Stress Loading Research Articles

Harnessing stimuli‐responsive biomaterials for advanced biomedical applications

AbstractCell behavior is intricately intertwined with the in vivo microenvironment and endogenous pathways. The ability to guide cellular behavior toward specific goals can be achieved by external stimuli, notably electricity, light, ultrasound, and magnetism, simultaneously harnessed through biomaterial‐mediated responses. These external triggers become focal points within the body due to interactions with biomaterials, facilitating a range of cellular pathways: electrical signal transmission, biochemical cues, drug release, cell loading, and modulation of mechanical stress. Stimulus‐responsive biomaterials hold immense potential in biomedical research, establishing themselves as a pivotal focal point in interdisciplinary pursuits. This comprehensive review systematically elucidates prevalent physical stimuli and their corresponding biomaterial response mechanisms. Moreover, it delves deeply into the application of biomaterials within the domain of biomedicine. A balanced assessment of distinct physical stimulation techniques is provided, along with a discussion of their merits and limitations. The review aims to shed light on the future trajectory of physical stimulus‐responsive biomaterials in disease treatment and outline their application prospects and potential for future development. This review is poised to spark novel concepts for advancing intelligent, stimulus‐responsive biomaterials.

InSAR- and PCA-Based Inversion Reveals the Surface Deformation and Earthquake Sequence in the Weiyuan-Rongxian Shale Gas Field

In recent years, the rapid expansion and development of the shale gas industry in the Sichuan Basin has coincided with a series of unexpected moderate-sized earthquakes. Given that the Sichuan Basin is situated within a stable interior block, the focal mechanism of the 2019 earthquake sequence (ML4.7, ML5.4, and ML5.2) in the Weiyuan-Rongxian area remains a subject of debate. In this study, we propose a joint InSAR- and PCA- based inversion method utilizing the distributed Mogi model to investigate the spatial-temporal characteristics of a gas reservoir and evaluate the induced Coulomb stress change. The surface deformation derived from Sentinel-1 data between 2015 and 2021 was consistent with the spatial distribution of production wells, and it correlated with the temporal changes in reservoir volume associated with the shale gas operating process. The Coulomb stress loading on the regional faults suggests that human activities associated with shale gas operation likely triggered the three moderate earthquakes. Furthermore, our results indicate Coulomb stress loadings of 10 kPa, 15 kPa, 5 kPa, 3 kPa, and 87 kPa on the Dongxingchang fault, Gaoqiao fault, Dayaokou fault, Niujingao fault, and Lijiachang fold, respectively. Consequently, fluid injection and extraction during shale gas development could be contributing to the elevated seismic activity in the Weiyuan-Rongxian area.

The importance of mechanosensitive cell mediated prostaglandin and nitric oxide synthesis in the pathogenesis of apical periodontitis: comparative with chronic periodontitis

ObjectivesMechano-sensitive odontoblast cells, which sense mechanical loading and various stresses in the tooth structure, synthesize early signaling molecules such as prostaglandin E2 (PGE2) and nitric oxide (NO) as an adaptive response. It is thought that these synthesized molecules can be used for the diagnosis and treatment of periodontal and periapical diseases. The aim of this study was to investigate the relationship between the severity of apical periodontitis (AP) and chronic periodontitis (CP) and serum (s) TNF-α, IL-10, PGE2 and NO levels, as well as PGE2 and NO levels in gingival crevicular fluid (GCF) samples.Materials & methodsA total of 185 subjects were divided into three categories: AP group (n = 85), CP group (n = 50) and healthy control group (n = 50). The AP group was divided into 3 subgroups according to abscess scoring (AS-PAI 1, 2 and 3) based on the periapical index. The CP group was divided into 4 subgroups according to the periodontitis staging system (PSS1, 2,3 and 4). After recording the demographic and clinical characteristics of all participants, serum (s) and gingival crevicular fluid (GCF) samples were taken. TNF-α, IL-10, PGE2 and NO levels were measured in these samples.ResultsUnlike serum measurements (sTNF-α, sIL-10, sNO and sPGE2), GCF-NO and GCF-PGE levels of the AP group were significantly higher than the control group in relation to abscess formation (54.4 ± 56.3 vs. 22.5 ± 12.6 µmol/mL, p < 0.001 and 100 ± 98 vs. 41 ± 28 ng/L, p < 0.001, respectively). Confirming this, the GCF-NO and GCF-PGE levels of the AS-PAI 1 group, in which abscesses have not yet formed, were found to be lower than those in AS-PAI 2 and 3, which are characterized by abscess formation [(16.7(3.7-117.8), 32.9(11.8-212.8) and 36.9(4.3-251.6) µmol/mL, p = 0,0131; 46.0(31.4–120.0), 69.6(40.3-424.2) and 74.4(32.1–471.0) ng/L, p = 0,0020, respectively]. Consistent with the increase in PSS, the levels of sTNF [29.8 (8.2-105.5) vs. 16.7(6.3–37.9) pg/mL, p < 0.001], sIL-10 [542(106–1326) vs. 190(69–411) pg/mL, p < 0.001], sNO [182.1(36.3–437) vs. 57.0(15.9–196) µmol/mL, p < 0.001], sPGE2 [344(82-1298) vs. 100(35-1178) ng/L, p < 0.001], GCF-NO [58.9 ± 33.6 vs. 22.5 ± 12.6 ng/L, p < 0.001] and GCF-PGE2 [ 99(37–365) vs. 30(13–119), p < 0.001] in the CP group were higher than the control group. Comparison ROC analysis revealed that the GCF-PGE2 test had the best diagnostic value for both AP and CP (sensitivity: 94.1 and 88.0; specificity: 64.0 and 78.0, respectively; p < 0.001).ConclusionsGCF-PE2 and GCF-NO have high diagnostic value in the determination of AP and CP, and can be selected as targets to guide treatment. In addition, the measurements of PGE2 and NO in GCF can be used as an important predictor of pulpal necrosis leading to abscess in patients with AP.Clinical relevanceIn this article, it is reported that syntheses of early signaling molecules such as PGE2 and NO can be used for the diagnosis and treatment target of periapical and periodontal infections.

Mineralocorticoid receptor overactivation in diabetes mellitus: role of O-GlcNAc modification.

Hypertension is a significant risk factor for microangiopathy and cardiovascular complications in diabetic patients. The efficacy of mineralocorticoid receptor (MR) antagonists in impeding the advancement of diabetic nephropathy, along with the reduction in active renin concentration observed in diabetic retinopathy, strongly implies the involvement of MR overactivation in diabetic complications. This review provides a comprehensive review of various mechanisms proposed for MR overactivation in diabetes mellitus. In particular, it focuses on post-translational MR modifications, including O-linkedN-acetylglucosamine modification and phosphorylation, which have been implicated in MR protein stabilization and overactivation under conditions of high glucose. Given the role of MR overactivation in hyperglycemia, it emerges as a promising therapeutic target for preventing diabetic complications. Post-translational modifications (PTMs), such as O-GlcNAcylation and phosphorylation, are related to MR overactivation in diabetes and metabolic syndrome. Aldosterone binding promotes the proteasomal degradation of MR. Under conditions of high glucose, O-GlcNAcylation, and PKCβ-mediated MR phosphorylation are increased. Salt loading and oxidative stress also increase MR phosphorylation through the EGER/ERK pathway. PTMs inhibit ubiquitin attachment to the MR and interfere with the receptor's aldosterone-induced proteasomal degradation. Consequently, they increase the sensitivity of the MR to aldosterone and exacerbate aldosterone-associated complications.

Remote monitoring of sleep disorder using FBG sensors and FSO transmission system enabled smart vest

Optical sensors, particularly fiber Bragg grating (FBG) sensors have achieved a fast ingress into the fields of medical diagnostic and vital signs monitoring. Wearable smart textiles equipped with FBG sensors are catching huge research attention in different applications for measurement and monitoring of physiological parameters. In this paper, we report a simple technique for remote monitoring of sleep disorder using a smart vest implemented with four FBG stress sensors located at different sides of the vest and free space optics (FSO) transmission system. The sleep disorder of the patient is monitored in real time through shifts in the original Bragg wavelengths of sensors by stress loading during random changes in patient’s sleeping postures. The reflected wavelength from a stress loaded sensor at a certain posture is transmitted over 0.5 km long FSO channel towards remote medical center, photodetected, and then can be processed in a PC to record the restlessness in a certain time interval in terms of total number of times sleeping postures are changed, total time spent at a certain posture etc. To correctly detect the stress loaded FBG sensor at the medical center, various parameters of FBG sensors and demultiplexer are carefully adjusted to minimize the power leakages from unloaded sensors that may result into errors in the detection. Maximum dynamic range around 45 dB has been achieved ensuring accurate detection. This study not only provides a cost-efficient and non-intrusive solution for monitoring the sleep disorder of patients but also can be used for real-time monitoring of various other ailments, such as lung, brain, and cardiac diseases in future.

Performance of reinforced concrete slabs subjected to simultaneous fire and blast loads

Reinforced concrete (RC) slabs might experience severe damage from multiple hazards such as fire, explosion, and impact during their service life. RC slabs under independent or sequential hazard such as fire or blast loading have been intensively investigated. In reality, fire and explosion often occur simultaneously instead of occurring one after the other as assumed in some previous studies. Simultaneous actions of thermal loading and blast loading on structures are likely to generate different responses or even different response modes and failure mechanisms of structures as compared to independent or sequential actions of the two loads on structures. However, very limited study has been conducted to investigate the performance of RC slabs under simultaneous fire and blast loads. This study investigates the dynamic performance of RC slabs subjected to concurrent fire and blast loads, considering the simultaneous actions of thermal-induced stress, deformation, material deterioration and blast loading. The numerical model is first calibrated with the test results of RC slab under fire or blast loading. With the calibrated numerical model, the effect of thermal stress induced by fire loading on the blast performance is investigated. The influences of fire duration before the occurrence of explosion, as well as the blast loading scenarios and RC slab parameters on the structural responses are investigated. The dynamic responses induced by blast loading after the fire action as usually assumed in the literature are also calculated and compared with those obtained from simultaneous fire and blast loads. Their implications on representing the effects of coupled concurrent fire and blast loads on structural performances are discussed.

Cyclic loading and unloading strain equations and damage evolution of gypsum specimens considering damping effects

This study aims to establish a strain instanton equation and damage factor evolution law for gypsum specimens by considering damping. First, damping energy is calculated based on the single-degree-of-freedom vibration model, and the instantaneous strain equation is obtained based on the stress balance equation. Second, the dissipation energy is divided into damping and damage energies, and a damage-factor correction algorithm is obtained. Third, cyclic loading and unloading tests were performed at different loading rates and stress amplitudes to verify the accuracy of the strain equation. Finally, the specimens’ magnitude curves and crack characteristics were monitored using moment–tensor acoustic emission simulations. The factors influencing the damping energy and strain equations, energy and damage evolution laws of the specimens, and damage patterns of the specimens at different loading rates were analysed. The results show that the instantaneous strain equation and the modified damage factor considering the damping effect can effectively reflect the deformation law and damage state of the specimens. In contrast, the damage to the specimens in the lower limit of the variable stress experiment was lower than that in the lower limit of the constant stress experiment. As the loading rate increases, the damage energy density of the specimen decreases, and the damage factor within a single cycle gradually decreases. As the loading rate increases, the number of crack events in the model increases significantly, size becomes more uniform, and sequentially exhibits dense and sparse distribution patterns, percentage of shear cracks decreases significantly, number of mixed cracks increases significantly, brittle behaviour of the specimen becomes obvious, and a complete damage state is attained known as the ‘crushed’ state. This study provides a theoretical reference for damage assessments of viscoelastic–plastic materials subjected to perturbing loads.

Fatigue damage evolution of modified recycled aggregate concrete

Basalt fiber (BF) and nano-silica (NS) are used to improve the properties of recycled aggregate concrete (RAC) and produce modified RAC (MRAC). The fatigue failure patterns of the MRAC were observed through a uniaxial compression fatigue test, and the reasons for the different patterns were explained. The effects of the stress level, replacement rate, and loading frequency on the fatigue life were investigated, and the effects of BF and NS on the fatigue strain, damage evolution, and energy dissipation evolution of MRAC were analyzed. The enhancement mechanism of BF and NS on RAC was revealed using microstructural analysis techniques, such as scanning electron microscopy (SEM) and computed tomography (CT). The results showed that the fatigue failure modes of the MRAC could be divided into split, shear, and mixed failures. The fatigue life and fatigue strain of RAC exhibited a pattern of initially increasing and subsequently decreasing with an increase in the BF content (from 0 kg m−3 to 3 kg m−3 and then to 6 kg m−3). At stress level of 0.80, the average fatigue life of the specimens increased by 76.15 % compared to RAC when the BF doping was 3 kg m−3; however, when the BF doping was increased to 6 kg m−3, the average fatigue life of the specimens increased by only 47.68 % compared to RAC. The mixed BF and NS improved the fatigue life of RAC more than the single mixed BF or NS. Fatigue equations and unified single logarithmic fatigue equations, including fiber parameters, were established to accurately describe the relationship between the fatigue stress level, fatigue life, and failure probability. The fatigue strain gradually decreases with increasing NS content (0–2 %); with increasing loading frequency (from 1 Hz to 10 Hz and then to 15 Hz), the fatigue strain gradually decreases. The fatigue life of the MRAC decreased dramatically at low loading frequencies (1 Hz) and then steadily increased as the loading frequency increased. BF and NS have an improving effect on the porosity of microstructure, improve the fatigue life of RAC, and BF exhibits a more significant improvement than NS. A composite fatigue damage model that comprehensively considers the contribution rates of NS and BF was established, and the fatigue damage evolution of the MRAC was predicted.

Experimental evaluation of stress history effect on compressibility characteristics of lime-stabilized expansive soils

ABSTRACT Lime stabilization has long been identified as an effective method for reducing the swelling potential of expansive soils. Despite numerous studies evaluating the volumetric behaviour of lime-stabilized expansive soils, the influence of stress history variations on deformation characteristics of these soils has not been adequately explored. This study specifically evaluates the impact of stress history conditions on compressibility characteristics of lime-stabilized expansive soils, with special attention to the rebound index at different loading stages. In this regard, one-dimensional consolidation-swell tests were conducted on samples containing different lime percentages (3% to 12%) under various stress history conditions. To include different stress history conditions, overconsolidation ratio (OCR), seating pressure, and loading step were varied during the induction of stress history in the samples. Results showed that OCR and seating pressure significantly influenced both the rebound (increased up to 118%) and compression indices (decreased up to 53%), while the loading step had a negligible impact on the compressibility properties of stabilized soils. Additionally, when comparing the relative importance of investigated parameters, it was revealed that, OCR had the highest influence on the rebound index (up to 118.0% increase), while the compression index was most significantly affected by lime percentage (up to 61.4% decrease).

Smith machine squats pose high risk to ACL graft integrity after the ACL reconstruction and conventional squats are a safer alternative.

The purpose of this study was to evaluate the impact of squats after the anterior cruciate ligament (ACL) reconstruction on the ACL graft, considering new data on biomechanics, posterior tibial slope (PTS)and anterolateral ligament (ALL). Utilising finite element analysis on the new 14-component knee joint model, we have evaluated stresses on the knee elements separately for the knee with a native double-bundle ACL and with a single-bundle ACL graft for the 5° and 14° PTS variants during both conventional and Smith machine horizontal squats. Replacing a native ACL with a single-bundle graft causes an overstrain on the graft compared to the intact ACL under all conditions. Stresses on the ACL, ACL graftand ALL are much higher during the Smith machine squats compared to the conventional ones. The stress on the menisci is 3.6-4.9 times higher with conventional squats. PTS at the squats' lowest point minimally affects ACL stress but impacts menisci. The single-bundle ACL reconstruction (ACLR) does not reproduce the biomechanics of the native ACL and increases stresses in most knee joint elements, according to the current study. Conventional squats are relatively safe for the ACL graft at their lowest point. Passing the half-squat position is the most dangerous point. Smith machine horizontal squats produce stress on the ACL graft several times higher than its estimated breaking load and dangerous stress levels on the ALL. During the rehabilitation following ACLR, it is advisable to prioritise the conventional squats over Smith machine squats until ligamentisation is complete. Level III.

Interpretation of Frequency Effect for High-Strength Steels with Three Different Strength Levels via Crystal Plasticity Finite Element Method.

The fatigue behavior of a high-strength bearing steel tempered under three different temperatures was investigated with ultrasonic frequency and conventional frequency loading. Three kinds of specimens with various yield strengths exhibited obvious higher fatigue strengths under ultrasonic frequency loading. Then, a 2D crystal plasticity finite element method was adopted to simulate the local stress distribution under different applied loads and loading frequencies. Simulations showed that the maximum residual local stress was much smaller under ultrasonic frequency loading in contrast to that under conventional frequency at the same applied load. It was also revealed that the maximum local stress increases with the applied load under both loading frequencies. The accumulated plastic strain was adopted as a fatigue indicator parameter to characterize the frequency effect, which was several orders smaller than that obtained under conventional loading frequencies when the applied load was fixed. The increment of accumulated plastic strain and the load stress amplitude exhibited a linear relationship in the double logarithmic coordinate system, and an improved fatigue life prediction model was established.

Permeability evolution of fractured coal subject to confining stress and true triaxial stress loading: experiment and mathematical model

The accurate elucidation and prediction of coal permeability evolution under stress loading conditions are crucial for coalbed methane production. In this study, flow experiments were conducted on six cylindrical coal samples and four cubic coal samples under both confining and true triaxial stress loading conditions, respectively. The structure and characteristic parameters of the fractures inside each coal sample were obtained using the computed tomography scanning system and image processing technologies. The coal permeability under both types of loading processes was calculated through the transient pulse method. A mathematical model was developed to assess the evolution of coal permeability under true triaxial loading based on the current true triaxial permeability model and fractal theory. The results revealed that during the confining pressure loading, the coal permeability decreased exponentially with effective stress and was effectively described using the SD model. Additionally, the coal permeability initially rapidly decreased, followed by a gradual decrease, and eventually stabilized at a constant value. Particularly, during the first three loading steps, the fracture aperture and corresponding permeability of the six cylindrical coal samples decreased by ∼51.79%–57.83% and ∼38.06%–42.12%, respectively. However, during the final three loading steps, the fracture aperture and corresponding permeability of the six coal samples decreased by ∼18.26%–23.08% and ∼22.15%–26.93%, respectively. Moreover, owing to the various crossing angles of complex fracture networks with each principal stress, the effect of each principal stress on the coal permeability evolution was highly anisotropic during triaxial stress loading. Particularly, the permeability of the ST1 sample decreased by 43.08%, 14.84%, and 42.08% during the loading of each principal stress. Similarly, the permeability of the ST2 sample decreased by ∼65.74%, 14.29%, and 19.97%. The permeability reductions for the ST3 sample were ∼34.03%, 55.85%, and 10.12%, while those for the ST4 sample were ∼35.97%, 46.51%, and 17.52%. The SD model failed to describe these anisotropic effects. Compared with the SD model, the improved model, based on the current true triaxial permeability model and fractal theory, effectively described the anisotropic effect of each principal stress on the permeability of coal samples with complex fracture networks under triaxial stress conditions.

A phase field approach to the fracture simulation of quasi-brittle structures with initial state

To solve the simulation problem of crack propagation in solid structures with initial stress, this paper proposes a phase field approach that considers the initial state of the quasi-brittle structure. By using the initial equilibrium iteration method, the estimated initial state of the structure, including initial stress, is transformed into internal stress loads of the structure. Thus, the problem of non-convergence caused by inaccurate initial state estimation of the structure in engineering calculations was solved, and an improved subproblem staggered iteration method was adopted to simulate crack propagation of the structure under external loads. The universality and computational accuracy of this method for different phase field models were verified by using pre made notched thin plates for the expansion of mode I and II cracks in different initial states. Among them, the calculation error using the PF_CZM model is within 1%, and the calculation error of the AT2 model increases with the initial stress, but is less than 7%. At the same time, the crack growth problem of cracked structures under different uniform initial stresses is accurately simulated, which reflects the applicability of this method to actual engineering. In addition, the study also verified the universal applicability of the adaptive refinement strategy proposed based on the AT2 model for other phase field models.

Full-Scale Modeling and FBGs Experimental Measurements for Thermal Analysis of Converter Transformer.

As the imbalance between power demand and load capacity in electrical systems becomes increasingly severe, investigating the temperature variations in transformers under different load stresses is crucial for ensuring their safe operation. The thermal analysis of converter transformers poses challenges due to the complexity of model construction. This paper develops a full-scale model of a converter transformer using a multi-core high-performance computer and explores its thermal state at 80%, 100%, and 120% loading ratios using the COUPLED iteration method. Additionally, to validate the simulation model, 24 FBGs are installed in the experimental transformer to record the temperature data. The results indicate a general upward trend in winding the temperature from bottom to top. However, an internal temperature rise followed by a decrease is observed within certain sections. Moreover, as the loading ratio increases, both the peak temperature and temperature differential of the transformer windings rise, reaching a peak temperature of 107.9 °C at a 120% loading ratio. The maximum discrepancy between the simulation and experimental results does not exceed 3.5%, providing effective guidance for the transformer design and operational maintenance.

Flexural Behaviour of RC Beam with Pond Flyash and ESP FlyAsh

The use of Supplementary Cementitious Materials (SCM) such as Fly ash, Granulated Slag and Silica fume as a replacement for Portland cement in concrete presents one viable solution with multiple benefits for the sustainable development of the construction industry. Out of various supplementary materials, Fly ash is the most widely used material worldwide. Fly ash has excellent structural and durability characteristics. The pore filling effect and pozzolanic properties of Flyash improves the properties of fresh and hardened concrete. In addition to the cost saving bythe replacement amount of cement; it reduces co2emission during the manufacture of Portland cement. In the present investigation, a controlled beam and six number of ESP flyash and Pond flyash beams of size 200 x 100 x 1700 mm were cast. This paper deals with the investigation on the flexural behaviour of beam with pond flyash and ESP (Electro static precipitated) flyash at various cement replacement levels of 4%, 6%, and 8% and the results are compared with controlled beam. The flexural test was conducted to determine the ultimate load carrying capacity of the beams and their corresponding mid span deflection, load point deflection, crack pattern, Stress vs strain are measured. The flexural strength of ESP flyash is increased 24.76% for 8% replacement level and pond flyash is increased 10.97 % for 6% replacement level than controlled beam respectively. This study revealed that the replacement of cement by flyash concrete provides higher compressive strength &amp; flexural strength compared with controlled concrete.

Fatigue characteristics of rubber isolation layers used in high speed railway ballastless tracks: A theoretical and experimental study

In order to enhance operational conditions for high-speed trains on long-span bridges, the utilization of rubber under-ballast mats were taken as a novel isolation layer in ballastless tracks. Due to the increased train axle load, it is imperative to conduct investigation into the fatigue properties of the rubber isolation layer, so as to ensure the smoothness of the railways. In this work, a series of fatigue tests were performed on the rubber isolation layer to obtain the influence of stress amplitude and loading cycles on its fatigue performance. The results demonstrate a pronounced non-linear load–displacement relationship of the rubber isolation layer with increasing load, while the fatigue endurance significantly decreases with escalating the stress amplitude. Moreover, considering the hyperelastic properties of rubber material, the Mooney-Rivlin constitutive model was employed in finite element simulations. Subsequently, the stress distributions of the rubber isolation layer were analyzed, and the fatigue life was evaluated based on Luo stress method. The rubber isolation layer exhibits localized damage that does not affect the overall performance after 32 years of normal service condition. Therefore, the fatigue performance of the rubber isolation layer remains reliability, providing assurance for the application in ballastless tracks on high-speed railway long-span bridges.

Analysis of cartilage loading and injury correlation in knee varus deformity.

Knee varus (KV) deformity leads to abnormal forces in the different compartments of the joint cavity and abnormal mechanical loading thus leading to knee osteoarthritis (KOA). This study used computer-aided design to create 3-dimensional simulation models of KOA with varying varus angles to analyze stress distribution within the knee joint cavity using finite element analysis for different varus KOA models and to compare intra-articular loads among these models. Additionally, we developed a cartilage loading model of static KV deformity to correlate with dynamic clinical cases of cartilage injury. Different KV angle models were accurately simulated with computer-aided design, and the KV angles were divided into (0°, 3°, 6°, 9°, 12°, 15°, and 18°) 7 knee models, and then processed with finite element software, and the Von-Mises stress distribution and peak values of the cartilage of the femoral condyles, medial tibial plateau, and lateral plateau were obtained by simulating the human body weight in axial loading while performing the static extension position. Finally, intraoperative endoscopy visualization of cartilage injuries in clinical cases corresponding to KV deformity subgroups was combined to find cartilage loading and injury correlations. With increasing varus angle, there was a significant increase in lower limb mechanical axial inward excursion and peak Von-Mises stress in the medial interstitial compartment. Analysis of patients' clinical data demonstrated a significant correlation between varus deformity angle and cartilage damage in the knee, medial plateau, and patellofemoral intercompartment. Larger varus deformity angles could be associated with higher medial cartilage stress loads and increased cartilage damage in the corresponding peak stress area. When the varus angle exceeds 6°, there is an increased risk of cartilage damage, emphasizing the importance of early surgical correction to prevent further deformity and restore knee function.

Thoughts of the February 20, 2023 Defne aftershock

On February 6 2023, two large earthquakes with magnitudes of Mw 7.8 (Pazarcık) and Mw 7.6 (Elbistan) occurred consecutively along the East Anatolian Fault Zone in eastern Turkey, causing enormous casualties and heavy damage. This devastating sequence of earthquakes was followed by the Defne aftershock on February 20 near Antakya province, which increased the damage and loss of life. Here, the teleseismic broadband P velocity waveforms are inverted to obtain the coseismic finite-fault slip distribution of the February 20, 2023 Defne aftershock. It was found that the rupture was controlled by the failure of a single asperity with the largest displacement of approximately 0.75 m, which occurred between 6 and 20 km depth. The source mechanism indicated a dominant left-lateral faulting with a significant normal component and released a total seismic moment of 5.85x1018 Nt.m. Coseismic Coulomb stress changes modelling showed that the Defne aftershock rupture was triggered by the earthquake sequence and that the February 6 Pazarcık earthquake had a dominant effect. In the stress modelling carried out on the Dead Sea Fault, the northern segment of the fault remained in the region of significant positive stress loading. Considering the positive stress load over 1 bar created by the earthquake sequence and the Defne aftershock ruptures, as well as the fact that no major earthquake has occurred for more than 600 years, it is clear that the probability of rupture in the northern part has increased significantly and the seismic hazard is high.

Durability of concrete subjected to acidic exposure under flexural loading

The durability of concrete under combined acidic exposure and flexural loading was studied. Concrete specimens were made and subjected to up to 168 days of exposure to flexural loading (stress levels of 0, 0.35 and 0.50 of the 28 day flexural strength) and an acidic environment. Concrete properties such as neutralisation depth, mass change, compressive strength and flexural strength were measured. The compositions of different samples were determined by means of X-ray diffraction and chemical analysis and the microstructure of samples was examined using scanning electron microscopy. The results showed that, with an increase in stress level from 0 to 0.50, the performance of the concrete deteriorated gradually and the deterioration in the tension zone was greater than that in the compression zone. The concrete performance improved within 28 days but deteriorated dramatically afterwards. The acidic solution reacted with the cement paste, leading to the formation of harmful gypsum and the decomposition and dissolution of cement hydration products. An increase in stress level increased the porosity of the concrete, accelerating the rate of acid erosion, which led to a deterioration of concrete performance.

Influence of weak interlayer thickness on mechanical response and failure behavior of rock under true triaxial stress condition

In this study, we meticulously investigate the influence of the thickness of weak interlayer on mechanical response and failure behavior of rock mass near the free surface of tunnel, with the aid of a true triaxial test system. We simulated the true triaxial stress condition of rock mass containing weak interlayer proximate to the excavation boundary, where one face remains free, while others are subjected to loading stress and increasing tangential stress. The experimental results reveal a distinct change in the fracture morphology near the free surface of rock mass as the thickness of weak interlayer increases, concomitant with a gradual decrease in the fractal dimension. With the increase of the thickness of weak interlayer, the failure characteristics of rock mass change from a “binary” to a “unitary” feature, i.e. mixed tension-shear failure near the free surface and shear failure far away from the free surface changes to mixed tension-shear failure that only occurs near the free surface. Moreover, an inverse relationship is observed between the bearing capacity of the rock mass and the thickness of weak interlayer. Conversely, the peak strain in the tangential stress direction increases with the increase of the thickness of weak interlayer, illustrating that the slip shear strain of rock block positioned above the weak interlayer is gradually formed, and governs the strain behavior of rock mass in the tangential stress direction with the increases of the thickness of weak interlayer. By employing the finite-discrete element method (FDEM), we replicated the failure process of surrounding rocks containing weak interlayers near the free surface of tunnel, demonstrating considerable congruity with our physical test results. In light of the failure characteristics of surrounding rocks containing weak interlayers, we advocated a localized area priority reinforcement support strategy, prioritizing regions with weak interlayers. Numerical simulations verified the effectiveness of this approach in controlling fracture proliferation in surrounding rocks and inhibiting the splitting failure of surrounding rocks containing weak interlayers near the free surface of tunnel.