To evaluate the self-healing performance of asphalt mixture under repeated loads, indoor three-point bending fatigue tests and self-healing tests were conducted on asphalt mixture AC-13. The stress control mode was selected to test the fatigue resistance of the mixture, and the dissipated energy recovery value and visco-elastic ratio were proposed to evaluate the self-healing performance of the mixture. The experimental results show that there is a good linear relationship between fatigue life and fatigue stress, and the damage degree to the mixture is exponentially related to the load times. The numerical dispersion of flexural tensile modulus is large, which is not suitable for evaluating the self-healing performance of the mixture. As the number of loading cycles increases, the hysteresis dissipated energy of the mixture gradually decreases and tends to stabilize. After the loading interval, due to the self-healing effect, the visco-elastic performance of the asphalt material is partially restored. The initial dissipated energy before and after interval can be used as an evaluation index for self-healing behavior, and there is a good linear relationship between the initial dissipated energy and the damage degree. Due to the deformation migration of the mixture during the initial loading stage before and after interval, the visco-elastic ratio has changed, and this change becomes more pronounced with the damage degree of the mixture, indicating that the self-healing ability of the mixture has also been improved.