This study focused on the compressive fatigue performance of nano-silica (NS) modified recycled aggregate concrete (RAC). 108 prism specimens with varying replacement ratios (i.e., 0 %, 50 %, and 100 %), NS soaking concentrations (i.e., 0 %, 1 %, 2 %, and 3 %), and stress levels Smax (i.e., 0.75, 0.8, 0.85, and 0.90) were designed for compressive fatigue test. The failure process and failure modes for the specimens were observed, the fatigue life curves of NS modified RAC under different design parameters were measured. Moreover, the relationships between different design parameters and fatigue life, fatigue strength were analyzed. The results revealed that the failure modes for specimens with different design parameters were mainly shear failure, conical failure and mixed failure. Fatigue life exhibited significant changes under different stress levels, decreasing notably with increasing stress levels. As the recycled coarse aggregate (RCA) replacement ratio increased, fatigue life demonstrated a decreasing trend. Based on the two-parameter Weibull distribution function, the fatigue life equation considering the influence of variable parameters under different failure probabilities was proposed. When the failure probability was 0.5, the specimen with a NS soaking concentration of 2 % exhibited the highest fatigue strength at the same replacement ratio.