The present study was undertaken to assess the beneficial role of M. puriens in infertile men (n=60) [normozoospermic infertile men (n=20), oligozoospermic (n=20) and asthenozoospermic (n=20)]. Age-matched 60 healthy men having normal semen parameters and who had previously initiated at least one pregnancy earlier were included as controls. Infertile subjects were prescribed M. puriens seed powder (5 g / day) orally for three months. For carrying out morphological and biochemical analysis, semen samples was collected twice, i.e. first before starting the treatment and there after three months of treatment, suggested a define role of oxidative stress in male infertility and the ability of M. puriens to treat such infertility. The semen samples collected from subjects and controls were evaluated for sperm count, motility, DNA damage, apoptosis, total ROS and the levels of lipid peroxides by standard techniques. Results demonstrated decreased sperm count and motility in infertile subjects. Moreover, elevated levels of total ROS, lipid peroxides, apoptosis and DNA damage was observed in the infertile men. Treatment with M. puriens significantly decreased ROS, LPO, apoptosis and DNA damage Moreover, following treatment with M. puriens, we observed a significantly improved sperm count and motility in infertile men. (poster)