two reported cases of RMS with FUS::TFCP2 fusion and a round cell component. Methods/Case Report We present a rare case of RMS in lymph nodes with FUS::TFCP2 translocation in a 29-year- old female with a history of spindle cell rhabdomyosarcoma in the bilateral maxilla. The original tumor exhibited a distinctive spindle and epithelioid phenotype, coexpressing myogenic markers, epithelial markers, and ALK. FUS::TFCP2 translocation was confirmed, representing an uncommon subset of RMS. After chemotherapy, radiation, and surgery, the patient developed multiple bilateral pathologically enlarged cervical lymph nodes. Excision revealed metastatic rhabdomyosarcoma involving lymph nodes with a predominantly round cell and epithelioid morphology, with approximately 5% spindle cell growth, resembling the pattern identified in the primary resection. Results (if a Case Study enter NA) NA Conclusion Previous reports suggest that RMS with FUS::TFCP2 fusion displays a biphasic pattern, comprising solid proliferation of round cells in superficial areas and spindle cells in deeper regions. The altered cell morphology observed in our case may be attributed to the varied distribution pattern of each component with lesion depth and the cellular stress response. Previous literature reported that radiation stress potentially leads to biological adaptations of tumor cells and tumor radioresistance. Our findings underscore the distinctive phenotype of RMS with FUS::TFCP2 fusion, characterized by the coexpression of myogenic and epithelial markers, along with ALK positivity. Understanding the cellular adaptations of RMS cells could inform the development of novel clinical interventions aimed at enhancing radiosensitization and improving therapeutic efficacy, ultimately enhancing patient survival.

Variation of suspended-sediment caused by tidal asymmetry and wave effects

Suspended sediment plays an important role in coastal topography evolution and ecological environment change. To obtain a clear picture of the underlying mechanisms, we studied the response of suspended sediment dynamics to tidal current and wave-current interactions using the wave-current-sediment model of SCHISM. The results revealed evident tidal asymmetry in the study area, and showed that the suspended sediment concentration (SSC) markedly changes within a tidal cycle. We also disassembled the wave–current interactions to determine the contribution of each physical mechanism of the wave and hydrodynamic models. Regarding the importance of various effects of wave-current interactions on SSC, the wave-induced bottom shear stress and wave-induced radiation stress should be considered. The importance of advection in horizontal space is comparable to that of wave-induced bottom shear stress and wave-induced radiation stress, and is greater than that of the other types of wave energy advection. This study successfully explained all the mechanisms that influence the variation of SSC to the southwest of Hainan Island, which is helpful for coastal management and could provide a reference for other coastal areas.

Leucine restriction ameliorates Fusobacterium nucleatum-driven malignant progression and radioresistance in nasopharyngeal carcinoma

Radiotherapy resistance is the main cause of treatment failure among patients with nasopharyngeal carcinoma (NPC). Recently, increasing evidence has linked the presence of intratumoral Fusobacterium nucleatum (Fn) with the malignant progression and therapeutic resistance of multiple tumor types, but its influence on NPC has remained largely unknown. We found that Fn is prevalent in the tumor tissue of patients with NPC and is associated with radioresistance. Fn invaded and proliferated inside NPC cells and aggravated tumor progression. Mechanistically, Fn slowed mitochondrial dysfunction by promoting mitochondrial fusion and decreasing ROS generation, preventing radiation-induced oxidative damage. Fn inhibited PANoptosis by the SLC7A5/leucine-mTORC1 axis during irradiation stress, thus promoting radioresistance. Treatment with the mitochondria-targeted antibiotics or dietary restriction of leucine reduced intratumoral Fn load, resensitizing tumors to radiotherapy invivo. These findings demonstrate that Fn has the potential to be a predictive marker for radioresistance and to help guide individualized treatment for patients with NPC.

Effects of thermal and UV stress on the polar and non-polar metabolome of photosymbiotic jellyfish and sea anemones

Recently, the impacts of climate change, notably ocean warming and solar ultraviolet radiation, have led to significant stress and mortality in cnidarians. The objective of this study is to decode the metabolic responses of sea anemones Entacmaea quadricolor and upside-down jellyfish Cassiopea andromeda upon exposure to thermal and ultraviolet stress. Gas chromatography-mass spectrometry and ultraperformance liquid chromatography coupled with high-resolution mass spectrometry targeting polar and non-polar metabolites were applied. In total, 72 polar and 242 lipophilic metabolites were detected in jellyfish and sea anemones, respectively. Amino acids are the major metabolite class in jellyfish, and triacylglycerides are the predominant lipids in jellyfish and anemones. Exposure to stressors led to metabolic alterations, marked by elevated amino acids in jellyfish and increased amino acids and sugar alcohols in sea anemones at 34 °C and after four days of ultraviolet radiation. Non-polar metabolome analysis indicated distinct responses to ultraviolet radiation and thermal stress in both species.

Shading and Water Addition Alleviate the Elemental Limitations of the Early Restoration Community in a Stressful Environment.

Shading and water addition are essential management measures to improve seed germination and early seedling survival; however, little is known about their effects on leaf stoichiometry and nutrient status. We established 90 plant communities with shading and water addition gradients on a rocky hill; leaves of their dominant woody plant species were collected to measure elemental concentrations, and then, stoichiometric variation and nutrient status were analysed. The results showed that the overall effects of shading and water addition significantly altered the concentrations and ratios of nutrient elements; shading largely affected leaf K and P, while water addition mainly affected leaf N and P. The interactions between shading and water addition were significant for most species but disappeared at the community level. Consequently, the nutrient status in leaves was improved by promoting the concentrations and balances of nutrient elements. However, the responses to shading and water addition were marked by species-specific differences, with some plants forming a sensitive group and others distinguished by conservatism. Our findings show that management of the physical environment could improve nutrient element utilization in leaves and alleviate the nutrient limitations. For our site conditions, mild shading (25-35%) and adequate water addition (30 L·m-2) in the early stage of vegetation restoration is recommended to advance community assembly by improving nutrient physiology, directly diminishing the stress of water scarcity and excessive irradiation. These findings explore the underlying mechanisms of shading and water addition that could promote community development and provide guidance for restoration practice.

Long-term observations of the turbid outflow plume from the Russian River, California

Understanding the mechanisms that spread freshwater away from small river systems and form turbid, low-salinity coastal plumes is crucial for assessing water quality in coastal waters. We present an analysis of 15 years (January 2004 to December 2018) of daily MODIS Aqua satellite data and in situ instrument data on the turbid freshwater plume that forms off the Russian River (California, USA), a prototypical Mediterranean-climate, small mountainous river system (SMRS). We present per-pixel statistical metrics and regression analyses to identify and quantify the controls on the extent and configuration of the plume exerted by river discharge, waves, winds, and tides. While freshwater outflow exhibits a persistent signal in nearshore waters, a large-scale plume only extends offshore into coastal waters during high river flow, when plume turbidity can be detected more than 10 km offshore from the river mouth. Our results show times when wave radiation stress exceeds outflow inertia, confining the plume within the surf zone and leading to an absence of detectable plume turbidity in coastal waters. Although tidal currents significantly influence the plume near the inlet, wind forcing is the primary control on plume shape and extent in coastal waters, deflecting the turbid outflow more than 30 km upcoast or downcoast of the river mouth with respective wind directions. Coriolis forcing is also significant and observed most clearly during periods of high river discharge and low wind forcing. In addition to introducing novel remote sensing methodology for SMRS plume analyses, these findings highlight the complex interplay of forcing related to tides, river discharge, winds, and waves in shaping the behavior of SMRS plumes. New insights include the impact of tides on larger discharges, the role of Coriolis forcing in SMRS plumes, and the effect of cross-shore winds on plume compression. Further, by considering the Russian River as a model for SMRS, this study can be used to ground-truth existing numerical models of small river plumes and to contribute to understanding critical for managing coastal water quality and nearshore ecosystems.

PPM1D activity promotes cellular transformation by preventing senescence and cell death

Cell cycle checkpoints, oncogene-induced senescence and programmed cell death represent intrinsic barriers to tumorigenesis. Protein phosphatase magnesium-dependent 1 (PPM1D) is a negative regulator of the tumour suppressor p53 and has been implicated in termination of the DNA damage response. Here, we addressed the consequences of increased PPM1D activity resulting from the gain-of-function truncating mutations in exon 6 of the PPM1D. We show that while control cells permanently exit the cell cycle and reside in senescence in the presence of DNA damage caused by ionising radiation or replication stress induced by the active RAS oncogene, RPE1-hTERT and BJ-hTERT cells carrying the truncated PPM1D continue proliferation in the presence of DNA damage, form micronuclei and accumulate genomic rearrangements revealed by karyotyping. Further, we show that increased PPM1D activity promotes cell growth in the soft agar and formation of tumours in xenograft models. Finally, expression profiling of the transformed clones revealed dysregulation of several oncogenic and tumour suppressor pathways. Our data support the oncogenic potential of PPM1D in the context of exposure to ionising radiation and oncogene-induced replication stress.

Engineering Entomopathogenic Fungi Using Thermal-Responsive Polymer to Boost Their Resilience against Abiotic Stresses.

Entomopathogenic fungi offer an ecologically sustainable and highly effective alternative to chemical pesticides for managing plant pests. However, the efficacy of mycoinsecticides in pest control suffers from environmental abiotic stresses, such as solar UV radiation and temperature fluctuations, which seriously hinder their practical application in the field. Herein, we discovered that the synthetic amphiphilic thermal-responsive polymers are able to significantly enhance the resistance of Metarhizium robertsii conidia against thermal and UV irradiation stresses. The thermosensitive polymers with extremely low cytotoxicity and good biocompatibility can be engineered onto the M. robertsii conidia surface by anchoring hydrophobic alkyl chains. Further investigations revealed that polymer supplementation remarkably augmented the capacity for penetration and the virulence of M. robertsii under heat and UV stresses. Notably, broad-spectrum entomopathogenic fungi can be protected by the polymers. The molecular mechanism was elucidated through exploring RNA sequencing and in vivo/vitro enzyme activity assays. This work provides a novel avenue for fortifying the resilience of entomopathogenic fungi, potentially advancing their practical application as biopesticides.

Effects of simulated space conditions on CD4+ T cells: a multi modal analysis.

The immune system is an intricate network of cellular components that safeguards against pathogens and aberrant cells, with CD4+ T cells playing a central role in this process. Human space travel presents unique health challenges, such as heavy ion ionizing radiation, microgravity, and psychological stress, which can collectively impede immune function. The aim of this research was to examine the consequences of simulated space stressors on CD4+ T cell activation, cytokine production, and gene expression. CD4+ T cells were obtained from healthy individuals and subjected to Fe ion particle radiation, Photon irradiation, simulated microgravity, and hydrocortisone, either individually or in different combinations. Cytokine levels for Th1 and Th2 cells were determined using multiplex Luminex assays, and RNA sequencing was used to investigate gene expression patterns and identify essential genes and pathways impacted by these stressors. Simulated microgravity exposure resulted in an apparent Th1 to Th2 shift, evidenced on the level of cytokine secretion as well as altered gene expression. RNA sequencing analysis showed that several gene pathways were altered, particularly in response to Fe ions irradiation and simulated microgravity exposures. Individually, each space stressor caused differential gene expression, while the combination of stressors revealed complex interactions. The research findings underscore the substantial influence of the space exposome on immune function, particularly in the regulation of T cell responses. Future work should focus expanding the limited knowledge in this field. Comprehending these modifications will be essential for devising effective strategies to safeguard the health of astronauts during extended space missions. The effects of simulated space stressors on CD4+ T cell function are substantial, implying that space travel poses a potential threat to immune health. Additional research is necessary to investigate the intricate relationship between space stressors and to develop effective countermeasures to mitigate these consequences.

Flow characteristics of the rip current system adjacent to a coastal vertical structure for irregular waves

Rip currents are common hazards found on many beaches around the world. The present research examines the rip current flow features adjacent to a coastal vertical structure with total reflection function to the incident waves. The laboratory experiments were conducted over the planar beach for both regular and irregular waves to explore the specific phenomenon for the irregular waves, and a higher-order Boussinesq equation model was adopted in the simulations to analyze the formation mechanism of the flow features. The study results show that, the standing wave pattern for the irregular wave is much weaker than that for the regular wave with inducing only one apparent node rip at the first node line in the reflection wave area. Moreover, the specific “single-vortex” flow pattern was formed in the crossing wave field for the irregular wave tests. This specific flow pattern is found essentially induced by the larger wave reflection rate of the vertical structure, which leads to the strong lateral flow against the downstream longshore current. This specific flow pattern prefers to present for the smaller wave incident angles and larger wave heights and periods, and leads to the feeding flow volume rates discharged more in the form of lateral flow. The C-shaped lateral flow is found mainly induced by the longshore gradient of the wave set-up instead of the non-uniform wave radiation stress nearshore.

Degradation mechanism of SiC diodes under thermal and irradiation stress

Abstract Silicon carbide (SiC)-based diodes are widely used due to their high temperature resistance. In this paper, breakdown voltage of 4H-SiC JBS diodes and capacitance-voltage of 4H-SiC MOS capacitors with identical interfacial structure were both measured at high temperature to study their interfacial properties. By analyzing the variation of interfacial properties, the correlation between thermal stress and failure mode of 4H-SiC JBS diodes was further established to reveal their degradation mechanism. During initial high temperature storage, interfacial negative effective charge density of 4H-SiC JBS diodes may increase, leading to the decrease of breakdown voltage. As storage time increases, interfacial charge density began reducing, resulting in the increase of breakdown voltage. Avalanche luminescence verifies that the variation of interfacial charge density under thermal stress led to the degradation of 4H-SiC JBS diodes and further affected their breakdown voltage. Finally, degradation mechanism of SiC-JBS, SiC-SBD and SiC-PIN diodes under irradiation stress was investigated. After irradiation, forward current of some SiC diodes increased at a small forward voltage. However, the reverse characteristics deteriorated obviously and even failed.

Versatile Papertronics: Photo-Induced Synapse and Security Applications on Papers.

Paper is a readily available material in nature. Its recyclability, eco-friendliness, portability, flexibility, and affordability make it a favored substrate for researchers seeking cost-effective solutions. Electronic devices based on solution process are fabricated on paper and banknotes using PVK and SnO2 nanoparticles. The devices manufactured on paper substrates exhibit photosynaptic behavior under ultraviolet pulse illumination, stemming from numerous interactions on the surface of the SnO2 nanoparticles. A light-modulated artificial synapse device is realized on a paper at a low voltage bias of -0.01V, with an average recognition rate of 91.7% based on the Yale Face Database. As a security device on a banknote, 400 devices in a 20 × 20 array configuration exhibited random electrical characteristics owing to the local morphology of the SnO2 nanoparticles and differences in the depletion layer width at the SnO2/PVK interface. The security Physically Unclonable Functions (PUF) key based on the current distribution extracted at -1V show unpredictable reproducibility with 50% uniformity, 48.7% inter-Hamming distance, and 50.1% bit-aliasing rates. Moreover, the device maintained its properties for more than 210 days under a curvature radius of 8.75mm and bias and UV irradiation stress conditions.

Blocking ACSL6 Compromises Autophagy via FLI1-Mediated Downregulation of COLs to Radiosensitize Lung Cancer.

Lung cancer (LC) is the leading cause of cancer-related mortality worldwide. Radiotherapy is the main component of LC treatment; however, its efficacy is often limited by radioresistance development, resulting in unsatisfactory clinical outcomes. Here, we foundthat LC radiosensitivity is up-regulated by decreased expression of long-chain acyl-CoA synthase 6 (ACSL6) after irradiation. Deletion of ACSL6 results in significant elevation of Friend leukemia integration 1 transcription factor (FLI1) and a marked decline of collagens (COLs). Blocking of ACSL6 impairs the tumor growth and upregulates FLI1, which reduces the levels of COLs and compromises irradiation-induced autophagy, leading to considerable therapeutic benefits during radiotherapy. Moreover, the direct interaction between ACSL6 and FLI1 and engagement between FLI1 and COLs indicates the involvement of the ACSL6-FLI1-COL axis. Finally, the potently adjusted autophagy flux reduces its otherwise contributive capability in surviving irradiation stress and leads to satisfactory radiosensitization for LC radiotherapy. These results demonstrate that enhanced ACSL6 expression promotes the aggressive performance of irradiated LC through increased FLI1-COL-mediated autophagy flux. Thus, the ACSL6-FLI1-Col-autophagy axis may be targeted to enhance the radiosensitivity of LC and improve the management of LC in radiotherapy.

Theoretical study of the MWCNT particle layer and size impact on sodium alginate heat transfer

This paper theoretically studies the effects of the size of multiwalled carbon nanotube (MWCNT) nanoparticles and layers on the flow of sodium alginate (SA) base fluid in a vertical channel. The nanoparticles are used to improve the thermal characteristics of the base fluid. The nanolayer shows the relationship between the particles and the base fluid, justifying the rise in thermal conductivity, even at a low volume of the nanoparticle in the base fluid. The mechanics of the fluid through the channels are developed using nonlinear models of coupled higher order differentials analyzed using the adomian decomposition method, an analytical scheme. The nanolayer effect of MWCNT particles on pure sodium alginate enhances heat transfer by 31.83% upon a step increase of 0.4 from 0.2 nm. Additionally, the combined effects of the rheological parameters of particle size, radiation and shear stress lead to a high heat transfer rate. The results obtained from the analysis were verified with results obtained from the literature for simple conditions, which validated the analysis. The results of this study may provide meaningful insight into the physical application of the sodium alginate.