Subjective Stress Research Articles

Reducing neuroendocrine psychosocial stress response through socio-emotional dyadic but not mindfulness online training.

Stress-related diseases pose significant health risks and show wide prevalence. Empirical evidence suggests that contemplative practices, such as socio-emotional dyadic mental exercises, hold promise in mitigating the adverse effects of stress and promoting psychosocial well-being. This study aimed to investigate the differential effects of two online contemplative mental training programs on the psychosocial stress response: the first involved classic mindfulness practices, while the second incorporated a socio-emotional dyadic approach known as Affect Dyad. The study was conducted as part of the longitudinal CovSocial project's phase 2 in the context of the COVID-19 pandemic. 140 individuals participated in the Trier Social Stress Task (TSST), where the psychosocial stress response was assessed with cortisol saliva samples and subjective stress questionnaires in a cross-sectional design after the active training groups finished their intervention period. Participants were randomly assigned to the socio-emotional training group, mindfulness-based training group, or a control group that did not receive any training. Both training programs consisted of a ten-week intervention period with a daily 12-minute app-based mental training practice and weekly 2-hour online coaching sessions led by mental training teachers. Results showed that the socio-emotional Dyad group but not the mindfulness-based group exhibited significantly lower cortisol levels at 10, 20, 30, and 40 minutes after the stressor as well as lower total cortisol output compared to the control group during the TSST, indicating a reduced hormonal stress response to a social stressor. Subjective markers did not show differences between the three groups. These findings indicate that the daily socio-emotional dyadic practice, which emphasizes non-judgmental and empathic listening as well as the acceptance of challenging emotions in the presence of others within one's daily life context, may serve as a protective factor against the adverse effects of psychosocial stress triggered by the fear of negative social judgments. Given the high prevalence of stress-related diseases, such online mental training programs based on dyadic practices may thus represent an efficient and scalable approach for stress reduction.

Wall motion assessment by feature tracking in pediatric patients with coronary anomalies undergoing dobutamine stress CMR.

Left ventricular (LV) wall motion assessment is an important adjunct in addition to perfusion defects in assessing ischemic changes. This study aims to investigate the feasibility and utility of performing feature tracking (FT) in pediatric patients with coronary anomalies undergoing dobutamine stress CMR to assess wall motion abnormalities (WMA) and perfusion defects. This is a retrospective study where 10 patients with an inducible first-pass perfusion (FPP) defect and 10 without were selected. Global LV circumferential strain/strain rate (GCS/GCSR) was measured at rest and at peak stress (systole and diastole) using a commercially available feature tracking software. Peak GCS and GCSR were compared to indexed wall motion score (WMSI) between groups with and without FPP defect and in subjects with and without WMA. The median age of patients was 13.5 years (Q1, 11 years; Q3, 15 years). Five subjects had qualitatively WMA at peak stress. A moderate correlation of GCS with WMSI at peak stress (0.48, p = 0.026) and a significant difference between GCS at rest and stress in patients with no inducible WMA (p = 0.007) were seen. No significant difference was noted in GCS between rest and stress in patients with WMA (p = 0.13). There was a larger absolute GCS/GCSR at peak stress in subjects with no inducible FPP defect or WMA. Smaller absolute GCS and a lack of significant change in GCS at peak stress in those with inducible WMA or perfusion defect are suggestive of compromised LV deformation in subjects with inducible WMA. Given these findings, GCS derived from CMR-FT may be used to objectively assess WMA in pediatric patients undergoing stress CMR.

Subjective Stress Appraisals Over Time: the Evolving Structure of the COVID-19 Stressor Scale.

The COVID-19 Stressors Scale measures individuals' appraisals of stressors related to the pandemic. Measurement of perceptions of stressors is necessary to understand the socioemotional impacts of not only the COVID-19 pandemic, but other disasters. The study examined the factor structure of the scale among adults in the U.S. over six time points. A shortened version was used, and the fit was examined over time. The results of the study show contextual appraisals change over time and offer important implications for the measurement of stressfulness of disasters, a critical step in designing and assessing impacts of social programs aimed to reduce the deleterious effects of disasters.

Effect of casozepine administration on stress in dogs during a veterinary examination – A randomized placebo-controlled trial

The aim of the study was to investigate the stress-reducing effect of a casozepine before a veterinary examination in dogs. It should be examined whether the dogs are less stressed during a standardized veterinary examination after an oral application of casozepine over 2 days and whether the administration has an influence on the salivary concentrations of the stress hormones vasopressin and cortisol. Across the study group (n=36), a significantly lower stress score (P=0.0026) and lower mean (P=0.01) and maximum (P=0.024) pulse rates were seen at follow-up after casozepine administration, in contrast to the placebo group (n=26). Salivary vasopressin concentrations increased during follow-up in the placebo group (P=0.04), whereas they remained the same in the casozepine group. Cortisol concentrations increased during follow-up in the casozepin group (P=0.01). The results indicate that although dogs in both groups remained excited at follow-up, short-term casozepine administration before a veterinary visit had a weak stress-reducing effect in dogs based on subjective stress scoring and pulse rate.

Cognitive Training Prevents Stress-Induced Working Memory Deficits

BackgroundWorking memory is a fundamental cognitive process that is critically involved in planning, comprehension, reasoning, and problem solving. Acute stress has been shown to impair working memory. This stress-induced working memory deficit has profound implications for cognitive functioning in everyday life as well as for stress-related mental disorders. Here, we tested whether a cognitive training intervention would make working memory more resistant to disruptive effects of acute stress. MethodsIn a preregistered, fully crossed between-subjects design with the factors stress (vs. control) and cognitive training (vs. sham), 123 healthy men and women (ages 18–35 years) completed a daily cognitive training program targeting working memory–related processes or a sham training over a period of 6 weeks. After this 6-week training intervention, participants underwent a standardized stress or control manipulation shortly before their working memory performance was tested. ResultsAs expected, the exposure to acute stress led to a significant working memory impairment in the sham training group. Critically, although the subjective, autonomic, and endocrine stress responses were comparable in the 2 training groups, this stress-induced working memory impairment was abolished in the intervention training group. ConclusionsThese results are the first to show that a cognitive training intervention directed at prefrontal and hippocampal functioning can prevent the detrimental effects of stressful events on working memory performance.

Effects of natural sound on human stress recovery based on EEG techniques

Natural sounds are an essential part of a restorative environment. Although numerous studies have established the positive impact of natural sounds on human health and well-being, few have examined the differences between natural sounds on human stress recovery. This study examined the impact of natural sounds on stress recovery by comparing a silent environment (control group) with three experimental groups exposed to flowing water sound, birdsong, and wind sounds. The investigation entailed the assessment of subjective assessments and EEG signals from 30 subjects (12 males and 18 females). The subjective evaluations indicated that the PRS scores for the sounds of flowing water and birdsong were superior to those of the silent environment. The EEG results revealed that EEG-α activity was more pronounced in response to natural sounds than the silent environment, with birdsong evoking the most significant EEG-α activity. Wind sounds increased the mental stress of the subjects. Conversely, birdsong and flowing water sound were beneficial for alleviating mental stress. Additionally, the analysis of event-related potentials (ERP) demonstrated that natural sounds elicited higher P300 amplitudes in central and parietal lobe sensors and had little effect on the frontal region. The study also demonstrated the correlation between EEG and subjective stress evaluations, providing insights into stress reduction theories and offering practical suggestions for optimizing the acoustic environment in urban settings.

Effect of Auriculotherapy on Stress: A Systematic Review and Meta-Analysis.

Background: Auriculotherapy, a form of therapy that involves stimulating specific points on the ear auricle, has garnered attention for its potential in holistic stress management in adults, aligning with broader patient-centered therapeutic approaches. Objective: The aim of this study was to evaluate the effectiveness of auriculotherapy for stress relief in adults. Methods: A comprehensive search of nine databases (PubMed, Scopus, CINAHL, Web of Science, Ovid Medline, Cochrane Library, RISS, KMbase, and KISS) was performed, yielding 553 studies. Of these, 12 were selected for meta-analysis based on the inclusion criteria, which considered demographic data, types of auriculotherapy, intervention characteristics, auricular points, and stress-related outcomes. The risk of bias was also evaluated for each selected study. Results: The meta-analysis results (n = 12) indicated that auriculotherapy was significantly superior to the control group in terms of subjective stress index, blood pressure, heart rate variability, and pulse rate, as well as improving low-frequency (LF) and high-frequency (HF) heart rate components and their ratio (LF/HF) in adults. Additionally, the subgroup analysis indicated a trend where the effect size of acupressure may be larger than that of acupuncture. Conclusions: Our findings underscore auriculotherapy's efficacy in reducing stress in adults, advocating for its integration into nursing curriculums as a viable clinical intervention for stress management. Promoting its application in clinical environments could complement holistic, patient-centric care paradigms.

REM Sleep Preserves Affective Response to Social Stress-Experimental Study.

Sleep's contribution to affective regulation is insufficiently understood. Previous human research has focused on memorizing or rating affective pictures and less on physiological affective responsivity. This may result in overlapping definitions of affective and declarative memories and inconsistent deductions for how rapid eye movement sleep (REMS) and slow-wave sleep (SWS) are involved. Literature associates REMS theta (4-8 Hz) activity with emotional memory processing, but its contribution to social stress habituation is unknown. Applying selective sleep stage suppression and oscillatory analyses, we investigated how sleep modulated affective adaptation toward social stress and retention of neutral declarative memories. Native Finnish participants (N = 29; age, M = 25.8 years) were allocated to REMS or SWS suppression conditions. We measured physiological (skin conductance response, SCR) and subjective stress response and declarative memory retrieval thrice: before laboratory night, the next morning, and after 3 d. Linear mixed models were applied to test the effects of condition and sleep parameters on emotional responsivity and memory retrieval. Greater overnight increase in SCR toward the stressor emerged after suppressed SWS (intact REMS) relative to suppressed REMS (20.1% vs 6.1%; p = 0.016). The overnight SCR increase was positively associated with accumulated REMS theta energy irrespective of the condition (r = 0.601; p = 0.002). Subjectively rated affective response and declarative memory recall were comparable between the conditions. The contributions of REMS and SWS to habituation of social stress are distinct. REMS theta activity proposedly facilitates the consolidation of autonomic affective responses. Declarative memory consolidation may not have greater dependence on intact SWS relative to intact REMS.

Acute psychosocial stress modulates neural and behavioral substrates of cognitive control.

Acute psychosocial stress affects learning, memory, and attention, but the evidence for the influence of stress on the neural processes supporting cognitive control remains mixed. We investigated how acute psychosocial stress influences performance and neural processing during the Go/NoGo task-an established cognitive control task. The experimental group underwent the Trier Social Stress Test (TSST) acute stress induction, whereas the control group completed personality questionnaires. Then, participants completed a functional magnetic resonance imaging (fMRI) Go/NoGo task, with self-report, blood pressure and salivary cortisol measurements of induced stress taken intermittently throughout the experimental session. The TSST was successful in eliciting a stress response, as indicated by significant Stress > Control between-group differences in subjective stress ratings and systolic blood pressure. We did not identify significant differences in cortisol levels, however. The stress induction also impacted subsequent Go/NoGo task performance, with participants who underwent the TSST making fewer commission errors on trials requiring the most inhibitory control (NoGo Green) relative to the control group, suggesting increased vigilance. Univariate analysis of fMRI task-evoked brain activity revealed no differences between stress and control groups for any region. However, using multivariate pattern analysis, stress and control groups were reliably differentiated by activation patterns contrasting the most demanding NoGo trials (i.e., NoGo Green trials) versus baseline in the medial intraparietal area (mIPA, affiliated with the dorsal attention network) and subregions of the cerebellum (affiliated with the default mode network). These results align with prior reports linking the mIPA and the cerebellum to visuomotor coordination, a function central to cognitive control processes underlying goal-directed behavior. This suggests that stressor-induced hypervigilance may produce a facilitative effect on response inhibition which is represented neurally by the activation patterns of cognitive control regions.

Perceived parental rejection and gaming disorder among adolescents: the mediating role of subjective stress and depressive symptoms

ABSTRACT Previous research suggests that both stress and depression, as well as parental rejection, are important factors in the development of gaming disorder (GD), but no studies so far have proposed a pathway leading from parental rejection via depression and stress to GD. The study aimed to examine the relationship between GD and perceived parental rejection, stress, and depressive symptoms, and to test the moderating effects of sex on these relationships. Data were collected among 1239 adolescents, with an average age of M = 16.77 (SD = .70), 50.3% of whom were females. 1.9% of adolescents met the criteria for GD (2.4% of boys and 1.4% of girls). Higher perceived parental rejection and higher levels of stress and depression were related to more GD symptoms, among male and female adolescents alike. Perceived parental rejection had no direct effect on GD. Only the indirect effects of parental rejection via depression on GD were significant. Research suggests that adolescents who report higher levels of parental rejection are more susceptible to depression and more likely to use gaming as a coping mechanism.

The Individual as Moderator of Variable Relations - A Configural Approach.

Moderators are variables that change the relations among other variables. Moderators are variables that are substantive just as the variables whose relations are moderated. In the present article, we propose using individuals as moderators. Specifically, we propose using Configural Frequency Analysis, that is, investigating moderators from a person-oriented perspective. The question asked is whether variable relations vary across individuals. Base models are specified for Configural Frequency Analysis that allow one to identify individuals that differ in variable relations. In a data example, it is shown that not a single individual in a sample of alcoholics shows the pattern of association between subjective stress and beer consumption that was found for the entire sample. Extensions of the configural moderator model are discussed.

Cold pressor stress effects on cardiac repolarization

The cold pressor test (CPT) elicits strong cardiovascular reactions via activation of the sympathetic nervous system (SNS), yielding subsequent increases in heart rate (HR) and blood pressure (BP). However, little is known on how exposure to the CPT affects cardiac ventricular repolarization. Twenty-eight healthy males underwent both a bilateral feet CPT and a warm water (WW) control condition on two separate days, one week apart. During pre-stress baseline and stress induction cardiovascular signals (ECG lead II, Finometer BP) were monitored continuously. Salivary cortisol and subjective stress ratings were assessed intermittently. Corrected QT (QTc) interval length and T-wave amplitude (TWA) were assessed for each heartbeat and subsequently aggregated individually over baseline and stress phases, respectively. CPT increases QTc interval length and elevates the TWA. Stress-induced changes in cardiac repolarization are only in part and weakly correlated with cardiovascular and cortisol stress-reactivity. Besides its already well-established effects on cardiovascular, endocrine, and subjective responses, CPT also impacts on cardiac repolarization by elongation of QTc interval length and elevation of TWA. CPT effects on cardiac repolarization share little variance with the other indices of stress reactivity, suggesting a potentially incremental value of this parameter for understanding psychobiological adaptation to acute CPT stress.

Assessment of subjective well-being of healthcare workers in response to heat and personal protective equipment under controlled conditions using a standardized protocol

BackgroundDue to climate change, the increasing frequency of hot summer days and heat waves can result in occupational heat strain, especially in non-air-conditioned workplaces. Healthcare workers (HCW) engaged in patient care are particularly affected, as they are additionally exposed to physical stress. The use of personal protective equipment (PPE) can aggravate heat strain in HCW. This study aimed to examine the subjective well-being of HCW when exposed to heat and PPE under controlled conditions.MethodsThis study was designed as a randomized crossover trial. Participants performed standardized healthcare tasks in a climatic chamber for approximately 3.5 h at different indoor temperatures (22 °C and 27 °C) and varied working conditions (with or without PPE). The effects on participants’ subjective well-being, encompassing thermal, physiological and psychological stress were assessed using a customized questionnaire.ResultsHeat had a greater effect than PPE on thermal, physical and psychological stress. Conversely, PPE had a greater effect on physical demand and effort. For the majority of outcomes, combined exposure to heat and PPE resulted in the highest perceived discomfort. Furthermore, the participants reported increased sweating and other discomforts when working at elevated temperatures or with PPE.ConclusionsIn this study, heat and PPE, but particularly the combination of both factors, were identified as unfavorable working environments. Although the trials were conducted in a controlled environment, the outcomes provide valuable information about the effect of heat and PPE on HCW in a real-life setting. Furthermore, the design used in this study can be beneficial in evaluating the effect of mitigation strategies.

Cross-sectional associations of self-perceived stress and hair cortisol with metabolic outcomes and microvascular complications in type 2 diabetes.

Increasing evidence supports chronic psychological stress as a risk factor for the development of type 2 diabetes. Much less is known, however, about the role of chronic stress in established diabetes. The aim of the current study was to comprehensively assess chronic stress in a sample of 73 patients with type 2 diabetes and 48 non-diabetic control participants, and to investigate associations with indicators of glycemic control (HbA1c), insulin resistance (HOMA-IR), β-cell functioning (C-peptide), illness duration, and the presence of microvascular complications. Chronic stress was measured using questionnaires [the Perceived Stress Scale (PSS), the Screening Scale of the Trier Inventory of Chronic Stress (SSCS), the Perceived Health Questionnaire (PHQ) as well as the Questionnaire on Stress in Patients with Diabetes-Revised (QSD-R)]; hair cortisol was used as a biological indicator. We found that patients with type 2 diabetes had higher levels of hair cortisol in comparison to the control group (F(1,112) = 5.3; p = 0.023). Within the diabetic group, higher hair cortisol was associated with a longer duration of the illness (r = 0.25, p = 0.04). General perceived stress did not show significant associations with metabolic outcomes in type 2 diabetes patients. In contrast, higher diabetes-related distress, as measured with the QSD-R, was associated with lower glycemic control (r = 0.28, p = 0.02), higher insulin resistance (r = 0.26, p = 0.03) and a longer duration of the illness (r = 0.30, p = 0.01). Our results corroborate the importance of chronic psychological stress in type 2 diabetes. It appears, however, that once type 2 diabetes has developed, diabetes-specific distress gains in importance over general subjective stress. On a biological level, increased cortisol production could be linked to the course of the illness.

Evaluating perceived side effects of SARS-CoV2 mRNA vaccines by lifestyle factors and nutritional status: Perspectives from a pilot study

Nutritional status, sex, and physical activity have been implicated in severe COVID-19 illness; however, the role of lifestyle factors and nutritional status in determining an individual's response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccines is less well characterized. We evaluated whether self-reported side effects following SARS-CoV2 vaccination differed by body mass index (BMI) and lifestyle factors. We further evaluated whether associations between lifestyle, nutritional status, and self-reported side effects differed by sex or use of hormone-based medications. A survey was administered between May–September 2021 to collect respondents' self-reported demographics, dietary patterns, physical activity, medication and supplement use, history of COVID-19 illness, and SARS-CoV2 vaccine side effects. A total of 82 participants (61.2 % female, 38.8 % male) completed the survey and were included in the final analysis. Females trended toward reporting a greater level of subjective stress (71 %) and engaged in less physical activity (43.2 %) compared to males. While severity of COVID-19 illness and vaccine side effects did not differ by sex and there were no differences in dietary patterns between individuals reporting mild vs. more severe side effects, individuals with a higher BMI trended toward reporting a greater severity of vaccine side effects. Survey participants who engaged in physical activity for more than 30 min per day trended toward reporting a lower severity of side effects compared to those exercising for 30 min a day or less after the first dose (86.7 % vs. 50.0 %), whereas the opposite trend was observed following the second mRNA vaccine dose. In addition, survey participants reporting higher stress levels experienced a greater severity of side effects of the first SARS-CoV2 mRNA vaccine dose compared to those reporting lower stress levels (42.9 % vs. 2.0 %). Further, a greater percentage (75 %) of respondents taking combined oral contraceptives reported experiencing side effects following the first SARS-CoV2 mRNA vaccine dose, whereas participants not using hormone-based contraceptives were more likely to report not experiencing side effects (61.3 %). Together, our findings suggest that self-reported side effects from SARS-CoV2 mRNA vaccines differ by lifestyle characteristics and use of combined oral contraceptives. Further investigation is warranted to determine whether targeting these lifestyle factors is an effective strategy to mitigate vaccine side effects, and whether public health education pertaining to lifestyle and anticipated side effects may reduce the barriers to vaccine acceptance.

Neural correlates of stress-reactive rumination in depression – The role of childhood trauma and social anxiety

Recent work showed an association of prefrontal dysfunctions in patients with Major Depressive Disorder (MDD) and social stress induced rumination. However, up to date it is unclear which etiological features of MDD might cause prefrontal dysfunctions. In the study at hand, we aimed to replicate recent findings, that showed prefrontal activation alterations during the Trier Social Stress Test (TSST) and subsequently increased stress-reactive rumination in MDD compared to healthy controls. Moreover, we aimed to explore the role of adverse childhood experiences and other clinical variables in this relationship. N = 55 patients currently suffering from MDD and n = 42 healthy controls (HC) underwent the TSST, while cortical activity in areas of the Cognitive Control Network (CCN) was measured via functional near-infrared spectroscopy (fNIRS). The TSST successfully induced a stress reaction (physiologically, as well as indicated by subjective stress ratings) and state rumination in all subjects with moderate to large effect sizes. In comparison to HC, MDD patients showed elevated levels of state rumination with large effect sizes, as well as a typical pattern of reduced cortical oxygenation during stress in the CCN with moderate effect sizes. Self-reported emotional abuse and social anxiety were moderately positively associated with increased stress-reactive rumination. Within the MDD sample, emotional abuse was negatively and social anxiety positively associated with cortical oxygenation within the CCN with moderate to large effect sizes. In conclusion, our results replicate previous findings on MDD-associated prefrontal hypoactivity during stress and extends the research toward specific subtypes of depression.

A cross-sectional mental-health survey of Chinese postgraduate students majoring in stomatology post COVID-19 restrictions.

The psychological status of Chinese postgraduate students majoring in stomatology after the COVID-19 restrictions still remains unclear. The objective of this study is to evaluate the mental status through a cross-sectional survey and gather related theoretical evidence for psychological intervention on postgraduate students majoring in stomatology. An online survey was administered, and subjective well-being, anxiety, stress and depression symptoms were assessed using the 5-item World Health Organization Well-Being Index (WHO-5), item Generalized Anxiety Disorder Scale (GAD-7), 10-item Perceived Stress Scale (PSS-10), and Patient Health Questionnaire-9 (PHQ-9), respectively, wherein suicidal ideation and sleep-related problems were measured with PHQ-9 and Insomnia Severity Index (ISI). A total of 208 participants who completed one questionnaire were considered as valid. It was found that female respondents generally exhibited significantly higher levels of PSS-10, PHQ-9, and GAD-7 scores and shorter physical activity hours than male students. Students from rural areas demonstrated significantly higher levels of PHQ-9, suicidal ideation, and less portion of good or fair family economic support. Additionally, individuals from only-child families reported increased levels of activity hours (1.78 ± 2.07, p = 0.045) and a higher portion (55.10%, p = 0.007) of having clear future plan as compared with multiple-child families. The risk factors for anxiety symptoms (GAD-7 score) were higher scores of PSS-10 (OR = 1.15, 95% CI = 1.09-1.22), PHQ-9 (OR = 1.35, 95% CI = 1.22-1.49), and ISI-7 (OR = 1.14, 95% CI = 1.06-1.23), while owning a clear graduation plan was the protective factor (OR = 0.55, 95% CI = 0.31-0.98). Moreover, the risk factors for depressive symptoms (PHQ-9) included PSS-10 (OR = 1.10, 95% CI = 1.04-1.16), GAD-7 (OR = 1.38, 95% CI = 1.25-1.52), suicidal ideation (OR = 5.66, 95% CI = 3.37-9.51), and ISI-7 (OR = 1.17, 95% CI = 1.09-1.25). Approximately 98.08% of Chinese postgraduates studying stomatology reported experiencing at least moderate stress after the COVID-19 restrictions. Within the limitations of this study, senior students were more inclined to stress, while anxiety symptoms were related to severer levels of stress, depression, and insomnia. Depressive symptoms were associated with higher levels of stress, anxiety, insomnia, suicidal ideation, and lower levels of self-reported well-being. Thus, psychological interventions for postgraduates should be timely and appropriately implemented by strengthening well-being, reasonably planning for the future, and good physique, thereby mitigating the psychological issues after COVID-19 restrictions.

Psychological preservation of volunteers during the war: An empirical analysis

The article presents the results of an empirical study of the psychological self-preservation of volunteers with varying lengths of volunteer experience. The main structural components of psychological self preservation, the level of subjective stress, and the psychological safety of the individual are identified. The presence of meaning in life and personal characteristics such as extraversion, friendliness, conscientiousness, and openness to new experiences were examined. The use of basic coping strategies in stressful situations was analysed. In order to study the psychological self-preservation of the personality of volunteers through structural components, including cognitive, emotional, behavioural, and social, the following psychodiagnostic methods were used: Ukrainian adaptation of the short five-factor personality questionnaire (TIPI-UKR); “Express diagnostics of the psychological safety of the individual”; Questionnaire of the Perceived Stress Scale PSS-10; The Meaning of Life Questionnaire MLQ 2006, and the method of psychological diagnostics of coping mechanisms (E. Heim). Psychological self-preservation implies the ability of a person to effectively adapt to negative events and the ability to think positively and rationally assess the situation. This implies the ability to manage emotions, create a positive social environment, and have the resources to restore mental and physical health after difficult life events. It was found that in the subjects, with an increase in the duration of volunteer work, the level of subjective stress increases and the level of feeling of psychological safety decreases, which also indicates that volunteer work is a complex multifaceted process and requires resources and energy. However, with regard to the presence of meaning in life, it can be seen that with increasing experience of volunteering, there is a higher level of presence and search for meaning in life. It can be assumed that volunteer work and helping others gives a sense of self realisation, significance, and personal importance. The search for meaning in life is relevant for all the subjects studied and reflects the current situation of self-realisation both professional and personal life and serves as a structural element of the psychological self-preservation framework, giving meaning and awareness to a person's activities. Further study of the structural components of psychological self-preservation requires the development and implementation of psychological training on the development of resistance to stressful situations, taking into account the presented results of empirical research

골다공증 진단 여성노인의 삶의 질 영향요인

The purpose of this study was to investigate osteoporosis prevalence and factors influencing quality of life (HRQoL) among older Korean women with osteoporosis. The study design was a retrospective study using secondary data analysis. Data for 1,679 women aged 65 and older from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016 to 2020 were included. Linear regression analysis was conducted for influential factors on HRQoL, measured by the Euro Quality of Life-5D (EQ-5D). The prevalence of osteoporosis among older women was found to be 39.6%. Significant variations in quality of life were observed across demographic factors such as age, residence, marital status, household type, household income, education level, and economic activity. Similarly, health-related characteristics including depression, subjective health status, comorbidity, activity limitation, stress perception, alcohol consumption, body mass index, exercise, and aerobic activity showed statistically significant differences in the quality of life. Participants had an average quality of life score of 0.84 ± 0.005. Factors influencing quality of life included household type, household income, subjective health status, depression, activity limitation, stress levels, age, and body mass index. Quality of life was higher among those living alone, with higher household income, better subjective health status, lower levels of depression and activity restriction, reduced stress levels, younger age, and lower body mass index. The model's explanatory power was 34.1%. These findings underscore the necessity for comprehensive and individualized nursing intervention programs.

Feasibility of intranasal human milk as stem cell therapy in preterm infants with intraventricular hemorrhage.

Intraventricular hemorrhage (IVH) is a common cause of preterm brain injury. Fresh parent's own milk (POM) contains pluripotent stem cells (SCs) that produce neuronal cells in-vitro. The permeable neonatal blood brain barrier potentially allows SC delivery. We performed the first prospective trial (clinicaltrials.gov NCT04225286) of feasibility of intranasal POM (IPOM) in preterm infants with IVH and described SC content of POM samples. 37 Infants (mean gestation 27.7 ± 2.6 weeks, birthweight 1030 ± 320 g) with IVH (35.1% grade IV) were recruited from two tertiary Toronto NICUs. IPOM was given ideally twice daily until 28 days of age. Tolerance and adverse reactions were collected and 162 administering providers surveyed. There were no major adverse reactions. Provider surveys suggested acceptability, although potential provider and subject stress requires further study. Milk cell analysis suggests wide variability between parents. This phase 1 study demonstrated IPOM was tolerated and feasible in preterm infants.